Advances in cancer research最新文献_第5页

Frailty assessment in geriatric radiation oncology. 老年放射肿瘤学中的虚弱评估。

Advances in cancer research Pub Date : 2024-01-01 Epub Date: 2024-08-23 DOI: 10.1016/bs.acr.2024.07.003

Rahmi Atil Aksoy, Vildan Kaya

引用次数: 0

Protein Tyrosine Phosphatase regulation by Reactive Oxygen Species. 活性氧对蛋白酪氨酸磷酸酶的调控。

Advances in cancer research Pub Date : 2024-01-01 Epub Date: 2024-05-24 DOI: 10.1016/bs.acr.2024.05.002

Colin L Welsh, Lalima K Madan

{"title":"Protein Tyrosine Phosphatase regulation by Reactive Oxygen Species.","authors":"Colin L Welsh, Lalima K Madan","doi":"10.1016/bs.acr.2024.05.002","DOIUrl":"https://doi.org/10.1016/bs.acr.2024.05.002","url":null,"abstract":"Protein Tyrosine Phosphatases (PTPs) help to maintain the balance of protein phosphorylation signals that drive cell division, proliferation, and differentiation. These enzymes are also well-suited to redox-dependent signaling and oxidative stress response due to their cysteine-based catalytic mechanism, which requires a deprotonated thiol group at the active site. This review focuses on PTP structural characteristics, active site chemical properties, and vulnerability to change by reactive oxygen species (ROS). PTPs can be oxidized and inactivated by H2O2 through three non-exclusive mechanisms. These pathways are dependent on the coordinated actions of other H2O2-sensitive proteins, such as peroxidases like Peroxiredoxins (Prx) and Thioredoxins (Trx). PTPs undergo reversible oxidation by converting their active site cysteine from thiol to sulfenic acid. This sulfenic acid can then react with adjacent cysteines to form disulfide bonds or with nearby amides to form sulfenyl-amide linkages. Further oxidation of the sulfenic acid form to the sulfonic or sulfinic acid forms causes irreversible deactivation. Understanding the structural changes involved in both reversible and irreversible PTP oxidation can help with their chemical manipulation for therapeutic intervention. Nonetheless, more information remains unidentified than is presently known about the precise dynamics of proteins participating in oxidation events, as well as the specific oxidation states that can be targeted for PTPs. This review summarizes current information on PTP-specific oxidation patterns and explains how ROS-mediated signal transmission interacts with phosphorylation-based signaling machinery controlled by growth factor receptors and PTPs.","PeriodicalId":94294,"journal":{"name":"Advances in cancer research","volume":"162 ","pages":"45-74"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141790738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Racial disparities, cancer and response to oxidative stress. 种族差异、癌症和对氧化应激的反应。

Advances in cancer research Pub Date : 2019-01-01 Epub Date: 2019-04-23 DOI: 10.1016/bs.acr.2019.03.012

Jie Zhang, Zhi-Wei Ye, Danyelle M Townsend, Chanita Hughes-Halbert, Kenneth D Tew

引用次数: 0

Macroenvironment-gene-microenvironment interactions in ultraviolet radiation-induced melanomagenesis. 紫外线辐射诱导黑色素瘤形成过程中的大环境-基因-微环境相互作用

Advances in cancer research Pub Date : 2019-01-01 Epub Date: 2019-04-23 DOI: 10.1016/bs.acr.2019.03.008

Xuan Mo, Sarah Preston, M Raza Zaidi

引用次数: 13

Disparities in Obesity, Physical Activity Rates, and Breast Cancer Survival. 肥胖、体力活动率和癌症生存率的差异。

Advances in cancer research Pub Date : 2017-01-01 Epub Date: 2016-10-31 DOI: 10.1016/bs.acr.2016.08.002

M E Ford, G Magwood, E T Brown, K Cannady, M Gregoski, K D Knight, L L Peterson, R Kramer, A Evans-Knowell, D P Turner

{"title":"Disparities in Obesity, Physical Activity Rates, and Breast Cancer Survival.","authors":"M E Ford, G Magwood, E T Brown, K Cannady, M Gregoski, K D Knight, L L Peterson, R Kramer, A Evans-Knowell, D P Turner","doi":"10.1016/bs.acr.2016.08.002","DOIUrl":"https://doi.org/10.1016/bs.acr.2016.08.002","url":null,"abstract":"The significantly higher breast cancer (BCa) mortality rates of African-American (AA) women compared to non-Hispanic (NHW) white women constitute a major US health disparity. Investigations have primarily focused on biological differences in tumors to explain more aggressive forms of BCa in AA women. The biology of tumors cannot be modified, yet lifestyle changes can mitigate their progression and recurrence. AA communities have higher percentages of obesity than NHWs and exhibit inefficient access to care, low socioeconomic status, and reduced education levels. Such factors are associated with limited healthy food options and sedentary activity. AA women have the highest prevalence of obesity than any other racial/ethnic/gender group in the United States. The social ecological model (SEM) is a conceptual framework on which interventions could be developed to reduce obesity. The SEM includes intrapersonal factors, interpersonal factors, organizational relationships, and community/institutional policies that are more effective in behavior modification than isolation from the participants' environmental context. Implementation of SEM-based interventions in AA communities could positively modify lifestyle behaviors, which could also serve as a powerful tool in reducing risk of BCa, BCa progression, and BCa recurrence in populations of AA women.","PeriodicalId":94294,"journal":{"name":"Advances in cancer research","volume":"133 ","pages":"23-50"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.acr.2016.08.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41224636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Applying a Conceptual Framework to Maximize the Participation of Diverse Populations in Cancer Clinical Trials. 应用概念框架最大限度地提高不同人群参与癌症临床试验的比例。

