EJC paediatric oncology最新文献

{"title":"General support of physical exercise programs in pediatric oncology but differences in perception by childhood cancer care professionals at European and North-African/Arab centers","authors":"Moatasem El-Ayadi ,&nbsp;Kyra Druivenga ,&nbsp;Thomas Perwein ,&nbsp;Gunther Nussbaumer ,&nbsp;Filippo Spreafico ,&nbsp;Maura Massimino ,&nbsp;Shady Fadel ,&nbsp;Nisreen Amayiri ,&nbsp;Nisrine Khoubila ,&nbsp;Laila Hessissen ,&nbsp;Omar Chamdine ,&nbsp;Natàlia Rodríguez ,&nbsp;Gemma Calaf Valls ,&nbsp;Andres Morales la Madrid ,&nbsp;Christine Dahl ,&nbsp;Darren Hargrave ,&nbsp;Elwira Szychot ,&nbsp;Simon Bailey ,&nbsp;Dannis G. van Vuurden ,&nbsp;Martin Benesch ,&nbsp;Christof M. Kramm","doi":"10.1016/j.ejcped.2024.100147","DOIUrl":"https://doi.org/10.1016/j.ejcped.2024.100147","url":null,"abstract":"<div><h3>Purpose</h3><p>To explore the perception of physical exercise programs for pediatric oncology patients among childhood cancer care professionals. We also aimed at comparing such perceptions between cultures. Healthcare professionals’ endorsement may be essential for initiating and promoting such programs.</p></div><div><h3>Methods</h3><p>An anonymous survey was designed and administered voluntarily to childhood cancer care professionals (including pediatric oncologists, nurses, and physiotherapists) in European, North-African and Arab pediatric oncology centers.</p></div><div><h3>Results</h3><p>Five-hundred-and twenty-eight professionals from 14 sites answered the survey. Most respondents considered physical exercise programs as a suitable therapeutic approach for pediatric cancer patients with a potential positive contribution to survival (81%), wellbeing (82%), quality of life (80%), and self-esteem (75%). 91% of respondents would also support the future introduction of physical exercise programs into standard pediatric oncological care. There was a comparatively higher appreciation of physical exercise programs among European centers compared to North-African / Arab centers.</p></div><div><h3>Conclusion</h3><p>We registered a broad acceptance of physical exercise programs among all European and North-African / Arab childhood cancer care professionals. The positive perception was independent of any pre-existing experience with such programs and seems therefore representative. This finding may encourage the further promotion of physical exercise programs in pediatric oncology.</p></div>","PeriodicalId":94314,"journal":{"name":"EJC paediatric oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772610X24000060/pdfft?md5=dc315874b71ece9e44492cf63c376405&pid=1-s2.0-S2772610X24000060-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139737844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overview of current European practice for the management of patients with intracranial germ cell tumours","authors":"Manuel Diezi ,&nbsp;Barry Pizer ,&nbsp;Matthew J. Murray ,&nbsp;on behalf of the SIOP-Europe Brain Tumour Group - Central Nervous System (CNS) Germ Cell Tumour (GCT) Subgroup","doi":"10.1016/j.ejcped.2024.100146","DOIUrl":"10.1016/j.ejcped.2024.100146","url":null,"abstract":"<div><p>Central nervous system germ cell tumours (CNS GCT) form a diverse group of tumour entities, including germinoma, yolk sac tumour, embryonal carcinoma, choriocarcinoma, teratoma, and mixed tumours. Incidence peaks in the second decade, predominantly in males. Incidence rates vary globally, higher in Asia, suggesting genetic factors are important. CNS GCTs split into pure germinomas and non-germinomatous GCTs (NGGCT), influencing prognosis/treatment. Serum and CSF markers (alpha-fetoprotein, human chorionic gonadotropin) aid diagnosis, potentially avoiding neurosurgical biopsy. Histological features are distinguished by immunohistochemical staining. Studies have identified specific microRNAs in serum/CSF at diagnosis as promising biomarkers. Mutated pathways have been identified, but targeted therapies have shown limited success to date. Diagnosis involves recognising symptoms like raised intracranial pressure, endocrinological, and ophthalmological disturbances. MRI imaging is crucial for diagnosis and guiding treatment decisions. Treatment strategies vary, as pure germinomas respond well to