Calcified Tissue International最新文献_第6页

Association Between Dietary Acid Load and Grip Strength in Adults 50 Years and Older: A Cross-Sectional Study. 50 岁及以上成年人膳食酸负荷与握力之间的关系：一项横断面研究

IF 3.3 3区医学

Calcified Tissue International Pub Date : 2024-10-01 Epub Date: 2024-07-24 DOI: 10.1007/s00223-024-01258-5

Elsa M Konieczynski, Lisa Ceglia, Elise Reitshamer, Bess Dawson-Hughes

{"title":"Association Between Dietary Acid Load and Grip Strength in Adults 50 Years and Older: A Cross-Sectional Study.","authors":"Elsa M Konieczynski, Lisa Ceglia, Elise Reitshamer, Bess Dawson-Hughes","doi":"10.1007/s00223-024-01258-5","DOIUrl":"10.1007/s00223-024-01258-5","url":null,"abstract":"Minimal data exist on whether the acid-base balance of the diet is linked to muscle strength. The aim of this study was to determine if dietary acid load is associated with grip strength in a nationally representative sample of middle- to older-age adults. We examined the cross-sectional association of grip strength with dietary acid load quantified through potential renal acid load (PRAL) and net endogenous acid production (NEAP) in 4,059 adults aged 50 years and older in the 2011-2014 NHANES survey cycles. PRAL and NEAP were estimated from two 24-h recalls and categorized into sex-specific quartiles. Grip strength was measured on a dynamometer. Multiple linear regression models were used to determine the associations of PRAL and NEAP (as quartiles) with grip strength for men and women separately, adjusting for total energy, age, race/ethnicity, weight, physical activity, smoking, serum 25-hydroxyvitamin D, and estimated glomerular filtration rate. Mean grip strength was 26.8 ± 0.2 kg in women and 43.0 ± 0.4 kg in men. Adjusted grip strength was inversely associated with quartiles of PRAL (ptrend = 0.049) and NEAP (ptrend = 0.034) in women with quartile 4 vs 1 differences of - 1.21 and - 1.08 kg (both p < 0.05), respectively. Adjusted grip strength was not associated with PRAL or NEAP in men. Overall, we found inverse associations between dietary acid load and grip strength in middle- and older-age women, suggesting that an alkaline diet may be important in maintaining muscle strength in this population. There was no association between dietary acid load and grip strength in men.","PeriodicalId":9601,"journal":{"name":"Calcified Tissue International","volume":" ","pages":"373-381"},"PeriodicalIF":3.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141751187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Higher Plasma Copper Exposure was Adversely Associated with Skeletal Muscle Indicators in Chinese Children Aged 6–9 Years: A Cross-Sectional Study 中国 6-9 岁儿童较高的血浆铜暴露量与骨骼肌指标呈负相关：一项横断面研究

IF 4.2 3区医学

Calcified Tissue International Pub Date : 2024-09-18 DOI: 10.1007/s00223-024-01287-0

Jie Xu, Jing Lan, Qiaoting Huang, Abubakar Tarawally, Lan Huang, Zheqing Zhang, Gengdong Chen

