The EPMA journal最新文献

{"title":"Identification of clinical trait-related lncRNA and mRNA biomarkers with weighted gene co-expression network analysis as useful tool for personalized medicine in ovarian cancer.","authors":"Na Li, Xianquan Zhan","doi":"10.1007/s13167-019-00175-0","DOIUrl":"10.1007/s13167-019-00175-0","url":null,"abstract":"<p><strong>Relevance: </strong>The pathogenesis and biomarkers of ovarian cancer (OC) remain not well-known in diagnosis, effective therapy, and prognostic assessment in OC personalized medicine. The novel identified lncRNA and mRNA biomarkers from gene co-expression modules associated with clinical traits provide new insight for effective treatment of ovarian cancer.</p><p><strong>Purpose: </strong>Long non-coding RNAs (lncRNAs) are relevant to tumorigenesis via multiple mechanisms. This study aimed to investigate cancer-specific lncRNAs and mRNAs, and their related networks in OCs.</p><p><strong>Methods: </strong>This study comprehensively analyzed lncRNAs and mRNAs with associated competing endogenous RNA (ceRNA) network and lncRNA-RNA binding protein-mRNA network in the OC tissues in the Cancer Genome Atlas, including 2562 cancer-specific lncRNAs (<i>n</i> = 352 OC tissues) and 5000 mRNAs (<i>n</i> = 359 OC tissues). The weighted gene co-expression network analysis (WGCNA) was used to construct the co-expression gene modules and their relationship with clinical traits. The statistically significant difference of identified lncRNAs and mRNAs was confirmed with qRT-PCR in OC cells.</p><p><strong>Results: </strong>An lncRNA-based co-expression module was significantly correlated with patient age at initial pathologic diagnosis, lymphatic invasion, tissues source site, and vascular invasion, and identified 16 lncRNAs (ACTA2-AS1, CARD8-AS1, HCP5, HHIP-AS1, HOTAIRM1, ITGB2-AS1, LINC00324, LINC00605, LINC01503, LINC01547, MIR31HG, MIR155HG, OTUD6B-AS1, PSMG3-AS1, SH3PXD2A-AS1, and ZBED5-AS1) that were significantly related to overall survival in OC patients. An mRNA-based co-expression module was significantly correlated with patient age at initial pathologic diagnosis, lymphatic invasion, tumor residual disease, and vascular invasion; and identified 21 hub-mRNA molecules and 11 mRNAs (FBN3, TCF7L1, SBK1, TRO, TUBB2B, PLCG1, KIAA1549, PHC1, DNMT3A, LAMA1, and C10orf82) that were closely linked with OC patients' overall survival. Moreover, the prognostic model of five-gene signature (OTUD6B-AS1, PSMG3-AS1, ZBED5-AS1, SBK1, and PLCG1) was constructed to predict risk score in OC patients. Furthermore, starBase bioinformatics constructed the lncRNA-miRNA-mRNA and lncRNA-RNA binding protein-mRNA networks in OCs.</p><p><strong>Conclusion: </strong>These new findings showed that lncRNA-related networks in OCs are a useful resource for identification of biomarkers in OCs.</p>","PeriodicalId":94358,"journal":{"name":"The EPMA journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90445919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Status of stem cells in diabetic nephropathy: predictive and preventive potentials","authors":"B. Baban, J. Liu, S. Payne, W. Abebe, Jack C. Yu, M. Mozaffari","doi":"10.1186/s13167-016-0070-6","DOIUrl":"https://doi.org/10.1186/s13167-016-0070-6","url":null,"abstract":"","PeriodicalId":94358,"journal":{"name":"The EPMA journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86981097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental and lifestyle risk factors of breast cancer in Malta—a retrospective case-control study","authors":"J. Cauchi, L. Camilleri, C. Scerri","doi":"10.1186/s13167-016-0069-z","DOIUrl":"https://doi.org/10.1186/s13167-016-0069-z","url":null,"abstract":"","PeriodicalId":94358,"journal":{"name":"The EPMA journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87308937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EPMA-World Congress 2015","authors":"O. Golubnitschaja, Manuel Debald, W. Kuhn, K. Yeghiazaryan, Rostyslav V Bubnov, V. Goncharenko, U. Lushchyk, G. Grech, K. Konieczka","doi":"10.1186/s13167-016-0054-6","DOIUrl":"https://doi.org/10.1186/s13167-016-0054-6","url":null,"abstract":"","PeriodicalId":94358,"journal":{"name":"The EPMA journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72603235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First results of the double-blind randomized placebo-controlled multicenter clinical trial of DIM-based therapy designed as personalized approach to reverse prostatic intraepithelial neoplasia (PIN)","authors":"M. Paltsev, V. Kiselev, V. Drukh, E. Muyzhnek, I. Kuznetsov, E. Andrianova, Pavel Baranovskiy","doi":"10.1186/s13167-016-0057-3","DOIUrl":"https://doi.org/10.1186/s13167-016-0057-3","url":null,"abstract":"","PeriodicalId":94358,"journal":{"name":"The EPMA journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74074612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of calcitonin gene-related peptide antagonist on the cardiovascular events, mortality, and prostaglandin E2 production by nitrate-induced tolerant rats with acute myocardial infarction","authors":"T. Kezeli, T. Rukhadze, N. Gongadze, G. Sukoyan, N. Dolidze, M. Chipashvili, M. Mirziashvili","doi":"10.1186/s13167-016-0055-5","DOIUrl":"https://doi.org/10.1186/s13167-016-0055-5","url":null,"abstract":"","PeriodicalId":94358,"journal":{"name":"The EPMA journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91516901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilization of the clinical laboratory for the implementation of concussion biomarkers in collegiate football and the necessity of personalized and predictive athlete specific reference intervals","authors":"Stefanie Schulte, Natalie N. Rasmussen, Joseph W. McBeth, Patrick Q. Richards, Eric M Yochem, David J. Petron, Frederick G. Strathmann","doi":"10.1186/s13167-016-0050-x","DOIUrl":"https://doi.org/10.1186/s13167-016-0050-x","url":null,"abstract":"","PeriodicalId":94358,"journal":{"name":"The EPMA journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85675268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of aceclofenac and bovine serum albumin interaction using fluorescence quenching method for predictive, preventive, and personalized medicine","authors":"Sabiha Ferdowsy Koly, S. Kundu, Shaila Kabir, M. S. Amran, Md. Zakir Sultan","doi":"10.1186/s13167-015-0047-x","DOIUrl":"https://doi.org/10.1186/s13167-015-0047-x","url":null,"abstract":"","PeriodicalId":94358,"journal":{"name":"The EPMA journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81413654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HTRF: a technology tailored for biomarker determination—novel analytical detection system suitable for detection of specific autoimmune antibodies as biomarkers in nanogram level in different body fluids","authors":"L. Einhorn, K. Krapfenbauer","doi":"10.1186/s13167-015-0046-y","DOIUrl":"https://doi.org/10.1186/s13167-015-0046-y","url":null,"abstract":"","PeriodicalId":94358,"journal":{"name":"The EPMA journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88564650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioabsorbable polymers in cancer therapy: latest developments","authors":"A. Fonseca, A. Serra, J. Coelho","doi":"10.1186/s13167-015-0045-z","DOIUrl":"https://doi.org/10.1186/s13167-015-0045-z","url":null,"abstract":"","PeriodicalId":94358,"journal":{"name":"The EPMA journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89060946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}