{"title":"The potential role of major dissection observed on optical frequency-domain imaging in optimal lumen expansion after coronary intravascular lithotripsy: a comparative analysis with calcium fractures.","authors":"Kotaro Miyata, Taku Asano, Takahiro Suzuki, Masafumi Ono, Jiro Aoki","doi":"10.1007/s12928-025-01145-2","DOIUrl":"10.1007/s12928-025-01145-2","url":null,"abstract":"","PeriodicalId":9439,"journal":{"name":"Cardiovascular Intervention and Therapeutics","volume":" ","pages":"998-1000"},"PeriodicalIF":5.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christopher Brown, Michael Ryan, Marcella Kelley, Christin Thompson, Candace Gunnarsson, James Hermiller
{"title":"The need for future coronary access in older medicare beneficiaries following transcatheter aortic-valve replacement.","authors":"Christopher Brown, Michael Ryan, Marcella Kelley, Christin Thompson, Candace Gunnarsson, James Hermiller","doi":"10.1007/s12928-025-01171-0","DOIUrl":"10.1007/s12928-025-01171-0","url":null,"abstract":"<p><strong>Background: </strong>While approximately 17% of patients less than 80 years old require coronary access in the 7 years following their TAVR, the need for coronary access among older TAVR patients is unknown.</p><p><strong>Methods: </strong>We examined the percentage of Medicare beneficiaries aged 80-90 years that require coronary access [percutaneous coronary intervention (PCI) or angiogram] in the 8 years following their TAVR using data from the Medicare 5% Standard Analytic File (2011-2021). The need for coronary access in older patients was estimated for all TAVRs, TAVR patients with and without a history of PCI, and TAVR patients with and without coronary artery disease (CAD) using time-to-event models adjusted for age, sex, race, region, ECI score, concomitant CABG, CAD, PCI, and current or recent smoker status. Multivariate log-gamma regressions were used to estimate the total cost of hospitalizations requiring coronary access post-TAVR.</p><p><strong>Results: </strong>A total of 6845 patients met inclusion criteria. The incidence rates for undergoing PCI or angiogram at 1, 3, 5, and 8 years were 1.9%, 4.0%, 5.5%, and 6.3%, respectively. TAVR patients with PCI demonstrated higher rates of coronary intervention compared to those without PCI (10.2% vs. 6.2% at 8 years, respectively). Similarly, TAVR patients with a prior CAD diagnosis exhibited increased rates of coronary intervention compared to those without a prior CAD diagnosis (7.4% vs. 2.1% at 8 years, respectively). The mean adjusted cost of hospitalizations requiring coronary access was $30,170 [95% Confidence Interval: $27,865-$32,665].</p><p><strong>Conclusions: </strong>Approximately 6.8% of older TAVR patients require coronary access in the 8 years following their index procedure. The presence of a prior PCI or CAD diagnosis is associated with an increased requirement for subsequent coronary access.</p>","PeriodicalId":9439,"journal":{"name":"Cardiovascular Intervention and Therapeutics","volume":" ","pages":"900-908"},"PeriodicalIF":5.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Long-term effects of statin and anticoagulant therapy on restenosis after drug-coated balloon angioplasty for femoropopliteal artery disease: results from the POPCORN registry.","authors":"Yoshinori Tsubakimoto, Mitsuyoshi Takahara, Yoshimitsu Soga, Osamu Iida, Yusuke Tomoi, Daizo Kawasaki, Akiko Tanaka, Yasutaka Yamauchi, Kazuki Tobita, Amane Kozuki, Masahiko Fujihara, Kenji Ando","doi":"10.1007/s12928-025-01172-z","DOIUrl":"10.1007/s12928-025-01172-z","url":null,"abstract":"<p><p>Drug-coated balloon (DCB) angioplasty is an effective endovascular therapy for femoropopliteal artery (FPA) disease in patients with peripheral artery disease (PAD). However, the long-term impact of statin and anticoagulant therapy on restenosis after DCB treatment remains unclear. This multicenter observational study analyzed data from 2507 PAD patients undergoing DCB angioplasty for symptomatic FPA disease in the POPCORN registry. Patients were classified into three groups based on medication status at the time of revascularization: No medication, One medication (statin or anticoagulant), and Two medications (both). Additional analyses were performed to separately evaluate statins, DOACs, and warfarin. Cox proportional hazards models with mixed effects assessed the association between medication use and restenosis risk in the short-term (< 1 year) and longer-term periods. In the short-term, neither one nor two medications significantly reduced restenosis risk. In contrast, during the longer-term period, One medication was associated with reduced restenosis (HR: 0.78, 95% CI: 0.64-0.95; P = 0.014), and Two medications showed further benefit (HR: 0.66, 95% CI: 0.46-0.95; P = 0.025). Based on additional analyses, both statin and DOAC use were independently associated with reduced restenosis risk, while warfarin showed no significant benefit. Statin and anticoagulant therapies did not reduce short-term restenosis but significantly lowered longer-term risks. These findings support the role of these medications in improving the durability of revascularization following DCB treatment for FPA disease. Particularly, additional analyses indicated that the benefit in the longer-term was primarily driven by statin and DOAC use.</p>","PeriodicalId":9439,"journal":{"name":"Cardiovascular Intervention and Therapeutics","volume":" ","pages":"881-889"},"PeriodicalIF":5.