ACTRIIA-Fc (sotaterept)在临床前模型中通过平衡TGF-b/BMP信号逆转肺血管重构以减轻肺动脉高压(PAH)

C26. LET IT BLEED: ENDOTHELIAL INJURY AND ANGIOGENESIS IN PULMONARY HYPERTENSION Pub Date : 2019-05-01 DOI:10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4395

S. Joshi, June Liu, R. Pearsall, Gang Li, Ravindra Kumar

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引用次数: 4

摘要

研究支持:加速ActRIIA-Fc通过减少Smad2/3过度激活和重新平衡肺动脉和右心室的激活蛋白/BMP信号，逆转肺血管重构，改善肺血流动力学，改善右心室功能。这些变化可能会转化为比目前可用的多环芳烃治疗方法明显的临床益处。右心室收缩压

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ACTRIIA-Fc (Sotatercept) Reverses Pulmonary Vascular Remodeling to Attenuate Pulmonary Arterial Hypertension (PAH) by Rebalancing TGF-b/BMP Signaling in a Preclinical Model

Acknowledements Paul B. Yu, M.D., Ph.D. Research Support: Acceleron ActRIIA-Fc reverses pulmonary vascular remodeling, improves pulmonary hemodynamics, and improves RV function by reducing Smad2/3 overactivation and rebalancing activin/BMP signaling in pulmonary arteries and RV. These changes could potentially translate to distinct clinical benefit over currently available therapies for PAH. Right Ventricular Systolic Pressure

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C26. LET IT BLEED: ENDOTHELIAL INJURY AND ANGIOGENESIS IN PULMONARY HYPERTENSION

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