Cancer Translational Medicine最新文献_第2页

Coenzyme Q10 and resveratrol abrogate paclitaxel-induced hepatotoxicity in rats 辅酶Q10和白藜芦醇可消除紫杉醇引起的大鼠肝毒性

Cancer Translational Medicine Pub Date : 2019-10-01 DOI: 10.4103/ctm.ctm_31_19

Elias Adikwu, N. Ebinyo, L. Harris

{"title":"Coenzyme Q10 and resveratrol abrogate paclitaxel-induced hepatotoxicity in rats","authors":"Elias Adikwu, N. Ebinyo, L. Harris","doi":"10.4103/ctm.ctm_31_19","DOIUrl":"https://doi.org/10.4103/ctm.ctm_31_19","url":null,"abstract":"Background: Hepatotoxicity is one of the adverse effects that may characterize the clinical use of paclitaxel (PCL). This study examined the protective effects of coenzyme Q10 (CoQ10) and resveratrol (RSV) on PCL-induced hepatotoxicity in albino rats. Methods: Forty-five adult male albino rats randomized into nine groups of n = 5 were used. Group 1 (placebo control) and Group 2 (solvent control) received 0.2 mL of normal saline and corn oil intraperitoneally (ip) daily for 5 days, respectively. Groups 3–5 received CoQ10 (20 mg/kg), RSV (20 mg/kg), and CoQ10 + RSV ip daily for 5 days, respectively. Group 6 received a dose of 20 mg/kg of PCL ip on the 5th day. Groups 7–9 were pretreated daily with CoQ10 (20 mg/kg), RSV (20 mg/kg), and CoQ10 + RSV ip for 5 days and treated with a dose of PCL on the 5th day, respectively. Rats were sacrificed after treatment; liver samples were estimated for histology and biochemical markers. Serum samples were estimated for liver function markers. Results: The liver of PCL-treated rats showed necrosis which correlates with significant (P < 0.001) increases in serum and liver biochemical indexes; gamma glutamyl transferase, lactate dehydrogenase, bilirubin, aminotransferases, alkaline phosphatase, and malondialdehyde levels when compared to control. Liver superoxide dismutase, catalase, glutathione peroxidase, and glutathione levels were significantly (P < 0.001) decreased in PCL-treated rats when compared to control. Importantly, PCL-induced hepatotoxicity was significantly mitigated in CoQ10 (P < 0.05), RSV (P < 0.01), and CoQ10 + RSV (P < 0.001) pretreated rats when compared to PCL. Conclusion: CoQ10 and RSV were effective against PCL-induced hepatotoxicity in albino rats.","PeriodicalId":9428,"journal":{"name":"Cancer Translational Medicine","volume":"34 1","pages":"65 - 71"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83182592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Advances on the components of fibrinolytic system in malignant tumors 恶性肿瘤纤维蛋白溶解系统成分的研究进展

Cancer Translational Medicine Pub Date : 2019-07-01 DOI: 10.4103/ctm.ctm_14_19

Zengzheng Ge, Xiaoyan Xu, Z. Ge, S. Zhou, Xiulin Li, Kai Yao, Lan-qin Deng

引用次数: 0

Protective activity of selenium against 5-fluorouracil-induced nephrotoxicity in rats 硒对5-氟尿嘧啶所致大鼠肾毒性的保护作用

