{"title":"Nomogram predicting 2 year overall survival in dialysis patients with lower extremity peripheral arterial disease after endovascular therapy: a multicenter prospective cohort study.","authors":"Jen-Kuang Lee, I-Shiang Tzeng, I-Chih Chen, Shih-Jung Jang, Chien-An Hsieh, Kuan-Liang Liu, Hsin-Hua Chou, Hsuan-Li Huang","doi":"10.1007/s12928-025-01161-2","DOIUrl":"https://doi.org/10.1007/s12928-025-01161-2","url":null,"abstract":"<p><p>Two year overall survival (OS) is crucial for treating symptomatic lower extremity arterial disease (LEAD). This study aimed to develop a nomogram to predict 2 year OS in dialysis patients with LEAD following endovascular therapy (EVT), addressing the gap in data for this high-risk population. This study, conducted at three centers in Taiwan between July 2005 and December 2019, included 593 dialysis patients (349 in the development group and 244 in the validation group). Multivariate logistic regression was used to identify 2 year OS predictors. The nomogram's predictive accuracy, discriminative ability, and clinical utility were evaluated using receiver-operating characteristic curves, calibration curves, the Hosmer-Lemeshow (HL) test, and decision curve analysis (DCA). The mean patient age was 68.4 ± 11.1 years (56% men); 251 died within 2 years (median follow-up 2.42 years), and the 2 year OS rates were similar between groups (59.3% vs. 55.0%, P = 0.220). Multivariate analysis revealed elevated neutrophil-to-lymphocyte ratio, congestive heart failure, chronic atrial fibrillation, use of renin-angiotensin-aldosterone system inhibitors, and prognostic nutritional index as predictors of 2 year OS. The areas under the curve were 0.822 (95% confidence interval [CI] 0.773-0.870) and 0.838 (95% CI 0.789-0.887) in the development and validation groups, respectively. The HL tests χ2 values were 11.61 (P = 0.170) and 6.706 (P = 0.569). DCA showed that this model was practical for 10-90% survival probabilities. This nomogram accurately predicts 2 year OS in dialysis patients with symptomatic LEAD post-EVT. This model can aid clinicians in personalized risk stratification and treatment planning in real-world clinical practice.</p>","PeriodicalId":9439,"journal":{"name":"Cardiovascular Intervention and Therapeutics","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A pilot study on coronary microvascular dysfunction in obstructive hypertrophic cardiomyopathy: impact of percutaneous transluminal septal myocardial ablation.","authors":"Taikan Terauchi, Daigo Hiraya, Kyohei Usami, Takumi Yaguchi, Hiroaki Watabe, Tomoya Hoshi, Tomoko Ishizu","doi":"10.1007/s12928-025-01154-1","DOIUrl":"https://doi.org/10.1007/s12928-025-01154-1","url":null,"abstract":"<p><p>Coronary microvascular dysfunction (CMD) is well-characterized in the context of coronary artery disease, but its relationship to obstructive hypertrophic cardiomyopathy (oHCM) is poorly understood. In addition, the impact of percutaneous transluminal septal myocardial ablation (PTSMA) on CMD has not been fully evaluated. Between October 2023 and May 2024, PTSMA was performed on 10 patients with oHCM. A pressure guidewire in the left anterior descending artery (LAD) was used to invasively assess CMD before and after the procedure. Measurements were recorded for resting full-cycle ratio (RFR), fractional flow reserve (FFR), coronary flow reserve (CFR), and index of microcirculatory resistance (IMR). The 10 patients had a median age of 66 [57-75] years, with a resting left ventricular pressure gradient of 44 [17-84] mmHg, measured via catheterization. Prior to PTSMA, the RFR measured in the LAD was 0.93 [0.91-0.96], and the FFR was 0.95 [0.92-0.95], which were both within normal limits. However, the CFR was reduced to 1.8 [1.6-2.1], and the IMR was elevated to 31 [25-39], which indicated CMD. Post-procedure, the left ventricular pressure gradient decreased to 5 [2-8] mmHg, CFR improved to 2.5 [2.2-3.6], and IMR decreased to 22 [17-26], indicating improvement in CMD. In patients with oHCM, myocardial hypertrophy contributes to left ventricular outflow tract obstruction and CMD. This study demonstrated that PTSMA as a septal reduction therapy improved the left ventricular pressure gradient and CMD.