Cardiovascular Journal of Africa最新文献_第6页

Development of National Anticoagulation Guidelines for Pregnant Women with Mechanical Heart Valves in Rwanda. 卢旺达机械心脏瓣膜孕妇国家抗凝指南的制定。

IF 0.7 4区医学

Cardiovascular Journal of Africa Pub Date : 2026-03-06 DOI: 10.5830/CVJA-2025-104

Emmanuel Rusingiza, Vongai Mlambo, Nicole Schulick, David Ntirushwa, Helen Mucyo, Esubalew Woldeyes Asfaw, Diomede Ntasumbumuyange, Sandra Havyarimana, Evariste Ntaganda, Ceeya Bolman, Yihan Lin

{"title":"Development of National Anticoagulation Guidelines for Pregnant Women with Mechanical Heart Valves in Rwanda.","authors":"Emmanuel Rusingiza, Vongai Mlambo, Nicole Schulick, David Ntirushwa, Helen Mucyo, Esubalew Woldeyes Asfaw, Diomede Ntasumbumuyange, Sandra Havyarimana, Evariste Ntaganda, Ceeya Bolman, Yihan Lin","doi":"10.5830/CVJA-2025-104","DOIUrl":"https://doi.org/10.5830/CVJA-2025-104","url":null,"abstract":"Background: The number of Rwandan women of reproductive age receiving mechanical heart valve prostheses for rheumatic heart disease is increasing. Effective anticoagulation management during pregnancy is essential to prevent valve thrombosis but poses significant risks to both mother and foetus if not carefully tailored.Objective: This article describes the multidisciplinary development of national guidelines for anticoagulation management in pregnant women with mechanical heart valves in Rwanda, integrating local clinical realities with international best practices.Methods: Guideline development involved a three-stage process: (1) a stakeholder workshop to assess current practices and challenges, (2) iterative drafting and feedback from clinicians and policymakers, and (3) validation by representatives from key medical specialties. The process incorporated evidence from local studies, international guidelines, and the lived experiences of patients and providers.Results: The resulting guidelines emphasise preconception counselling, individualised risk assessment, and clear algorithms for adjusting anticoagulation regimens by gestational age. Practical considerations such as medication availability, laboratory capacity, and provider training are addressed to ensure feasibility in low-resource settings.Conclusion: These national guidelines aim to standardise anticoagulation management for pregnant women with mechanical heart valves in Rwanda, improving maternal and foetal outcomes. The approach provides a model for adapting evidence-based care to resource-limited environments.","PeriodicalId":9434,"journal":{"name":"Cardiovascular Journal of Africa","volume":"37 1","pages":"69-79"},"PeriodicalIF":0.7,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148276082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of the value of stress echocardiography in latent left ventricular outflow tract obstruction in non-hypertrophic cardiomyopathy. 应激超声心动图在非肥厚性心肌病潜伏性左室流出道梗阻中的价值分析。

IF 0.7 4区医学

Cardiovascular Journal of Africa Pub Date : 2026-03-06 DOI: 10.5830/CVJA-2025-095

Ying Zhou, Luping Long, Yan Jiang, Jun Xu, Bin Shen

引用次数: 0

Clinical and echocardiographic characteristics of patients presenting with pulmonary hypertension due to congenital heart disease. 先天性心脏病所致肺动脉高压患者的临床及超声心动图特征

IF 0.7 4区医学

Cardiovascular Journal of Africa Pub Date : 2026-03-06 DOI: 10.5830/CVJA-2025-094

