Translational gastroenterology and hepatology最新文献

{"title":"Autoantibody positivity in chronic hepatitis C pre- and post-direct-acting antiviral therapy: a prospective multicenter south Korean study.","authors":"Su Hyun Choi, Gwang Hyeon Choi, Eun Sun Jang, Youn Jae Lee, Young Seok Kim, In Hee Kim, Sung Bum Cho, Byung Seok Lee, Kyung-Ah Kim, Woo Jin Chung, Dahye Baik, Moran Ki, Sook-Hyang Jeong","doi":"10.21037/tgh-24-134","DOIUrl":"https://doi.org/10.21037/tgh-24-134","url":null,"abstract":"<p><strong>Background: </strong>Hepatitis C virus (HCV) infection causes extrahepatic manifestations involving B-cell dysregulation and autoantibody production. This study aimed to elucidate the positivity rates of four autoantibodies [anti-nuclear antibody (ANA), anti-smooth muscle antibody (ASMA), anti-liver kidney microsomal type 1 (anti-LKM1), and anti-mitochondrial antibody (AMA)] in patients with chronic hepatitis C (CHC) before and after direct-acting antiviral (DAA) therapy compared to those in healthy controls.</p><p><strong>Methods: </strong>This study enrolled prospectively collected plasma samples from 201 CHC patients [median age, 62 years; 49.8% women; 100% sustained virological response (SVR)] from eight hospitals before and after DAA therapy and 127 healthy individuals. Autoantibodies were detected using indirect immunofluorescence.</p><p><strong>Results: </strong>The positivity rate of ANA was higher in CHC patients than in healthy controls (32.3% <i>vs.</i> 21.3%, P=0.03) at pretreatment (PreTx) and decreased at SVR (32.3% <i>vs.</i> 23.9%, P=0.009). Female sex and higher globulin levels were related to ANA positivity in the control and CHC patient groups. Thirty-seven (57%) of 65 patients with ANA-positive HCV at PreTx maintained ANA-positivity at SVR. Among the 136 ANA-negative patients at PreTx, 11 (8%) showed newly positive ANA conversion at SVR. Patients with ANA positivity at SVR (n=48) were older and had a higher proportion of advanced liver disease than ANA-negative patients (n=153).</p><p><strong>Conclusions: </strong>ANA positivity was observed in one-third of CHC patients at PreTx, which was significantly higher than that in healthy controls and decreased after SVR. CHC patients with ANA positivity after SVR were older and had more advanced liver disease than those with ANA negativity, suggesting persistent immune dysregulation after cure.</p>","PeriodicalId":94362,"journal":{"name":"Translational gastroenterology and hepatology","volume":"10 ","pages":"24"},"PeriodicalIF":3.8,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12056100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between cholecystectomy and chronic kidney disease risk: a nationally retrospective cohort study.","authors":"Jiwon Yu, Sangwoo Park, Seogsong Jeong, Sun Jae Park, Jihun Song, Hye Jun Kim, Jaewon Lee, Ahryoung Ko, Si Nae Oh, Sang Min Park","doi":"10.21037/tgh-24-98","DOIUrl":"https://doi.org/10.21037/tgh-24-98","url":null,"abstract":"<p><strong>Background: </strong>Cholecystectomy, a common surgery, has been associated to various health issues. Some evidence suggests associations between gallbladder removal and elevated risks of metabolic and cardiovascular diseases. However, the potential association between cholecystectomy and chronic kidney disease (CKD) remains understudied. This study aims to investigate the potential relationship between cholecystectomy and CKD risk using a large, population-based cohort.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted using data from the National Health Insurance Service (NHIS) of Korea [2011-2019]. A total of 2,885 participants who underwent cholecystectomy were matched with 8,653 controls. We matched 2,885 cholecystectomy patients with 8,653 controls (1:3 ratio) by sex and propensity score. The incidence of CKD was followed from the surgery date until death or 2019.</p><p><strong>Results: </strong>During a mean follow-up time of 6.04 years, 239 CKD cases were identified. The risk of CKD was significantly increased in the cholecystectomy group compared with the non-cholecystectomy group after adjustment for covariates [adjusted hazard ratio (aHR) 1.89; 95% confidence interval (CI): 1.55-2.31]. This association was observed more than 3 years after cholecystectomy (aHR 1.68; 95% CI: 1.38-2.05) and were consistent across strata of sex, age group, household income, physical activity, and smoking status.