Cardiovascular Journal of Africa最新文献

{"title":"The early-term effects of the minimally invasive extracorporeal circulation on atrial fibrillation development in patients who underwent coronary artery bypass grafting.","authors":"Seyhan Yilmaz, Ertan Aydın, Bilge Olgun Keleş","doi":"10.5830/CVJA-2026-011","DOIUrl":"https://doi.org/10.5830/CVJA-2026-011","url":null,"abstract":"<p><strong>Objective: </strong>The minimised extracorporeal circulation (MiECC) system is an alternative to the classical extracorporeal circulation (ECC) system in coronary artery bypass grafting (CABG) surgery. Some publications reported that there are few studies on the relationship between this application and the development of postoperative atrial fibrillation (POAF) and that differences in results were observed. We aimed to evaluate the possible relationship between the use of MiECC and the development of early atrial fibrillation (AF) in isolated on-pump CABG patients.</p><p><strong>Methods: </strong>This study was conducted in patients who underwent isolated on-pump CABG surgery. Patients with known preoperative AF were not included in the study. Patients were examined in Group 1: classical ECC group and Group 2: MiECC group.</p><p><strong>Results: </strong>The mean age of a total of 38 patients included in the study was found to be 62,03 ± 9,58. The AF development was found to be 0,13 ± 0,34. Group 1 and Group 2 groups did not differ with respect to aortic cross-clamp time, cardiopulmonary bypass (CPB) duration, and the number of distal anastomoses (p value was 0,809, 0,473, and 0,116, respectively). No statistically significant difference was found between the two groups in terms of postoperative AF development (p = 0.337).</p><p><strong>Conclusion: </strong>According to our evaluation based on the results of our study, we conclude that MiECC usage in isolated on-pump CABG does not independently reduce the incidence of postoperative AF. Since existing literature presents divergent findings, we believe that studies focusing on the development of POAF and including more patients would be useful.</p>","PeriodicalId":9434,"journal":{"name":"Cardiovascular Journal of Africa","volume":"37 2","pages":"203-207"},"PeriodicalIF":0.7,"publicationDate":"2026-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148315860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative analysis of the effects of moderate vs mild hypothermia on serum neuron-specific enolase, S100β, and near-infrared spectroscopy during cardiopulmonary bypass-assisted open-heart surgery: a single-centre study.","authors":"Feyza Tulek, Bahar Oc, Oguzhan Arun, Ali Unlu, Mehmet Oc, Jale Bengi Celik, Serkan Yildirim, Ates Duman","doi":"10.5830/CVJA-2026-004","DOIUrl":"10.5830/CVJA-2026-004","url":null,"abstract":"<p><strong>Purpose: </strong>Neurological injury remains a critical concern in cardiac surgery despite advancements in surgical and anaesthetic techniques. Hypothermia is commonly utilised for neuroprotection during cardiopulmonary bypass (CPB); however, the optimal temperature range remains undetermined. This study evaluates the neuroprotective effectiveness of mild versus moderate hypothermia by assessing neuron-specific enolase (NSE) and S100β levels, near-infrared spectroscopy (NIRS) cerebral oxygenation, and cognitive function in patients undergoing CPB-assisted open-heart surgery.</p><p><strong>Methods: </strong>Forty elective coronary artery bypass grafting (CABG) patients were randomised to mild (32-34°C, n = 20) or moderate (28-32°C, n = 20) hypothermia groups. Serum NSE and S100β levels were measured preoperatively and at 0, 12, 24, and 48 hours postoperatively. Cerebral oxygenation via NIRS and Mini-Mental State Examination (MMSE) scores were evaluated preoperatively and at 24 and 48 hours postoperatively. This is a single-centre study. The primary outcome was the between-group difference in S100β levels at 24 and 48 hours; all other variables were predefined secondary outcomes.</p><p><strong>Results: </strong>Postoperative NSE levels increased in both groups, with no significant intergroup differences (p > 0.05). However, S100β levels were significantly lower in the moderate hypothermia group at 24 and 48 hours (p = 0.012, p = 0.004). NIRS values and MMSE scores remained comparable between groups (p > 0.05).</p><p><strong>Conclusion: </strong>Our findings suggest that moderate hypothermia may offer improved neuroprotection by attenuating S100β release without adversely affecting cerebral oxygenation or cognitive outcomes. Although these results are encouraging, further validation through larger, multicentre studies is warranted before definitive conclusions can be drawn.