发布求助
文献互助 智能选刊 最新文献

Cancer Genomics & Proteomics最新文献

筛选
英文 中文
Impact of Prospero Homeobox-1 (PROX-1) οn the Oncogenic Phenotypes of Hepatocellular Carcinoma Cells. Prospero Homeobox-1 (PROX-1) 对肝细胞癌细胞致癌表型的影响
IF 2.5 4区 医学
Cancer Genomics & Proteomics Pub Date : 2024-04-27 DOI: 10.21873/cgp.20448
Ji-Yun Hong, Sun-Young Park, Young-Lan Park, Ga-Ram You, Jae Hyun Yoon, Young-Eun Joo, Sung Kyu Choi, Sung-Bum Cho
{"title":"Impact of Prospero Homeobox-1 (PROX-1) οn the Oncogenic Phenotypes of Hepatocellular Carcinoma Cells.","authors":"Ji-Yun Hong, Sun-Young Park, Young-Lan Park, Ga-Ram You, Jae Hyun Yoon, Young-Eun Joo, Sung Kyu Choi, Sung-Bum Cho","doi":"10.21873/cgp.20448","DOIUrl":"https://doi.org/10.21873/cgp.20448","url":null,"abstract":"Transcriptional factor prospero homeobox-1 (PROX-1) is crucial for the embryonic development of various organs and cell fate specification. It exhibits either an oncogenic or tumor suppressive activity depending on cancer types. However, the relationship between PROX-1 and hepatocellular carcinoma (HCC) remains obscure. This study was conducted to investigate the effect of PROX-1 on the invasive and oncogenic phenotypes of human HCC cells.","PeriodicalId":9516,"journal":{"name":"Cancer Genomics & Proteomics","volume":"17 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140805896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Germline MYOF1::WNK4 and VPS25::MYOF1 Chimeras Generated by the Constitutional Translocation t(17;19)(q21;p13) in Two Siblings With Myelodysplastic Syndrome. 骨髓增生异常综合征两兄妹的胚系MYOF1::WNK4和VPS25::MYOF1嵌合体由染色体t(17;19)(q21;p13)转位产生。
IF 2.5 4区 医学
Cancer Genomics & Proteomics Pub Date : 2024-04-27 DOI: 10.21873/cgp.20446
Ioannis Panagopoulos, Kristin Andersen, Vidar Stavseth, Synne Torkildsen, Sverre Heim, Maren Randi Tandsæther
{"title":"Germline MYOF1::WNK4 and VPS25::MYOF1 Chimeras Generated by the Constitutional Translocation t(17;19)(q21;p13) in Two Siblings With Myelodysplastic Syndrome.","authors":"Ioannis Panagopoulos, Kristin Andersen, Vidar Stavseth, Synne Torkildsen, Sverre Heim, Maren Randi Tandsæther","doi":"10.21873/cgp.20446","DOIUrl":"https://doi.org/10.21873/cgp.20446","url":null,"abstract":"Constitutional chromosomal aberrations are rare in hematologic malignancies and their pathogenetic role is mostly poorly understood. We present a comprehensive molecular characterization of a novel constitutional chromosomal translocation found in two siblings - sisters - diagnosed with myelodysplastic syndrome (MDS).","PeriodicalId":9516,"journal":{"name":"Cancer Genomics & Proteomics","volume":"41 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140806172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genomic Frequencies of Dynamic DNA Sequences and Mammalian Lifespan. 动态 DNA 序列的基因组频率与哺乳动物的寿命
IF 2.5 4区 医学
Cancer Genomics & Proteomics Pub Date : 2024-04-27 DOI: 10.21873/cgp.20443
Marianna Martella, Nadia Carlesso, Zoë A E Waller, Guido Marcucci, Flavia Pichiorri, Steven S Smith
{"title":"Genomic Frequencies of Dynamic DNA Sequences and Mammalian Lifespan.","authors":"Marianna Martella, Nadia Carlesso, Zoë A E Waller, Guido Marcucci, Flavia Pichiorri, Steven S Smith","doi":"10.21873/cgp.20443","DOIUrl":"https://doi.org/10.21873/cgp.20443","url":null,"abstract":"Dynamic DNA sequences (i.e. sequences capable of forming hairpins, G-quadruplexes, i-motifs, and triple helices) can cause replication stress and associated mutations. One example of such a sequence occurs in the RACK7 gene in human DNA. Since this sequence forms i-motif structures at neutral pH that cause replication stress and result in spontaneous deletions in prostate cancer cells, our initial aim was to determine its potential utility as a biomarker of prostate cancer.","PeriodicalId":9516,"journal":{"name":"Cancer Genomics & Proteomics","volume":"63 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140805894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fusion of Platelet Derived Growth Factor Receptor Alpha (PDGFRA) With Ubiquitin Specific Peptidase 8 (USP8) in a Calcified Chondroid Mesenchymal Neoplasm Harboring t(4;15)(q12;q21) as a Sole Aberration. 钙化软骨间充质肿瘤中的血小板衍生生长因子受体α（PDGFRA）与泛素特异性肽酶 8（USP8）融合，其中 t(4;15)(q12;q21)是唯一的畸变。