{"title":"Higher Plasma Copper Exposure was Adversely Associated with Skeletal Muscle Indicators in Chinese Children Aged 6–9 Years: A Cross-Sectional Study","authors":"Jie Xu, Jing Lan, Qiaoting Huang, Abubakar Tarawally, Lan Huang, Zheqing Zhang, Gengdong Chen","doi":"10.1007/s00223-024-01287-0","DOIUrl":"https://doi.org/10.1007/s00223-024-01287-0","url":null,"abstract":"It is unclear whether blood concentrations of copper (Cu), magnesium (Mg), and calcium (Ca) influence skeletal muscle mass and strength in children. We aimed to explore the associations between plasma Cu, Mg, and Ca and skeletal muscle indicators in Chinese children. A total of 452 children aged 6 to 9 years old were recruited for this cross-sectional study. Whole body lean soft tissue mass (WLSTM), trunk lean soft tissue mass (TLSTM), and appendicular skeletal muscle mass (ASMM) were measured using dual-energy X-ray absorptiometry. Parameters of these indicators divided by Height2 (Ht2) and Weight (Wt) at the corresponding sites were calculated. Handgrip strength was also measured. Parameters of skeletal muscle indicators and handgrip strength that were below the sex-specific 20th percentile were considered low levels. Plasma concentrations of Cu, Mg, and Ca were measured using ICP-MS. After adjusting for several potential covariates, among the total subjects, for every one standard deviation increase in Cu concentrations, there was a 0.939% decrease in WLSTM/Wt, a 0.415% decrease in TLSTM/Wt, and a 0.47% decrease in ASMM/Wt. For every one standard deviation increase in Cu concentrations, there was a higher odd (OR: 1.36, 95%CI 1.06, 1.75) of low WLSTM/Wt, TLSTM/Wt (OR: 1.33, 95%CI 1.03, 1.71), ASMM/Ht2 (OR: 1.32, 95%CI 1.02, 1.69), as well as ASMM/Wt (OR: 1.56, 95%CI 1.23, 1.99). No significant associations were found between Mg, Ca, and most skeletal muscle indicators. Higher plasma Cu concentrations were adversely associated with skeletal muscle indicators at multiple sites in Chinese children.","PeriodicalId":9601,"journal":{"name":"Calcified Tissue International","volume":"16 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142249771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dental Abnormalities in Osteogenesis Imperfecta: A Systematic Review 成骨不全症的牙齿异常：系统综述

IF 4.2 3区医学

Calcified Tissue International Pub Date : 2024-09-18 DOI: 10.1007/s00223-024-01293-2

Laura Ventura, Sara J. E. Verdonk, Lidiia Zhytnik, Angela Ridwan-Pramana, Marjolijn Gilijamse, Willem H. Schreuder, Kirsten A. van Gelderen-Ziesemer, Ton Schoenmaker, Dimitra Micha, Elisabeth M. W. Eekhoff

{"title":"Dental Abnormalities in Osteogenesis Imperfecta: A Systematic Review","authors":"Laura Ventura, Sara J. E. Verdonk, Lidiia Zhytnik, Angela Ridwan-Pramana, Marjolijn Gilijamse, Willem H. Schreuder, Kirsten A. van Gelderen-Ziesemer, Ton Schoenmaker, Dimitra Micha, Elisabeth M. W. Eekhoff","doi":"10.1007/s00223-024-01293-2","DOIUrl":"https://doi.org/10.1007/s00223-024-01293-2","url":null,"abstract":"Osteogenesis imperfecta (OI) is a rare genetic disorder characterized by fragile bones and skeletal deformities. Individuals with OI may have dental abnormalities such as dentinogenesis imperfecta (DI) type I, malocclusions, and unerupted or missing teeth. This review comprehensively examines these dental abnormalities to assess their prevalence among the OI population and explore potential differences across different clinical types of OI and pathogenic variants. In accordance with the PRISMA guidelines, a systematic literature search in PubMed, Embase, and Web of Science was conducted that included articles up to June 2024. Out of 672 articles screened, 34 were included. The included studies confirmed that dental abnormalities are prevalent in OI, with DI prevalence ranging from approximately 20 to 48%. Those with a more severe skeletal phenotype (OI type III/IV) exhibited more dental abnormalities than those with a milder skeletal phenotype (OI type I). Notably, OI type V individuals generally do not have DI, although a few isolated cases have been reported. The prevalence of occlusion types varied: Class I occlusion ranged from 14.8 to 50% and Class II malocclusion ranged from 0 to 37.5%, while Class III malocclusion from 4.1 to 84%. This differs from the general population, where Class III malocclusion is typically the least common. Open bites, cross-bites, and unerupted and missing teeth are also commonly reported, particularly in OI types III and IV. This review emphasizes the need for comprehensive dental examinations in OI due to the high prevalence of dental abnormalities. Additionally, the review draws attention to the lack of clear guidelines for diagnosing DI.","PeriodicalId":9601,"journal":{"name":"Calcified Tissue International","volume":"95 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142249770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Irisin Ameliorates Muscle Atrophy by Inhibiting the Upregulation of the Ubiquitin‒Proteasome System in Chronic Kidney Disease 鸢尾素通过抑制慢性肾病患者泛素-蛋白酶体系统的上调改善肌肉萎缩状况

IF 4.2 3区医学

Calcified Tissue International Pub Date : 2024-09-16 DOI: 10.1007/s00223-024-01283-4

