发布求助
文献互助 智能选刊 最新文献

Cancer discovery最新文献

筛选
英文 中文
Immune Concept-Informed AI Improves Immunotherapy Response Prediction. 基于免疫概念的AI改进免疫治疗反应预测。
IF 29.5 1区 医学
Cancer discovery Pub Date : 2026-09-01 DOI: 10.1158/2159-8290.CD-RW2026-078
{"title":"Immune Concept-Informed AI Improves Immunotherapy Response Prediction.","authors":"","doi":"10.1158/2159-8290.CD-RW2026-078","DOIUrl":"10.1158/2159-8290.CD-RW2026-078","url":null,"abstract":"","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":" ","pages":"OF1"},"PeriodicalIF":29.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Translational Challenges and Opportunities in mRNA Cancer Vaccines mRNA癌症疫苗的转化挑战与机遇
IF 28.2 1区 医学
Cancer discovery Pub Date : 2026-09-01 DOI: 10.1158/2159-8290.cd-25-1456
Seong Dong Jeong, Benjamin R. Schrank, James J. Mancuso, Betty Y.S. Kim, Wen Jiang, Padmanee Sharma
{"title":"Translational Challenges and Opportunities in mRNA Cancer Vaccines","authors":"Seong Dong Jeong, Benjamin R. Schrank, James J. Mancuso, Betty Y.S. Kim, Wen Jiang, Padmanee Sharma","doi":"10.1158/2159-8290.cd-25-1456","DOIUrl":"https://doi.org/10.1158/2159-8290.cd-25-1456","url":null,"abstract":"Messenger RNA (mRNA) cancer vaccines have progressed rapidly, with personalized platforms such as mRNA-4157 and BNT122 demonstrating feasibility, safety, and durable immune activity but limited scalability. Off-the-shelf constructs, including BNT111 and BNT113, enable faster, broader deployment, yet they risk reduced precision or immune tolerance. These complementary approaches reveal key translational dualities: personalization versus shared antigen (off-the-shelf), potency versus safety, and speed versus durability. This mini-review synthesizes emerging clinical evidence and outlines strategies such as modular vaccine design, prime–boost vaccination regimens, and adaptive trial frameworks to reconcile these trade-offs and advance scalable, durable mRNA vaccines for broad oncologic impact. Significance: By dissecting the competing design pressures that shape mRNA vaccine performance, this mini-review proposes integrative strategies, spanning modular architectures, prime–boost regimens, and adaptive trials, to reconcile immunologic potency with manufacturability and safety, charting a roadmap toward next-generation cancer vaccines.","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":"271 1","pages":""},"PeriodicalIF":28.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-Read Haplotype Phasing Resolves Allelic Configuration as a Missing Layer of Precision Oncology. 长读单倍型相位分解等位基因配置作为精确肿瘤学缺失的一层。
IF 29.5 1区 医学
Cancer discovery Pub Date : 2026-09-01 DOI: 10.1158/2159-8290.CD-26-0839
Josh N Vo, Yi-Mi Wu, Rui Wang, Tiffany Pham, Xuhong Cao, Sophie Yeung, Mingyu Park, Yelena Kleyman-Smith, Guo Ci Teo, Alyssa J Wu, Anne Li, James C Estill, Lakshmi P Kunju, Chen Yang, Dan R Robinson, Arul M Chinnaiyan
{"title":"Long-Read Haplotype Phasing Resolves Allelic Configuration as a Missing Layer of Precision Oncology.","authors":"Josh N Vo, Yi-Mi Wu, Rui Wang, Tiffany Pham, Xuhong Cao, Sophie Yeung, Mingyu Park, Yelena Kleyman-Smith, Guo Ci Teo, Alyssa J Wu, Anne Li, James C Estill, Lakshmi P Kunju, Chen Yang, Dan R Robinson, Arul M Chinnaiyan","doi":"10.1158/2159-8290.CD-26-0839","DOIUrl":"10.1158/2159-8290.CD-26-0839","url":null,"abstract":"<p><p>Short-read sequencing cannot determine whether co-occurring variants within a cancer gene lie on the same allele (cis) or opposing alleles (trans), a distinction with direct therapeutic consequences: trans configurations confirm biallelic tumor suppressor inactivation, whereas cis configurations generate compound oncogenic alleles with enhanced activity. Among 768 patients with prostate, breast, or ovarian cancers, we used mutational signatures to nominate cryptic genomic instability cases lacking a causative biallelic event on short-read sequencing. Long-read nanopore sequencing resolved 32 of 46 cryptic cases (69.6%) through methylation detection, long insertion resolution, and structural variant characterization, confirming trans inactivation in every resolved tumor suppressor case. Analysis of 4,496 MiOncoSeq samples identified 17,519 multi-hit gene pairs, 78.7% of which exceeded the 500 bp short-read phasing limit, and long-read phasing revealed recurrent compound cis alleles in NOTCH1, PIK3CA, PDGFRB, and KIT. Haplotype phasing addresses an overlooked gap in cancer variant interpretation and warrants integration into precision oncology.</p>","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":" ","pages":""},"PeriodicalIF":29.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148872816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dendritic Cells Establish and Maintain Tertiary Lymphoid Structure and Function. 树突状细胞建立和维持三级淋巴结构和功能。
IF 29.5 1区 医学
Cancer discovery Pub Date : 2026-09-01 DOI: 10.1158/2159-8290.CD-RW2026-075
{"title":"Dendritic Cells Establish and Maintain Tertiary Lymphoid Structure and Function.","authors":"","doi":"10.1158/2159-8290.CD-RW2026-075","DOIUrl":"10.1158/2159-8290.CD-RW2026-075","url":null,"abstract":"","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":" ","pages":"OF1"},"PeriodicalIF":29.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148808296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ZFP36L2 Drives Stress-Responsive Plasticity in Regeneration and Cancer. ZFP36L2驱动再生和癌症的应力响应塑性。