IF 2.5 4区 医学
Cancer Genomics & Proteomics Pub Date : 2024-04-27 DOI: 10.21873/cgp.20444
Ioannis Panagopoulos, Kristin Andersen, Ludmila Gorunova, Ingvild Lobmaier
{"title":"Fusion of Platelet Derived Growth Factor Receptor Alpha (PDGFRA) With Ubiquitin Specific Peptidase 8 (USP8) in a Calcified Chondroid Mesenchymal Neoplasm Harboring t(4;15)(q12;q21) as a Sole Aberration.","authors":"Ioannis Panagopoulos, Kristin Andersen, Ludmila Gorunova, Ingvild Lobmaier","doi":"10.21873/cgp.20444","DOIUrl":"https://doi.org/10.21873/cgp.20444","url":null,"abstract":"The term \"calcified chondroid mesenchymal neoplasm\" was introduced in 2021 to describe a group of tumors characterized by various morphological features, including the formation of cartilage or chondroid matrix. These tumors frequently carry chimeric genes where the 5'-end partner gene is fibronectin 1 and the 3'-end partner gene codes for receptor tyrosine kinase. Our study explores fusion of the genes platelet-derived growth factor receptor alpha (PDGFRA) and ubiquitin-specific peptidase 8 (USP8) in calcified chondroid mesenchymal neoplasm.","PeriodicalId":9516,"journal":{"name":"Cancer Genomics & Proteomics","volume":"28 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140805935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engineering of an EPHA2-Targeted Monobody for the Detection of Colorectal Cancer. 用于检测结直肠癌的 EPHA2 靶向单体的工程设计
IF 2.5 4区 医学
Cancer Genomics & Proteomics Pub Date : 2024-04-27 DOI: 10.21873/cgp.20447
Akhil Venu, Ying Zhang, Jihyoun Seong, Yeongjin Hong, Wan-Sik Lee, Jung-Joon Min
{"title":"Engineering of an EPHA2-Targeted Monobody for the Detection of Colorectal Cancer.","authors":"Akhil Venu, Ying Zhang, Jihyoun Seong, Yeongjin Hong, Wan-Sik Lee, Jung-Joon Min","doi":"10.21873/cgp.20447","DOIUrl":"https://doi.org/10.21873/cgp.20447","url":null,"abstract":"Colorectal cancer (CRC) is the third most common cancer worldwide, and is second only to lung cancer with respect to cancer-related deaths. Noninvasive molecular imaging using established markers is a new emerging method to diagnose CRC. The human ephrin receptor family type-A 2 (hEPHA2) oncoprotein is overexpressed at the early, but not late, stages of CRC. Previously, we reported development of an E1 monobody that is specific for hEPHA2-expressing cancer cells both in vitro and in vivo. Herein, we investigated the ability of the E1 monobody to detect hEPHA2 expressing colorectal tumors in a mouse model, as well as in CRC tissue.","PeriodicalId":9516,"journal":{"name":"Cancer Genomics & Proteomics","volume":"19 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140806150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic Analyses of Primary Liver Cancer Cell Lines: Correspondence With Morphological Features of Original Tumors. 原发性肝癌细胞系的基因分析：原发性肝癌细胞系的基因分析：与原发性肿瘤形态学特征的对应关系
IF 2.5 4区 医学
Cancer Genomics & Proteomics Pub Date : 2024-04-27 DOI: 10.21873/cgp.20445
Jun Akiba, Sachiko Ogasawara, Hirohisa Yano
{"title":"Genetic Analyses of Primary Liver Cancer Cell Lines: Correspondence With Morphological Features of Original Tumors.","authors":"Jun Akiba, Sachiko Ogasawara, Hirohisa Yano","doi":"10.21873/cgp.20445","DOIUrl":"https://doi.org/10.21873/cgp.20445","url":null,"abstract":"Advancements in genetic analysis technologies have led to establishment of molecular classifications systems for primary liver cancers. The correlation between pathological morphology and genetic mutations in hepatocellular carcinoma (HCC) is becoming increasingly evident. To construct appropriate experimental models, it is crucial to select cell lines based on their morphology and genetic mutations. In this study, we conducted comprehensive genetic analyses of primary liver cancer cell lines and examined their correlations with morphology.","PeriodicalId":9516,"journal":{"name":"Cancer Genomics & Proteomics","volume":"13 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140805841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of a Gene Expression Signature to Predict the Risk of Early Recurrence and the Degree of Immune Cell Infiltration in Triple-negative Breast Cancer. 鉴定基因表达特征以预测三阴性乳腺癌的早期复发风险和免疫细胞浸润程度
