Translational gastroenterology and hepatology最新文献

{"title":"Splenic injuries following upper endoscopic procedures: a systematic review of cases.","authors":"Brett M Behers, Benjamin J Behers, Anthony J Thompson, William C Hixson, Rushabh S Shah, Marc L Bernstein","doi":"10.21037/tgh-24-93","DOIUrl":"https://doi.org/10.21037/tgh-24-93","url":null,"abstract":"<p><strong>Background: </strong>Splenic injury is a rare complication of upper endoscopic procedures described in case reports. These injuries can result in significant morbidity due to the spleen's vascularity and propensity for intraperitoneal bleeds. This review aims to collect data regarding patient characteristics, procedural factors, clinical presentations and treatment courses for analysis.</p><p><strong>Methods: </strong>A systematic review of case reports on PubMed, Embase, and Web of Science was conducted for splenic injuries following upper endoscopic procedures (as of 14 July 2023). A total of 52 cases from 50 reports were included. All cases were from case reports or series, including conference abstracts, published in English. Cases were excluded if they were: not published in English; dealt with splenic injuries not following upper endoscopic procedures, including colonoscopy; documented a later complication of an upper endoscopic procedure, such as a migrating stent; not case reports or case series, such as review articles. Risk of bias was analyzed with Joanna Briggs Institute critical appraisal tools. Cases were analyzed using descriptive statistics.</p><p><strong>Results: </strong>The mean age was 56 years, with a median of 55 years, and a range of 21-86 years. Prior abdominal surgeries were identified in 31% of cases (16/52), and chronic pancreatitis in 15% (9/52). Procedural difficulty was reported in 21% (11/52). Most occurred following endoscopic retrograde cholangiopancreatography (ERCP) (71%, 37/52). Common symptoms were abdominal pain (79%, 41/52), hypotension and/or tachycardia (67%, 35/52), and postoperative drops in hemoglobin (58%, 30/52). Mean time to symptom onset was 21 hours, with a median of 4 hours, and a range of 0-144 hours. Most were diagnosed with computerized tomography (69%, 36/52), followed by laparotomy (17%, 9/52). Most were treated surgically (76%, 40/52). Most patients recovered fully (82%, 42/51).</p><p><strong>Conclusions: </strong>Splenic injury is a rare complication of upper endoscopy that should be considered given the risk for delayed diagnosis and mortality. Most patients presented with abdominal pain and signs of hemorrhagic shock, although many had delayed onset of symptoms. Potential risk factors include prior abdominal surgeries, chronic pancreatitis, and difficult or prolonged procedures. Our review was limited by a low number of cases and inconsistent reporting of variables, which limited our statistical analysis.</p>","PeriodicalId":94362,"journal":{"name":"Translational gastroenterology and hepatology","volume":"10 ","pages":"34"},"PeriodicalIF":3.8,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12056098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left hepatectomy extended to paracaval segment and anterior vena cava wall, with autologous venous graft reconstruction of middle hepatic vein under veno-venous bypass and \"in situ\" hypothermic liver perfusion: a surgical technique.","authors":"Federico Passagnoli, Ilenia Bartolini, Matteo Risaliti, Benedetta Pesi, Maria Novella Ringressi, Tommaso Nelli, Merve Onkaya, Giacomo Batignani","doi":"10.21037/tgh-24-80","DOIUrl":"https://doi.org/10.21037/tgh-24-80","url":null,"abstract":"<p><p>Surgical resection is the gold standard for the treatment of intrahepatic cholangiocarcinoma, whenever possible. In selected patients with involvement of the inferior vena cava, the hepatic veins or both, an aggressive surgery requiring vascular resection-reconstruction can be safely performed in experienced hands. Different approaches, including \"ex situ\", \"ante situm\" and \"in situ\" liver resection with or without the use of veno-venous bypass or cold liver perfusion can be used. We present the case of a 70-year-old woman presenting with a 5.5 cm mass located in the segment I compatible