Advances in cancer research最新文献_第2页

The glycosylation landscape of prostate cancer tissues and biofluids. 前列腺癌组织和生物流体的糖基化图谱

Advances in cancer research Pub Date : 2024-01-01 Epub Date: 2024-04-25 DOI: 10.1016/bs.acr.2024.04.005

Jordan Hartig, Lyndsay E A Young, Grace Grimsley, Anand S Mehta, Joseph E Ippolito, Robin J Leach, Peggi M Angel, Richard R Drake

{"title":"The glycosylation landscape of prostate cancer tissues and biofluids.","authors":"Jordan Hartig, Lyndsay E A Young, Grace Grimsley, Anand S Mehta, Joseph E Ippolito, Robin J Leach, Peggi M Angel, Richard R Drake","doi":"10.1016/bs.acr.2024.04.005","DOIUrl":"https://doi.org/10.1016/bs.acr.2024.04.005","url":null,"abstract":"An overview of the role of glycosylation in prostate cancer (PCa) development and progression is presented, focusing on recent advancements in defining the N-glycome through glycomic profiling and glycoproteomic methodologies. Glycosylation is a common post-translational modification typified by oligosaccharides attached N-linked to asparagine or O-linked to serine or threonine on carrier proteins. These attached sugars have crucial roles in protein folding and cellular recognition processes, such that altered glycosylation is a hallmark of cancer pathogenesis and progression. In the past decade, advancements in N-glycan profiling workflows using Matrix Assisted Laser Desorption/Ionization Mass Spectrometry Imaging (MALDI-MSI) technology have been applied to define the spatial distribution of glycans in PCa tissues. Multiple studies applying N-glycan MALDI-MSI to pathology-defined PCa tissues have identified significant alterations in N-glycan profiles associated with PCa progression. N-glycan compositions progressively increase in number, and structural complexity due to increased fucosylation and sialylation. Additionally, significant progress has been made in defining the glycan and glycopeptide compositions of prostatic-derived glycoproteins like prostate-specific antigen in tissues and biofluids. The glycosyltransferases involved in these changes are potential drug targets for PCa, and new approaches in this area are summarized. These advancements will be discussed in the context of the further development of clinical diagnostics and therapeutics targeting glycans and glycoproteins associated with PCa progression. Integration of large scale spatial glycomic data for PCa with other spatial-omic methodologies is now feasible at the tissue and single-cell levels.","PeriodicalId":94294,"journal":{"name":"Advances in cancer research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141736300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Redox pathways in melanoma. 黑色素瘤的氧化还原途径

Advances in cancer research Pub Date : 2024-01-01 Epub Date: 2024-06-24 DOI: 10.1016/bs.acr.2024.06.002

Jie Zhang, Zhi-Wei Ye, Danyelle M Townsend, Kenneth D Tew

引用次数: 0

Role of antioxidants in modulating anti-tumor T cell immune resposne. 抗氧化剂在调节抗肿瘤 T 细胞免疫反应中的作用

Advances in cancer research Pub Date : 2024-01-01 Epub Date: 2024-06-13 DOI: 10.1016/bs.acr.2024.05.003

Nathaniel Oberholtzer, Stephanie Mills, Shubham Mehta, Paramita Chakraborty, Shikhar Mehrotra

引用次数: 0

Molecular landscape of prostate cancer bone metastasis. 前列腺癌骨转移的分子图谱。

Advances in cancer research Pub Date : 2024-01-01 Epub Date: 2024-05-11 DOI: 10.1016/bs.acr.2024.04.007

Santanu Maji, Amit Kumar, Luni Emdad, Paul B Fisher, Swadesh K Das

引用次数: 0

Prostate MRI for the detection of clinically significant prostate cancer: Update and future directions. 用于检测具有临床意义的前列腺癌的前列腺磁共振成像：最新进展和未来方向。

Advances in cancer research Pub Date : 2024-01-01 Epub Date: 2024-04-25 DOI: 10.1016/bs.acr.2024.04.002