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The prognostic value of small psoas muscle area in patients undergoing mitral transcatheter edge-to-edge repair.","authors":"Ryo Shigeno, Masaki Miyasaka, Takao Morikawa, Arudo Hiraoka, Atsushi Hirohata","doi":"10.1007/s12928-025-01156-z","DOIUrl":"10.1007/s12928-025-01156-z","url":null,"abstract":"<p><p>Sarcopenia may be more advanced in high-surgical-risk patients undergoing mitral transcatheter edge-to-edge repair (M-TEER). However, the clinical significance of psoas muscle area (PMA), measured by computed tomography (CT) as an index of sarcopenia, remains uncertain in this population. To determine the association between PMA and clinical outcomes following M-TEER in high-risk patients. Of 238 patients who underwent M-TEER at our facility between January 2019 and July 2023, 214 patients with available preoperative CT were enrolled. Bilateral cross-sectional PMA was measured at the L4 vertebra level and indexed to body surface area. Patients in the lowest sex-specific tertile of index PMA were classified as the smaller PMA group, and the remainder as the larger PMA group. The composite outcome comprised heart failure hospitalization or all-cause death. The mean age and median Society of Thoracic Surgeons score was 80.6 ± 9.0 years and 11.6% (interquartile range 7.3%-17.1%). Seventy-one patients were assigned to the smaller PMA group, and 143 to the larger PMA group. At 1 year, the smaller PMA group had higher rates of the composite outcome and heart failure hospitalization than the larger PMA group (composite outcome: 46.5% versus 26.6%, P = 0.003; heart failure hospitalization: 35.1% versus 17.3%, P = 0.006). The rate of all-cause death was numerically higher in the smaller PMA group, though the difference was not statistically significant (25.4% versus 16.1%, P = 0.10). Decreased PMA measured by preprocedural CT in patients undergoing M-TEER was associated with adverse clinical outcomes.</p>","PeriodicalId":9439,"journal":{"name":"Cardiovascular Intervention and Therapeutics","volume":" ","pages":"964-972"},"PeriodicalIF":5.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stefano Rosato, Fausto Biancari, Marco Barbanti, Giuseppe Tarantini, Marco Ranucci, Giuliano Costa, Timo Mäkikallio, Gian Paolo Ussia, Giovanni Baglio, Mahin Tatari, Gabriella Badoni, Paola D'Errigo
{"title":"Five-year outcomes after surgical versus transcatheter aortic valve replacement with new generation devices from the prospective OBSERVANT studies.","authors":"Stefano Rosato, Fausto Biancari, Marco Barbanti, Giuseppe Tarantini, Marco Ranucci, Giuliano Costa, Timo Mäkikallio, Gian Paolo Ussia, Giovanni Baglio, Mahin Tatari, Gabriella Badoni, Paola D'Errigo","doi":"10.1007/s12928-025-01155-0","DOIUrl":"10.1007/s12928-025-01155-0","url":null,"abstract":"<p><p>The efficacy and durability of transcatheter (TAVR) over surgical aortic valve replacement (SAVR) for severe aortic stenosis (AS) has been demonstrated in randomized studies, but these findings were not confirmed in several observational studies. This is an analysis of 5706 AS patients who underwent SAVR from 2010 and 2012, and 2989 AS patients who underwent TAVR from 2017 and 2018 from the prospective OBSERVANT I and II studies. TAVR procedures were performed with new-generation devices. Five-year all-cause mortality was the primary outcome of this analysis. Propensity score matching yielded 1008 pairs of TAVR and SAVR patients. The mean EuroSCORE II was comparable between the study cohorts (TAVR 4.7 ± 4.0% and SAVR 4.5 ± 5.7%, p = 0.419). At 5 years, TAVR was associated with higher mortality (44.4% vs. 33.2%, HR 1.36, 95%CI 1.18-1.57, Log-rank test p < 0.001), major adverse cardiac and cerebrovascular events (MACCEs) (49.3% vs. 37.9%, HR 1.32, 95%CI 1.15-1.51, Log-rank test p < 0.001), permanent pacemaker implantation (23.1% vs. 9.3%, HR 2.72, 95%CI 2.14-3.45, Log-rank test p < 0.001) and percutaneous coronary intervention rates (3.7% vs. 1.2%, HR 3.44, 95%CI 1.76-6.71, Log-rank test p < 0.001) compared to SAVR. Age ≤ 80 years, male gender, EuroSCORE II ≤ 4.0%, absence of coronary artery disease and absence of diabetes were associated with higher 5-year mortality after TAVR compared to SAVR. TAVR had a significantly higher 5-year mortality than SAVR both in patients with left ventricular ejection fraction ≤ 50% and > 50%. This observational study from prospective data showed that TAVR using new-generation devices was associated with increased rates of all-cause mortality compared to SAVR at 5 years. These findings should be viewed considering the non-randomized nature of this study and may be attributable to the characteristics of patients selected for TAVR, rather than the procedure itself.</p>","PeriodicalId":9439,"journal":{"name":"Cardiovascular Intervention and Therapeutics","volume":" ","pages":"943-953"},"PeriodicalIF":5.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Treatment of right coronary artery occlusion using the side-hole anchor balloon technique in antegrade approach.","authors":"Ritsu Yoshida, Takayuki Ogawa, Yosuke Kayama","doi":"10.1007/s12928-025-01190-x","DOIUrl":"https://doi.org/10.1007/s12928-025-01190-x","url":null,"abstract":"","PeriodicalId":9439,"journal":{"name":"Cardiovascular Intervention and Therapeutics","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}