</p><p><strong>Conclusions: </strong>Post-cholecystectomy patients might have a higher risk of CKD, and this increased risk could persist over time. Further long-term and in-depth studies are needed to explore the association between cholecystectomy and CKD.</p>","PeriodicalId":94362,"journal":{"name":"Translational gastroenterology and hepatology","volume":"10 ","pages":"27"},"PeriodicalIF":3.8,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12056102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new dawn in cancer immunotherapy: the promise of mutant <i>KRAS</i>-specific vaccines.","authors":"Sheela Ruby Damle, Venu Gopal Pillarisetty, Rachael Ann Safyan, Elena Gabriela Chiorean","doi":"10.21037/tgh-24-121","DOIUrl":"https://doi.org/10.21037/tgh-24-121","url":null,"abstract":"","PeriodicalId":94362,"journal":{"name":"Translational gastroenterology and hepatology","volume":"10 ","pages":"20"},"PeriodicalIF":3.8,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12056101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LOAd703 and chemotherapy combination in pancreatic cancer: insights from the LOKON001 study.","authors":"Ziad Abuhelwa, Dae Won Kim","doi":"10.21037/tgh-24-139","DOIUrl":"https://doi.org/10.21037/tgh-24-139","url":null,"abstract":"","PeriodicalId":94362,"journal":{"name":"Translational gastroenterology and hepatology","volume":"10 ","pages":"21"},"PeriodicalIF":3.8,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12056096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neoadjuvant mFOLFIRINOX for resectable pancreatic cancer: increasing evidence, ongoing challenges.","authors":"Taylor Neilson, Jordan M Cloyd","doi":"10.21037/tgh-24-135","DOIUrl":"https://doi.org/10.21037/tgh-24-135","url":null,"abstract":"","PeriodicalId":94362,"journal":{"name":"Translational gastroenterology and hepatology","volume":"10 ","pages":"22"},"PeriodicalIF":3.8,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12056118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-linear relationship between Dietary Inflammatory Index and constipation: threshold identification and insights from NHANES [2005-2010] and Mendelian randomization analysis.","authors":"Shuxun Wei, Jin Qian, Minghao Zou, Ye Qian, Wenxuan Zhou, Yangjuan Gu, Lili Tang, Hui Liu, Chengjing Zhang","doi":"10.21037/tgh-24-99","DOIUrl":"https://doi.org/10.21037/tgh-24-99","url":null,"abstract":"<p><strong>Background: </strong>With the acceleration of the pace of life and changes in dietary habits, functional gastrointestinal disorders, especially constipation, have become a significant public health issue affecting health and quality of life of people worldwide. Given the limitations of traditional treatments, adjusting dietary structure has become a more economical and convenient therapeutic approach. We aimed to explore the associations between the Dietary Inflammatory Index (DII) and constipation in this study.</p><p><strong>Methods: </strong>This study was based on the National Health and Nutrition Examination Survey (NHANES) data from 2005-2010, utilizing bowel movement frequency and stool characteristics questionnaires to determine constipation status, and calculating the DII based on 24-hour dietary recall data. To assess the relationship between the DII and constipation, we employed three models, which were further explored through inverse probability of treatment weighting (IPTW), restricted cubic splines (RCS) analysis, and Mendelian randomization.