</p>","PeriodicalId":9434,"journal":{"name":"Cardiovascular Journal of Africa","volume":"37 2","pages":"208-214"},"PeriodicalIF":0.7,"publicationDate":"2026-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148315778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mid-term results of bicuspid aortic valve repair with a new technique, the Ozbek procedure.","authors":"Baburhan Ozbek, Murat Ugur","doi":"10.5830/CVJA-2026-007","DOIUrl":"https://doi.org/10.5830/CVJA-2026-007","url":null,"abstract":"<p><strong>Introduction: </strong>Aortic valve insufficiency has been reported in approximately one-third of patients with a bicuspid aortic valve (BAV). In this study, we describe a new use of an old aortic repair technique and report its mid-term results.</p><p><strong>Methods: </strong>Twenty patients with BAV who underwent surgery for aortic valve insufficiency between January 2017 and March 2025 were retrospectively evaluated. All patients who underwent aortic valve repair using the Ozbek technique were included in the study. One case of moderate postoperative aortic insufficiency was identified via transoesophageal echocardiography (TEE), requiring reinforcement of the commissural sutures during the surgery.</p><p><strong>Results: </strong>There was no permanent pacemaker requirement, stroke, revision due to bleeding, or mortality in the early postoperative period. The mean follow-up duration was 59.0 ± 16.8 months; all patients were asymptomatic or had a NYHA Class I functional status. There was moderate aortic insufficiency in seven patients (35%), and no reoperations were needed during the follow-up period.</p><p><strong>Conclusion: </strong>The Ozbek Technique, which allows commissural stabilisation, leaflet augmentation, and preservation of annulus growth potential, might be considered an alternative method for aortic valve repair. Multi-centre studies reporting long-term outcomes are needed to demonstrate the effectiveness of this technique.</p>","PeriodicalId":9434,"journal":{"name":"Cardiovascular Journal of Africa","volume":"37 2","pages":"223-228"},"PeriodicalIF":0.7,"publicationDate":"2026-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148283349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between PRECISE-DAPT score and clinical Outcomes: a subgroup analysis of the DAPT-TR registry.","authors":"Berat Uğuz, Ahmet Öz, Ömer Kertmen, İlyas Çetin, Lütfü Bekar, Ferit Böyük, Serkan Asil, Mehmet Cansel, Hakan Taşolar, Mehdi Zoghi","doi":"10.5830/CVJA-2026-005","DOIUrl":"https://doi.org/10.5830/CVJA-2026-005","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate whether a PRECISE-DAPT score ≥ 25 identifies a high-risk phenotype associated with adverse ischemic and bleeding outcomes, hospitalisation, and mortality among patients treated with fixed-dose acetylsalicylic acid and clopidogrel.</p><p><strong>Methods: </strong>We conducted a prespecified subgroup analysis of the DAPT-TR registry, a prospective, multicentre observational cohort including 1,500 patients who were initiated on fixed-dose combination dual antiplatelet therapy (aspirin 75 mg/day plus clopidogrel 75 mg/day) for the treatment of acute and stable coronary artery disease. Patients were stratified according to PRECISE-DAPT score categories (≥ 25 vs < 25). Six-month clinical outcomes, including all-cause and cardiovascular hospitalisation, myocardial infarction, stent thrombosis, BARC type 1 bleeding, all-cause mortality, cardiovascular mortality, and stroke, were compared between groups. Multivariable logistic regression analysis was performed to evaluate independent associations between PRECISE-DAPT score categories and clinical outcomes.</p><p><strong>Results: </strong>Of 1,500 patients, 344 (22.9%) had a PRECISE-DAPT score ≥ 25. Compared with patients with a PRECISE-DAPT score < 25, those with a PRECISE-DAPT score ≥ 25 were older (mean age 71.9 vs. 60.8 years; p < 0.001), more frequently female, and had significantly more comorbidities and reduced LVEF. At 6 months, patients with a PRECISE-DAPT score ≥ 25 experienced higher rates of all-cause hospitalisation (19.5% vs. 10.9%; p < 0.001), cardiovascular hospitalisation (11.6% vs. 6.7%; p = 0.003), stent thrombosis (2.6% vs. 1.0%; p = 0.029), and BARC type 1 bleeding (7.5% vs. 2.2%; p < 0.001). All-cause mortality (1.7% vs. 0.2%; p = 0.003) and cardiovascular mortality (1.2% vs. 0.1%; p = 0.011) were also significantly higher. After adjustment, a PRECISE-DAPT score ≥ 25 remained independently associated with mortality (OR: 3.8; 95% CI: 1.2-12.1) and hospitalisation (OR: 2.1; 95% CI: 1.5-3.1).