Case Reports in Neurological Medicine最新文献

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Into a Shaking Limbo: Case Report of a Nonneoplastic Limbic Encephalitis with Faciobrachial Dystonic Seizures and Parkinsonism. 非肿瘤性边缘脑炎伴面臂肌张力障碍发作和帕金森病1例报告。
IF 0.9
Case Reports in Neurological Medicine Pub Date : 2020-03-15 eCollection Date: 2020-01-01 DOI: 10.1155/2020/3796807
Vijay Renga
{"title":"Into a Shaking Limbo: Case Report of a Nonneoplastic Limbic Encephalitis with Faciobrachial Dystonic Seizures and Parkinsonism.","authors":"Vijay Renga","doi":"10.1155/2020/3796807","DOIUrl":"https://doi.org/10.1155/2020/3796807","url":null,"abstract":"<p><p>This case report describes a rare but classic presentation of a non-paraneoplastic, antibody-mediated limbic encephalitis. The clinical course did put us in a limbo as it evolved from seizure to Parkinsonism and then from metastasis to stroke, before it finally announced itself by its pathognomonic finding. Knowledge of this rare condition is important as early identification and treatment can change the course.</p>","PeriodicalId":9615,"journal":{"name":"Case Reports in Neurological Medicine","volume":"2020 ","pages":"3796807"},"PeriodicalIF":0.9,"publicationDate":"2020-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/3796807","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37808775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bilateral Femoral Neuropathy: A Rare Complication of Drug Overdose due to Prolonged Posturing in Lithotomy Position. 双侧股神经病变:一个罕见的并发症药物过量,由于长时间的体位取石。
IF 0.9
Case Reports in Neurological Medicine Pub Date : 2020-03-10 eCollection Date: 2020-01-01 DOI: 10.1155/2020/2352850
D Tsiptsios, D Daud, K Tsamakis, E Rizos, A Anastadiadis, A Cassidy
{"title":"Bilateral Femoral Neuropathy: A Rare Complication of Drug Overdose due to Prolonged Posturing in Lithotomy Position.","authors":"D Tsiptsios,&nbsp;D Daud,&nbsp;K Tsamakis,&nbsp;E Rizos,&nbsp;A Anastadiadis,&nbsp;A Cassidy","doi":"10.1155/2020/2352850","DOIUrl":"https://doi.org/10.1155/2020/2352850","url":null,"abstract":"<p><strong>Background: </strong>Bilateral femoral neuropathy is an uncommon complication of various surgical and nonsurgical procedures, such as pelvic/abdominal surgery or vaginal delivery. <i>Case Report</i>. We report a case of a 41-year-old male who was found unresponsive against the wall in a \"lithotomy-type\" position with both knees flexed at approximately 90 degrees and both hips flexed and externally rotated at approximately 90 and 60 degrees, respectively, 24-48 hours after a drug overdose (combination of dihydrocodeine, paracetamol, diazepam, and amitriptyline). During his recovery, he complained of severe bilateral proximal lower limb weakness and bilateral distal lower limb pain and allodynia. His symptoms were initially attributed to critical illness myopathy/neuropathy (CIMN). However, thorough clinical and neurophysiological evaluation revealed that his symptoms were due to severe bilateral femoral neuropathies.</p><p><strong>Conclusions: </strong>To our knowledge, this is the first reported case of bilateral femoral nerve palsy due to prolonged posturing in a \"lithotomy-type\" position in the context of a drug overdose.</p>","PeriodicalId":9615,"journal":{"name":"Case Reports in Neurological Medicine","volume":"2020 ","pages":"2352850"},"PeriodicalIF":0.9,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/2352850","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37788639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A Transforaminal Endoscopic Surgical Technique for Treating Lumbar Disc Herniation in the Setting of Spina Bifida. 经椎间孔内窥镜手术技术治疗脊柱裂腰椎间盘突出症。
IF 0.9
Case Reports in Neurological Medicine Pub Date : 2020-03-09 eCollection Date: 2020-01-01 DOI: 10.1155/2020/1076847
Albert E Telfeian, Adetokunbo Oyelese, Jared Fridley, Rohaid Ali, Deus Cielo, Ziya L Gokaslan
{"title":"A Transforaminal Endoscopic Surgical Technique for Treating Lumbar Disc Herniation in the Setting of Spina Bifida.","authors":"Albert E Telfeian,&nbsp;Adetokunbo Oyelese,&nbsp;Jared Fridley,&nbsp;Rohaid Ali,&nbsp;Deus Cielo,&nbsp;Ziya L Gokaslan","doi":"10.1155/2020/1076847","DOIUrl":"https://doi.org/10.1155/2020/1076847","url":null,"abstract":"<p><p>Recent literature suggests that adult patients with spina bifida receive surgery for degenerative disc disease at higher rates than the general population. However, sometimes the complex anatomic features of co-occurring spina bifida and lumbar disc herniation can significantly challenge standard surgical techniques. Here, the technical steps are presented for treating a foraminal lumbar 4-5-disc herniation in the setting of a patient with multifaceted degenerative and spina bifida occulta anatomy. Utilized is a minimally invasive approach that does not require general anesthesia or fusion and allows the patient to leave the same day. To the best of our knowledge, this is the first-reported case of endoscopic surgical decompression of a lumbar disc in a patient with spina bifida.