with an intrahepatic cholangiocarcinoma. A left hepatectomy extended to the segment I, right paracaval portion along with the resection of the anterior wall of the vena cava and the middle hepatic vein, together with its subsequent reconstruction using the autologous left branch of the portal vein was performed using a veno-venous bypass and hypothermic \"in situ\" liver perfusion. Major liver resections with vascular reconstructions that require more than 60 minutes of clamping and veno-venous bypass can be accomplished more safely using \"in situ\" cooling of the liver. The postoperative course was characterized by mild hepatic failure and the patient was discharged on postoperative day 20. In the five years of follow-up, the patient was in good clinical condition and disease-free, but in 2023, she passed away for a disease recurrence.</p>","PeriodicalId":94362,"journal":{"name":"Translational gastroenterology and hepatology","volume":"10 ","pages":"31"},"PeriodicalIF":3.8,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12056123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autoantibody positivity in chronic hepatitis C pre- and post-direct-acting antiviral therapy: a prospective multicenter south Korean study.","authors":"Su Hyun Choi, Gwang Hyeon Choi, Eun Sun Jang, Youn Jae Lee, Young Seok Kim, In Hee Kim, Sung Bum Cho, Byung Seok Lee, Kyung-Ah Kim, Woo Jin Chung, Dahye Baik, Moran Ki, Sook-Hyang Jeong","doi":"10.21037/tgh-24-134","DOIUrl":"https://doi.org/10.21037/tgh-24-134","url":null,"abstract":"<p><strong>Background: </strong>Hepatitis C virus (HCV) infection causes extrahepatic manifestations involving B-cell dysregulation and autoantibody production. This study aimed to elucidate the positivity rates of four autoantibodies [anti-nuclear antibody (ANA), anti-smooth muscle antibody (ASMA), anti-liver kidney microsomal type 1 (anti-LKM1), and anti-mitochondrial antibody (AMA)] in patients with chronic hepatitis C (CHC) before and after direct-acting antiviral (DAA) therapy compared to those in healthy controls.</p><p><strong>Methods: </strong>This study enrolled prospectively collected plasma samples from 201 CHC patients [median age, 62 years; 49.8% women; 100% sustained virological response (SVR)] from eight hospitals before and after DAA therapy and 127 healthy individuals. Autoantibodies were detected using indirect immunofluorescence.</p><p><strong>Results: </strong>The positivity rate of ANA was higher in CHC patients than in healthy controls (32.3% <i>vs.</i> 21.3%, P=0.03) at pretreatment (PreTx) and decreased at SVR (32.3% <i>vs.</i> 23.9%, P=0.009). Female sex and higher globulin levels were related to ANA positivity in the control and CHC patient groups. Thirty-seven (57%) of 65 patients with ANA-positive HCV at PreTx maintained ANA-positivity at SVR. Among the 136 ANA-negative patients at PreTx, 11 (8%) showed newly positive ANA conversion at SVR. Patients with ANA positivity at SVR (n=48) were older and had a higher proportion of advanced liver disease than ANA-negative patients (n=153).</p><p><strong>Conclusions: </strong>ANA positivity was observed in one-third of CHC patients at PreTx, which was significantly higher than that in healthy controls and decreased after SVR. CHC patients with ANA positivity after SVR were older and had more advanced liver disease than those with ANA negativity, suggesting persistent immune dysregulation after cure.</p>","PeriodicalId":94362,"journal":{"name":"Translational gastroenterology and hepatology","volume":"10 ","pages":"24"},"PeriodicalIF":3.8,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12056100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between cholecystectomy and chronic kidney disease risk: a nationally retrospective cohort study.","authors":"Jiwon Yu, Sangwoo Park, Seogsong Jeong, Sun Jae Park, Jihun Song, Hye Jun Kim, Jaewon Lee, Ahryoung Ko, Si Nae Oh, Sang Min Park","doi":"10.21037/tgh-24-98","DOIUrl":"https://doi.org/10.21037/tgh-24-98","url":null,"abstract":"<p><strong>Background: </strong>Cholecystectomy, a common surgery, has been associated to various health issues. Some evidence suggests associations between gallbladder removal and elevated risks of metabolic and cardiovascular diseases. However, the potential association between cholecystectomy and chronic kidney disease (CKD) remains understudied. This study aims to investigate the potential relationship between cholecystectomy and CKD risk using a large, population-based cohort.