Cancer cell & microenvironment最新文献_第2页

The regulation of snail: on the ubiquitin edge 蜗牛的调控:在泛素边缘上

Cancer cell & microenvironment Pub Date : 2017-07-03 DOI: 10.14800/CCM.1567

Qian Yu, Binhua P. Zhou, Yadi Wu

引用次数: 12

Emerging role of SHARPIN in hepatocellular carcinoma progression SHARPIN在肝细胞癌进展中的新作用

Cancer cell & microenvironment Pub Date : 2017-05-24 DOI: 10.14800/CCM.1540

Yasuo Tanaka, R. Tateishi, K. Koike

引用次数: 1

Inhibition of nucleo-cytoplasmic shuttling through XPO1/CRM1: a unique therapeutic approach for treatment of haematological and solid malignancies 通过XPO1/CRM1抑制核细胞质穿梭:治疗血液病和实体恶性肿瘤的独特治疗方法

Cancer cell & microenvironment Pub Date : 2017-03-13 DOI: 10.14800/CCM.1516

S. Sneha, P. NagareR., Bindhya Sadhanandhan, Ram Shankar, S. Suresh, T. Ganesan, M. Garg

{"title":"Inhibition of nucleo-cytoplasmic shuttling through XPO1/CRM1: a unique therapeutic approach for treatment of haematological and solid malignancies","authors":"S. Sneha, P. NagareR., Bindhya Sadhanandhan, Ram Shankar, S. Suresh, T. Ganesan, M. Garg","doi":"10.14800/CCM.1516","DOIUrl":"https://doi.org/10.14800/CCM.1516","url":null,"abstract":"Cancer is one of the leading cause of morbidity and mortality worldwide. Regulated nucleo-cytoplasmic shuttling is very crucial for maintaining cellular homeostasis. Emerging evidence suggests that deregulation of the nucleo-cytoplasmic transport results in abnormal cell growth, cell cycle, apoptosis, tumor progression and drug resistance. Exportin-1 (also called as chromosome region maintenance 1) belongs to karyopherin-β superfamily and is the main mediator of nuclear export in several cell types. The XPO1 / CRM1 protein is overexpressed in liposarcoma, Ewing sarcoma, ovarian carcinoma, pancreatic cancer, hepatocellular carcinoma, lung carcinoma, osteosarcoma, gastric carcinoma, melanoma, glioma, acute myeloid leukemia, acute lymphocytic leukemia, chronic myeloid/lymphoid leukemia as well as multiple myeloma. Hot spot mutations were observed in many cancers. Higher levels of XPO1 / CRM1 are associated with poor prognosis, resistance to chemotherapy and recurrence in a large number of human malignancies. There are growing evidence that provided the foundation that inhibition of nuclear export by inhibiting nuclear export receptor ( XPO1 ) might be a potential targeted therapeutic approach for the treatment of human cancers in the clinic. In the present review, we will discuss the role of XPO1 in cancers and potential of selective inhibitors of nuclear export ( XPO1 inhibitors) to restore the normal function of tumor suppressor and growth regulatory proteins by blocking their export. Selinexor (KPT-330) is an orally available, highly potent and is being tested in human phase-I/II clinical trials in both haematological and solid malignancies.","PeriodicalId":9576,"journal":{"name":"Cancer cell & microenvironment","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82105586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A double-edged sword - the role of human ADAM17 in NK cell activity 一把双刃剑——人类ADAM17在NK细胞活性中的作用

Cancer cell & microenvironment Pub Date : 2017-02-06 DOI: 10.14800/CCM.1495

Dominik Schmiedel, O. Mandelboim, Pinchas Tsukerman

引用次数: 0

Tumor treating field therapy in non-MGMT-Methylated newly diagnosed glioblastoma: is there a role for temozolomide? 非mtmt甲基化新诊断胶质母细胞瘤的肿瘤治疗野疗法:替莫唑胺是否有作用?

Cancer cell & microenvironment Pub Date : 2017-01-30 DOI: 10.14800/CCM.1502

H. Robins, J. Kuo, D. Deming

引用次数: 0

Many are better than one - next generation multivariate biomarkers for precision oncology 许多都比一个更好——精准肿瘤学的下一代多变量生物标志物