Cancer Translational Medicine Pub Date : 2019-07-01 DOI: 10.4103/ctm.ctm_26_19

Elias Adikwu, N. Ebinyo, Beauty Amgbare

{"title":"Protective activity of selenium against 5-fluorouracil-induced nephrotoxicity in rats","authors":"Elias Adikwu, N. Ebinyo, Beauty Amgbare","doi":"10.4103/ctm.ctm_26_19","DOIUrl":"https://doi.org/10.4103/ctm.ctm_26_19","url":null,"abstract":"Background: The nephrotoxic effect of 5-fluorouracil (5-FU) involves alterations in renal function markers and kidney morphology. This study assessed the protective effect of selenium (Se) on 5-FU-induced alterations in renal function markers and kidney morphology in albino rats. Materials and Methods: Forty adult albino rats of (n = 5) used were randomly grouped. Groups B-D received 0.125 mg/kg, 0.25 mg/kg and 0.50 mg/kg of Se intraperitoneally (ip) daily for 5 days, respectively. Group E received 20 mg/kg of 5-FU ip daily for 5 days. Groups F-H received 0.125 mg/kg, 0.25 mg/kg, and 0.5 mg/kg of Se before receiving 20 mg/kg of 5-FU ip daily for 5 days, respectively. Group A (Control) received 0.2 mL of normal saline ip daily for 5 days. Rats were sacrificed on the 6th day, and blood samples were collected and evaluated for markers of serum renal function. Kidneys were assessed for oxidative stress indices and histology. Results: The nephrotoxic effect of 5-FU was characterized by statistically significant (P < 0.001) elevations in creatinine, urea, uric acid, and malondialdehyde levels in comparison to control. Furthermore, significant (P < 0.001) decreases in potassium, sodium, chloride, bicarbonate, glutathione (GSH), catalase, superoxide dismutase, and GSH peroxidase levels were obtained in 5-FU-treated rats in comparison to control. Necroses of kidney tubular epithelial cells and atrophic glomeruli were observed in rats administered with 5-FU. However, 5-FU-induced nephrotoxic changes were significantly downregulated in a dose-dependent fashion in rats supplemented with 0.125 mg/kg (P < 0.05), 0.25 mg/kg (P < 0.01), and 0.50 mg/kg (P < 0.001) of Se when compared to 5-FU treated rats. Conclusion: Supplementation with Se may have clinical benefit in nephrotoxicity caused by 5-FU.","PeriodicalId":9428,"journal":{"name":"Cancer Translational Medicine","volume":"74 1","pages":"50 - 55"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83743228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A patient with persistent foot swelling after ankle sprain: B-Cell lymphoblastic lymphoma mimicking soft-tissue sarcoma 一例踝关节扭伤后持续足部肿胀患者:模拟软组织肉瘤的b细胞淋巴母细胞淋巴瘤

Cancer Translational Medicine Pub Date : 2019-07-01 DOI: 10.4103/ctm.ctm_22_19

Crystal Montgomery-Goecker, Andrew A. Martin, C. Timmons, D. Rakheja, V. Rajaram, H. Luu

引用次数: 0

OSMCC: An online survival analysis tool for Merkel cell carcinoma OSMCC:默克尔细胞癌的在线生存分析工具

Cancer Translational Medicine Pub Date : 2019-07-01 DOI: 10.4103/ctm.ctm_19_19

U. Saddozai, Qiang Wang, Xiaoxiao Sun, Yifang Dang, Jiajia Lv, Junfang Xin, Wan Zhu, Yongqiang Li, Xinying Ji, Xiangqian Guo

{"title":"OSMCC: An online survival analysis tool for Merkel cell carcinoma","authors":"U. Saddozai, Qiang Wang, Xiaoxiao Sun, Yifang Dang, Jiajia Lv, Junfang Xin, Wan Zhu, Yongqiang Li, Xinying Ji, Xiangqian Guo","doi":"10.4103/ctm.ctm_19_19","DOIUrl":"https://doi.org/10.4103/ctm.ctm_19_19","url":null,"abstract":"Aims: To develop a free accessible online tool to identify the prognostic markers for Merkel cell carcinoma (MCC) and to estimate the significance of interested gene in a cohort of clinical patients. Settings and Design: R package is used to calculate and plot the Kaplan–Meier survival curve. Subjects and Methods: An online search engine was developed by combining MCC datasets with available anatomoclinical data in Gene Expression Omnibus. In current study, genomic expression profile of thirty patients comprising 42985 probes and 21651 genes was evaluated. Patients were divided into first quartile, second quartile, and third quartile. Information about different cancer patients of varying stages (Stage I–IV) was stored using median survival scale of 14.5 months. Data were stored in SQL Server database and hosted on Windows Server 2008 using Apache Tomcat application server. Statistical Analysis Used: Log-rank test was applied and P < 0.05 was considered statistically significant. Results: An Online Survival analysis tool for MCC abbreviating as OSMCC was developed, which can assess the expression level relevance of various genes on the clinical outcome in MCC patients. By OSMCC, the survival curve could be displayed, and the hazard ratio with 95% confidence intervals and log-rank P value can also be calculated. Conclusions: The study demonstrated the ability of OSMCC to identify and analyze transcriptome and clinical datasets for MCC through prognosis significance analysis. So far, OSMCC is the first advanced and specific tool for the prognostic measurement of MCC. Furthermore, OSMCC can prove to be a highly valuable database for the preliminary assessment and identification of potential MCC prognostic biomarkers. OSMCC is accessible at http://bioinfo.henu.edu.cn/MCC/MCCList.jsp.","PeriodicalId":9428,"journal":{"name":"Cancer Translational Medicine","volume":"26 1","pages":"47 - 49"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82852721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progress in diagnosis and treatment of mixed adenoneuroendocrine carcinoma of biliary-pancreatic system 胆胰混合性腺神经内分泌癌的诊断与治疗进展

