Anti-inflammatory & anti-allergy agents in medicinal chemistry最新文献

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Evaluation of the Capparis Herbacea Willd's Chemistry, Antioxidant and Cytotoxic Activity. 草芥化学、抗氧化和细胞毒活性的评价。

Anti-inflammatory & anti-allergy agents in medicinal chemistry Pub Date : 2023-01-01 DOI: 10.2174/0118715230281697231115074426

Orynbassar Tleuberlina, Asem Mamurova, Zhanar Iskakova, Yelaman Aibuldinov, Ainagul Kolpek, Yeldar Kopishev, Gulbarshyn Satbaeva, Zhazira Mukazhanova, Meruyert Kurmanbayeva

{"title":"Evaluation of the Capparis Herbacea Willd's Chemistry, Antioxidant and Cytotoxic Activity.","authors":"Orynbassar Tleuberlina, Asem Mamurova, Zhanar Iskakova, Yelaman Aibuldinov, Ainagul Kolpek, Yeldar Kopishev, Gulbarshyn Satbaeva, Zhazira Mukazhanova, Meruyert Kurmanbayeva","doi":"10.2174/0118715230281697231115074426","DOIUrl":"10.2174/0118715230281697231115074426","url":null,"abstract":"Background: The Capparidaceae family includes the medicinal herb Capparis herbacea Willd. The aerial and underground parts of plant C.herbacea were studied for their chemical composition, antioxidant, and cytotoxic properties.Methods: Using gas chromatography with mass spectrometric detection (7890A/5975C), 94 chemicals were identified in ethanol extract from leaves, roots, seeds, and stems of C. herbacea. Main components were (leaves) phytol 18.16%, hexanedioic acid, bis(2-ethylhexyl) ester 16.75%, vitamin E 11.95%, (roots) sucrose 13.94%, hexadecanoic acid, ethylester 22.80%, octadecanoic acid, ethylester 37.77%; (seeds) hexadecanoic acid, ethylester 13.96%, ethyl9.cis.,11.trans.-octadecadienoate 48.54%, bis(2-ethylhexyl) phthalate 9.77%; (stems) 1-propene-1,2,3-tricarboxylic acid, tributyl ester 42.69%, and tributylacetylcitrate 19.63%. Nine components were identified in the makeup of the C. herbacea sample's essential oil using the method of chromatography-mass spectrometry.Results: The main components were (in%): T-cadinol (29.56), meta-cymene (16.12), pulegone (14.11), and σ-amorphene (12.26). Chloroform and methanol extracts of Capparis herbacia roots at concentrations of 1 mg/ml showed higher average antioxidant activity, while ethyl acetate root extract at concentrations of 0.75 and 1 mg/ml showed higher average antioxidant activity compared to gallic acid AOA.Conclusion: In addition, plant extracts have cytotoxic activity. Essential oils of leaves and stems, fruit and roots of Capparis herbacia plants exhibited cytotoxicity, all larvae died, and larval mortality was 96%.","PeriodicalId":94368,"journal":{"name":"Anti-inflammatory & anti-allergy agents in medicinal chemistry","volume":" ","pages":"261-272"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138453450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reduction of eNOS in Vascular Smooth Muscle by Salt Independently of Hypertension. 盐对血管平滑肌中 eNOS 的影响与高血压无关。

Anti-inflammatory & anti-allergy agents in medicinal chemistry Pub Date : 2016-01-01 Epub Date: 2016-09-22 DOI: 10.2174/1871523015666160922164224

Natalia L. Rukavina Mikusic, María I. Rosón, Silvana L. Della Penna, Marcelo R Choi, Susana Gorzalczany, Elsa Zotta, Jorge E Toblli, Belisario E Fernández

{"title":"Reduction of eNOS in Vascular Smooth Muscle by Salt Independently of Hypertension.","authors":"Natalia L. Rukavina Mikusic, María I. Rosón, Silvana L. Della Penna, Marcelo R Choi, Susana Gorzalczany, Elsa Zotta, Jorge E Toblli, Belisario E Fernández","doi":"10.2174/1871523015666160922164224","DOIUrl":"https://doi.org/10.2174/1871523015666160922164224","url":null,"abstract":"Background: Endothelial nitric oxide synthase (eNOS) is known to be expressed in endothelium and smooth muscle cells of arteries. The aim of this study was to investigate the expression of eNOS in intimal and medial layer of aorta from rats fed with a high salt diet and its modulation by losartan and tempol.Methods: Rats were fed during three weeks with: normal salt diet (NS, 0.4% NaCl); high salt diet (HS, 8% NaCl); NS plus tempol 1 mM (NS-T); HS plus tempol (HS-T); NS plus losartan 40mg.kg-1 (NS-L) and HS plus losartan (HS-L). Systolic blood pressure was recorded by the tail cuff method. Rats were then anaesthetized and the thoracic aorta and small arteries (bronchial branches of aorta) were processed to evaluate the expression of eNOS and aquaporin-1 (AQP-1) by immunohistochemistry.Results: HS group showed increased systolic blood pressure, increased eNOS and AQP-1 immunoexpression in the aorta intimal layer, and decreased eNOS immunoexpression in the aorta medial layer, respect to NS group. Losartan and tempol prevented hypertension and changes in the expression of eNOS and AQP-1 of the intimal layer. However, only tempol increased the expression of eNOS elicited by sodium overload in the medial layer of the aorta and small arteries respect to HS group.Conclusions: A high salt diet decreases eNOS expression in vascular smooth muscle layers of aorta and small arteries, which is reversed by tempol. These results suggest an adverse effect of oxidative stress on vascular eNOS in rats fed a high salt diet independently of hypertension.","PeriodicalId":94368,"journal":{"name":"Anti-inflammatory & anti-allergy agents in medicinal chemistry","volume":"15 2","pages":"135-144"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140041222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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