</p>","PeriodicalId":9439,"journal":{"name":"Cardiovascular Intervention and Therapeutics","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Feasibility of guiding catheter exchange using extension wire in percutaneous coronary intervention after transcatheter aortic valve replacement.","authors":"Makoto Saigan, Masaki Miyasaka, Daishi Tazawa, Momo Kosuga, Manabu Maeda, Yun Teng, Natsuko Satomi, Yuta Kobayashi, Masaki Nakashima, Yusuke Enta, Yoshiko Munehisa, Yukihiro Hayatsu, Norio Tada","doi":"10.1007/s12928-025-01159-w","DOIUrl":"https://doi.org/10.1007/s12928-025-01159-w","url":null,"abstract":"<p><p>Percutaneous coronary intervention (PCI) after transcatheter aortic valve replacement (TAVR) is technically challenging because of the presence of the transcatheter heart valve (THV), which complicates coronary artery engagement. Owing to their flexibility, diagnostic catheters (DCs) facilitate coronary access, but require subsequent exchange to guiding catheters (GCs) for PCI. The feasibility of using an extension wire (EW) to facilitate DC-to-GC exchange in this context remains unexplored. A retrospective analysis was conducted at our institution, examining 11 PCI cases performed after TAVR between January 6, 2020, and June 1, 2024, in which an EW was employed to transition from a DC to a GC. Clinical, angiographic, and procedural data were reviewed. Procedural success was defined as a successful DC-to-GC exchange and completion of PCI. DC-to-GC exchange using an EW was successfully achieved in all 11 cases (100%). Revascularization was achieved in 10/11 cases (91%). The lesions were uniformly classified as American College of Cardiology/American Heart Association Type B2/C. The GCs included Judkins-type in 7/11 cases (64%) and backup-type in 4/11 cases (36%). The THV types included SAPIEN in 6/11 cases (55%), Evolut in 3/11 cases (27%), and Navitor in 2/11 cases (18%). A 6Fr GC was utilized in 10/11 cases (91%), and rotational atherectomy was performed in 1/11 cases (9%). The use of an EW to facilitate the transition from DC to GC in PCI after TAVR resulted in high procedural success, providing a feasible approach for addressing complex lesions and optimizing procedural outcomes.</p>","PeriodicalId":9439,"journal":{"name":"Cardiovascular Intervention and Therapeutics","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Iatrogenic laceration of the atrial septum during catheter ablation for atrial fibrillation in a patient with multiple atrial septal defects.","authors":"Koji Nakagawa, Yoichi Takaya, Teiji Akagi, Takashi Miki, Hiroshi Morita, Shinsuke Yuasa","doi":"10.1007/s12928-025-01163-0","DOIUrl":"https://doi.org/10.1007/s12928-025-01163-0","url":null,"abstract":"","PeriodicalId":9439,"journal":{"name":"Cardiovascular Intervention and Therapeutics","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of initial direction of Navitor transcatheter heart valve delivery system on final valve orientation and coronary access.","authors":"Hirokazu Miyashita, Tomoki Ochiai, Daisuke Sato, Yoichi Sugiyama, Kunihiko Shimizu, Noriaki Moriyama, Koki Shishido, Futoshi Yamanaka, Kazuki Tobita, Takashi Matsumoto, Shingo Mizuno, Yutaka Tanaka, Masato Murakami, Shigeru Saito","doi":"10.1007/s12928-025-01158-x","DOIUrl":"https://doi.org/10.1007/s12928-025-01158-x","url":null,"abstract":"<p><p>Data on the impact of the initial Navitor transcatheter heart valve (THV) deployment orientation on the final valve orientation in transcatheter aortic valve implantation (TAVI) assessed using post-implantation computed tomography (CT) is scarce. This study aimed to assess the impact of the initial deployment orientation of Navitor THV on the final orientation and neocommissural overlap with the coronary arteries. Additionally, the incidence of commissural misalignment (CMA) of Navitor THV and its impact on coronary access and short-term