Shiyuan Wang, Yajing Pan, Qi Pang, Aihua Zhang

{"title":"Irisin Ameliorates Muscle Atrophy by Inhibiting the Upregulation of the Ubiquitin‒Proteasome System in Chronic Kidney Disease","authors":"Shiyuan Wang, Yajing Pan, Qi Pang, Aihua Zhang","doi":"10.1007/s00223-024-01283-4","DOIUrl":"https://doi.org/10.1007/s00223-024-01283-4","url":null,"abstract":"Muscle atrophy is a common complication of chronic kidney disease (CKD). Irisin, a novel muscle cytokine, protects against muscle atrophy, but its specific role in CKD-associated muscle atrophy requires further elucidation. Because the ubiquitin–proteasome system (UPS) plays an important role in CKD muscle atrophy, our study will explore whether irisin affects UPS and alleviate CKD-associated muscle atrophy. In this study, an adenine-fed mouse model of CKD and urotension II (UII)-induced C2C12 myotubes were used as in vivo and in vitro models of muscle atrophy. The results showed that renal function, mouse weight, and the cross-sectional area (CSA) of skeletal muscles were significantly improved in CKD mice treated with irisin. Moreover, irisin effectively mitigated the decreases in phosphorylated Forkhead box O 3a (p-FOXO3A) levels and increases in the levels of E3 ubiquitin ligases, such as muscle RING finger 1 (MuRF1) and muscle atrophy F-box (MAFbx/atrogin1), in both the muscles of CKD mice and UII-induced C2C12 myotubes. In addition, irisin significantly increased the expression levels of myogenic differentiation factor D (MyoD) in the muscles of CKD mice. Our study is the first to demonstrate that irisin ameliorates skeletal muscle atrophy by inhibiting UPS upregulation and improving satellite cell differentiation in CKD.","PeriodicalId":9601,"journal":{"name":"Calcified Tissue International","volume":"13 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142249772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex-Specific Association of Clinical Parameters and Components of Femoral Bone Quality in Patients Undergoing Total Hip Arthroplasty 全髋关节置换术患者临床参数与股骨骨质成分的性别特异性关联

IF 4.2 3区医学

Calcified Tissue International Pub Date : 2024-09-14 DOI: 10.1007/s00223-024-01286-1

Assil-Ramin Alimy, Maximilian Lenard Thiessen, André Strahl, Christoph Kolja Boese, Simon von Kroge, Frank Timo Beil, Tim Rolvien, Christian Ries

{"title":"Sex-Specific Association of Clinical Parameters and Components of Femoral Bone Quality in Patients Undergoing Total Hip Arthroplasty","authors":"Assil-Ramin Alimy, Maximilian Lenard Thiessen, André Strahl, Christoph Kolja Boese, Simon von Kroge, Frank Timo Beil, Tim Rolvien, Christian Ries","doi":"10.1007/s00223-024-01286-1","DOIUrl":"https://doi.org/10.1007/s00223-024-01286-1","url":null,"abstract":"Poor bone quality is a critical factor associated with an increased risk of complications after total hip arthroplasty (THA). However, no consistent recommendations have yet been established for assessing indicators of bone quality preoperatively. Thus, it remains unclear which preoperatively available and readily accessible parameters are most closely associated with femoral bone quality. Here, we obtained femoral neck specimens from 50 patients undergoing THA. Preoperative Dual-energy X-ray absorptiometry (DXA) scans, pelvic radiographs, and laboratory parameters were analyzed. In the obtained specimens, bone microstructure was assessed using micro-CT and histomorphometry. Additionally, matrix mineralization and osteocyte lacunar morphology were evaluated using quantitative backscattered electron imaging. Our analysis revealed that DXA-derived T-scores correlated with trabecular microstructure. Furthermore, radiographic indices and body mass index correlated differentially with aspects of bone quality in women and men. Contrary to previous observations, no correlation was found between serum vitamin D levels and osteoid indices, nor between clinical parameters and matrix mineralization. Age was strongly associated with the number of mineralized osteocyte lacunae, a factor that appeared to be independent of sex. Taken together, our study demonstrates that no single preoperatively available parameter exhibits a strong and consistent association with femoral bone quality. However, DXA remains a reliable preoperative measure for determining the trabecular microstructure of the femoral neck. In clinical practice, surgeons should adopt an individualized approach to preoperative assessments by considering age, sex, BMI, and radiographic indices to enhance their insight into femoral bone quality, particularly when DXA is unavailable.","PeriodicalId":9601,"journal":{"name":"Calcified Tissue International","volume":"1 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142249775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Osteocyte Sptbn1 Deficiency Alters Cell Survival and Mechanotransduction Following Formation of Plasma Membrane Disruptions (PMD) from Mechanical Loading 骨细胞 Sptbn1 基因缺陷会改变细胞存活率和机械负荷形成质膜破坏 (PMD) 后的机械传导性