</p>","PeriodicalId":9615,"journal":{"name":"Case Reports in Neurological Medicine","volume":"2020 ","pages":"1076847"},"PeriodicalIF":0.9,"publicationDate":"2020-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/1076847","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37788638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on "CPEO and Mitochondrial Myopathy in a Patient with DGUOK Compound Heterozygous Pathogenetic Variant and mtDNA Multiple Deletions". 对“DGUOK复合杂合致病变异和mtDNA多缺失患者的CPEO和线粒体肌病”的评论。
IF 0.9
Case Reports in Neurological Medicine Pub Date : 2020-03-07 eCollection Date: 2020-01-01 DOI: 10.1155/2020/5846971
Josef Finsterer
{"title":"Comment on \"CPEO and Mitochondrial Myopathy in a Patient with <i>DGUOK</i> Compound Heterozygous Pathogenetic Variant and mtDNA Multiple Deletions\".","authors":"Josef Finsterer","doi":"10.1155/2020/5846971","DOIUrl":"https://doi.org/10.1155/2020/5846971","url":null,"abstract":"","PeriodicalId":9615,"journal":{"name":"Case Reports in Neurological Medicine","volume":"2020 ","pages":"5846971"},"PeriodicalIF":0.9,"publicationDate":"2020-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/5846971","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37849633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unusual Phenotype and Disease Trajectory in Kearns-Sayre Syndrome. 卡恩斯-塞尔综合征的异常表型和疾病轨迹。
IF 0.9
Case Reports in Neurological Medicine Pub Date : 2020-02-27 eCollection Date: 2020-01-01 DOI: 10.1155/2020/7368527
Josef Finsterer, Michael Winklehner, Claudia Stöllberger, Thomas Hummel
{"title":"Unusual Phenotype and Disease Trajectory in Kearns-Sayre Syndrome.","authors":"Josef Finsterer, Michael Winklehner, Claudia Stöllberger, Thomas Hummel","doi":"10.1155/2020/7368527","DOIUrl":"10.1155/2020/7368527","url":null,"abstract":"<p><strong>Objective: </strong>To describe unusual course and unusual phenotypic features in an adult patient with Kearns-Sayre syndrome (KSS). <i>Case Report</i>. The patient is a 49-year-old male with KSS, diagnosed clinically upon the core features, namely, onset before the age 20 of years, pigmentary retinopathy, and ophthalmoparesis, and the complementary features, namely, elevated CSF protein, cardiac conduction defects, and cerebellar ataxia. The patient presented also with other previously described features, such as diabetes, short stature, white matter lesions, hypoacusis, migraine, hepatopathy, steatosis hepatis, hypocorticism (hyponatremia), and cataract. Unusual features the patient presented with were congenital anisocoria, severe caries, liver cysts, pituitary enlargement, desquamation of hands and feet, bone chondroma, aortic ectasia, dermoidal cyst, and sinusoidal polyposis. The course was untypical since most of the core phenotypic features developed not earlier than in adulthood.</p><p><strong>Conclusions: </strong>KSS is a multisystem disease, but the number of tissues affected is higher than so far anticipated. KSS should be considered even if core features develop not earlier than in adulthood and if unusual features accompany the presentation.</p>","PeriodicalId":9615,"journal":{"name":"Case Reports in Neurological Medicine","volume":"2020 ","pages":"7368527"},"PeriodicalIF":0.9,"publicationDate":"2020-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/7368527","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37743726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Early Aggressive Immunotherapy Improves Functional Outcome in Chronic Immune Sensory Polyradiculopathy. 早期积极免疫治疗改善慢性免疫感觉性多神经根病的功能结局。
IF 0.9
Case Reports in Neurological Medicine Pub Date : 2020-02-20 eCollection Date: 2020-01-01 DOI: 10.1155/2020/6595086
Jasmine Shimin Koh, James Wei Min Tung, Genevieve Lynn Yu Tan-Yu, Thirugnanam Umapathi