Advances in cancer research Pub Date : 2017-01-01 Epub Date: 2016-10-05 DOI: 10.1016/bs.acr.2016.08.004

A Napoles, E Cook, T Ginossar, K D Knight, M E Ford

{"title":"Applying a Conceptual Framework to Maximize the Participation of Diverse Populations in Cancer Clinical Trials.","authors":"A Napoles, E Cook, T Ginossar, K D Knight, M E Ford","doi":"10.1016/bs.acr.2016.08.004","DOIUrl":"10.1016/bs.acr.2016.08.004","url":null,"abstract":"The underrepresentation of ethnically diverse populations in cancer clinical trials results in the inequitable distribution of the risks and benefits of this research. Using a case study approach, we apply a conceptual framework of factors associated with the participation of diverse population groups in cancer clinical trials developed by Dr. Jean Ford and colleagues to increase understanding of the specific strategies, and barriers and promoters addressed by these strategies, that resulted in marked success in accrual of racially and ethnically diverse populations in cancer clinical research. Results indicate that the studies presented were able to successfully engage minority participants due to the creation and implementation of multilevel, multifaceted strategies that included: culturally and linguistically appropriate outreach, education, and research studies that were accessible in local communities; infrastructure to support engagement of key stakeholders, clinicians, and organizations serving minority communities; testimonials by ethnically diverse cancer survivors; availability of medical interpretation services; and providing infrastructure that facilitated the engagement in clinical research of clinicians who care for minority patient populations. These strategic efforts were effective in addressing limited awareness of trials, lack of opportunities to participate, and acceptance of engagement in cancer clinical trials. Careful attention to the context and population characteristics in which cancer clinical trials are conducted will be necessary to address disparities in research participation and cancer outcomes. These studies illustrate that progress on minority accrual into clinical research requires intentional efforts to overcome barriers at all three stages of the accrual process: awareness, opportunity, and acceptance of participation.","PeriodicalId":94294,"journal":{"name":"Advances in cancer research","volume":"133 ","pages":"77-94"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141285711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unusual Suspects in the Twilight Zone Between the Hsp90 Interactome and Carcinogenesis. Hsp90相互作用组与癌症发生之间 "黄昏地带 "的非同寻常嫌疑人

Advances in cancer research Pub Date : 2016-01-01 Epub Date: 2015-10-23 DOI: 10.1016/bs.acr.2015.08.001

Evangelia Vartholomaiou, Pablo C Echeverría, Didier Picard

{"title":"Unusual Suspects in the Twilight Zone Between the Hsp90 Interactome and Carcinogenesis.","authors":"Evangelia Vartholomaiou, Pablo C Echeverría, Didier Picard","doi":"10.1016/bs.acr.2015.08.001","DOIUrl":"https://doi.org/10.1016/bs.acr.2015.08.001","url":null,"abstract":"The molecular chaperone Hsp90 has attracted a lot of interest in cancer research ever since cancer cells were found to be more sensitive to Hsp90 inhibition than normal cells. Why that is has remained a matter of debate and is still unclear. In addition to increased Hsp90 dependence for some mutant cancer proteins and modifications of the Hsp90 machinery itself, a number of other characteristics of cancer cells probably contribute to this phenomenon; these include aneuploidy and overall increased numbers and levels of defective and mutant proteins, which all contribute to perturbed proteostasis. Work over the last two decades has demonstrated that many cancer-related proteins are Hsp90 clients, and yet only few of them have been extensively investigated, selected either on the basis of their obvious function as cancer drivers or because they proved to be convenient biomarkers for monitoring the effects of Hsp90 inhibitors. The purpose of our review is to go beyond these \"usual suspects.\" We established a workflow to select poorly studied proteins that are related to cancer processes and qualify as Hsp90 clients. By discussing and taking a fresh look at these \"unusual suspects,\" we hope to stimulate others to revisit them as novel therapeutic targets or diagnostic markers. ","PeriodicalId":94294,"journal":{"name":"Advances in cancer research","volume":"129 ","pages":"1-30"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138815625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 42

Hsp90 in Cancer: Transcriptional Roles in the Nucleus. Hsp90在肿瘤中的转录作用。

Advances in cancer research Pub Date : 2016-01-01 Epub Date: 2015-10-12 DOI: 10.1016/bs.acr.2015.08.002

Stuart K Calderwood, Len Neckers

{"title":"Hsp90 in Cancer: Transcriptional Roles in the Nucleus.","authors":"Stuart K Calderwood, Len Neckers","doi":"10.1016/bs.acr.2015.08.002","DOIUrl":"https://doi.org/10.1016/bs.acr.2015.08.002","url":null,"abstract":"Hsp90 plays a key role in fostering metabolic pathways essential in tumorigenesis through its functions as a molecular chaperone. Multiple oncogenic factors in the membrane and cytoplasm are thus protected from degradation and destruction. Here, we have considered Hsp90's role in transcription in the nucleus. Hsp90 functions both in regulating the activity of sequence-specific transcription factors such as nuclear receptors and HSF1, as well as impacting more globally acting factors that act on chromatin and RNA polymerase II. Hsp90 influences transcription by modulating histone modification mediated by its clients SMYD3 and trithorax/MLL, as well as by regulating the processivity of RNA polymerase II through negative elongation factor. It is not currently clear how the transcriptional role of Hsp90 may be influenced by the cancer milieu although recently discovered posttranslational modification of the chaperone may be involved. Dysregulation of Hsp90 may thus influence malignant processes both by modulating the function of specific transcription factors and effects on more globally acting general components of the transcriptional machinery. ","PeriodicalId":94294,"journal":{"name":"Advances in cancer research","volume":"129 ","pages":"89-106"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0