M M Henema, F E Smit, S C Brown, L Botes

{"title":"Clinical and echocardiographic characteristics of patients presenting with pulmonary hypertension due to congenital heart disease.","authors":"M M Henema, F E Smit, S C Brown, L Botes","doi":"10.5830/CVJA-2025-094","DOIUrl":"https://doi.org/10.5830/CVJA-2025-094","url":null,"abstract":"Background: This study aimed to assess patients' clinical and echocardiographic features in pulmonary hypertension (PH) due to congenital heart disease (CHD).Methods: The main inclusion criterion was a mean pulmonary arterial pressure (mPAP) ≥ 25 mmHg measured at right heart catheterisation (RHC). All patients underwent clinical examination, electrocardiography, transthoracic echocardiogram, and a six-minute walk test (6MWT).Results: Seventy-five patients with a median age of 9.98 years (IQR 7.97-17.1 years) were included. Simple ventricular septal defect (VSD) was the most common lesion. The median mPAP on right catheterisation was 52 mmHg (IQR 49-67 mmHg). Right ventricle (RV) dysfunction was observed in all patients, confirmed by prolonged right ventricular MPI, reduced S', decreased TAPSE, and impaired calculated RV free wall strain. The pulmonary valve annulus was markedly dilated in all patients, evidenced by a median z-score of 4.23. The combination of using the RVSP of more than 50 mmHg plus a pulmonary annulus z-score of more than 3 to predict PVR of more than 3 Wood units m² had a high sensitivity of 82.4% but a low specificity of 14.3%.Conclusion: Our patients exhibited dilation on the right side, especially the pulmonary arteries, which could serve as an early warning for PH. An elevated peak RVSP and a dilated pulmonary artery should alert the physician to the possibility of PH. An echocardiogram should only be used as a screening tool for diagnosing pulmonary hypertension.","PeriodicalId":9434,"journal":{"name":"Cardiovascular Journal of Africa","volume":"37 1","pages":"53-61"},"PeriodicalIF":0.7,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148275932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic value of systemic immune-inflammation index in patients with non-valvular atrial fibrillation: SII score in patients using DOACs. 非瓣膜性房颤患者全身免疫炎症指数的预后价值：使用DOACs患者的SII评分。

IF 0.7 4区医学

Cardiovascular Journal of Africa Pub Date : 2026-02-20 DOI: 10.5830/CVJA-2025-107

Kahraman Cosansu, Sabiye Yilmaz, Cagin Mustafa Ureyen, Mustafa Gokhan Vural

{"title":"Prognostic value of systemic immune-inflammation index in patients with non-valvular atrial fibrillation: SII score in patients using DOACs.","authors":"Kahraman Cosansu, Sabiye Yilmaz, Cagin Mustafa Ureyen, Mustafa Gokhan Vural","doi":"10.5830/CVJA-2025-107","DOIUrl":"https://doi.org/10.5830/CVJA-2025-107","url":null,"abstract":"Background: The systemic immune-inflammation index (SII) is a simple parameter that has been used to predict adverse outcomes in different clinical settings. The prognostic value of SII, an innovative biomarker of inflammation, in non-valvular atrial fibrillation (NVAF) patients has not been assessed. The aim of this study was to evaluate the prognostic value of SII in NVAF patients who were under direct oral anticoagulant (DOAC) medication.Methods: A total of 467 patients with NVAF treated with DOACs from 2018 to 2021 were retrospectively enrolled in this cohort study. Demographics, medication, and outcome data were collected for each patient. SII was calculated from complete blood counts as the ratio of neutrophil-to-lymphocyte count multiplied by the platelet count. The primary outcome was major adverse events (MAEs), which include major bleeding, stroke, and death.Results: Logistic regression analyses showed that the SII score was an important predictor of outcomes in NVAF patients.Conclusion: The SII may be a successful, non-invasive, and cost-effective parameter for predicting bleeding and stroke in patients with NVAF. It may be used as a useful risk stratification tool for these patients.","PeriodicalId":9434,"journal":{"name":"Cardiovascular Journal of Africa","volume":"37 1","pages":"20-26"},"PeriodicalIF":0.7,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148276108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atrial fibrillation ablation in patients with mobile thrombus on pacemaker leads. Prospective single-centre study including 33 patients on anticoagulants. 起搏器导联上有可移动血栓的心房颤动消融。前瞻性单中心研究，包括33例使用抗凝剂的患者。

IF 0.7 4区医学

Cardiovascular Journal of Africa Pub Date : 2026-02-20 DOI: 10.5830/CVJA-2025-091

