发布求助
文献互助 智能选刊 最新文献

Cancer discovery最新文献

筛选
英文 中文
Synchronous L1 Retrotransposition Drives Chromosomal Rearrangements in Cancer. 同步L1反转录驱动癌症中的染色体重排。
IF 33.3 1区 医学
Cancer discovery Pub Date : 2026-05-01 DOI: 10.1158/2159-8290.CD-RW2026-033
{"title":"Synchronous L1 Retrotransposition Drives Chromosomal Rearrangements in Cancer.","authors":"","doi":"10.1158/2159-8290.CD-RW2026-033","DOIUrl":"10.1158/2159-8290.CD-RW2026-033","url":null,"abstract":"","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":" ","pages":"OF1"},"PeriodicalIF":33.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147615869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tissue-Specific Spatial Regulation of Innate Immune Checkpoints in Cancer. 肿瘤中先天免疫检查点的组织特异性空间调控。
IF 33.3 1区 医学
Cancer discovery Pub Date : 2026-05-01 DOI: 10.1158/2159-8290.CD-25-2112
Ana Stojanovic, Sebastiano Giorgetta, David Vonhören, Eva I Krieghoff-Henning, Michael Platten, Sonja Loges, Sonia Tugues, Adelheid Cerwenka
{"title":"Tissue-Specific Spatial Regulation of Innate Immune Checkpoints in Cancer.","authors":"Ana Stojanovic, Sebastiano Giorgetta, David Vonhören, Eva I Krieghoff-Henning, Michael Platten, Sonja Loges, Sonia Tugues, Adelheid Cerwenka","doi":"10.1158/2159-8290.CD-25-2112","DOIUrl":"10.1158/2159-8290.CD-25-2112","url":null,"abstract":"<p><p>NK and innate lymphoid cells (ILC) regulate tissue homeostasis and immune responses by acting as early sensors of cellular stress and tissue dysfunction. Their functions are tightly controlled by regulatory circuits, often referred to as checkpoints, and are profoundly shaped by local environments. In cancer, tissue perturbations cause immune cell recruitment, spatial redistribution, and accordant functional adaptations. In this review, we discuss how tissue-specific cues regulate NK/ILC functions in cancer, and how local regulatory circuits shape their cellular states and effector programs. We address how targeting innate checkpoints could aid existing therapies and inform novel strategies for treating solid malignancies.</p><p><strong>Significance: </strong>Recent progress in spatial and tissue-resolved immunology has highlighted the crucial influence of the tumor microenvironment and local cellular interactions on shaping immune cell compartmentalization and the tissue- and niche-driven specialization within the tumor tissue. This review redefines immune checkpoints not merely as static brakes on effector function, but as dynamic regulatory units that orchestrate immune cell adaptation to the evolving tumor milieu. We elucidate how NK cells and other innate lymphocytes undergo spatiotemporal adaptation across distinct tumor niches and provide an integrated understanding of innate checkpoint biology to unveil innovative therapeutic opportunities for modulating immune reactivity in solid malignancies.</p>","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":" ","pages":"857-875"},"PeriodicalIF":33.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146112464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thymic Health Tied to Cancer Risk and Treatment Responses. 胸腺健康与癌症风险和治疗反应有关。
IF 33.3 1区 医学
Cancer discovery Pub Date : 2026-05-01 DOI: 10.1158/2159-8290.CD-NW2026-0028
{"title":"Thymic Health Tied to Cancer Risk and Treatment Responses.","authors":"","doi":"10.1158/2159-8290.CD-NW2026-0028","DOIUrl":"10.1158/2159-8290.CD-NW2026-0028","url":null,"abstract":"<p><p>A deep-learning model applied to chest CT scans reveals that variation in thymus health tracks with both cancer susceptibility and clinical response after treatment with checkpoint inhibitors. The findings point to routine imaging data as a scalable approach to risk assessment and therapy selection, and highlight the underappreciated role of thymic function in shaping cancer outcomes.</p>","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":" ","pages":"OF1"},"PeriodicalIF":33.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147509672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nearly 40% of Cancers Could Be Prevented. 近40%的癌症是可以预防的。
IF 33.3 1区 医学
Cancer discovery Pub Date : 2026-05-01 DOI: 10.1158/2159-8290.CD-NW2026-0026