Shaun Trecarten, Abhijit G Sunnapwar, Geoffrey D Clarke, Michael A Liss

{"title":"Prostate MRI for the detection of clinically significant prostate cancer: Update and future directions.","authors":"Shaun Trecarten, Abhijit G Sunnapwar, Geoffrey D Clarke, Michael A Liss","doi":"10.1016/bs.acr.2024.04.002","DOIUrl":"https://doi.org/10.1016/bs.acr.2024.04.002","url":null,"abstract":"Purpose of review: In recent decades, there has been an increasing role for magnetic resonance imaging (MRI) in the detection of clinically significant prostate cancer (csPC). The purpose of this review is to provide an update and outline future directions for the role of MRI in the detection of csPC.Recent findings: In diagnosing clinically significant prostate cancer pre-biopsy, advances include our understanding of MRI-targeted biopsy, the role of biparametric MRI (non-contrast) and changing indications, for example the role of MRI in screening for prostate cancer. Furthermore, the role of MRI in identifying csPC is maturing, with emphasis on standardization of MRI reporting in active surveillance (PRECISE), clinical staging (EPE grading, MET-RADS-P) and recurrent disease (PI-RR, PI-FAB). Future directions of prostate MRI in detecting csPC include quality improvement, artificial intelligence and radiomics, positron emission tomography (PET)/MRI and MRI-directed therapy.Summary: The utility of MRI in detecting csPC has been demonstrated in many clinical scenarios, initially from simply diagnosing csPC pre-biopsy, now to screening, active surveillance, clinical staging, and detection of recurrent disease. Continued efforts should be undertaken not only to emphasize the reporting of prostate MRI quality, but to standardize reporting according to the appropriate clinical setting.","PeriodicalId":94294,"journal":{"name":"Advances in cancer research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141736297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements in computer vision and pathology: Unraveling the potential of artificial intelligence for precision diagnosis and beyond. 计算机视觉和病理学的进步：发掘人工智能在精准诊断及其他方面的潜力。

Advances in cancer research Pub Date : 2024-01-01 Epub Date: 2024-06-26 DOI: 10.1016/bs.acr.2024.05.006

Justin Chang, Bryce Hatfield

{"title":"Advancements in computer vision and pathology: Unraveling the potential of artificial intelligence for precision diagnosis and beyond.","authors":"Justin Chang, Bryce Hatfield","doi":"10.1016/bs.acr.2024.05.006","DOIUrl":"https://doi.org/10.1016/bs.acr.2024.05.006","url":null,"abstract":"The integration of computer vision into pathology through slide digitalization represents a transformative leap in the field's evolution. Traditional pathology methods, while reliable, are often time-consuming and susceptible to intra- and interobserver variability. In contrast, computer vision, empowered by artificial intelligence (AI) and machine learning (ML), promises revolutionary changes, offering consistent, reproducible, and objective results with ever-increasing speed and scalability. The applications of advanced algorithms and deep learning architectures like CNNs and U-Nets augment pathologists' diagnostic capabilities, opening new frontiers in automated image analysis. As these technologies mature and integrate into digital pathology workflows, they are poised to provide deeper insights into disease processes, quantify and standardize biomarkers, enhance patient outcomes, and automate routine tasks, reducing pathologists' workload. However, this transformative force calls for cross-disciplinary collaboration between pathologists, computer scientists, and industry innovators to drive research and development. While acknowledging its potential, this chapter addresses the limitations of AI in pathology, encompassing technical, practical, and ethical considerations during development and implementation.","PeriodicalId":94294,"journal":{"name":"Advances in cancer research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141736276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protein Tyrosine Phosphatase regulation by Reactive Oxygen Species. 活性氧对蛋白酪氨酸磷酸酶的调控。

Advances in cancer research Pub Date : 2024-01-01 Epub Date: 2024-05-24 DOI: 10.1016/bs.acr.2024.05.002

