Canadian Medical Association journal最新文献

{"title":"Lupus vulgaris in a 58-year-old man.","authors":"Chen Wang, Jianjun Qiao","doi":"10.1503/cmaj.241343","DOIUrl":"10.1503/cmaj.241343","url":null,"abstract":"","PeriodicalId":9609,"journal":{"name":"Canadian Medical Association journal","volume":"197 8","pages":"E215"},"PeriodicalIF":9.4,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Les personnes en fauteuil roulant.","authors":"Lisa Freeman","doi":"10.1503/cmaj.241433-f","DOIUrl":"10.1503/cmaj.241433-f","url":null,"abstract":"","PeriodicalId":9609,"journal":{"name":"Canadian Medical Association journal","volume":"197 7","pages":"E201-E202"},"PeriodicalIF":9.4,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11867597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sodium-glucose cotransporter 2 (SGLT2) inhibitors and risk of chronic kidney disease-mineral and bone disorders in patients with type 2 diabetes mellitus and stage 1-3 chronic kidney disease.","authors":"Daniel Hsiang-Te Tsai, Albert Tzu-Ming Chuang, Kuan-Hung Liu, Shih-Chieh Shao, Edward Chia-Cheng Lai","doi":"10.1503/cmaj.240922","DOIUrl":"10.1503/cmaj.240922","url":null,"abstract":"<p><strong>Background: </strong>In patients with type 2 diabetes mellitus and chronic kidney disease (CKD), sodium-glucose cotransporter 2 (SGLT2) inhibitors improve renal outcomes, but may transiently affect biochemical markers of CKD-mineral and bone disorders (CKD-MBD). We sought to evaluate the long-term risk of CKD-MBD associated with use of SGLT2 inhibitors in this patient population.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study, employing a target trial emulation framework and using electronic medical records of patients from 9 hospitals in Taiwan (2016-2023). We included adults with type 2 diabetes mellitus and stage 1-3 CKD who had newly started either an SGLT2 inhibitor or, as a comparison group, a glucagon-like peptide-1 receptor agonist (GLP-1 RA). The primary outcome was a composite of incident biochemical abnormalities (serum phosphate > 1.5 mmol/L, serum calcium < 2.1 mmol/L, serum intact parathyroid hormone [iPTH] > 6.9 pmol/L, or serum 25-hydroxyvitamin D < 49.9 nmol/L).</p><p><strong>Results: </strong>The cohort included 13 379 patients receiving SGLT2 inhibitors (<i>n</i> = 11 920) or GLP-1 RAs (<i>n</i> = 1459) with a median follow-up of 3.3 years. Compared with GLP-1 RAs, SGLT2 inhibitors were associated with a lower cumulative incidence of the composite primary outcome (hazard ratio [HR] 0.82, 95% confidence interval [CI] 0.79-0.86), hyperphosphatemia (HR 0.83, 95% CI 0.76-0.91), hypocalcemia (HR 0.82, 95% CI 0.78-0.86), high serum iPTH levels (HR 0.66, 95% CI 0.57-0.78), and low serum 25-hydroxyvitamin D levels (HR 0.65, 95% CI 0.47-0.90).</p><p><strong>Interpretation: </strong>Use of SGLT2 inhibitors was associated with a lower incidence of biochemical abnormalities related to CKD-MBD than GLP-1 RAs. These agents may be considered to reduce risk of CKD-MBD in patients with type 2 diabetes mellitus and stage 1-3 CKD.</p>","PeriodicalId":9609,"journal":{"name":"Canadian Medical Association journal","volume":"197 7","pages":"E178-E189"},"PeriodicalIF":9.4,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11867598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Petechial periflexural exanthem associated with parvovirus B19 infection in an 18-year-old.","authors":"Emilio Berna-Rico, Carlos Azcarraga-Llobet, Javier Pérez-Bootello","doi":"10.1503/cmaj.241176","DOIUrl":"10.1503/cmaj.241176","url":null,"abstract":"","PeriodicalId":9609,"journal":{"name":"Canadian Medical Association journal","volume":"197 7","pages":"E191"},"PeriodicalIF":9.4,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11867596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypotension posturale chez un patient VIH-positif : Insuffisance surrénalienne due aux interactions fluticasone–cobicistat.","authors":"Serena Dienes, Robert Nunn, Alison Lai","doi":"10.1503/cmaj.240796-f","DOIUrl":"10.1503/cmaj.240796-f","url":null,"abstract":"","PeriodicalId":9609,"journal":{"name":"Canadian Medical Association journal","volume":"197 7","pages":"E195-E198"},"PeriodicalIF":9.4,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11867593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Saignement post-amygdalectomie chez l’enfant.","authors":"Jennifer M Siu, Evan J Propst, Nikolaus E Wolter","doi":"10.1503/cmaj.240891-f","DOIUrl":"10.1503/cmaj.240891-f","url":null,"abstract":"","PeriodicalId":9609,"journal":{"name":"Canadian Medical Association journal","volume":"197 7","pages":"E199-E200"},"PeriodicalIF":9.4,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11867603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sur papier.","authors":"Holly Bodger","doi":"10.1503/cmaj.241840-f","DOIUrl":"10.1503/cmaj.241840-f","url":null,"abstract":"","PeriodicalId":9609,"journal":{"name":"Canadian Medical Association journal","volume":"197 7","pages":"E203"},"PeriodicalIF":9.4,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11867600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trust during a prolonged journey with trigeminal neuralgia.","authors":"Isabella Spensieri","doi":"10.1503/cmaj.241308","DOIUrl":"10.1503/cmaj.241308","url":null,"abstract":"","PeriodicalId":9609,"journal":{"name":"Canadian Medical Association journal","volume":"197 7","pages":"E193-E194"},"PeriodicalIF":9.4,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11867599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bispecific antibody toxicities.","authors":"Joanne Britto, Hira Mian, Gwynivere A Davies, Amaris K Balitsky","doi":"10.1503/cmaj.241384","DOIUrl":"10.1503/cmaj.241384","url":null,"abstract":"","PeriodicalId":9609,"journal":{"name":"Canadian Medical Association journal","volume":"197 7","pages":"E190"},"PeriodicalIF":9.4,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11867601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interoperability of health data: the importance of including physicians.","authors":"Ashley P Miller, Kathleen Ross, Edward M Brown, Chandi Chandrasena, Onil Bhattacharya","doi":"10.1503/cmaj.151780-l","DOIUrl":"10.1503/cmaj.151780-l","url":null,"abstract":"","PeriodicalId":9609,"journal":{"name":"Canadian Medical Association journal","volume":"197 7","pages":"E192"},"PeriodicalIF":9.4,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11867602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}