Cancer cell & microenvironment Pub Date : 2017-01-09 DOI: 10.14800/CCM.1484

Jinyan Du, D. Kirouac, B. Schoeberl

引用次数: 0

Dendritic cell targeting vaccine for HPV-associated cancer 树突状细胞靶向疫苗用于hpv相关癌症

Cancer cell & microenvironment Pub Date : 2017-01-02 DOI: 10.14800/CCM.1482

Wenjie Yin, D. Duluc, HyeMee Joo, SangKon Oh

{"title":"Dendritic cell targeting vaccine for HPV-associated cancer","authors":"Wenjie Yin, D. Duluc, HyeMee Joo, SangKon Oh","doi":"10.14800/CCM.1482","DOIUrl":"https://doi.org/10.14800/CCM.1482","url":null,"abstract":"Dendritic cells (DCs) are major antigen presenting cells that can efficiently prime and activate cellular immune responses. Delivering antigens to in vivo DCs has thus been considered as a promising strategy that could allow us to mount T cell-mediated therapeutic immunity against cancers in patients. Successful development of such types of cancer vaccines that can target in vivo DCs, however, requires a series of outstanding questions that need to be addressed. These include the proper selection of which DC surface receptors, specific DC subsets and DC activators that can further enhance the efficacy of vaccines by promoting effector T cell infiltration and retention in tumors and their actions against tumors. Supplementing these areas of research with additional strategies that can counteract tumor immune evasion mechanisms is also expected to enhance the efficacy of such therapeutic vaccines against cancers. After more than a decade of study, we have concluded that antigen targeting to DCs via CD40 to evoke cellular responses is more efficient than targeting antigens to the same types of DCs via eleven other DC surface receptors tested. In recent work, we have further demonstrated that a prototype vaccine (anti-CD40-HPV16.E6/7, a recombinant fusion protein of anti-human CD40 and HPV16.E6/7 protein) for HPV16-associated cancers can efficiently activate HPV16.E6/7-specific T cells, particularly CD8+ T cells, from the blood of HPV16+ head-and-neck cancer patients. Moreover, anti-CD40-HPV16.E6/7 plus poly(I:C) can mount potent therapeutic immunity against TC-1 tumor expressing HPV16.E6/7 protein in human CD40 transgenic mice. In this manuscript, we thus highlight our recent findings for the development of novel CD40 targeting immunotherapeutic vaccines for HPV16-associated malignancies. In addition, we further discuss several of key questions that still remain to be addressed for enhancing therapeutic immunity elicited by our prototype vaccine against HPV16-associated malignancies.","PeriodicalId":9576,"journal":{"name":"Cancer cell & microenvironment","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87487707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Brain derived neutrophic factor (BDNF) coordinates lympho-vascular metastasis through a fibroblast-governed paracrine axis in the tumor microenvironment. 脑源性中性营养因子(BDNF)在肿瘤微环境中通过成纤维细胞调控的旁分泌轴协调淋巴血管转移。

Cancer cell & microenvironment Pub Date : 2017-01-01 Epub Date: 2017-07-10 DOI: 10.14800/ccm.1566

Tilahun Jiffar, Turker Yilmaz, Junegoo Lee, Yair Miller, Lei Feng, Adel El-Naggar, Michael E Kupferman

{"title":"Brain derived neutrophic factor (BDNF) coordinates lympho-vascular metastasis through a fibroblast-governed paracrine axis in the tumor microenvironment.","authors":"Tilahun Jiffar, Turker Yilmaz, Junegoo Lee, Yair Miller, Lei Feng, Adel El-Naggar, Michael E Kupferman","doi":"10.14800/ccm.1566","DOIUrl":"https://doi.org/10.14800/ccm.1566","url":null,"abstract":"It has long been known that the tumor microenvironment contributes to the proliferation and survival of neoplasms through the constant interaction with the stromal and immune compartments. In this investigation, we explored the role of cancer-associated fibroblasts (CAFs) in the regulation of the tumor microenvironment in head and neck squamous cell carcinoma (HNSCC) though a complex intercellular BDNF-TrkB signaling system. Our studies show that conditioned media derived from patient-derived CAFs promoted HNSCC cell proliferation, in vitro cell migration, cell invasion and chemotherapy resistance, compared to normal fibroblasts. Furthermore, examination of the in vivo impact of CAF pathophysiology in the tumor microenvironment in animal xenograft models revealed that HNSCC cell lines in combination with CAFs promoted tumor growth and increased incidence of lymphovascular metastasis as compared to injection of tumor cells or CAF cells alone. Using pharmacological and genetic alterations, we mechanistically demonstrate the critical importance of BDNF-TrkB signaling in the tumor microenvironment. These investigations further support the rationale for BDNF/TRKB targeted therapy against in the treatment of HNSCC.","PeriodicalId":9576,"journal":{"name":"Cancer cell & microenvironment","volume":"4 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.14800/ccm.1566","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35459535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Protein synthesis inhibition enhances paraptotic death induced by inhibition of cyclophilins in glioblastoma cells. 蛋白合成抑制增强胶质母细胞瘤细胞亲环蛋白抑制诱导的旁细胞性死亡。

Cancer cell & microenvironment Pub Date : 2017-01-01 Epub Date: 2017-10-02

Lin Wang, Justin H Gundelach, Richard J Bram

{"title":"Protein synthesis inhibition enhances paraptotic death induced by inhibition of cyclophilins in glioblastoma cells.","authors":"Lin Wang, Justin H Gundelach, Richard J Bram","doi":"","DOIUrl":"","url":null,"abstract":"Treatment of cancer is frequently unsuccessful related to the loss of apoptotic signaling in malignant cells. This is a particular problem for high-grade gliomas, such as Glioblastoma Multiforme (GBM), which are almost universally fatal within a year or so of diagnosis. Novel therapies that capitalize on non-apoptotic cell death pathways may yield more effective outcomes, if their underlying mechanisms can be more completely deciphered. In a recent publication (ref 10), the mechanisms by which cellular cyclophilins support GBM cell survival have been identified. Inhibition of cyclophilins activated paraptosis, which relied on a combination of endoplasmic reticulum (ER) stress and transient activation of autophagy. An important aspect of this effect was the relative rates of cap-dependent versus cap-independent protein synthesis, which were differentially modulated by protein synthesis inhibitors or mTOR inhibition. Although cycloheximide has previously been characterized as an inhibitor of paraptosis, in the case of cyclophilin inhibition, it appears to significantly enhance stress-related paraptosis and cell death. This work reveals an important role for cap-independent protein translation and autophagy in the ability of GBM cells to resist non-apoptotic death, and adds to our understanding of the events that underlie paraptosis.","PeriodicalId":9576,"journal":{"name":"Cancer cell & microenvironment","volume":"4 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35560067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The regulation of snail: on the ubiquitin edge. 蜗牛的调控:在泛素边缘上。

Cancer cell & microenvironment Pub Date : 2017-01-01 Epub Date: 2017-07-03

Qian Yu, Binhua P Zhou, Yadi Wu

引用次数: 0