IF 4.2 3区医学

Calcified Tissue International Pub Date : 2024-09-14 DOI: 10.1007/s00223-024-01285-2

Mackenzie L. Hagan, Anik Tuladhar, Kanglun Yu, Dima W. Alhamad, Husam Bensreti, Jennifer Dorn, Victor M. Piedra, Nicholas Cantu, Eric G. Stokes, Daniel Blumenthal, Rachel L. Roberts, Vanshika Balayan, Sarah M. Bass, Thomas Dickerson, Anabel Liyen Cartelle, Marlian Montesinos-Cartagena, Mohamed E. Awad, Alberto A. Castro, Theodore Garland, Marion A. Cooley, Maribeth Johnson, Mark W. Hamrick, Paul L. McNeil, Meghan E. McGee-Lawrence

{"title":"Osteocyte Sptbn1 Deficiency Alters Cell Survival and Mechanotransduction Following Formation of Plasma Membrane Disruptions (PMD) from Mechanical Loading","authors":"Mackenzie L. Hagan, Anik Tuladhar, Kanglun Yu, Dima W. Alhamad, Husam Bensreti, Jennifer Dorn, Victor M. Piedra, Nicholas Cantu, Eric G. Stokes, Daniel Blumenthal, Rachel L. Roberts, Vanshika Balayan, Sarah M. Bass, Thomas Dickerson, Anabel Liyen Cartelle, Marlian Montesinos-Cartagena, Mohamed E. Awad, Alberto A. Castro, Theodore Garland, Marion A. Cooley, Maribeth Johnson, Mark W. Hamrick, Paul L. McNeil, Meghan E. McGee-Lawrence","doi":"10.1007/s00223-024-01285-2","DOIUrl":"https://doi.org/10.1007/s00223-024-01285-2","url":null,"abstract":"We and others have shown that application of high-level mechanical loading promotes the formation of transient plasma membrane disruptions (PMD) which initiate mechanotransduction. We hypothesized that increasing osteocyte cell membrane fragility, by disrupting the cytoskeleton-associated protein β2-spectrin (Sptbn1), could alter osteocytic responses and bone adaptation to loading in a PMD-related fashion. In MLO-Y4 cells, treatment with the spectrin-disrupting agent diamide or knockdown of Sptbn1 via siRNA increased the number of PMD formed by fluid shear stress. Primary osteocytes from an osteocyte-targeted DMP1-Cre Sptbn1 conditional knockout (CKO) model mimicked trends seen with diamide and siRNA treatment and suggested the creation of larger PMD, which repaired more slowly, for a given level of stimulus. Post-wounding cell survival was impaired in all three models, and calcium signaling responses from the wounded osteocyte were mildly altered in Sptbn1 CKO cultures. Although Sptbn1 CKO mice did not demonstrate an altered skeletal phenotype as compared to WT littermates under baseline conditions, they showed a blunted increase in cortical thickness when subjected to an osteogenic tibial loading protocol as well as evidence of increased osteocyte death (increased lacunar vacancy) in the loaded limb after 2 weeks of loading. The impaired post-wounding cell viability and impaired bone adaptation seen with Sptbn1 disruption support the existence of an important role for Sptbn1, and PMD formation, in osteocyte mechanotransduction and bone adaptation to mechanical loading.","PeriodicalId":9601,"journal":{"name":"Calcified Tissue International","volume":"36 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142249773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling the Mechanisms of Hypertrophy-Induced Matrix Mineralization and Modifications in Articular Chondrocytes. 揭示肥大诱导关节软骨细胞基质矿化和改变的机制