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted using data from the National Health Insurance Service (NHIS) of Korea [2011-2019]. A total of 2,885 participants who underwent cholecystectomy were matched with 8,653 controls. We matched 2,885 cholecystectomy patients with 8,653 controls (1:3 ratio) by sex and propensity score. The incidence of CKD was followed from the surgery date until death or 2019.</p><p><strong>Results: </strong>During a mean follow-up time of 6.04 years, 239 CKD cases were identified. The risk of CKD was significantly increased in the cholecystectomy group compared with the non-cholecystectomy group after adjustment for covariates [adjusted hazard ratio (aHR) 1.89; 95% confidence interval (CI): 1.55-2.31]. This association was observed more than 3 years after cholecystectomy (aHR 1.68; 95% CI: 1.38-2.05) and were consistent across strata of sex, age group, household income, physical activity, and smoking status.</p><p><strong>Conclusions: </strong>Post-cholecystectomy patients might have a higher risk of CKD, and this increased risk could persist over time. Further long-term and in-depth studies are needed to explore the association between cholecystectomy and CKD.</p>","PeriodicalId":94362,"journal":{"name":"Translational gastroenterology and hepatology","volume":"10 ","pages":"27"},"PeriodicalIF":3.8,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12056102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new dawn in cancer immunotherapy: the promise of mutant <i>KRAS</i>-specific vaccines.","authors":"Sheela Ruby Damle, Venu Gopal Pillarisetty, Rachael Ann Safyan, Elena Gabriela Chiorean","doi":"10.21037/tgh-24-121","DOIUrl":"https://doi.org/10.21037/tgh-24-121","url":null,"abstract":"","PeriodicalId":94362,"journal":{"name":"Translational gastroenterology and hepatology","volume":"10 ","pages":"20"},"PeriodicalIF":3.8,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12056101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LOAd703 and chemotherapy combination in pancreatic cancer: insights from the LOKON001 study.","authors":"Ziad Abuhelwa, Dae Won Kim","doi":"10.21037/tgh-24-139","DOIUrl":"https://doi.org/10.21037/tgh-24-139","url":null,"abstract":"","PeriodicalId":94362,"journal":{"name":"Translational gastroenterology and hepatology","volume":"10 ","pages":"21"},"PeriodicalIF":3.8,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12056096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neoadjuvant mFOLFIRINOX for resectable pancreatic cancer: increasing evidence, ongoing challenges.","authors":"Taylor Neilson, Jordan M Cloyd","doi":"10.21037/tgh-24-135","DOIUrl":"https://doi.org/10.21037/tgh-24-135","url":null,"abstract":"","PeriodicalId":94362,"journal":{"name":"Translational gastroenterology and hepatology","volume":"10 ","pages":"22"},"PeriodicalIF":3.8,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12056118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-linear relationship between Dietary Inflammatory Index and constipation: threshold identification and insights from NHANES [2005-2010] and Mendelian randomization analysis.","authors":"Shuxun Wei, Jin Qian, Minghao Zou, Ye Qian, Wenxuan Zhou, Yangjuan Gu, Lili Tang, Hui Liu, Chengjing Zhang","doi":"10.21037/tgh-24-99","DOIUrl":"https://doi.org/10.21037/tgh-24-99","url":null,"abstract":"<p><strong>Background: </strong>With the acceleration of the pace of life and changes in dietary habits, functional gastrointestinal disorders, especially constipation, have become a significant public health issue affecting health and quality of life of people worldwide. Given the limitations of traditional treatments, adjusting dietary structure has become a more economical and convenient therapeutic approach. We aimed to explore the associations between the Dietary Inflammatory Index (DII) and constipation in this study.