chemotherapy and radiotherapy, or craniospinal radiotherapy alone, with excellent outcomes; in contrast NGGCTs demand aggressive combined chemo-radiotherapy, yielding generally inferior outcomes. Teratomas are typically chemo-/radio-resistant, requiring surgical intervention. Relapses need re-staging and (re-)biopsy consideration. Relapsed germinomas, though rare, may be cured with standard-dose chemotherapy and re-irradiation, or high-dose chemotherapy with stem-cell-transplantation, with/without further radiation. The more commonly observed NGGCT relapses have poor prognosis, even with thiotepa-based high-dose chemotherapy and stem-cell-transplantation delivered with curative intent. In summary, CNS GCT management integrates clinical, radiological, and histological findings, along with serum and CSF markers, for tailored treatment. Ongoing research aims to incorporate microRNA markers and molecular pathology for improved diagnosis, prognostication, and therapeutic intervention.</p></div>","PeriodicalId":94314,"journal":{"name":"EJC paediatric oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772610X24000059/pdfft?md5=a38d7e7f06eaebc345e355e75f9cd4f3&pid=1-s2.0-S2772610X24000059-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139885760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overview of current European practice for the management of patients with intracranial germ cell tumours","authors":"Manuel Diezi, Barry Pizer, Matthew J. Murray","doi":"10.1016/j.ejcped.2024.100146","DOIUrl":"https://doi.org/10.1016/j.ejcped.2024.100146","url":null,"abstract":"","PeriodicalId":94314,"journal":{"name":"EJC paediatric oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139826065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical presentation and outcome of invasive mould disease in paediatric patients with acute lymphoblastic leukaemia","authors":"Didi Bury ,&nbsp;Corline E.J. Parmentier ,&nbsp;Wim J.E. Tissing ,&nbsp;Rob Pieters ,&nbsp;Louis J. Bont ,&nbsp;Roger J. Brüggemann ,&nbsp;Tom F.W. Wolfs","doi":"10.1016/j.ejcped.2024.100143","DOIUrl":"10.1016/j.ejcped.2024.100143","url":null,"abstract":"<div><h3>Background</h3><p>Childhood acute lymphoblastic leukaemia (ALL) cure rates have improved, but invasive mould disease (IMD) remains a life-threatening complication. Here, we evaluate the epidemiology, clinical presentation, treatment and outcome of IMD in paediatric patients with ALL.</p></div><div><h3>Methods</h3><p>Patients (1–18 years) treated according to the Dutch Childhood Oncology Group (DCOG) ALL-11 protocol from 2012–2021 were analysed for probable and proven IMD. Data was extracted from the Dutch national registry and the electronic health care system.</p></div><div><h3>Results</h3><p>Among 643 patients with ALL, 47 (7.3%) were diagnosed with a probable (n = 29) or proven (n = 18) IMD. Aspergillosis was diagnosed in 42 (89%) patients. Forty-one episodes (87%) occurred during the induction (n = 20) and first consolidation (n = 21) course. The median age at ALL diagnosis was 5 years [IQR 3–10] in the overall group versus 14 years [IQR 7–16] in the IMD group. Two-third of the patients did not receive mould-active prophylaxis. The most prevalent clinical symptoms at presentation were persistent fever and respiratory symptoms. The lungs were the most common site of infection with involvement in 44 (94%) patients, followed by the CNS in 16 (34%) patients. The 6-week and 12-week mortality rate after IMD diagnosis was 10.6% and 14.9%, respectively.</p></div><div><h3>Discussion and conclusion</h3><p>In our paediatric cohort a notable incidence of probable and proven IMD was observed during the early stages of treatment. Remarkable is the high frequency of CNS involvement. These findings highlight the importance of effective prophylactic strategies and warrant early brain imaging.