Grigory A Gromyko, Dmitry U Shchekochikhin, Afsoon Fayez, Alexandr N Lischuk

{"title":"Atrial fibrillation ablation in patients with mobile thrombus on pacemaker leads. Prospective single-centre study including 33 patients on anticoagulants.","authors":"Grigory A Gromyko, Dmitry U Shchekochikhin, Afsoon Fayez, Alexandr N Lischuk","doi":"10.5830/CVJA-2025-091","DOIUrl":"https://doi.org/10.5830/CVJA-2025-091","url":null,"abstract":"Introduction: Mobile thrombus on pacemaker leads is a common phenomenon seen during intracardiac echocardiography in patients undergoing catheter ablation of atrial fibrillation (AF).Purpose: The purpose of our study is to assess the safety of RF ablation of atrial fibrillation in patients with mobile thrombus on pacemaker leads.Methods: A total of 33 patients with AF and previously implanted cardiac pacemakers who had undergone radiofrequency pulmonary vein isolation since January 1st, 2015, were studied. All patients were anticoagulated with vitamin K antagonists (VKAs) or novel oral anticoagulants (NOACs), at least three weeks before the procedure. All procedures were guided by intracardiac echocardiography. Patients were divided into two groups: group 1 (15 patients with mobile thrombus on pacemaker leads) and group 2 (18 patients without mobile thrombus on device leads).Results: The mean age of the pacemaker patients was 66,8 ± 7.7 years. The average thrombus length was 8.0 ± 3.3 mm. There were no differences in preprocedural anticoagulation with VKA or NOAC between groups (13% versus 17% for VKA, p = 1.0). Paroxysmal AF was less prevalent in the thrombus group (40% versus 83%, p = 0.01). There were no complications of AF ablation or arrythmia recurrence procedures in either group during the 30-day postoperative period.Conclusions: Radiofrequency ablation of AF can be safely performed in patients with mobile thrombus on pacemaker leads. Patients with persistent atrial fibrillation have an increased risk of pacemaker lead thrombus formation.","PeriodicalId":9434,"journal":{"name":"Cardiovascular Journal of Africa","volume":"37 1","pages":"43-48"},"PeriodicalIF":0.7,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148275939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The ACEF II scoring model in patients undergoing isolated coronary artery bypass grafting surgery: A single centre validation study. 孤立冠状动脉旁路移植术患者的ACEF II评分模型：单中心验证研究

IF 0.7 4区医学

Cardiovascular Journal of Africa Pub Date : 2026-02-20 DOI: 10.5830/CVJA-2025-092

Selen Öztürk

{"title":"The ACEF II scoring model in patients undergoing isolated coronary artery bypass grafting surgery: A single centre validation study.","authors":"Selen Öztürk","doi":"10.5830/CVJA-2025-092","DOIUrl":"https://doi.org/10.5830/CVJA-2025-092","url":null,"abstract":"Introduction: Estimating the mortality rate of patients after cardiac surgery is an important issue in clinical practice. The age, creatinine, and ejection fraction (ACEF) score is one of those scoring models developed for this purpose.We aimed to validate themortality scoringmodel,ACEF II (age, creatinine, ejection fraction, hematocrit, and emergency of the surgery), in the patient population undergoing isolated coronary artery bypass grafting surgery.Methods: Patients with coronary artery disease who underwent isolated coronary artery bypass grafting were retrospectively analysed. Data from January 2022 to December 2022 are included. ACEF II scoring model points were calculated. The efficacy of this model in predicting 30-day mortality was determined by the receiver operating characteristic (ROC) curve.Results: 429 patients were included in the analysis. One-month mortality was 6.1% (n = 26). There was a statistically significant difference in terms of age, ejection fraction, heart failure, creatinine, hematocrit, ACEF scores, status of operation (elective/emergency), and cardiopulmonary bypass time. (p = 0.001; p < 0.01). The cut-off value of the ACEF II score and area under the ROC curve were, respectively, 4.2 and 0.992. The risk of mortality in cases with an ACEF II score above 4.2 was found to be 2.238 (95% CI: 1.628-3.076) times higher. In multivariate Logistic regression analysis, ACEF II Score and heart failure were significant risk factors (p < 0.05).Conclusions: We concluded that the ACEF II score and heart failure were independent risk factors for mortality. ACEF II has a good ability to discriminate for predicting mortality in the cardiac surgical population.","PeriodicalId":9434,"journal":{"name":"Cardiovascular Journal of Africa","volume":"37 1","pages":"27-31"},"PeriodicalIF":0.7,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148276111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case report of a patient with acenocoumarol resistance following therapy for infective endocarditis with rifampicin and gentamicin combination therapy. 利福平与庆大霉素联合治疗感染性心内膜炎后出现阿塞诺古美尔耐药1例报告。

