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C26. LET IT BLEED: ENDOTHELIAL INJURY AND ANGIOGENESIS IN PULMONARY HYPERTENSION最新文献

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Does Veno-Venous Extracoporeal Membrane Oxygenation Reduce Pulmonary Arterial Pressure at Alveolar Hypoxia? A Porcine Experimental Study 肺泡缺氧时，静脉-静脉孔外膜氧合能降低肺动脉压吗?猪的实验研究
C26. LET IT BLEED: ENDOTHELIAL INJURY AND ANGIOGENESIS IN PULMONARY HYPERTENSION Pub Date : 2019-05-01 DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4390
B. Holzgraefe, Håkan Kalzén, A. Larsson
{"title":"Does Veno-Venous Extracoporeal Membrane Oxygenation Reduce Pulmonary Arterial Pressure at Alveolar Hypoxia? A Porcine Experimental Study","authors":"B. Holzgraefe, Håkan Kalzén, A. Larsson","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4390","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4390","url":null,"abstract":"","PeriodicalId":9568,"journal":{"name":"C26. LET IT BLEED: ENDOTHELIAL INJURY AND ANGIOGENESIS IN PULMONARY HYPERTENSION","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77501834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ACTRIIA-Fc (Sotatercept) Reverses Pulmonary Vascular Remodeling to Attenuate Pulmonary Arterial Hypertension (PAH) by Rebalancing TGF-b/BMP Signaling in a Preclinical Model ACTRIIA-Fc (sotaterept)在临床前模型中通过平衡TGF-b/BMP信号逆转肺血管重构以减轻肺动脉高压(PAH)
C26. LET IT BLEED: ENDOTHELIAL INJURY AND ANGIOGENESIS IN PULMONARY HYPERTENSION Pub Date : 2019-05-01 DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4395
S. Joshi, June Liu, R. Pearsall, Gang Li, Ravindra Kumar
{"title":"ACTRIIA-Fc (Sotatercept) Reverses Pulmonary Vascular Remodeling to Attenuate Pulmonary Arterial Hypertension (PAH) by Rebalancing TGF-b/BMP Signaling in a Preclinical Model","authors":"S. Joshi, June Liu, R. Pearsall, Gang Li, Ravindra Kumar","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4395","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4395","url":null,"abstract":"Acknowledements Paul B. Yu, M.D., Ph.D. Research Support: Acceleron ActRIIA-Fc reverses pulmonary vascular remodeling, improves pulmonary hemodynamics, and improves RV function by reducing Smad2/3 overactivation and rebalancing activin/BMP signaling in pulmonary arteries and RV. These changes could potentially translate to distinct clinical benefit over currently available therapies for PAH. Right Ventricular Systolic Pressure","PeriodicalId":9568,"journal":{"name":"C26. LET IT BLEED: ENDOTHELIAL INJURY AND ANGIOGENESIS IN PULMONARY HYPERTENSION","volume":"145 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84781384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Cyclic Car Peptide Targets Pulmonary Vascular Endothelium and Enhances the Efficacy of Prostacyclin in Experimental Pulmonary Hypertension 环Car肽靶向肺血管内皮并增强前列环素治疗实验性肺动脉高压的疗效
C26. LET IT BLEED: ENDOTHELIAL INJURY AND ANGIOGENESIS IN PULMONARY HYPERTENSION Pub Date : 2019-05-01 DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4401
L. Yung, P. Yang, T. Dinter, G. Bocobo, Z. Augur, A. Waxman, D. Man, P. Yu
{"title":"Cyclic Car Peptide Targets Pulmonary Vascular Endothelium and Enhances the Efficacy of Prostacyclin in Experimental Pulmonary Hypertension","authors":"L. Yung, P. Yang, T. Dinter, G. Bocobo, Z. Augur, A. Waxman, D. Man, P. Yu","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4401","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4401","url":null,"abstract":"","PeriodicalId":9568,"journal":{"name":"C26. LET IT BLEED: ENDOTHELIAL INJURY AND ANGIOGENESIS IN PULMONARY HYPERTENSION","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87511794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting HIF-2a for the Treatment of Pulmonary Arterial Hypertension 靶向HIF-2a治疗肺动脉高压
C26. LET IT BLEED: ENDOTHELIAL INJURY AND ANGIOGENESIS IN PULMONARY HYPERTENSION Pub Date : 2019-05-01 DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4412
Z. Dai, M. Zhu, Y. Peng, N. Machireddy, C. Evans, R. Machado, X. Zhang, Y. Zhao
{"title":"Targeting HIF-2a for the Treatment of Pulmonary Arterial Hypertension","authors":"Z. Dai, M. Zhu, Y. Peng, N. Machireddy, C. Evans, R. Machado, X. Zhang, Y. Zhao","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4412","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4412","url":null,"abstract":"","PeriodicalId":9568,"journal":{"name":"C26. LET IT BLEED: ENDOTHELIAL INJURY AND ANGIOGENESIS IN PULMONARY HYPERTENSION","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87755691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CCR2- and CCR5-Mediated Crosstalk Between Macrophages and Pulmonary-Artery Smooth Muscle Cells Drives Pulmonary Hypertension 巨噬细胞与肺动脉平滑肌细胞间CCR2-和ccr5介导的串扰驱动肺动脉高压
C26. LET IT BLEED: ENDOTHELIAL INJURY AND ANGIOGENESIS IN PULMONARY HYPERTENSION Pub Date : 2019-05-01 DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4410
S. Abid, E. Marcos, A. Parpaleix, V. Amsellem, M. Breau, Amal Houssaini, Nora Vienney, P. Validire, M. LeFevre, G. Derumeaux, Steve Evans, C. Hubeau, M. Delcroix, R. Quarck, S. Adnot, L. Lipskaia