</p><p><strong>Results: </strong>Individuals with a higher DII exhibited a higher risk of constipation. In the unadjusted model, participants in the highest quartile (Q4) had a 2.85-fold increased risk of constipation compared to those in the lowest quartile (Q1) [odds ratio (OR): 2.85; 95% confidence interval (CI): 1.78-4.56; P<0.001], with similar results observed in various adjusted models and IPTW adjusted models. RCS analysis revealed a nonlinear relationship between the DII and constipation, with a threshold value (DII =0.974) beyond which the risk of constipation significantly increased. Subgroup analysis showed that gender, income level, and diabetes status affected the relationship between the DII and constipation. Mendelian randomization analysis did not find any significant causal relationships for components of the DII, except for energy intake.</p><p><strong>Conclusions: </strong>There is a nonlinear relationship between the DII and the risk of constipation, with a threshold value of 0.974, and differences in the risk of constipation associated with the DII across different income, gender, and diabetes status groups. These findings provide a basis for using the DII as a strategy for the prevention and intervention of constipation.</p>","PeriodicalId":94362,"journal":{"name":"Translational gastroenterology and hepatology","volume":"10 ","pages":"25"},"PeriodicalIF":3.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12056116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a basement membrane-associated immune prognostic model for hepatocellular carcinoma.","authors":"Qiji Ma, Yun Wang, Jie Xing, Tielin Wang, Gang Wang","doi":"10.21037/tgh-24-89","DOIUrl":"https://doi.org/10.21037/tgh-24-89","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Hepatocellular carcinoma (HCC), one of the most common malignant tumors worldwide, has a poor prognosis primarily due to its invasive and metastatic characteristics. Cancer invasion through basement membrane (BM) is the pivotal initial step in tumor dissemination and metastasis. This study aimed to identify gene signatures associated with the BM to enhance the overall prognosis of HCC.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;In this study, we performed multiple bioinformatics analyses based on the RNA sequencing (RNA-seq) data and clinical information from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets. An unsupervised consistent cluster analysis was conducted on 370 HCC patients, categorizing them into two distinct groups based on the expression profiles of 222 BM-related genes. Differentially expressed genes (DEGs) between these clusters were identified, followed by functional enrichment analysis. To explore the differences between the groups, the Estimation of STromal and Immune cells in MAlignant Tumours using Expression data (ESTIMATE) and Cell type Identification By Estimating Relative Subsets Of known RNA Transcripts (CIBERSORT) algorithms were applied, along with the analysis of immune checkpoint molecules and human leukocyte antigen (HLA) expression levels. This helped in understanding the relationship between the HCC immune microenvironment and BM-related genes. A prognostic model was constructed using univariate Cox and least absolute shrinkage and selection operator (LASSO) regression analyses, with its performance subsequently estimated and validated. Additionally, hub biomarkers genes were identified using machine learning techniques, followed by an analysis of their functions and relationships with clinical characteristics. Finally, single-cell clustering analysis was employed to further investigate the expression distribution of these genes within the HCC immune microenvironment.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Following consistent cluster analysis, two groups were identified: the BM high group and the BM low group. Among the 6,221 DEGs between the two groups, 5,863 were upregulated and 358 were downregulated, with enrichment functions primarily associated with extracellular matrix (ECM) organization, cell adhesion, immune response, and metabolism. The expression levels of BM-related genes were found to regulate the HCC immune microenvironment. Using univariate Cox regression analysis, 60 prognostic BM-related genes were identified, leading to the establishment of an 11-gene prognostic model named BMscore to predict the overall survival (OS) of HCC patients. The high BMscore group indicated worse prognosis, and the model's predictive performance was validated using the GEO dataset. &lt;i&gt;P3H1&lt;/i&gt; and &lt;i&gt;ADAMTS5&lt;/i&gt; were identified as hub biomarkers, playing roles in cell proliferation and ECM metabolism, with their expression distributions mapped respectively.