IF 2.5 4区 医学
Cancer Genomics & Proteomics Pub Date : 2024-04-27 DOI: 10.21873/cgp.20450
Keiko Sato, Kentaro Miura, Shoma Tamori, Kazunori Akimoto
{"title":"Identification of a Gene Expression Signature to Predict the Risk of Early Recurrence and the Degree of Immune Cell Infiltration in Triple-negative Breast Cancer.","authors":"Keiko Sato, Kentaro Miura, Shoma Tamori, Kazunori Akimoto","doi":"10.21873/cgp.20450","DOIUrl":"https://doi.org/10.21873/cgp.20450","url":null,"abstract":"Patients with triple-negative breast cancer (TNBC) have a high rate of recurrence within 3 years of diagnosis and a high rate of death within 5 years compared to other subtypes. The number of clinical trials investigating various new agents and combination therapies has recently increased; however, current strategies benefit only a minority of patients. This study aimed to identify specific genes that predict patients at high risk of recurrence and the immune status of the tumor microenvironment at an early stage, thereby providing insight into potential therapeutic targets to improve clinical outcomes in TNBC patients.","PeriodicalId":9516,"journal":{"name":"Cancer Genomics & Proteomics","volume":"25 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140805868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Important Role of GPX1 and NF-κB Signaling Pathway in Human Gastric Cancer: Implications for Cell Proliferation and Invasion. GPX1 和 NF-κB 信号通路在人类胃癌中的重要作用：对细胞增殖和侵袭的影响
IF 2.5 4区 医学
Cancer Genomics & Proteomics Pub Date : 2024-04-26 DOI: 10.21873/cgp.20449
Byeong Il Jang, Ji Yoon Jung, Sung Ae Koh, Kyung Hee Lee
{"title":"The Important Role of GPX1 and NF-κB Signaling Pathway in Human Gastric Cancer: Implications for Cell Proliferation and Invasion.","authors":"Byeong Il Jang, Ji Yoon Jung, Sung Ae Koh, Kyung Hee Lee","doi":"10.21873/cgp.20449","DOIUrl":"https://doi.org/10.21873/cgp.20449","url":null,"abstract":"Glutathione peroxidases (GPXs) are crucial antioxidant enzymes, counteracting reactive oxygen species (ROS). GPX overexpression promotes proliferation and invasion in cancer cells. Glutathione peroxidase-1 (GPX1), the most abundant isoform, contributes to invasion, migration, cisplatin resistance, and proliferation in various cancers. Nuclear factor-kappa B (NF-[Formula: see text]B) participates in cell proliferation, apoptosis, and tumor progression. The inhibition of NF-[Formula: see text]B expression reduces the malignancy of esophageal squamous cell carcinoma. This study aimed to explore the GPX1 and NF-[Formula: see text]B signaling pathways and their correlation with gastric cancer cell proliferation and invasion.","PeriodicalId":9516,"journal":{"name":"Cancer Genomics & Proteomics","volume":"6 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140805845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deregulated circRNAs in Epithelial Ovarian Cancer With Activity in Preclinical In Vivo Models: Identification of Targets and New Modalities for Therapeutic Intervention. 在临床前体内模型中具有活性的上皮性卵巢癌中失调的 circRNAs：确定治疗干预的靶点和新模式。
IF 2.5 4区 医学
Cancer Genomics & Proteomics Pub Date : 2024-04-26 DOI: 10.21873/cgp.20442
Ulrich H Weidle, Fabian Birzele