</p></div>","PeriodicalId":94314,"journal":{"name":"EJC paediatric oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772610X24000023/pdfft?md5=dcf6a8ca939cc20cc7d0a0e04a505189&pid=1-s2.0-S2772610X24000023-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139635670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Very rare tumors are not so rare in children","authors":"Daniel Orbach ,&nbsp;Ines Brecht ,&nbsp;Andrea Ferrari","doi":"10.1016/j.ejcped.2024.100144","DOIUrl":"10.1016/j.ejcped.2024.100144","url":null,"abstract":"","PeriodicalId":94314,"journal":{"name":"EJC paediatric oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772610X24000035/pdfft?md5=0868c338a1dd9de16cdb13cdbec5f29f&pid=1-s2.0-S2772610X24000035-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139539281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal autoimmune disease and its association with childhood cancer: A population-based case-control study in Denmark","authors":"Helen T. Orimoloye ,&nbsp;Nicholas Nguyen ,&nbsp;Chuanjie Deng ,&nbsp;Chai Saechao ,&nbsp;Beate Ritz ,&nbsp;Jorn Olsen ,&nbsp;Johnni Hansen ,&nbsp;Julia E. Heck","doi":"10.1016/j.ejcped.2024.100145","DOIUrl":"10.1016/j.ejcped.2024.100145","url":null,"abstract":"<div><h3>Background</h3><p>Autoimmune diseases have been linked to an increased risk of pregnancy-related complications. A family history of autoimmune diseases may be related to the risk of childhood cancer based on similar histocompatibility antigens. We utilized data from national registries in Denmark to examine associations between maternal autoimmune disease and cancer in their offspring.</p></div><div><h3>Methods</h3><p>We linked data from several national registries in Denmark to identify childhood cancer cases in children &lt;20 years diagnosed between 1977 to 2016. Controls were selected from the Central Population Register and matched to cases by birth year and sex (25:1). Mothers with autoimmune disease diagnosed in pregnancy or prior were identified from the National Patient Register. Multivariable conditional logistic regression analyses were used to estimate associations between maternal autoimmune diseases and childhood cancer in offspring.</p></div><div><h3>Results</h3><p>Autoimmune diseases (all types) were positively associated with all childhood cancers combined (Odds Ratio (OR) = 1.25, 95% CI 1.06, 1.47), acute lymphoblastic leukemia (OR =1.52, 95% CI 1.09, 2.13), Burkitt lymphoma (OR = 2.69, 95% CI 1.04, 6.97), and central nervous system tumors (OR = 1.45, 95% CI 1.06, 1.99), especially astrocytoma (OR = 2.27, 95% CI 1.36, 3.77) and glioma (OR = 1.75, 95% CI 1.13, 2.73). When we examined mothers with rheumatoid arthritis, we observed an increased association for all cancers (OR = 2.15, 95% CI 1.40, 3.30), acute lymphoblastic leukemia (OR = 3.55, 95% CI 1.69, 7.47), and central nervous system tumors (OR = 2.91, 95% CI 1.46, 5.82), especially glioma (OR = 3.58, 95% CI 1.40, 9.18) in offspring.</p></div><div><h3>Conclusion</h3><p>There is a positive association between maternal autoimmune disease and childhood cancer. This association is especially prominent in the offspring of women with rheumatoid arthritis.</p></div>","PeriodicalId":94314,"journal":{"name":"EJC paediatric oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772610X24000047/pdfft?md5=022095a0a64475d0752ca567a7fd564e&pid=1-s2.0-S2772610X24000047-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139637284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infections in children and adolescents with Acute Leukemia","authors":"Fabianne Carlesse ,&nbsp;Ana Virginia Lopes de Sousa","doi":"10.1016/j.ejcped.2024.100142","DOIUrl":"10.1016/j.ejcped.2024.100142","url":null,"abstract":"<div><p>The incidence and spectrum of infections in pediatric leukemia patients vary depending on the type of leukemia. AML, which involves intensive chemotherapeutic regimes, leads to profound and prolonged neutropenia, making children more susceptible to infection. The intensity of chemotherapy, the duration of neutropenia, and antimicrobial prophylaxis implementation all affect the risk of life-threatening infections. In AML studies have shown that during intensive treatment, children experience more than one episode of infection, with majority being bacteremias. Viridans group <em>Streptococci</em> comprises around 20% of all isolates. Infection related deaths range from 5.4% to 7.3% during chemotherapy being more frequent on intensive phase. Invasive fungal infections (IFI) were highly associated with mortality specially caused by <em>Aspergillus</em> spp. In ALL induction and consolidation phases posing a higher risk for infections due