Colin L Welsh, Lalima K Madan

{"title":"Protein Tyrosine Phosphatase regulation by Reactive Oxygen Species.","authors":"Colin L Welsh, Lalima K Madan","doi":"10.1016/bs.acr.2024.05.002","DOIUrl":"https://doi.org/10.1016/bs.acr.2024.05.002","url":null,"abstract":"Protein Tyrosine Phosphatases (PTPs) help to maintain the balance of protein phosphorylation signals that drive cell division, proliferation, and differentiation. These enzymes are also well-suited to redox-dependent signaling and oxidative stress response due to their cysteine-based catalytic mechanism, which requires a deprotonated thiol group at the active site. This review focuses on PTP structural characteristics, active site chemical properties, and vulnerability to change by reactive oxygen species (ROS). PTPs can be oxidized and inactivated by H2O2 through three non-exclusive mechanisms. These pathways are dependent on the coordinated actions of other H2O2-sensitive proteins, such as peroxidases like Peroxiredoxins (Prx) and Thioredoxins (Trx). PTPs undergo reversible oxidation by converting their active site cysteine from thiol to sulfenic acid. This sulfenic acid can then react with adjacent cysteines to form disulfide bonds or with nearby amides to form sulfenyl-amide linkages. Further oxidation of the sulfenic acid form to the sulfonic or sulfinic acid forms causes irreversible deactivation. Understanding the structural changes involved in both reversible and irreversible PTP oxidation can help with their chemical manipulation for therapeutic intervention. Nonetheless, more information remains unidentified than is presently known about the precise dynamics of proteins participating in oxidation events, as well as the specific oxidation states that can be targeted for PTPs. This review summarizes current information on PTP-specific oxidation patterns and explains how ROS-mediated signal transmission interacts with phosphorylation-based signaling machinery controlled by growth factor receptors and PTPs.","PeriodicalId":94294,"journal":{"name":"Advances in cancer research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141790738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Racial disparities, cancer and response to oxidative stress. 种族差异、癌症和对氧化应激的反应。

Advances in cancer research Pub Date : 2019-01-01 Epub Date: 2019-04-23 DOI: 10.1016/bs.acr.2019.03.012

Jie Zhang, Zhi-Wei Ye, Danyelle M Townsend, Chanita Hughes-Halbert, Kenneth D Tew

引用次数: 0

Macroenvironment-gene-microenvironment interactions in ultraviolet radiation-induced melanomagenesis. 紫外线辐射诱导黑色素瘤形成过程中的大环境-基因-微环境相互作用

Advances in cancer research Pub Date : 2019-01-01 Epub Date: 2019-04-23 DOI: 10.1016/bs.acr.2019.03.008

Xuan Mo, Sarah Preston, M Raza Zaidi

引用次数: 13

Disparities in Obesity, Physical Activity Rates, and Breast Cancer Survival. 肥胖、体力活动率和癌症生存率的差异。

Advances in cancer research Pub Date : 2017-01-01 Epub Date: 2016-10-31 DOI: 10.1016/bs.acr.2016.08.002

M E Ford, G Magwood, E T Brown, K Cannady, M Gregoski, K D Knight, L L Peterson, R Kramer, A Evans-Knowell, D P Turner

{"title":"Disparities in Obesity, Physical Activity Rates, and Breast Cancer Survival.","authors":"M E Ford, G Magwood, E T Brown, K Cannady, M Gregoski, K D Knight, L L Peterson, R Kramer, A Evans-Knowell, D P Turner","doi":"10.1016/bs.acr.2016.08.002","DOIUrl":"https://doi.org/10.1016/bs.acr.2016.08.002","url":null,"abstract":"The significantly higher breast cancer (BCa) mortality rates of African-American (AA) women compared to non-Hispanic (NHW) white women constitute a major US health disparity. Investigations have primarily focused on biological differences in tumors to explain more aggressive forms of BCa in AA women. The biology of tumors cannot be modified, yet lifestyle changes can mitigate their progression and recurrence. AA communities have higher percentages of obesity than NHWs and exhibit inefficient access to care, low socioeconomic status, and reduced education levels. Such factors are associated with limited healthy food options and sedentary activity. AA women have the highest prevalence of obesity than any other racial/ethnic/gender group in the United States. The social ecological model (SEM) is a conceptual framework on which interventions could be developed to reduce obesity. The SEM includes intrapersonal factors, interpersonal factors, organizational relationships, and community/institutional policies that are more effective in behavior modification than isolation from the participants' environmental context. Implementation of SEM-based interventions in AA communities could positively modify lifestyle behaviors, which could also serve as a powerful tool in reducing risk of BCa, BCa progression, and BCa recurrence in populations of AA women.","PeriodicalId":94294,"journal":{"name":"Advances in cancer research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.acr.2016.08.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41224636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10