IF 29.5 1区 医学
Cancer discovery Pub Date : 2026-09-01 DOI: 10.1158/2159-8290.CD-RW2026-077
{"title":"ZFP36L2 Drives Stress-Responsive Plasticity in Regeneration and Cancer.","authors":"","doi":"10.1158/2159-8290.CD-RW2026-077","DOIUrl":"10.1158/2159-8290.CD-RW2026-077","url":null,"abstract":"","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":" ","pages":"OF1"},"PeriodicalIF":29.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148839354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut Microbiome Metabolism Links High Fat Diets to Immunotherapy Efficacy. 肠道微生物代谢将高脂肪饮食与免疫治疗效果联系起来。
IF 29.5 1区 医学
Cancer discovery Pub Date : 2026-09-01 DOI: 10.1158/2159-8290.CD-RW2026-071
{"title":"Gut Microbiome Metabolism Links High Fat Diets to Immunotherapy Efficacy.","authors":"","doi":"10.1158/2159-8290.CD-RW2026-071","DOIUrl":"10.1158/2159-8290.CD-RW2026-071","url":null,"abstract":"","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":" ","pages":"OF1"},"PeriodicalIF":29.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148764399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Following the Genetic Breadcrumbs of MPNs 跟随mpn的遗传面包屑
IF 28.2 1区 医学
Cancer discovery Pub Date : 2026-09-01 DOI: 10.1158/2159-8290.cd-26-1265
Gaurav Agarwal, Vijay G. Sankaran
{"title":"Following the Genetic Breadcrumbs of MPNs","authors":"Gaurav Agarwal, Vijay G. Sankaran","doi":"10.1158/2159-8290.cd-26-1265","DOIUrl":"https://doi.org/10.1158/2159-8290.cd-26-1265","url":null,"abstract":"Summary: We provide an overview of a recent study in Cancer Discovery by Leongamornlert and colleagues involving genomic profiling of 30 patients with myeloproliferative neoplasms using available blood or bone marrow samples to assess what factors underlie disease evolution or predict stability. See related article by Leongamornlert et al., p. 1843","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":"21 1","pages":""},"PeriodicalIF":28.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multiplexed In Vivo Screen Pinpoints Drivers of Breast Cancer Aneuploidies. 多重体内筛选确定乳腺癌非整倍体的驱动因素。
IF 29.5 1区 医学
Cancer discovery Pub Date : 2026-09-01 DOI: 10.1158/2159-8290.CD-RW2026-069
{"title":"Multiplexed In Vivo Screen Pinpoints Drivers of Breast Cancer Aneuploidies.","authors":"","doi":"10.1158/2159-8290.CD-RW2026-069","DOIUrl":"10.1158/2159-8290.CD-RW2026-069","url":null,"abstract":"","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":" ","pages":"OF1"},"PeriodicalIF":29.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148711184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insights on Future Directions in Cancer Research from the AACR Trailblazer Cancer Research Grant Awardees. 美国癌症研究协会开拓者癌症研究基金获得者对癌症研究未来方向的见解。
IF 29.5 1区 医学
Cancer discovery Pub Date : 2026-09-01 DOI: 10.1158/2159-8290.CD-26-1356
Ana Luísa Correia, Karen O Dixon, J Justin Milner, Nathan H Parker, Theodore L Roth, Jonathan M Tsai, Jessalyn M Ubellacker, Natalie I Vokes, Samir Zaidi, Effie Apostolou, Adrienne Boire, Carla J Chibwesha, Yifat Merbl, Aaron M Newman, Tuomas Tammela
{"title":"Insights on Future Directions in Cancer Research from the AACR Trailblazer Cancer Research Grant Awardees.","authors":"Ana Luísa Correia, Karen O Dixon, J Justin Milner, Nathan H Parker, Theodore L Roth, Jonathan M Tsai, Jessalyn M Ubellacker, Natalie I Vokes, Samir Zaidi, Effie Apostolou, Adrienne Boire, Carla J Chibwesha, Yifat Merbl, Aaron M Newman, Tuomas Tammela","doi":"10.1158/2159-8290.CD-26-1356","DOIUrl":"https://doi.org/10.1158/2159-8290.CD-26-1356","url":null,"abstract":"","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":"16 9","pages":"1730-1738"},"PeriodicalIF":29.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148863758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondrial Complex I at the Crossroads of NK cell Dysfunction in Glioblastoma 线粒体复合体I在胶质母细胞瘤中NK细胞功能障碍的十字路口
IF 28.2 1区 医学
Cancer discovery Pub Date : 2026-09-01 DOI: 10.1158/2159-8290.cd-26-1267
Silvia Tiberti, Katayoun Rezvani, May Daher
{"title":"Mitochondrial Complex I at the Crossroads of NK cell Dysfunction in Glioblastoma","authors":"Silvia Tiberti, Katayoun Rezvani, May Daher","doi":"10.1158/2159-8290.cd-26-1267","DOIUrl":"https://doi.org/10.1158/2159-8290.cd-26-1267","url":null,"abstract":"Summary: Zhou and colleagues identify mitochondrial complex I activity, mediated through NDUFA9, as a critical determinant of natural killer (NK) cell metabolic fitness and antitumor function in glioblastoma. Their study links impaired oxidative phosphorylation to glutamine dependence, epigenetic repression of effector programs, and loss of NK cell activity, highlighting mitochondrial fitness as an actionable axis for improving cellular immunotherapy in solid tumors. See related article by Zhou et al., p. 1924","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":"43 1","pages":""},"PeriodicalIF":28.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信
小红书