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusio","PeriodicalId":94362,"journal":{"name":"Translational gastroenterology and hepatology","volume":"10 ","pages":"28"},"PeriodicalIF":3.8,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12056121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Staged preoperative evaluation of potential living donors for liver transplantation.","authors":"Camila Sotomayor, Daniel García, Patricia Rebolledo, Maria Pilar Dominguez, Antonia Pastoré, Pablo Achurra, Eduardo Viñuela, Juan Pablo Arab, Carlos Benitez, Alvaro Huete, Eduardo Briceño, Jorge Martinez, Nicolas Jarufe, Martin J Dib","doi":"10.21037/tgh-24-65","DOIUrl":"10.21037/tgh-24-65","url":null,"abstract":"<p><strong>Background: </strong>Living donor selection is crucial to minimize postoperative donor complications and to improve recipient outcomes. This study describes the selection process and evaluates the reasons for discarding potential donors in our living donor liver transplantation (LDLT) program.</p><p><strong>Methods: </strong>Retrospective descriptive analysis from all potential donors evaluated in our LDLT program between April 2018 and July 2021. Selection criteria included age 18-60 years old, no significant medical or mental comorbidities, ABO and anatomical suitability.</p><p><strong>Results: </strong>A total of 231 potential donors were evaluated. Mean age was 37.2±11.1 years and male gender in 51.9%. One hundred and one potential donors (43.7%) did not complete the evaluation, mainly because of availability of a deceased donor during the process (n=32; 13.9%), ABO incompatibility (n=14; 6.1%), progression or death of the recipient (n=20; 8.7%). Of the 130 who completed their radiological evaluation, 55 (42.3%) were anatomically unsuitable, mainly due to small liver remnant size (n=25/130; 19.2%) and steatosis (n=17/130; 13.1%). Out of the 231 potential donors, 75 were accepted as adequate donors (32.5%) and 36 candidates underwent liver donation (15.6%).</p><p><strong>Conclusions: </strong>Only one-third of all potential donors are suitable for donation and half of them will undergo surgery. Given that in our setting computed tomography (CT) has a lower cost than magnetic resonance imaging (MRI), starting with a CT scan decreases the high cost of further workup of donors that are not anatomically suitable for living liver donation.</p>","PeriodicalId":94362,"journal":{"name":"Translational gastroenterology and hepatology","volume":"10 ","pages":"2"},"PeriodicalIF":3.8,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-existing regeneration mechanisms in severe alcohol-related steatohepatitis.","authors":"Adrienne Lejeune, Peter Stärkel, Alexandre Louvet, Axel Hittelet, Céline Bazille, Boris Bastens, Hans Orlent, Luc Lasser, Xavier Dekoninck, Sergio Negrin Dastis, Jean Delwaide, Anja Geerts, Christophe Moreno, Chantal de Galocsy, Virginie Putzeys, Phillippe Langlet, Hendrik Reynaert, Sven Francque, Mina Komuta, Nicolas Lanthier","doi":"10.21037/tgh-24-92","DOIUrl":"10.21037/tgh-24-92","url":null,"abstract":"<p><strong>Background: </strong>Keratin 7 positive (K7⁺) cells are considered to be activated in case of impaired hepatocyte replication. Their exact role and their interaction with hepatocytes and macrophages also implicated in liver regeneration remain poorly characterized in humans. The aim of this study is to evaluate hepatocyte, K7⁺ cells and macrophage populations in severe alcohol-related steatohepatitis (sASH) and to link them with liver injury and patients' outcomes.</p><p><strong>Methods: </strong>Immunohistochemical and morphometric studies for total K7⁺ cells, macrophages (CD68⁺ cells), proliferative hepatocytes (Ki67⁺ hepatocytes) and proliferative K7⁺ cells (double K7⁺ and Ki67⁺) were performed on liver biopsies of patients with sASH recruited prospectively in 16 different centres. Patients were divided into improvers or non-improvers, according to mortality and model for end-stage liver disease (MELD) score change at 3 months.