</p><p><strong>Conclusion: </strong>A PRECISE-DAPT score ≥ 25 delineates a clinically vulnerable subgroup with elevated ischemic, haemorrhagic, and mortality risks, even under uniform fixed-dose DAPT. These findings suggest that the PRECISE-DAPT score may serve as a multidimensional prognostic tool beyond bleeding risk stratification.</p>","PeriodicalId":9434,"journal":{"name":"Cardiovascular Journal of Africa","volume":"37 2","pages":"198-202"},"PeriodicalIF":0.7,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148327075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of chronic administration of Cannabidiol and Cannabidiol-Selexipag combination on haematological parameters, oxidative stress, BNP, and TNF-α in a rat model of Pulmonary Arterial Hypertension.","authors":"Chayil Gunpath, Anand Nadar","doi":"10.5830/CVJA-2025-105","DOIUrl":"https://doi.org/10.5830/CVJA-2025-105","url":null,"abstract":"<p><strong>Background: </strong>Pulmonary arterial hypertension (PAH) is a progressive disorder characterized by pulmonary vasoconstriction and inflammation, leading to increased pulmonary pressure, right heart failure, and high mortality. Cannabidiol (CBD), a non-psychoactive cannabinoid, exhibits anti-inflammatory and antioxidant properties. This study investigates the therapeutic potential of CBD, alone and in combination with Selexipag, in a rat model of monocrotaline (MCT) -induced PAH.</p><p><strong>Methods: </strong>Forty male Sprague-Dawley rats were randomized into five groups: Control, MCT-Control, MCT-Selexipag, MCT-CBD, and MCT-CBD-Selexipag. PAH was induced with MCT (60 mg/kg, intraperitoneally). Treatments (CBD: 10 mg/kg; Selexipag: 3 mg/kg) were administered orally from day 21 to 31. Post-treatment, plasma brain natriuretic peptide (BNP), heart tumour necrosis factor-alpha (TNF-α), and total antioxidant capacity (T-AOC) in heart and plasma were measured, alongside a full haematological profile.</p><p><strong>Results: </strong>Combination therapy (CBD + Selexipag) significantly increased BNP expression and heart TAOC, while reducing plasma T-AOC, indicating enhanced cardiovascular stress modulation and antioxidant defence. The MCT-CBD group exhibited elevated TNF-α, haemoglobin, and platelet counts, suggesting a proinflammatory response. CBD monotherapy did not effectively reduce inflammation in PAH.</p><p><strong>Conclusion: </strong>CBD, when combined with Selexipag, may enhance BNP modulation and cardiac antioxidant capacity in PAH, supporting its potential as adjunct therapy for oxidative stress management. However, CBD alone may exacerbate inflammation and haematological abnormalities. Further studies are warranted to clarify the mechanisms and clinical relevance of these findings.</p><p><strong>Abbreviations: </strong>Cannabidiol Brain (CBD); Natriuretic Peptide (BNP); Pulmonary Arterial Hypertension (PAH); Tumour Necrosis FactorAlpha (TNF-α); Monocrotaline (MCT); Total Antioxidant Capacity (T-AOC).</p>","PeriodicalId":9434,"journal":{"name":"Cardiovascular Journal of Africa","volume":"37 2","pages":"149-157"},"PeriodicalIF":0.7,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148326320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kinesiophobia and associated variables in patients with atrial fibrillation combined with heart failure: A cross-sectional study from China.","authors":"Zhen Dai, Lewen Shao, Shaoling Li","doi":"10.5830/CVJA-2026-009","DOIUrl":"https://doi.org/10.5830/CVJA-2026-009","url":null,"abstract":"<p><strong>Objectives: </strong>While kinesiophobia is a recognised phenomenon in global cardiovascular rehabilitation, its prevalence and characteristics remain unexplored in the specific and growing population of patients hospitalised with atrial fibrillation and heart failure (AFHF). This study aims to investigate the prevalence of kinesiophobia and to identify its associated factors among hospitalised AFHF patients in China, thereby contributing to a broader understanding of this barrier to physical activity in a critical patient subgroup worldwide.</p><p><strong>Methods: </strong>In this cross-sectional study, participants were recruited through convenience sampling from a grade A general hospital in Hangzhou, Zhejiang Province, China. Participants completed questionnaires that included measures of kinesiophobia, self-efficacy, symptoms, depression, anxiety, medical coping strategies, social support, and demographic information.