{"title":"Deregulated circRNAs in Epithelial Ovarian Cancer With Activity in Preclinical In Vivo Models: Identification of Targets and New Modalities for Therapeutic Intervention.","authors":"Ulrich H Weidle, Fabian Birzele","doi":"10.21873/cgp.20442","DOIUrl":"https://doi.org/10.21873/cgp.20442","url":null,"abstract":"Epithelial ovarian cancer (EOC) is associated with a dismal prognosis due to development of resistance to chemotherapy and metastasis in the peritoneal cavity and distant organs. In order to identify new targets and treatment modalities we searched the literature for up- and and down-regulated circRNAs with efficacy in preclinical EOC-related in vivo systems. Our search yielded circRNAs falling into the following categories: cisplatin and paclitaxel resistance, transmembrane receptors, secreted factors, transcription factors, RNA splicing and processing factors, RAS pathway-related components, proteolysis and cell-cycle regulation, signaling-related proteins, and circRNAs regulating proteins in additional categories. These findings can be potentially translated by validation and manipulation of the corresponding targets, inhibition of circRNAs with antisense oligonucleotides (ASO), small interfering RNAs (siRNA) or small hairpin RNA (shRNA) or by reconstituting their activity.","PeriodicalId":9516,"journal":{"name":"Cancer Genomics & Proteomics","volume":"64 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140805937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CUL4A Ubiquitin Ligase Is an Independent Predictor of Overall Survival in Pancreatic Adenocarcinoma. CUL4A 泛素连接酶是胰腺癌总生存期的独立预测因子
IF 2.5 4区 医学
Cancer Genomics & Proteomics Pub Date : 2024-03-01 DOI: 10.21873/cgp.20438
Panagiotis Tavlas, Sofia Nikou, Christina Geramoutsou, Pinelopi Bosgana, Spyridon Champeris Tsaniras, Maria Melachrinou, Ioannis Maroulis, Vasiliki Bravou
{"title":"CUL4A Ubiquitin Ligase Is an Independent Predictor of Overall Survival in Pancreatic Adenocarcinoma.","authors":"Panagiotis Tavlas, Sofia Nikou, Christina Geramoutsou, Pinelopi Bosgana, Spyridon Champeris Tsaniras, Maria Melachrinou, Ioannis Maroulis, Vasiliki Bravou","doi":"10.21873/cgp.20438","DOIUrl":"10.21873/cgp.20438","url":null,"abstract":"<p><strong>Background/aim: </strong>Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with dismal prognosis. Genomic instability due to defects in cell-cycle regulation/mitosis or deficient DNA-damage repair is a major driver of PDAC progression with clinical relevance. Deregulation of licensing of DNA replication leads to DNA damage and genomic instability, predisposing cells to malignant transformation. While overexpression of DNA replication-licensing factors has been reported in several human cancer types, their role in PDAC remains largely unknown. We aimed here to examine the expression and prognostic significance of the DNA replication-licensing factors chromatin licensing and DNA replication factor 1 (CDT1), cell-division cycle 6 (CDC6), minichromosome maintenance complex component 7 (MCM7) and also of the ubiquitin ligase regulator of CDT1, cullin 4A (CUL4A), in PDAC.</p><p><strong>Materials and methods: </strong>Expression levels of CUL4, CDT1, CDC6 and MCM7 were evaluated by immunohistochemistry in 76 formalin-fixed paraffin-embedded specimens of PDAC patients in relation to DNA-damage response marker H2AX, clinicopathological parameters and survival. We also conducted bioinformatics analysis of data from online available databases to corroborate our findings.</p><p><strong>Results: </strong>CUL4A and DNA replication-licensing factors were overexpressed in patients with PDAC and expression of CDT1 positively correlated with H2AX. Expression of CUL4A and CDT1 positively correlated with lymph node metastasis. Importantly, elevated CUL4A expression was associated with reduced overall survival and was an independent indicator of poor prognosis on multivariate analysis.</p><p><strong>Conclusion: </strong>Our findings implicate CUL4A, CDT1, CDC6 and MCM7 in PDAC progression and identify CUL4A as an independent prognostic factor for this disease.</p>","PeriodicalId":9516,"journal":{"name":"Cancer Genomics & Proteomics","volume":"21 2","pages":"166-177"},"PeriodicalIF":2.5,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10905276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139995698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信