</p><p><strong>Methods: </strong>This study was based on the National Health and Nutrition Examination Survey (NHANES) data from 2005-2010, utilizing bowel movement frequency and stool characteristics questionnaires to determine constipation status, and calculating the DII based on 24-hour dietary recall data. To assess the relationship between the DII and constipation, we employed three models, which were further explored through inverse probability of treatment weighting (IPTW), restricted cubic splines (RCS) analysis, and Mendelian randomization.</p><p><strong>Results: </strong>Individuals with a higher DII exhibited a higher risk of constipation. In the unadjusted model, participants in the highest quartile (Q4) had a 2.85-fold increased risk of constipation compared to those in the lowest quartile (Q1) [odds ratio (OR): 2.85; 95% confidence interval (CI): 1.78-4.56; P<0.001], with similar results observed in various adjusted models and IPTW adjusted models. RCS analysis revealed a nonlinear relationship between the DII and constipation, with a threshold value (DII =0.974) beyond which the risk of constipation significantly increased. Subgroup analysis showed that gender, income level, and diabetes status affected the relationship between the DII and constipation. Mendelian randomization analysis did not find any significant causal relationships for components of the DII, except for energy intake.</p><p><strong>Conclusions: </strong>There is a nonlinear relationship between the DII and the risk of constipation, with a threshold value of 0.974, and differences in the risk of constipation associated with the DII across different income, gender, and diabetes status groups. These findings provide a basis for using the DII as a strategy for the prevention and intervention of constipation.</p>","PeriodicalId":94362,"journal":{"name":"Translational gastroenterology and hepatology","volume":"10 ","pages":"25"},"PeriodicalIF":3.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12056116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a basement membrane-associated immune prognostic model for hepatocellular carcinoma.","authors":"Qiji Ma, Yun Wang, Jie Xing, Tielin Wang, Gang Wang","doi":"10.21037/tgh-24-89","DOIUrl":"https://doi.org/10.21037/tgh-24-89","url":null,"abstract":"<p><strong>Background: </strong>Hepatocellular carcinoma (HCC), one of the most common malignant tumors worldwide, has a poor prognosis primarily due to its invasive and metastatic characteristics. Cancer invasion through basement membrane (BM) is the pivotal initial step in tumor dissemination and metastasis. This study aimed to identify gene signatures associated with the BM to enhance the overall prognosis of HCC.</p><p><strong>Methods: </strong>In this study, we performed multiple bioinformatics analyses based on the RNA sequencing (RNA-seq) data and clinical information from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets. An unsupervised consistent cluster analysis was conducted on 370 HCC patients, categorizing them into two distinct groups based on the expression profiles of 222 BM-related genes. Differentially expressed genes (DEGs) between these clusters were identified, followed by functional enrichment analysis. To explore the differences between the groups, the Estimation of STromal and Immune cells in MAlignant Tumours using Expression data (ESTIMATE) and Cell type Identification By Estimating Relative Subsets Of known RNA Transcripts (CIBERSORT) algorithms were applied, along with the analysis of immune checkpoint molecules and human leukocyte antigen (HLA) expression levels. This helped in understanding the relationship between the HCC immune microenvironment and BM-related genes. A prognostic model was constructed using univariate Cox and least absolute shrinkage and selection operator (LASSO) regression analyses, with its performance subsequently estimated and validated. Additionally, hub biomarkers genes were identified using machine learning techniques, followed by an analysis of their functions and relationships with clinical characteristics. Finally, single-cell clustering analysis was employed to further investigate the expression distribution of these genes within the HCC immune microenvironment.