{"title":"CCR2- and CCR5-Mediated Crosstalk Between Macrophages and Pulmonary-Artery Smooth Muscle Cells Drives Pulmonary Hypertension","authors":"S. Abid, E. Marcos, A. Parpaleix, V. Amsellem, M. Breau, Amal Houssaini, Nora Vienney, P. Validire, M. LeFevre, G. Derumeaux, Steve Evans, C. Hubeau, M. Delcroix, R. Quarck, S. Adnot, L. Lipskaia","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4410","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4410","url":null,"abstract":"","PeriodicalId":9568,"journal":{"name":"C26. LET IT BLEED: ENDOTHELIAL INJURY AND ANGIOGENESIS IN PULMONARY HYPERTENSION","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83114334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Locus 7q36.1 Harbors a Flow-Sensitive Endothelial Enhancer 基因座7q36.1含有一个血流敏感的内皮增强子
C26. LET IT BLEED: ENDOTHELIAL INJURY AND ANGIOGENESIS IN PULMONARY HYPERTENSION Pub Date : 2019-05-01 DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4393
H. T. Dương, D. Harrison, M. Krause, Ru-Ting Huang, Yun Fang
{"title":"Locus 7q36.1 Harbors a Flow-Sensitive Endothelial Enhancer","authors":"H. T. Dương, D. Harrison, M. Krause, Ru-Ting Huang, Yun Fang","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4393","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4393","url":null,"abstract":"","PeriodicalId":9568,"journal":{"name":"C26. LET IT BLEED: ENDOTHELIAL INJURY AND ANGIOGENESIS IN PULMONARY HYPERTENSION","volume":"42 4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82858693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Real-Time Characterization of Inflammatory Lung Injury 炎性肺损伤的实时表征
C26. LET IT BLEED: ENDOTHELIAL INJURY AND ANGIOGENESIS IN PULMONARY HYPERTENSION Pub Date : 2019-05-01 DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4402
P. Belvitch, H. Wang, Weiguo Chen, L. Meliton, J. G. Garcia, J. Jacobson, S. Dudek
{"title":"Real-Time Characterization of Inflammatory Lung Injury","authors":"P. Belvitch, H. Wang, Weiguo Chen, L. Meliton, J. G. Garcia, J. Jacobson, S. Dudek","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4402","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4402","url":null,"abstract":"","PeriodicalId":9568,"journal":{"name":"C26. LET IT BLEED: ENDOTHELIAL INJURY AND ANGIOGENESIS IN PULMONARY HYPERTENSION","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75454469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Female Sex Hormones Can Prevent but Not Reverse Established Pulmonary Arterial Hypertension in the SU5416/Chronic Hypoxia Model 在SU5416/慢性缺氧模型中，女性性激素可以预防但不能逆转已建立的肺动脉高压
C26. LET IT BLEED: ENDOTHELIAL INJURY AND ANGIOGENESIS IN PULMONARY HYPERTENSION Pub Date : 2019-05-01 DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4407
K. Chaudhary, Y. Deng, Anli Yang, K. Rowe, D. Stewart
{"title":"Female Sex Hormones Can Prevent but Not Reverse Established Pulmonary Arterial Hypertension in the SU5416/Chronic Hypoxia Model","authors":"K. Chaudhary, Y. Deng, Anli Yang, K. Rowe, D. Stewart","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4407","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4407","url":null,"abstract":"","PeriodicalId":9568,"journal":{"name":"C26. LET IT BLEED: ENDOTHELIAL INJURY AND ANGIOGENESIS IN PULMONARY HYPERTENSION","volume":"175 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85419873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dysregulated Wnt/Ca2+ Signaling Is Associated with Pericyte Hypercontractility and Proliferation in PAH Wnt/Ca2+信号失调与PAH周细胞过度收缩和增殖有关
C26. LET IT BLEED: ENDOTHELIAL INJURY AND ANGIOGENESIS IN PULMONARY HYPERTENSION Pub Date : 2019-05-01 DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4408
Abinaya Nathan, J. Uribe, A. Chakraborty, K. Yuan, E. Shamskhou, K. Suresh, L. Shimoda, V. D. Perez
{"title":"Dysregulated Wnt/Ca2+ Signaling Is Associated with Pericyte Hypercontractility and Proliferation in PAH","authors":"Abinaya Nathan, J. Uribe, A. Chakraborty, K. Yuan, E. Shamskhou, K. Suresh, L. Shimoda, V. D. Perez","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4408","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4408","url":null,"abstract":"","PeriodicalId":9568,"journal":{"name":"C26. LET IT BLEED: ENDOTHELIAL INJURY AND ANGIOGENESIS IN PULMONARY HYPERTENSION","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83487864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting Pathologic Hyaluronan Synthesis in Pulmonary Hypertension 针对肺动脉高压的病理性透明质酸合成
C26. LET IT BLEED: ENDOTHELIAL INJURY AND ANGIOGENESIS IN PULMONARY HYPERTENSION Pub Date : 2019-05-01 DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4413
Victor Tseng, J. Klienhenz, T. Murphy, E. Grayck, C. Hart
{"title":"Targeting Pathologic Hyaluronan Synthesis in Pulmonary Hypertension","authors":"Victor Tseng, J. Klienhenz, T. Murphy, E. Grayck, C. Hart","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4413","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4413","url":null,"abstract":"","PeriodicalId":9568,"journal":{"name":"C26. LET IT BLEED: ENDOTHELIAL INJURY AND ANGIOGENESIS IN PULMONARY HYPERTENSION","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80628886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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