IF 0.7 4区医学

Cardiovascular Journal of Africa Pub Date : 2026-02-20 DOI: 10.5830/CVJA-2025-090

M Luszczyn, K Nowakowska, I Kolasa, B Makowski

引用次数: 0

Echocardiographic diagnosis of a pulmonary artery sling: what kept it hidden for seven years? 超声心动图诊断肺动脉悬吊：是什么让它隐藏了七年？

IF 0.7 4区医学

Cardiovascular Journal of Africa Pub Date : 2026-02-20 DOI: 10.5830/CVJA-2025-089

Xi-Jun Zhu, Wen-Juan Qiu

{"title":"Echocardiographic diagnosis of a pulmonary artery sling: what kept it hidden for seven years?","authors":"Xi-Jun Zhu, Wen-Juan Qiu","doi":"10.5830/CVJA-2025-089","DOIUrl":"10.5830/CVJA-2025-089","url":null,"abstract":"Pulmonary artery sling (PAS) is a rare cardiovascular anomaly, occurring in approximately 1 in 17,000 individuals, often leading to severe tracheal compression and respiratory distress. This case report details the diagnosis, treatment, and follow-up of a seven-year-old female patient with PAS, a condition that remained undiagnosed for years despite multiple hospitalisations. Initially admitted at 4 weeks old for neonatal pneumonia, hypoxic encephalopathy, and patent ductus arteriosus (PDA), the patient underwent various treatments and misdiagnoses, including bronchopneumonia and congenital heart defects. It wasn't until she was seven years old, after presenting with fever, cough, and respiratory distress, that a third echocardiographic examination suggested PAS. This was later confirmed through Pulmonary Artery Computed Tomography Angiography (CTA) and Multi-Slice Spiral Computed Tomography (MSCT) Three-Dimensional (3D) reconstruction of the airway, revealing distal bronchus stenosis. The patient underwent successful end-to-side anastomosis of the left pulmonary artery to the main pulmonary artery, significantly improving her respiratory function and reducing hospitalisations for pneumonia. This case underscores the importance of considering PAS in differential diagnosis for children with unexplained respiratory symptoms and the role of repeated echocardiography in avoiding delayed diagnosis and treatment. Early detection and prompt surgical intervention are crucial in reducing mortality and morbidity associated with PAS.","PeriodicalId":9434,"journal":{"name":"Cardiovascular Journal of Africa","volume":"37 1","pages":"17-19"},"PeriodicalIF":0.7,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147644278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The molecular effects of lepidium sativum extract on damage in rats with cardiac damage caused by total circulatory arrest. 枸杞提取物对全循环骤停大鼠心脏损伤的分子作用。

IF 0.7 4区医学

Cardiovascular Journal of Africa Pub Date : 2026-02-20 DOI: 10.5830/CVJA-2025-096

Murat Ziya Bağış, Bişar Amaç, Yasemin Hacanli, Ezhar Ersöz, Muhammet Emin Güldür, İsmail Koyuncu, Kadir Egi

