Massimo Baudo, Serge Sicouri, Yoshiyuki Yamashita, Dimitrios Magouliotis, Francesco Cabrucci, Sarah Carnila, Basel Ramlawi
{"title":"Balloon-versus self-expandable transcatheter aortic valve implantation in small aortic annuli: a meta-analysis of randomized and propensity studies.","authors":"Massimo Baudo, Serge Sicouri, Yoshiyuki Yamashita, Dimitrios Magouliotis, Francesco Cabrucci, Sarah Carnila, Basel Ramlawi","doi":"10.1007/s12928-025-01105-w","DOIUrl":"https://doi.org/10.1007/s12928-025-01105-w","url":null,"abstract":"<p><p>The hemodynamic and clinical differences between balloon- (BEV) and self-expandable valves (SEV) are critical for patients with a small aortic annulus (SAA). This meta-analysis aims to evaluate the clinical and hemodynamic performance of these two systems in patients with severe aortic stenosis and SAA. A systematic review was conducted from inception to June 2024 for randomized and propensity-score studies comparing BEV and SEV outcomes in patients with a SAA. Reconstructed individual patient data (IPD) from Kaplan Meier curves was pooled for overall survival and rehospitalization for heart failure. Nine studies with 2856 patients met our inclusion criteria: 1427 in the BEV group and 1429 in the SEV group. SEV demonstrated superior hemodynamic performance, including improved iEOA (Standardized Mead Difference [SMD]: 0.52, p = 0.0012), lower mean gradients (SMD: - 0.89, p < 0.0001), and reduced PPM (Odds Ratio [OR]: 0.38, p < 0.0001) compared to BEV. BEV presented lower new pacemaker rates compared to SEV (OR: 1.52, p = 0.0447). There were no significant differences between SEV and BEV in terms of rates of > mild paravalvular leaks, early stroke, and Valve Academic Research Consortium-defined outcomes. Reconstructed IPD showed no significant differences in overall survival (Hazard Ratio [HR]: 0.95, p = 0.584) and rehospitalization for heart failure (HR: 1.05, p = 0.828) during follow-up. In patients with SAA undergoing TAVI the use of BEV was associated with higher frequency of PPM and/or pressure gradients. Similar early stroke, survival and rehospitalization rates were reported. Pacemaker rates were higher with SEV. Long-term follow-up studies are required, especially with newer-generation devices.</p>","PeriodicalId":9439,"journal":{"name":"Cardiovascular Intervention and Therapeutics","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Transcatheter edge-to-edge repair for a small mitral valve following surgical annuloplasty.","authors":"Ryo Shigeno, Takao Morikawa, Arudo Hiraoka, Misako Toki, Atsushi Hirohata","doi":"10.1007/s12928-025-01103-y","DOIUrl":"https://doi.org/10.1007/s12928-025-01103-y","url":null,"abstract":"","PeriodicalId":9439,"journal":{"name":"Cardiovascular Intervention and Therapeutics","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Predictors of the diuretic response in acute decompensated heart failure patients with severe aortic stenosis: sub-analysis of the LOHAS registry.","authors":"Takuma Takada, Kentaro Jujo, Takuro Abe, Kensuke Shimazaki, Yugo Nara, Hirofumi Hioki, Hideyuki Kawashima, Akihisa Kataoka, Makoto Nakashima, Masanori Yamamoto, Kazuki Mizutani, Masaki Izumo, Gaku Nakazawa, Ken Kozuma, Katsumi Saito, Yusuke Watanabe","doi":"10.1007/s12928-025-01100-1","DOIUrl":"10.1007/s12928-025-01100-1","url":null,"abstract":"<p><p>For severe aortic stenosis (AS) patients awaiting valve replacement, managing acute decompensated heart failure (ADHF) is crucial due to poor prognosis. The LOHAS registry evaluated the effect of tolvaptan in patients (mean age: 85 years) with severe AS and ADHF, demonstrating stable hemodynamics and sufficient diuresis. We investigated predictors of rapid successful decongestion. In the LOHAS study, eligible patients received tolvaptan (7.5 mg) on day 1 plus standard ADHF treatments. Patients were divided based on decongestion achievement on day 4. Of 59 enrolled, 35 (59%) achieved decongestion (decongestion group), and 24 (41%) remained congested (congestion group). Changes in body weight, renal function, and hemodynamics were comparable between groups over the first 4 days. However, the maximum inferior vena cava (IVC) diameter at admission was significantly larger in the decongestion group than the congestion group (12.6 ± 6.3 vs. 7.6 ± 4.8 mm, p = 0.007). ROC analysis revealed a cut-off of 11 mm for maximum IVC diameter to predict decongestion on day 4 (AUC: 0.73, 95% CI 0.58-0.88). In-hospital mortality was lower in the decongestion group (0% vs. 13%, p = 0.06). In conclusion, in this high-risk severe AS and ADHF population, adding tolvaptan to standard therapy may rapidly improve decompensation if patients have a sufficiently expanded IVC at admission. Maximum IVC diameter could predict successful decongestion with tolvaptan.