</p><p><strong>Results: </strong>Fifty-seven cases were included for histological and morphometrical assessment. Liver total K7⁺ cell expansion was positively correlated to the severity of the disease evaluated by the MELD score. A proportion of these K7⁺ cells were proliferating. The number of proliferating K7⁺ cells was less than the number of proliferating hepatocytes. Increased hepatocyte replication was correlated to a higher proliferative K7⁺ cell count. A higher number of macrophages was associated with a higher proliferation of both hepatocytes and K7⁺ cells. No difference of total K7⁺ cells, proliferative K7⁺ cells, proliferative hepatocytes or macrophages was observed between improvers and non-improvers.</p><p><strong>Conclusions: </strong>In biopsy-proven cases of sASH, proliferation of hepatocytes and K7⁺ cells occurs in parallel. This could suggest that liver progenitor cells begin to replicate even in the absence of massive hepatocyte senescence in humans, or that proliferating progenitor cells are capable of giving rise to hepatocytes with replicative skills. This is associated with macrophagic expansion, which is therefore considered beneficial. However, in this severe, life-threatening disease, these mechanisms remain insufficient to improve patient prognosis.</p>","PeriodicalId":94362,"journal":{"name":"Translational gastroenterology and hepatology","volume":"10 ","pages":"3"},"PeriodicalIF":3.8,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lymph node metastases status in esophageal squamous cell carcinoma following neoadjuvant chemoradiotherapy: a single-center cross-sectional study.","authors":"Anh Tuan Nguyen, Van Hiep Pham, Manh Thang Tran, Pham Nghia Do Nguyen","doi":"10.21037/tgh-24-76","DOIUrl":"10.21037/tgh-24-76","url":null,"abstract":"<p><strong>Background: </strong>The status of lymph node (LN) metastases in esophageal squamous cell carcinoma (ESCC) following neoadjuvant chemoradiation (NCRT) is not well understood but significantly affects patient prognosis and treatment options. We conducted this study to evaluate the distribution of LN metastases in patients with ESCC who received NCRT combined minimally invasive esophagectomy (MIE).</p><p><strong>Methods: </strong>From March 2019 to September 2023, patients with middle- and lower-third ESCC received NCRT, followed by MIE with two-field lymphadenectomy, were included in this study. The primary outcome was to examine the distribution of LN metastases and their correlation with the radiation fields. Secondary outcomes included identifying risk factors for LN metastases and their impact on long-term survival.</p><p><strong>Results: </strong>One hundred consecutive patients were included, and 4.11% had LN metastases. The median number of positive LN and the rate of LN metastases in the thoracic LN stations was lower than that of the abdominal region (1.5 and 2.84% <i>vs.</i> 2 and 5.94%, respectively). Over half of the patients had LN metastases within the radiation field. The multivariate analysis found that the LN metastases were associated with the ycN-stage [hazard ratio (HR) =2.03, 95% confidence interval (CI): 1.02-4.04, P=0.04]. Although the LN metastases were not significantly associated with either overall survival (OS) or disease-free survival (DFS) (P=0.89 and P=0.65, respectively), the number of LN removal ≥15 LN removals was significantly improved both OS and DFS (P=0.040 and P=0.049, respectively).</p><p><strong>Conclusions: </strong>In patients with middle- and lower-third ESCC who underwent NCRT followed by MIE, the rate of LN metastases in the abdominal region is higher than in the thoracic region. The majority of patients had LN metastases within the radiation field. Therefore, NCRT does not justify minimizing lymphadenectomy in ESCC; furthermore, a higher ycN-stage correlated with a higher incidence of LN metastases; higher ycN-stage correlates with higher LN metastases.</p>","PeriodicalId":94362,"journal":{"name":"Translational gastroenterology and hepatology","volume":"10 ","pages":"8"},"PeriodicalIF":3.8,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}