{"title":"The molecular effects of lepidium sativum extract on damage in rats with cardiac damage caused by total circulatory arrest.","authors":"Murat Ziya Bağış, Bişar Amaç, Yasemin Hacanli, Ezhar Ersöz, Muhammet Emin Güldür, İsmail Koyuncu, Kadir Egi","doi":"10.5830/CVJA-2025-096","DOIUrl":"https://doi.org/10.5830/CVJA-2025-096","url":null,"abstract":"Introduction: Cardiovascular diseases, which are non-communicable diseases, are among the leading causes of death worldwide.Objective: In this study, we aimed to investigate the efficacy of Lepidium sativum extract, which has antioxidant properties, in preventing cardiac damage in rats with cardiac damage induced by total circulatory arrest, using biochemical and histopathological methods.Methods: Twenty-four adult male Wistar albino rats weighing 200-250g were used in our study. These rats were randomly divided into four groups. Group 1 (Control, n = 6), Group 2 (Ischaemia (TCA), n = 6), Group 3 (Treatment 1, Ischaemia + Lepidium sativum, n = 6), Group 4 (Treatment 2, Lepidium sativum, n = 6). TOS, TOS, NRF-2, TNF-α, MDA, and HIF-1α parameters were measured in blood plasma and heart tissue using the ELISA kit method. In addition, baseline chemical parameters were examined in plasma. Histopathological examination of heart tissue was performed.Results: There were statistically significant differences between groups in terms of plasma MDA (p < 0.001), HIF-1α (p < 0.001), NRF-2 (p < 0.001), TAS (p < 0.001), TOS (p < 0.05), and TNF-α (p < 0.05) levels; in heart tissue, MDA (p < 0.05), HIF-1α (p < 0.05), NRF-2 (p < 0.05), TAS (p < 0.001), TOS (p < 0.05), and OSI (p < 0.05) parameters were found to be significant. TAS levels were highest in the LS group (p < 0.001), while TOS levels were highest in the Ischaemia group (p < 0.05).Conclusion: Lepidium sativum significantly improved cardiac damage in rats with TCA-induced cardiac damage by reducing MDA, HIF-1α, TNF-α, and TOS levels. In addition, histopathological examination revealed that cardiac myocytes had a more regular structure in the group administered the extract. Furthermore, we believe that this study provides valuable data in the field of cardiovascular molecular mechanisms.","PeriodicalId":9434,"journal":{"name":"Cardiovascular Journal of Africa","volume":"37 1","pages":"32-42"},"PeriodicalIF":0.7,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148276122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlates of serum thiamine levels among acute decompensated heart failure patients. 急性失代偿性心力衰竭患者血清硫胺素水平的相关性。

IF 0.7 4区医学

Cardiovascular Journal of Africa Pub Date : 2026-02-20 DOI: 10.5830/CVJA-2025-098

Busayo O Oguntola, Rasaq A Adebayo, Suraj A Ogunyemi, Tewogbade A Adedeji, Stephen O Oguntola, Olumide A Akinyele, Obafemi S Adesanya, Anthony O Akintomide

{"title":"Correlates of serum thiamine levels among acute decompensated heart failure patients.","authors":"Busayo O Oguntola, Rasaq A Adebayo, Suraj A Ogunyemi, Tewogbade A Adedeji, Stephen O Oguntola, Olumide A Akinyele, Obafemi S Adesanya, Anthony O Akintomide","doi":"10.5830/CVJA-2025-098","DOIUrl":"https://doi.org/10.5830/CVJA-2025-098","url":null,"abstract":"Background: Acute decompensated heart failure (ADHF) contributes adversely to health-related outcomes. Anorexia, early satiety, high metabolic rates, malnutrition, advanced age, and diuretic use characterise ADHF. This necessitated evaluating the correlates of low serum thiamine levels among ADHF patients in our facility.Methods: This was a case-control study. One hundred and ten participants (55 AHF patients with 55 age and sex-matched healthy controls) were recruited consecutively. All participants had a physical examination, resting 12-lead ECG, 2D transthoracic echocardiography and baseline laboratory investigations and serum thiamine. Data analysis was done using STATA 13.1.Results: The mean age of the study population was 45 (± 13.7) years. The mean serum thiamine levels among the ADHF and controls were 116.7 ± 31.6 nmol/L and 124.4 ± 29.8 nmol/L, respectively. Male gender, resting ECG QRS duration, and serum NT-proBNP independently predicted serum thiamine levels.Conclusion: In this study, male gender, NT-proBNP and QRS duration independently predicted serum thiamine levels.","PeriodicalId":9434,"journal":{"name":"Cardiovascular Journal of Africa","volume":"37 1","pages":"10-16"},"PeriodicalIF":0.7,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148276124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0