IF 3.3 3区医学

Calcified Tissue International Pub Date : 2024-09-01 Epub Date: 2024-06-25 DOI: 10.1007/s00223-024-01229-w

Ilhem Lilia Jaabar, Brittany Foley, Alberto Mezzetti, Françoise Pillier, Francis Berenbaum, Jessem Landoulsi, Xavier Houard

{"title":"Unraveling the Mechanisms of Hypertrophy-Induced Matrix Mineralization and Modifications in Articular Chondrocytes.","authors":"Ilhem Lilia Jaabar, Brittany Foley, Alberto Mezzetti, Françoise Pillier, Francis Berenbaum, Jessem Landoulsi, Xavier Houard","doi":"10.1007/s00223-024-01229-w","DOIUrl":"10.1007/s00223-024-01229-w","url":null,"abstract":"Chondrocyte hypertrophic differentiation is a main event leading to articular cartilage degradation in osteoarthritis. It is associated with matrix remodeling and mineralization, the dynamics of which is not well characterized during chondrocyte hypertrophic differentiation in articular cartilage. Based on an in vitro model of progressive differentiation of immature murine articular chondrocytes (iMACs) into prehypertrophic (Prehyp) and hypertrophic (Hyp) chondrocytes, we performed kinetics of chondrocyte differentiation from Prehyp to Hyp to follow matrix mineralization and remodeling by immunofluorescence, biochemical, molecular, and physicochemical approaches, including atomic force microscopy, scanning electron microscopy associated with energy-dispersive X-ray spectroscopy (SEM-EDS), attenuated total reflection infrared analyses, and X-ray diffraction. Chondrocyte apoptosis was determined by TUNEL assay. The results show the formation of a mineral phase 7 days after Hyp induction, which spreads within the matrices to form poorly crystalline carbonate-substituted hydroxyapatite after 14 days, then the proportions of crystalline relative to amorphous content increases over time. Hyp differentiation also induced a matrix turnover that occurs over the first 7 days, characterized by a decrease in type II collagen and aggrecan and the concomitant appearance of type X collagen. This is accompanied by an increase in the enzymatic activity of MMP-13, the main collagenase in cartilage. The number of apoptotic chondrocytes slightly increased with Hyp differentiation and SEM-EDS analyses detected phosphorus-rich structures that could correspond to apoptotic bodies. Our findings highlight the mechanisms of matrix remodeling events leading to the mineralization of articular cartilage that may occur in osteoarthritis.","PeriodicalId":9601,"journal":{"name":"Calcified Tissue International","volume":" ","pages":"269-282"},"PeriodicalIF":3.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-Term Follow-Up Data of Tumor-Induced Osteomalacia Managed with Surgery and/or Radiofrequency Ablation from a Single Center. 单个中心通过手术和/或射频消融治疗肿瘤诱发骨软化症的长期随访数据

IF 3.3 3区医学

Calcified Tissue International Pub Date : 2024-09-01 Epub Date: 2024-06-26 DOI: 10.1007/s00223-024-01249-6

Saba Samad Memon, Mohd Asif Patel, Anurag Lila, Swati Jadhav, Vijaya Sarathi, Manjiri Karlekar, Rohit Barnabas, Virendra Patil, Suyash Kulkarni, Krantikumar Rathod, Nalini Shah, Tushar Bandgar