</p><p><strong>Results: </strong>A total of 212 inpatients with AFHF (age: 21-91, mean age: 65.22 ± 10.30 years, 60.4% male) were included in the study, including 128 males (60.4%) and 84 females (39.6%). The findings revealed that a significant majority (71.2%) of patients experienced kinesiophobia (mean score: 40.60 ± 5.771). The results of multiple linear regression (MLR) analysis showed that the main variables associated with kinesiophobia in patients with AFHF were previous hospitalisation for heart disease, New York Heart Association (NYHA) classification, depression,medical coping styles, self-efficacy, and occupation, with six variables together explaining 44.2% of the total variation.</p><p><strong>Conclusion: </strong>Kinesiophobia was found to be common in patients with AFHF in China, influenced by various factors. We recommend that early evaluation of kinesiophobia be considered in patients with AFHF.</p>","PeriodicalId":9434,"journal":{"name":"Cardiovascular Journal of Africa","volume":"37 2","pages":"179-185"},"PeriodicalIF":0.7,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148315781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nationwide survey of the distribution of Catheterisation laboratories (Cath labs) in Ghana.","authors":"Benjamin Dabo Sarkodie, Bashiru Babatunde Jimah, Edmund Brakohiapa","doi":"10.5830/CVJA-2025-113","DOIUrl":"10.5830/CVJA-2025-113","url":null,"abstract":"<p><strong>Background: </strong>Catheterisation laboratories (Cath labs) are vital for diagnosing and treating cardiovascular and other vascular conditions. In Ghana, there is limited national-level data on the distribution and capacity of Cath labs. This study provides a nationwide overview of existing Cath labs, their equipment, and their functional scope.</p><p><strong>Methods: </strong>A descriptive cross-sectional survey of Cath labs in Ghana was conducted in September 2025. Data was collected on the number, location, equipment type (monoplane/biplane), and functional specialities (interventional cardiology [IC], interventional radiology [IR]). Information was verified through institutional sources and facility representatives.</p><p><strong>Results: </strong>A total of 10 Cath labs were identified in Ghana across nine facilities. Euracare hosts two Cath labs (one monoplane, one biplane). Of the total, nine (90%) are located in Accra and one (10%) in Kumasi. Eight facilities use monoplane systems, and Euracare is the only centre with a biplane system. Four facilities (Euracare, Korle Bu Teaching Hospital, Spectra, and Bank Hospital) offer both IC and IR services, while others are limited to IC.</p><p><strong>Conclusion: </strong>Cath lab services in Ghana are predominantly centred in Accra, with merely one facility located outside the capital. Euracare offers advanced imaging capabilities with two Cath labs, featuring the sole biplane system. Strategic planning is essential to enhance the availability of Cath labs nationwide and to improve access to advanced cardiovascular and interventional care.</p>","PeriodicalId":9434,"journal":{"name":"Cardiovascular Journal of Africa","volume":"37 2","pages":"194-197"},"PeriodicalIF":0.7,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148283339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of using 50 mL syringe manual thrombectomy catheter in patients with heavy thrombus burden undergoing primary percutaneous coronary intervention.","authors":"Arafa Gomaa Mohamed, Hamada Alsheikh, Mahmoud F Elshahat","doi":"10.5830/CVJA-2026-008","DOIUrl":"https://doi.org/10.5830/CVJA-2026-008","url":null,"abstract":"<p><strong>Background: </strong>Patients with ST-segment elevation myocardial infarction (STEMI) and heavy thrombus burden are at increased risk of distal embolisation and impaired reperfusion during primary percutaneous coronary intervention (PPCI). Conventional manual aspiration thrombectomy with a 30 mL syringe has shown limited benefit in large randomised trials. Increasing syringe volume to 50 mL may enhance suction efficiency and clot retrieval, offering a simple and cost-effective strategy to optimise reperfusion.</p><p><strong>Methods: </strong>In this prospective cohort study, 88 consecutive STEMI patients with angiographic thrombus burden grade 4-5 undergoing PPCI were included. Group I (n = 44) underwent thrombectomy with a 30 mL syringe, while Group II (n = 44) underwent thrombectomy with a 50 mL syringe using an Export Advance catheter. Primary endpoints were post-procedural thrombolysis in myocardial infarction (TIMI) 3 flow and myocardial blush grade (MBG). Secondary endpoints included ST-segment resolution, echocardiography recovery (wall motion score index [WMSI] and left ventricular ejection fraction [LVEF]), and 30-day adverse cardiovascular events.