{"title":"Early Aggressive Immunotherapy Improves Functional Outcome in Chronic Immune Sensory Polyradiculopathy.","authors":"Jasmine Shimin Koh,&nbsp;James Wei Min Tung,&nbsp;Genevieve Lynn Yu Tan-Yu,&nbsp;Thirugnanam Umapathi","doi":"10.1155/2020/6595086","DOIUrl":"https://doi.org/10.1155/2020/6595086","url":null,"abstract":"<p><p>Chronic immune sensory polyradiculopathy (CISP) is an uncommon and treatable inflammatory disorder of the proximal sensory nerve roots. Patients typically present with severe sensory ataxia, normal motor examination, unsteady gait, and normal nerve conduction studies (NCS). We describe an elderly man who presented with a two-week history of progressive numbness of both legs and recurrent falls. He had hyporeflexia, normal strength, severe proprioceptive, and vibration sense loss in both lower limbs and was unable to stand or walk because of severe sensory ataxia. The NCS and MR scan of the spine were normal. Tibial somatosensory evoked potentials revealed proximal conduction defect and localized the pathology to the lumbar sensory nerve roots proximal to the dorsal root ganglion. Cerebrospinal fluid showed cytoalbuminergic dissociation suggestive of inflammation. CISP was diagnosed; he was given aggressive immunotherapy consisting sequentially of corticosteroids with mycophenolate mofetil and three cycles of intravenous immunoglobulin after which he regained independent mobility. Unlike previous reports where patients presented months-years after symptom onset and improved after single-line immunotherapy, our patient presented fairly acutely and made dramatic improvement only after aggressive combination therapy. We urge physicians to recognize this uncommon neurologic cause of sensory ataxia where early aggressive treatment is crucial for better functional outcomes.</p>","PeriodicalId":9615,"journal":{"name":"Case Reports in Neurological Medicine","volume":"2020 ","pages":"6595086"},"PeriodicalIF":0.9,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/6595086","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37718730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Immediate Response to Chemotherapy in an Adult Neuroblastoma Patient Presenting with Cord Compression. 以脊髓受压为表现的成人神经母细胞瘤患者化疗的即时反应。
IF 0.9
Case Reports in Neurological Medicine Pub Date : 2020-02-19 eCollection Date: 2020-01-01 DOI: 10.1155/2020/6401497
Nedal Bukhari, Bachar Harfouch, Majid Shallal Alotaibi, Hulayel Al-Harbi, Omar Chamdine
{"title":"Immediate Response to Chemotherapy in an Adult Neuroblastoma Patient Presenting with Cord Compression.","authors":"Nedal Bukhari,&nbsp;Bachar Harfouch,&nbsp;Majid Shallal Alotaibi,&nbsp;Hulayel Al-Harbi,&nbsp;Omar Chamdine","doi":"10.1155/2020/6401497","DOIUrl":"https://doi.org/10.1155/2020/6401497","url":null,"abstract":"<p><p>We report a case of a 31-year-old female patient with high-risk neuroblastoma (NBL) who presented with a history of static back pain and bilateral lower limb weakness for almost a month. Her primary tumor was located in the right paraspinal region, causing spinal cord compression (SCC). Chemotherapy was administered with an immediate clinical improvement noted after 24 hours of starting treatment. We herein report the efficacy of chemotherapy in an adult neuroblastoma (aNBL) patient presenting with spinal cord compression.</p>","PeriodicalId":9615,"journal":{"name":"Case Reports in Neurological Medicine","volume":"2020 ","pages":"6401497"},"PeriodicalIF":0.9,"publicationDate":"2020-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/6401497","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37718729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A Patient with Combined CADASIL and MTHFR Homozygosity. 合并CADASIL和MTHFR纯合子的患者1例。
IF 0.9
Case Reports in Neurological Medicine Pub Date : 2020-02-17 eCollection Date: 2020-01-01 DOI: 10.1155/2020/4980847
Sidonie Ibrikji, Tarek El Halabi, Bassem Yamout
{"title":"A Patient with Combined CADASIL and MTHFR Homozygosity.","authors":"Sidonie Ibrikji,&nbsp;Tarek El Halabi,&nbsp;Bassem Yamout","doi":"10.1155/2020/4980847","DOIUrl":"https://doi.org/10.1155/2020/4980847","url":null,"abstract":"<p><p>Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is an inherited disorder caused by a mutation in the NOTCH 3 gene, characterized by early onset of subcortical lacunar infarcts in the absence of vascular risk factors and cerebral microbleeds. Homozygosity for the factor Methylenetetrahydrofolate Reductase (MTHFR) is also associated with lacunar stroke risk and cerebral small-vessel disease regardless of the homocysteine level. The coexistence of MTHFR C677T homozygosity and NOTCH 3 mutation has never been reported in the literature previously, and that brings up the challenge of antithrombotic treatment in the presence of cerebral microbleeds.</p>","PeriodicalId":9615,"journal":{"name":"Case Reports in Neurological Medicine","volume":"2020 ","pages":"4980847"},"PeriodicalIF":0.9,"publicationDate":"2020-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/4980847","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37702865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of Tocilizumab in Limbic Encephalitis with Anti-CASPR2 Antibodies. 托珠单抗治疗伴有抗caspr2抗体的边缘脑炎疗效观察。