valve performance were evaluated. Post-TAVI CT was analysed in 77 patients. Severe coronary artery overlap with THV neocommissure was defined as 0°-20° apart. CMA was categorized by angle deviation from the native commissures: aligned (0°-15°), mild (15°-30°), moderate (30°-45°), and severe (45°-60°). The Navitor delivery system was introduced via the femoral artery with the lock button facing the 3, 6, 9, and 12 o'clock positions. Initial Navitor THV deployment orientation had no impact on the incidence of severe coronary artery overlap. Severe CMA was observed in 80.0% at 3 o'clock, 66.7% at 6 o'clock, 53.8% at 9 o'clock, and 42.2% at 12 o'clock position (p = 0.12). Severe CMA was not associated with the success rate of coronary cannulation after TAVI, short-term valve haemodynamics, or the incidence of hypoattenuated leaflet thickening. Initial Navitor THV orientation did not affect coronary artery overlap or CMA. Moreover, CMA of the Navitor THV did not affect coronary access or short-term valve performance.</p>","PeriodicalId":9439,"journal":{"name":"Cardiovascular Intervention and Therapeutics","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mustafa Bilal Ozbay, Serhat Degirmen, Aysenur Gullu, Bede Nnaemeka Nriagu, Yasin Ozen, Ozlem Ozcan Celebi, Cagri Yayla
{"title":"Comparative outcomes of Myval versus contemporary transcatheter heart valves: a systematic review and meta-analysis.","authors":"Mustafa Bilal Ozbay, Serhat Degirmen, Aysenur Gullu, Bede Nnaemeka Nriagu, Yasin Ozen, Ozlem Ozcan Celebi, Cagri Yayla","doi":"10.1007/s12928-025-01153-2","DOIUrl":"10.1007/s12928-025-01153-2","url":null,"abstract":"<p><p>Transcatheter aortic valve replacement is a key intervention for high-risk patients with severe aortic stenosis. Myval, a newer transcatheter heart valve (THV), shows promise, but a comprehensive comparison with other THVs is lacking. This study evaluates the safety and efficacy of Myval compared with contemporary THVs. A systematic review and meta-analysis of six studies involving 2335 patients was performed. Primary outcomes included all-cause mortality, cardiovascular mortality, new permanent pacemaker implantation (PPI), device success, early safety, acute kidney injury, stroke, vascular complications, and valve regurgitation. Myval was associated with significantly lower rates of new PPI (RR, 0.62; 95% CI 0.45-0.86; P = .004), higher rates of device success (RR, 1.08; 95% CI 1.01-1.16; P = .02), and early safety (RR, 1.15; 95% CI 1.05-1.27; P = .003) compared with contemporary THVs. No significant differences were observed in all-cause mortality, cardiovascular mortality, acute kidney injury, stroke, vascular complications, and valve regurgitation. Myval may offer better short-term outcomes in terms of new PPI, device success, and early safety compared with contemporary THVs. Larger, prospective studies with longer follow-ups are needed to confirm these findings.</p>","PeriodicalId":9439,"journal":{"name":"Cardiovascular Intervention and Therapeutics","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ex vivo micro-computed tomography analysis of the fracking technique for a nodular calcification in the common femoral artery.","authors":"Norihito Nakamura, Yuki Matsumoto, Manabu Shiozaki, Sho Torii","doi":"10.1007/s12928-025-01152-3","DOIUrl":"https://doi.org/10.1007/s12928-025-01152-3","url":null,"abstract":"","PeriodicalId":9439,"journal":{"name":"Cardiovascular Intervention and Therapeutics","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The potential role of major dissection observed on optical frequency-domain imaging in optimal lumen expansion after coronary intravascular lithotripsy: a comparative analysis with calcium fractures.","authors":"Kotaro Miyata, Taku Asano, Takahiro Suzuki, Masafumi Ono, Jiro Aoki","doi":"10.1007/s12928-025-01145-2","DOIUrl":"https://doi.org/10.1007/s12928-025-01145-2","url":null,"abstract":"","PeriodicalId":9439,"journal":{"name":"Cardiovascular Intervention and Therapeutics","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}