</p><p><strong>Results: </strong>Baseline clinical and laboratory characteristics were comparable between groups. The 50 mL syringe group achieved higher rates of complete reperfusion (TIMI 3 flow: 77% vs. 59%, p = 0.04; MBG 3: 59% vs. 45%, p = 0.05). The primary composite endpoint of TIMI 3 flow plus MBG 3 was significantly greater in Group II (59% vs. 41%, p = 0.04). ST-segment resolution (68 % 15% vs. 55 ± 12%, p = 0.01), immediate post-PCI WMSI (1.7 ± 0.4 vs. 2.1 ± 0.5, p = 0.002), one-month WMSI (1.5 ± 0.3 vs. 1.8 ± 0.4, p = 0.001), and LVEF (54 ± 5% vs. 49 ± 6%, p = 0.002) were all superior in the 50 mL group. At 30 days, cardiovascular events were numerically lower with the 50 mL syringe (2.3% vs. 4.1%, p = 0.17), with no increase in procedural complications.</p><p><strong>Conclusion: </strong>In STEMI patients with high thrombus burden undergoing PPCI, manual thrombectomy with a 50 mL syringe improved reperfusion, myocardial recovery, and procedural outcomes compared with the conventional 30 mL syringe, without added risk. This low-cost, accessible modification may represent a practical alternative to mechanical aspiration systems, warranting validation in larger randomised trials.</p>","PeriodicalId":9434,"journal":{"name":"Cardiovascular Journal of Africa","volume":"37 2","pages":"186-193"},"PeriodicalIF":0.7,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148315768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the aortic root and ascending aorta in swine using CTA.","authors":"Xiaoyu Gao, Negin Hadjiabdolhamid, Nile Khai Luu, Alesh Ruben Polivka, Sabee Molloi","doi":"10.5830/CVJA-2026-003","DOIUrl":"https://doi.org/10.5830/CVJA-2026-003","url":null,"abstract":"<p><strong>Purpose: </strong>Swine are widely recognised as an essential experimental platform for evaluating prosthetic heart valves and testing novel catheter-based deployment methods. Our study aimed to establish baseline normative diameters for the aortic root and ascending aorta in swine using spiral computed tomography angiography (CTA), enhancing the success of preclinical research and device development.</p><p><strong>Methods: </strong>Our study involved thoracic CTA scans of 34 male swine, detailing the anatomical features of the aortic root and ascending aorta, and measuring the diameters at five key planes.</p><p><strong>Results: </strong>We conducted an additional analysis of the relationships among the chosen principal parameters.</p><p><strong>Conclusion: </strong>The baseline angiography of swine offers reference values for future studies.</p>","PeriodicalId":9434,"journal":{"name":"Cardiovascular Journal of Africa","volume":"37 2","pages":"165-172"},"PeriodicalIF":0.7,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148315783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Epstein-Barr Virus viremia and cardiac function in children and young adults with perinatally acquired HIV.","authors":"Samantha F Curtis, Andrew W McCrary, Ibrahim Daud, Myra Mahasi, Nathan M Thielman, Gerald S Bloomfield, Winstone Nyandiko","doi":"10.5830/CVJA-2025-109","DOIUrl":"10.5830/CVJA-2025-109","url":null,"abstract":"<p><strong>Introduction: </strong>Epstein-Barr virus (EBV) affects greater than 95% of the global population, and when acquired at an early age, results in poor control of viral replication and increased risk to subsequent chronic illnesses.</p><p><strong>Objective: </strong>To analye the association between EBV and early cardiac dysfunction.</p><p><strong>Methods: </strong>A cross-sectional echocardiographic study on children, adolescent and young adults living with human immunodeficiency virus (HIV) in Eldoret, Kenya. We collected echocardiograms, viral copy levels, and inflammatory markers. We compared EBV-positive participants to EBV-negative participants.</p><p><strong>Results: </strong>The majority of patients with EBV copies detected were male, median (25-75%) age of 15 (11-19) years and did not have signs of early cardiac dysfunction. No significant differences were observed in cardiac function between individuals with detectable and undetectable EBV copies (p = 0.472; p = 0.6140; p = 0.382 respectively).</p><p><strong>Conclusions: </strong>In this population of individuals, no significant difference in cardiac function between individuals with detectable and undetectable EBV copies was observed.</p>","PeriodicalId":9434,"journal":{"name":"Cardiovascular Journal of Africa","volume":"37 2","pages":"173-178"},"PeriodicalIF":0.7,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148315804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}