</p><p><strong>Results: </strong>Following consistent cluster analysis, two groups were identified: the BM high group and the BM low group. Among the 6,221 DEGs between the two groups, 5,863 were upregulated and 358 were downregulated, with enrichment functions primarily associated with extracellular matrix (ECM) organization, cell adhesion, immune response, and metabolism. The expression levels of BM-related genes were found to regulate the HCC immune microenvironment. Using univariate Cox regression analysis, 60 prognostic BM-related genes were identified, leading to the establishment of an 11-gene prognostic model named BMscore to predict the overall survival (OS) of HCC patients. The high BMscore group indicated worse prognosis, and the model's predictive performance was validated using the GEO dataset. <i>P3H1</i> and <i>ADAMTS5</i> were identified as hub biomarkers, playing roles in cell proliferation and ECM metabolism, with their expression distributions mapped respectively.</p><p><strong>Conclusio","PeriodicalId":94362,"journal":{"name":"Translational gastroenterology and hepatology","volume":"10 ","pages":"28"},"PeriodicalIF":3.8,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12056121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-existing regeneration mechanisms in severe alcohol-related steatohepatitis.","authors":"Adrienne Lejeune, Peter Stärkel, Alexandre Louvet, Axel Hittelet, Céline Bazille, Boris Bastens, Hans Orlent, Luc Lasser, Xavier Dekoninck, Sergio Negrin Dastis, Jean Delwaide, Anja Geerts, Christophe Moreno, Chantal de Galocsy, Virginie Putzeys, Phillippe Langlet, Hendrik Reynaert, Sven Francque, Mina Komuta, Nicolas Lanthier","doi":"10.21037/tgh-24-92","DOIUrl":"10.21037/tgh-24-92","url":null,"abstract":"<p><strong>Background: </strong>Keratin 7 positive (K7⁺) cells are considered to be activated in case of impaired hepatocyte replication. Their exact role and their interaction with hepatocytes and macrophages also implicated in liver regeneration remain poorly characterized in humans. The aim of this study is to evaluate hepatocyte, K7⁺ cells and macrophage populations in severe alcohol-related steatohepatitis (sASH) and to link them with liver injury and patients' outcomes.</p><p><strong>Methods: </strong>Immunohistochemical and morphometric studies for total K7⁺ cells, macrophages (CD68⁺ cells), proliferative hepatocytes (Ki67⁺ hepatocytes) and proliferative K7⁺ cells (double K7⁺ and Ki67⁺) were performed on liver biopsies of patients with sASH recruited prospectively in 16 different centres. Patients were divided into improvers or non-improvers, according to mortality and model for end-stage liver disease (MELD) score change at 3 months.</p><p><strong>Results: </strong>Fifty-seven cases were included for histological and morphometrical assessment. Liver total K7⁺ cell expansion was positively correlated to the severity of the disease evaluated by the MELD score. A proportion of these K7⁺ cells were proliferating. The number of proliferating K7⁺ cells was less than the number of proliferating hepatocytes. Increased hepatocyte replication was correlated to a higher proliferative K7⁺ cell count. A higher number of macrophages was associated with a higher proliferation of both hepatocytes and K7⁺ cells. No difference of total K7⁺ cells, proliferative K7⁺ cells, proliferative hepatocytes or macrophages was observed between improvers and non-improvers.</p><p><strong>Conclusions: </strong>In biopsy-proven cases of sASH, proliferation of hepatocytes and K7⁺ cells occurs in parallel. This could suggest that liver progenitor cells begin to replicate even in the absence of massive hepatocyte senescence in humans, or that proliferating progenitor cells are capable of giving rise to hepatocytes with replicative skills. This is associated with macrophagic expansion, which is therefore considered beneficial. However, in this severe, life-threatening disease, these mechanisms remain insufficient to improve patient prognosis.</p>","PeriodicalId":94362,"journal":{"name":"Translational gastroenterology and hepatology","volume":"10 ","pages":"3"},"PeriodicalIF":3.8,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}