{"title":"Nearly 40% of Cancers Could Be Prevented.","authors":"","doi":"10.1158/2159-8290.CD-NW2026-0026","DOIUrl":"10.1158/2159-8290.CD-NW2026-0026","url":null,"abstract":"<p><p>A massive study spanning 185 countries concludes that about four in 10 cancer cases are linked to modifiable risk factors such as smoking, infections, and alcohol consumption. Stratifying by sex, researchers found three in 10 cancer cases in women and one in two in men were due to modifiable risk factors. The findings \"reinforce the call for effective cancer prevention,\" the researchers say.</p>","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":" ","pages":"OF1"},"PeriodicalIF":33.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
More Questions Than Answers in Trial of GRAIL's Galleri. 圣杯画廊审判中的问题多于答案。
IF 33.3 1区 医学
Cancer discovery Pub Date : 2026-05-01 DOI: 10.1158/2159-8290.CD-NW2026-0025
{"title":"More Questions Than Answers in Trial of GRAIL's Galleri.","authors":"","doi":"10.1158/2159-8290.CD-NW2026-0025","DOIUrl":"10.1158/2159-8290.CD-NW2026-0025","url":null,"abstract":"<p><p>The NHS-Galleri trial, the first randomized, controlled trial of the multi-cancer early detection test Galleri, found that the test from GRAIL did not meet its primary endpoint, a reduction in late-stage cancers. Researchers say the result could be a consequence of the trial design, which used a surrogate endpoint rather than cancer-specific mortality, the standard measure.</p>","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":" ","pages":"OF1"},"PeriodicalIF":33.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cellobiose Fuels Engineered T-Cell Cytotoxicity. 纤维二糖燃料工程t细胞毒性。
IF 33.3 1区 医学
Cancer discovery Pub Date : 2026-05-01 DOI: 10.1158/2159-8290.CD-RW2026-032
{"title":"Cellobiose Fuels Engineered T-Cell Cytotoxicity.","authors":"","doi":"10.1158/2159-8290.CD-RW2026-032","DOIUrl":"10.1158/2159-8290.CD-RW2026-032","url":null,"abstract":"","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":" ","pages":"OF1"},"PeriodicalIF":33.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glucocorticoid Signaling Enables Immune Evasion of Disseminated Tumor Cells. 糖皮质激素信号使播散性肿瘤细胞免疫逃避。
IF 33.3 1区 医学
Cancer discovery Pub Date : 2026-05-01 DOI: 10.1158/2159-8290.CD-RW2026-037
{"title":"Glucocorticoid Signaling Enables Immune Evasion of Disseminated Tumor Cells.","authors":"","doi":"10.1158/2159-8290.CD-RW2026-037","DOIUrl":"10.1158/2159-8290.CD-RW2026-037","url":null,"abstract":"","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":" ","pages":"OF1"},"PeriodicalIF":33.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147622004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting Exposed Phosphatidylserine Boosts Antigen-Specific T-Cell Response. 靶向暴露的磷脂酰丝氨酸增强抗原特异性t细胞反应。
IF 33.3 1区 医学
Cancer discovery Pub Date : 2026-05-01 DOI: 10.1158/2159-8290.CD-RW2026-038
{"title":"Targeting Exposed Phosphatidylserine Boosts Antigen-Specific T-Cell Response.","authors":"","doi":"10.1158/2159-8290.CD-RW2026-038","DOIUrl":"10.1158/2159-8290.CD-RW2026-038","url":null,"abstract":"","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":" ","pages":"OF1"},"PeriodicalIF":33.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
OR7A10 Overexpression Boosts CAR-NK Therapy Against Solid Tumors. OR7A10过表达促进CAR-NK治疗实体瘤
IF 33.3 1区 医学
Cancer discovery Pub Date : 2026-05-01 DOI: 10.1158/2159-8290.CD-RW2026-034
{"title":"OR7A10 Overexpression Boosts CAR-NK Therapy Against Solid Tumors.","authors":"","doi":"10.1158/2159-8290.CD-RW2026-034","DOIUrl":"10.1158/2159-8290.CD-RW2026-034","url":null,"abstract":"","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":" ","pages":"OF1"},"PeriodicalIF":33.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147621976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engineered Catch Bonds Overcome T-Cell Tolerance in Cancer Therapy. 工程捕获键在癌症治疗中克服t细胞耐受性。
IF 33.3 1区 医学
Cancer discovery Pub Date : 2026-05-01 DOI: 10.1158/2159-8290.CD-RW2026-042
{"title":"Engineered Catch Bonds Overcome T-Cell Tolerance in Cancer Therapy.","authors":"","doi":"10.1158/2159-8290.CD-RW2026-042","DOIUrl":"https://doi.org/10.1158/2159-8290.CD-RW2026-042","url":null,"abstract":"","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":" ","pages":"OF1"},"PeriodicalIF":33.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信
小红书