to severe neutropenia. Infection related mortality in ALL is 2–4%, and infections are the main cause of treatment related deaths. IFI are significant concern with risk factors including age and treatment intensity. High risk include older children, delayed response during early induction therapy and corticosteroid administration. In summary, while survival rates for childhood leukemia have improved, the risk of infections, particularly bacterial and fungal infections, remains a significant concern, especially during intensive treatment phases. Ongoing research is needed to better understand and manage these infections in pediatric leukemia patients</p></div>","PeriodicalId":94314,"journal":{"name":"EJC paediatric oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772610X24000011/pdfft?md5=dfd47e6a4db77a35cfcc6e8cdb9af4da&pid=1-s2.0-S2772610X24000011-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139391715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Focus on melanotic neuroectodermal tumor of infancy","authors":"Malgorzata A. Krawczyk ,&nbsp;Malgorzata Styczewska ,&nbsp;Carla Fernandez ,&nbsp;Rita Alaggio ,&nbsp;Jaroslaw Szydlowski ,&nbsp;Ines B. Brecht ,&nbsp;Daniel Orbach ,&nbsp;Dominik T. Schneider ,&nbsp;Jelena Roganovic ,&nbsp;Gianni Bisogno ,&nbsp;Calogero Virgone ,&nbsp;Jan Godzinski ,&nbsp;Andrea Ferrari ,&nbsp;Nuno Jorge Farinha ,&nbsp;Tal Ben Ami ,&nbsp;Luca Bergamaschi ,&nbsp;Yves Réguerre ,&nbsp;Ewa Bien","doi":"10.1016/j.ejcped.2023.100141","DOIUrl":"https://doi.org/10.1016/j.ejcped.2023.100141","url":null,"abstract":"<div><p>Melanotic neuroectodermal tumor of infancy (MNTI) is a very rare benign neoplasm of probable neurocristic origin. It primarily affects children in the first year of life, with the median age at diagnosis of 4.5 months (range 0–804 months). It usually presents as a fast-growing, painless tumor developing within maxilla, skull bones or mandible but other locations are also possible, especially in older children. The cornerstone of treatment of MNTI is surgery, however local relapses after incomplete tumor excision are common, particularly in patients younger than 2 months of age. Rare cases of multiple recurrent, inoperable or metastatic MNTI pose therapeutic challenges. In such clinical scenarios, various regimens of neoadjuvant chemotherapy based on schemes for neuroblastoma or Ewing sarcoma have been used with partial regressions in some patients, enabling less mutilating delayed surgery. The use of radiotherapy is limited due to very young age of patients with MNTI. No targeted therapies have been found useful so far. Long-term prognosis of localized MNTI is favorable. However, extensive or recurrent lesions can result in functional or esthetic sequelae after surgical removal. Rare cases of malignant/metastatic tumors and MNTI diagnosed in older children have unfavorable outcomes. Further collaborative studies to establish standards of management in patients with MNTI are necessary to improve outcomes and diminish sequelae of surgery. This article presents a literature review on this very rare tumor entity, re-evaluated in the light of the experience gained in the national working groups joined together within the European Cooperative Study Group in Pediatric Rare Tumors (EXPeRT).</p></div>","PeriodicalId":94314,"journal":{"name":"EJC paediatric oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772610X23001393/pdfft?md5=6a40eec73154bab75a11d9695cb0ec6e&pid=1-s2.0-S2772610X23001393-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139099981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opportunities for interventional radiology in paediatric oncology","authors":"Fernando M. Gómez ,&nbsp;Allison Aguado ,&nbsp;Alex M. Barnacle ,&nbsp;Jurgen H. Runge ,&nbsp;Michael Temple","doi":"10.1016/j.ejcped.2023.100139","DOIUrl":"https://doi.org/10.1016/j.ejcped.2023.100139","url":null,"abstract":"<div><p>Interventional oncology (IO) has emerged as a pivotal field within interventional radiology (IR), gaining prominence in the past three decades. It has transcended its initial role in cancer care, expanding beyond biopsies and vascular access to offer a spectrum of percutaneous and transarterial procedures, transforming into a curative and palliative