IF 0.9
Case Reports in Neurological Medicine Pub Date : 2020-02-14 eCollection Date: 2020-01-01 DOI: 10.1155/2020/5697670
Maurizio Benucci, Luciana Tramacere, Maria Infantino, Mariangela Manfredi, Valentina Grossi, Arianna Damiani, Francesca Li Gobbi, Maristella Piccininni, Gaetano Zaccara, Massimo Cincotta
{"title":"Efficacy of Tocilizumab in Limbic Encephalitis with Anti-CASPR2 Antibodies.","authors":"Maurizio Benucci,&nbsp;Luciana Tramacere,&nbsp;Maria Infantino,&nbsp;Mariangela Manfredi,&nbsp;Valentina Grossi,&nbsp;Arianna Damiani,&nbsp;Francesca Li Gobbi,&nbsp;Maristella Piccininni,&nbsp;Gaetano Zaccara,&nbsp;Massimo Cincotta","doi":"10.1155/2020/5697670","DOIUrl":"https://doi.org/10.1155/2020/5697670","url":null,"abstract":"<p><p>We report the case of a 64-year-old man who presented with subacute memory, balance impairment, behavioral and mood changes, and epileptic seizures. Magnetic resonance imaging (MRI) showed bilateral hippocampal abnormalities. Brain [<sup>18</sup>F]-FDG fluorodeoxyglucose positron emission tomography (PET) revealed hypometabolism in both the temporal lobe as well as in the left insular and parietal regions. The clinical and neuroradiological picture and the detection of anti-CASPR2 antibodies in serum oriented the diagnosis towards autoimmune limbic encephalitis. Intravenous high-dose steroid and immunoglobulin treatments were ineffective. We did not use rituximab for the presence of antibodies to HbcAg positivity. Tocilizumab given intravenously 8 mg/kg once a month for six months and then subcutaneously 162 mg every week for six months resulted in clinical and neuroradiological improvement. These data support the efficacy of tocilizumab in autoimmune limbic encephalitis associated with anti-CASPR2 antibodies, which has been sporadically reported in the literature.</p>","PeriodicalId":9615,"journal":{"name":"Case Reports in Neurological Medicine","volume":"2020 ","pages":"5697670"},"PeriodicalIF":0.9,"publicationDate":"2020-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/5697670","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37687570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Treatment of a Woman with Inoperable Meningioma Using Mifepristone for 26 Years. 使用米非司酮治疗无法手术的脑膜瘤妇女 26 年。
IF 0.9
Case Reports in Neurological Medicine Pub Date : 2020-02-11 eCollection Date: 2020-01-01 DOI: 10.1155/2020/5162918
Maria das Dores Medina-Lopes, Luiz Augusto Casulari
{"title":"Treatment of a Woman with Inoperable Meningioma Using Mifepristone for 26 Years.","authors":"Maria das Dores Medina-Lopes, Luiz Augusto Casulari","doi":"10.1155/2020/5162918","DOIUrl":"10.1155/2020/5162918","url":null,"abstract":"<p><p>Meningioma treatment includes observation of its growth or surgery with or without associated radiotherapy. However, drug treatment can be used for tumors deemed inoperable because of their size and location. Due to the presence of progesterone receptors, the use of antiprogestin mifepristone is recommended. This study describes a case of inoperable meningioma treated with mifepristone for 26 years without interruption. The patient is a 45-year-old woman diagnosed with plaque meningioma, extending from the bottom of her right orbit, through the length of the small wing of the sphenoid, part of the large wing of the sphenoid, especially near the superior orbital fissure, and at the ceiling of the orbit. As this meningioma was considered inoperable, treatment with 200 mg oral mifepristone was administered uninterruptedly for 26 years. This treatment initially halted the growth of the meningioma and subsequently resulted in a small reduction of its volume; however, the meningioma has persisted until the last evaluation. After five years of mifepristone use, hydroxyurea was added for nine months but was discontinued due to anemia and leucopenia. In conclusion, mifepristone was useful for the survival of the patient for those 26 years. The drug interfered with the natural history of the meningioma, which generally evolves to death in such long follow-up durations without associated surgery or radiation therapy.</p>","PeriodicalId":9615,"journal":{"name":"Case Reports in Neurological Medicine","volume":"2020 ","pages":"5162918"},"PeriodicalIF":0.9,"publicationDate":"2020-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37674243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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