Cancer Translational Medicine Pub Date : 2019-04-01 DOI: 10.4103/ctm.ctm_5_19

Zengzheng Ge, H. Ling, Ming-Feng Li, Xiaoyan Xu, Y. Kai, Tongzhen Xu, Zengyu Ge, L. Zhou

引用次数: 0

Phosphorylation of BRCA1-associated protein 1 as an important mechanism in the evasion of tumorigenesis: A perspective brca1相关蛋白1的磷酸化在逃避肿瘤发生中的重要机制:一个观点

Cancer Translational Medicine Pub Date : 2019-04-01 DOI: 10.4103/ctm.ctm_1_19

G. Sharma, Anjali Geethadevi, Jyotsna Mishra, G. Anupa, K. Jadhav, K. Vikramdeo, D. Parashar

{"title":"Phosphorylation of BRCA1-associated protein 1 as an important mechanism in the evasion of tumorigenesis: A perspective","authors":"G. Sharma, Anjali Geethadevi, Jyotsna Mishra, G. Anupa, K. Jadhav, K. Vikramdeo, D. Parashar","doi":"10.4103/ctm.ctm_1_19","DOIUrl":"https://doi.org/10.4103/ctm.ctm_1_19","url":null,"abstract":"The human BRCA1-associated protein 1 (BAP1), a deubiquitinase, is a tumor suppressor protein known to be associated with a multicellular complex containing tumor suppressors, thereby coregulating various cellular processes such as DNA repair, gene transcription, cell cycle progression, and phosphorylation. Mutation and inactivation of BAP1 have long been reported in many malignancies and has been deployed in the prognosis of few malignancies. However, the mechanism of BAP1 regulation and its therapeutic significance have not been thoroughly explored. In addition to deubiquitination, BAP1 also responds to DNA damage and can induce cell death via apoptosis, necrosis, and ferroptosis. The mechanistic insight of BAP1-regulation is a complex subject and its thorough understanding would address the enigma of BAP1 mutation in malignancy. There are various tiers of regulation, though still needs to be explored, of BAP1 activity such as epigenetic regulation and posttranslational modification (PTM). Of various PTMs, posttranslational phosphorylation (PTP) has been poorly understood and meekly addressed in the literature. Here, we aim to provide an updated and integrated understanding of the PTP-mediated BAP1 regulation and its plausible role in cancer prevention. Exploring the functional consequence of BAP1 phosphorylation in its deubiquitinating potential might establish a new paradigm for its regulation in maintaining cellular homeostasis and cancer prevention.","PeriodicalId":9428,"journal":{"name":"Cancer Translational Medicine","volume":"535 1","pages":"25 - 32"},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86372317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Alzheimer’s Disease Susceptibility Genes in Malignant Breast Tumors 恶性乳腺肿瘤中的阿尔茨海默病易感基因

Cancer Translational Medicine Pub Date : 2019-04-01 DOI: 10.4103/2395-3977.261826