discipline. However, implementing IO in children presents distinctive challenges. While the technical aspects of IO procedures mirror those in adults, paediatric cases require specialised considerations. Radiologists must possess an in-depth understanding of the paediatric disease, tailor imaging modalities to the case, discern unique risks, and interpret disease markers specific to children. Notably, paediatric tumour biopsies demand significantly larger tissue samples for genetic sequencing, staging, and prognostication. Paediatric IO also confronts procedural disparities. Tumours in children may be larger relative to body size, necessitating precise radioembolisation dose calculations. The proximity of critical structures in small bodies amplifies the risk of collateral damage. When performing percutaneous ablation and endovascular therapies, these challenges must also be faced so that radiologists can navigate these complex clinical and technical considerations to ensure safe and effective interventions, all while prioritising the well-being of their young patients. This review summarises the current role and future opportunities for IO in paediatric cancer.</p></div>","PeriodicalId":94314,"journal":{"name":"EJC paediatric oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772610X2300137X/pdfft?md5=9500cc296b7416c07bbaacf9f6461cd5&pid=1-s2.0-S2772610X2300137X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139099982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shared decision making in primary malignant bone tumour surgery in children and young adults","authors":"Kiki Blom ,&nbsp;Peter Bekkering ,&nbsp;Marlieke Hagemeijer ,&nbsp;Marta Fiocco ,&nbsp;Gerard Schaap ,&nbsp;Michiel van de Sande ,&nbsp;Sander Dijkstra ,&nbsp;Bart Schreuder ,&nbsp;Ingrid van der Geest ,&nbsp;Paul Jutte ,&nbsp;Joris Ploegmakers ,&nbsp;Hans Merks ,&nbsp;Jos A.M. Bramer","doi":"10.1016/j.ejcped.2023.100138","DOIUrl":"10.1016/j.ejcped.2023.100138","url":null,"abstract":"<div><h3>Background</h3><p>Children and young adults needing surgery for a primary malignant bone tumour around the knee face a difficult, life changing decision. This study describes the level of shared decision making (SDM) experienced and preferred by these patients, parents and physicians in surgical consultations, and its relation to experienced decisional conflict and decisional regret.</p></div><div><h3>Methods</h3><p>Multicentre, cross-sectional cohort study. All patients who underwent surgery for a primary bone tumour around the knee in the Dutch designated orthopaedic oncological centres between 2012 and 2015, and their parents, were invited to complete the SDM-patient-Questionnaire (SDM-Q-9), Decisional Conflict Scale (DCS), Decisional Regret Scale (DRS) and Control Preferences Scale (CPS). Physicians completed the SDM- physician-Questionnaire (SDM-Q-Doc) and CPS.</p></div><div><h3>Results</h3><p>Twenty-four patients &gt;16 years with twenty-two parents, and ten parents of patients between 5 and 16 years old, completed the questionnaires. Patients’ median SDM-Q-9 score was 60 (8.9–97.8), parents’ 77.8 (8.9–100) and physicians’ 82.2 (66.7–97.8). The SDM-Q-9 scores of patients (rs=−0.753, p &lt; 0.01) and parents (rs=−0.850, p &lt; 0.01) correlated with their DCS scores. DCS scores were correlated with decisional regret in patients (rs=0.701 p &lt; 0.01) and parents (rs=0.405, p &lt; 0.05). Fourteen patients (78%), twenty-eight parents (96%) and twenty-three physicians (92%) preferred a shared relationship in decision making on type of surgery.</p></div><div><h3>Conclusions</h3><p>Patients, parents and physicians agree on sharing responsibility choosing a surgical option. Patients and parents who reported more involvement in the decision-making process experienced less decisional conflict; less decisional conflict was associated with less decisional regret. These findings show the importance of SDM in these life changing surgeries.</p></div>","PeriodicalId":94314,"journal":{"name":"EJC paediatric oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772610X23001368/pdfft?md5=1aa2511e6102e4ee0d6b34a17d56d949&pid=1-s2.0-S2772610X23001368-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139193374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}