</p>","PeriodicalId":9439,"journal":{"name":"Cardiovascular Intervention and Therapeutics","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Insights into balloon pulmonary angioplasty and the WHO functional class of chronic thromboembolic pulmonary hypertension patients: findings from the CTEPH AC registry.","authors":"Nobutaka Ikeda, Kohei Masaki, Kazuya Hosokawa, Kouta Funakoshi, Yu Taniguchi, Shiro Adachi, Takumi Inami, Jun Yamashita, Hitoshi Ogino, Ichizo Tsujino, Masaru Hatano, Nobuhiro Yaoita, Hiroto Shimokawahara, Nobuhiro Tanabe, Kayoko Kubota, Ayako Shigeta, Yoshito Ogihara, Koshin Horimoto, Yoshihiro Dohi, Takashi Kawakami, Yuichi Tamura, Koichiro Tatsumi, Kohtaro Abe","doi":"10.1007/s12928-025-01095-9","DOIUrl":"https://doi.org/10.1007/s12928-025-01095-9","url":null,"abstract":"<p><p>Advances in chronic thromboembolic pulmonary hypertension (CTEPH) treatment have improved prognosis, shifting focus towards symptom management. This study aimed to identify factors influencing the World Health Organization functional class (WHO-FC) in CTEPH patients. The CTEPH AC registry is a prospective, multicenter database from 35 Japanese institutions, analyzing data from August 2018 to July 2023. We examined factors associated with achieving WHO-FC I and WHO-FC changes over time in 1,270 patients. Significant factors for WHO-FC I achievement included male sex (odds ratio: 1.86, p = 0.019), age (0.98, p = 0.007), pulmonary vasodilator use (0.51, p = 0.001), post-balloon pulmonary angioplasty (BPA) (1.93, p = 0.010), lower mean pulmonary arterial pressure (0.94, p = 0.004), and lower pulmonary vascular resistance (PVR) (0.78, p = 0.006). Multivariate analysis showed that WHO-FC improvement correlated with male sex, baseline PVR, and BPA during follow-up. WHO-FC deterioration was associated with cancer, history of pulmonary endarterectomy and/or BPA at registration, bleeding risks, and thyroid disease or hormone therapy. BPA implementation is closely linked to symptomatic improvement and achieving WHO-FC I, while symptom worsening is often associated with patient-specific, difficult-to-control conditions.</p>","PeriodicalId":9439,"journal":{"name":"Cardiovascular Intervention and Therapeutics","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of body mass index on mortality, limb amputation, and bleeding in patients with lower extremity artery disease undergoing endovascular therapy.","authors":"Takuya Nakahashi, Hayato Tada, Yasuaki Takeji, Shota Inaba, Masafumi Hashimoto, Akihiro Nomura, Kenji Sakata, Masayuki Takamura","doi":"10.1007/s12928-024-01062-w","DOIUrl":"10.1007/s12928-024-01062-w","url":null,"abstract":"<p><p>The relation between Body Mass Index (BMI) and adverse outcomes after endovascular therapy (EVT) for patients with lower extremity artery disease (LEAD) remains incompletely understood. From April 2010 to March 2020, 199 consecutive patients who underwent EVT for LEAD were retrospectively analyzed. The patients were divided into three groups based on BMI; underweight < 18.5 kg/m<sup>2</sup>, normal weight ≥ 18.5 and < 25.0 kg/m<sup>2</sup>, and overweight ≥ 25.0 kg/m<sup>2</sup>. The endpoint of this study was a composite of all-cause mortality, major amputation, and major bleeding. Patients who were underweight often exhibited anemia (53.3 vs. 22.3 vs. 15.4%, respectively; p = 0.001) and severe chronic kidney disease (50.0 vs. 30.8 vs. 20.5%, respectively; p = 0.03). Furthermore, these patients had higher incidences of Trans-Atlantic Inter-Society Consensus class C or D lesions (40.0 vs. 20.0 vs. 10.3%, respectively; p = 0.01). During the median follow-up duration of 3.6 years (interquartile range: 1.2 to 6.7 years), there were 73 incidents of the composite endpoint. When the overweight group was assigned as the reference group, the adjusted hazard ratios for the composite endpoint for the underweight and normal weight patients were 3.67 (95% confidence interval [CI] 1.39-10.83, p = 0.008) and 2.35 (95% CI 1.06-6.23, p = 0.03), respectively. Kaplan-Meier curve demonstrated that the freedom from the composite endpoint for underweight, normal weight, and overweight patients was 41.6%, 60.0%, 83.8%, respectively (p < 0.001). These results suggest that there was an inverse association between BMI and adverse outcomes composed of mortality, limb amputation, and bleeding in patients with LEAD undergoing EVT.</p>","PeriodicalId":9439,"journal":{"name":"Cardiovascular Intervention and Therapeutics","volume":" ","pages":"112-121"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142495610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}