S. Lehrer, P. Rheinstein

{"title":"Alzheimer’s Disease Susceptibility Genes in Malignant Breast Tumors","authors":"S. Lehrer, P. Rheinstein","doi":"10.4103/2395-3977.261826","DOIUrl":"https://doi.org/10.4103/2395-3977.261826","url":null,"abstract":"Background: Cognitive problems have been reported in breast cancer patients after chemotherapy. A small group of older breast cancer survivors carrying the APOE4 gene, receiving chemotherapy, was at increased risk of long-term impairment of brain function. We have analyzed the expression of APOE and the next 23-ranked Alzheimer's disease (AD) susceptibility genes in malignant breast tumors. We wished to determine if these 24 genes might be related to breast cancer. Methods: To identify the most important AD susceptibility genes, we consulted the ALZGENE database (http:// www.alzgene.org/) which displays this information and regularly updates it. To analyze the effect of AD susceptibility genes on breast cancer, we used The Cancer Genome Atlas (TCGA). We analyzed TCGA data with cBioPortal for Cancer Genomics. cBioPortal provides visualization, analysis, and download of large-scale cancer genomic data sets. cBioPortal can analyze APOE in breast tumors but cannot distinguish its three alleles: E2, E3, and E4. Results: About 1.6% of the tumors had APOE amplification (copy number alteration). Two percent of the tumors had CD33 alterations. None of the tumors had APOE mutations. Two tumors had CD33 missense mutations of unknown significance. Expression heatmap shows that over- or underexpression of APOE and CD33 was correlated in most of the tumors. APOE alteration significantly co-occurred with CD33 and CD2AP. Conclusion: Alterations of certain cancer genes tend to co-occur, indicating that they may work in tandem to drive tumor formation and development. This may be the case with the co-occurring alterations of APOE, CD33, and CD2AP. It would be important to know which APOE allele(s) were co-occurrent with CD33 and CD2AP and whether co-occurrence in the tumor predicted increased risk of AD. This information could help in identification of specific risk factors for breast cancer-related cognitive decline in older women, which has important implications for oncology care.","PeriodicalId":9428,"journal":{"name":"Cancer Translational Medicine","volume":"175 1","pages":"42 - 46"},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88466188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Surface-Enhanced Raman Spectroscopy to study the biological activity of anticancer agent 表面增强拉曼光谱研究抗癌剂的生物活性

Cancer Translational Medicine Pub Date : 2019-04-01 DOI: 10.4103/ctm.ctm_18_19

Guoyu Qiu, Xiaohui Xu, L. Ji, Ruiping Ma, Zi-long Dang, Huan Yang

引用次数: 1

The prognostic role of lactate in patients who achieved return of spontaneous circulation after cardiac arrest: A systematic review and meta-analysis 乳酸在心脏骤停后恢复自然循环患者中的预后作用:一项系统回顾和荟萃分析

Cancer Translational Medicine Pub Date : 2019-01-01 DOI: 10.4103/ctm.ctm_6_19

Dongni Ren, Xin Wang, Y. Tu

{"title":"The prognostic role of lactate in patients who achieved return of spontaneous circulation after cardiac arrest: A systematic review and meta-analysis","authors":"Dongni Ren, Xin Wang, Y. Tu","doi":"10.4103/ctm.ctm_6_19","DOIUrl":"https://doi.org/10.4103/ctm.ctm_6_19","url":null,"abstract":"Aim: The aim of the study is to conduct a systematic review and meta-analysis of data showing the association of lactate levels with mortality and neurologic outcome in patients who achieved return of spontaneous circulation (ROSC) after cardiac arrest. Methods: An electronic search of PubMed, Embase, Web of Science, and Cochrane Library databases was conducted. Lactate levels at 0, 6, 12, 24, and 48 h after ROSC in survivors versus nonsurvivors and in good versus poor neurologic outcome patients were extracted. Continuous variable and odds ratio were applied for data analysis. Inverse-variance fixed effects model with 95% confidence interval (CI) was used depending on interstudy heterogeneity. Results: A total of 18 articles meeting the study criteria were included for systematic review and 15 for meta-analysis. The results showed that initial serum lactate levels in nonsurvivors were significantly higher than survivors (standardized mean difference [SMD] = −0.43; 95% CI = [−0.52, −0.33]; P < 0.00001), and a higher lactate level at admission was associated with increased hospital mortality. In addition, initial serum lactate levels were significantly higher in poor neurologic outcome patients than good neurologic outcome patients (SMD = −0.44; 95% CI = [−0.54, −0.34]; P < 0.00001), and initial higher lactate level was associated with poor neurologic outcome. There was a statistically significant difference in lactate levels at 6, 12, 24, and 48 h after ROSC, among survivors versus nonsurvivors and among patients presenting good neurologic outcome versus poor neurologic outcome. However, the included studies had small sample size and highly inconsistent data. Conclusions: Higher lactate levels were associated with increased mortality and poor neurologic outcome. Lower lactate levels or faster lactate clearance was associated with higher survival and good neurologic outcome.","PeriodicalId":9428,"journal":{"name":"Cancer Translational Medicine","volume":"92 1","pages":"1 - 9"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91051656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3