{"title":"Long-Term Follow-Up Data of Tumor-Induced Osteomalacia Managed with Surgery and/or Radiofrequency Ablation from a Single Center.","authors":"Saba Samad Memon, Mohd Asif Patel, Anurag Lila, Swati Jadhav, Vijaya Sarathi, Manjiri Karlekar, Rohit Barnabas, Virendra Patil, Suyash Kulkarni, Krantikumar Rathod, Nalini Shah, Tushar Bandgar","doi":"10.1007/s00223-024-01249-6","DOIUrl":"10.1007/s00223-024-01249-6","url":null,"abstract":"Data on radiofrequency ablation (RFA) in tumor-induced osteomalacia (TIO) are restricted to case reports (~ 11 patients) and long-term follow-up data are further scarce. We describe our experience on managing TIO from a tertiary care center in India. Retrospective study of patients with localized TIO was performed and clinical, biochemical, treatment and follow-up details were retrieved. Normalization of serum phosphorus in absence of phosphate supplementation was defined as remission. Of 33 patients (23 males), 24 patients underwent surgery as first-line treatment, and early remission, delayed remission (> 1 month for phosphorus normalization) and persistence were observed 12, 3, and 9 patients at a median follow-up of 5 (4-9) years. The gender, age, tumor size, location of tumors and FGF23 levels were not statistically different in patients who were in remission after surgery versus those with persistent disease. Second/third line treatment included conventional medical treatment and/or repeat surgery (n = 3), radiotherapy (n = 3), peptide receptor radionuclide therapy (n = 1), RFA (n = 1). Two patients had transient worsening (weeks) of weakness post-surgery. 10 patients underwent RFA (first-line n = 9); at the last follow-up 5 (4-10) years, 7 are in remission. Two of three persistent disease patients had large tumors (5.6 and 3.6 cm). There were no RFA-related complications except local ulcer in one. Although persistent disease was present in a few patients in both arms, there was no recurrence in either RFA or surgical cohort. RFA provide durable response similar to surgery, persistence requires multi-modality treatment.","PeriodicalId":9601,"journal":{"name":"Calcified Tissue International","volume":" ","pages":"242-250"},"PeriodicalIF":3.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Suppression of YAP Ameliorates Cartilage Degeneration in Ankle Osteoarthritis via Modulation of the Wnt/β-Catenin Signaling Pathway. 抑制 YAP 可通过调节 Wnt/β-Catenin 信号通路改善踝关节骨关节炎的软骨退化。

IF 3.3 3区医学

Calcified Tissue International Pub Date : 2024-09-01 Epub Date: 2024-07-02 DOI: 10.1007/s00223-024-01242-z

Zhengrui Fan, Xingwen Zhao, Jianxiong Ma, Hongqi Zhan, Xinlong Ma

{"title":"Suppression of YAP Ameliorates Cartilage Degeneration in Ankle Osteoarthritis via Modulation of the Wnt/β-Catenin Signaling Pathway.","authors":"Zhengrui Fan, Xingwen Zhao, Jianxiong Ma, Hongqi Zhan, Xinlong Ma","doi":"10.1007/s00223-024-01242-z","DOIUrl":"10.1007/s00223-024-01242-z","url":null,"abstract":"Ankle osteoarthritis is a relatively understudied condition and the molecular mechanisms involved in its development are not well understood. This investigation aimed to explore the role and underlying molecular mechanisms of Yes-associated protein (YAP) in rat ankle osteoarthritis. The results demonstrated that YAP expression levels were abnormally increased in the ankle osteoarthritis cartilage model. In addition, knockdown of YAP expression was shown to hinder the imbalance in ECM metabolism induced by IL-1β in chondrocytes, as demonstrated by the regulation of matrix metalloproteinase (MMP)-3, MMP-9, and MMP-13, a disintegrin, metalloprotease with thrombospondin motifs, aggrecan, and collagen II expression. Additional studies revealed that downregulation of YAP expression markedly inhibited the overexpression of β-catenin stimulated by IL-1β. Furthermore, inhibition of the Wnt/β-catenin signaling pathway reversed the ECM metabolism imbalance caused by YAP overexpression in chondrocytes. It is important to note that the YAP-specific inhibitor verteporfin (VP) significantly delayed the progression of ankle osteoarthritis. In conclusion, the findings highlighted the crucial role of YAP as a regulator in modulating the progression of ankle osteoarthritis via the Wnt/β-catenin signaling pathway. These findings suggest that pharmacological inhibition of YAP can be an effective and critical therapeutic target for alleviating ankle osteoarthritis.","PeriodicalId":9601,"journal":{"name":"Calcified Tissue International","volume":" ","pages":"283-297"},"PeriodicalIF":3.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141490982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is Mixed Pain Really Common in Adult CNO? 混合性疼痛在成人 CNO 中真的常见吗？

IF 3.3 3区医学

Calcified Tissue International Pub Date : 2024-09-01 Epub Date: 2024-06-21 DOI: 10.1007/s00223-024-01246-9

Danxiang Shen, Xiang Liu, Yuwei Wang, Di Jin, Zhenhua Ying, Chen Li

引用次数: 0