Singapore medical journal最新文献_第5页

Application of plasma phosphorylated tau 217 in a memory clinic focusing on Chinese patients. 血浆磷酸化tau 217在以中国患者为中心的记忆临床中的应用。

IF 1.9

Singapore medical journal Pub Date : 2026-07-10 DOI: 10.4103/singaporemedj.SMJ-2025-225

Yat Fung Shea, Yi Ling Wong, Pak Lam Chan, Ka Keung Yam, Felix Chi Kin Wong, Tsz King Wong, King Pui Florence Chan, Yi Wah Eva Cheung, Henry Ka Fung Mak, Sau Man Mary Ip, Wai Chi Chan, Koon Ho Chan, Patrick Ka Chun Chiu, Ching Wan Lam

{"title":"Application of plasma phosphorylated tau 217 in a memory clinic focusing on Chinese patients.","authors":"Yat Fung Shea, Yi Ling Wong, Pak Lam Chan, Ka Keung Yam, Felix Chi Kin Wong, Tsz King Wong, King Pui Florence Chan, Yi Wah Eva Cheung, Henry Ka Fung Mak, Sau Man Mary Ip, Wai Chi Chan, Koon Ho Chan, Patrick Ka Chun Chiu, Ching Wan Lam","doi":"10.4103/singaporemedj.SMJ-2025-225","DOIUrl":"10.4103/singaporemedj.SMJ-2025-225","url":null,"abstract":"Introduction: Plasma phosphorylated tau (P-tau) 217 has not been extensively studied in the Chinese population in a real-world memory clinic for detecting Alzheimer's disease (AD). This study aimed to determine a local cut-off for plasma P-tau 217 in a Chinese population and apply it to a similar cohort of patients in our memory clinic, evaluating its impact on diagnostic outcomes in a real-world setting.Methods: Ninety-eight patients were offered measurement of plasma P-tau 217 using S-PLEX ® . The validation cohort, consisting of 48 patients who underwent amyloid positron emission tomography (PET), was used to determine the cut-offs for plasma P-tau 217 and posttest probabilities through receiver operating curve analysis. Unsupervised clustering analysis was also used to derive the cut-off. These cut-offs were applied to an application cohort ( n = 50) without amyloid PET to study the clinical impact.Results: The sensitivity and specificity of the test, using a single cut-off of plasma P-tau 217 >10.08 pg/mL, were 86.67% and 88.89%, respectively. Unsupervised clustering analysis generated a cut-off of >11.69 pg/mL. After applying the two determined cut-offs in the application cohort, 50% of patients clinically diagnosed with AD were reclassified as non-AD, while 16.7% of patients initially diagnosed as non-AD were reclassified as AD. Using a post-test probability cut-off of >39.41%, the classification of AD and non-AD patients had a sensitivity of 93.33% and a specificity of 88.89%.Conclusion: Plasma P-tau 217 is useful in diagnosing AD among Chinese patients in a memory clinic with diverse underlying aetiologies of cognitive impairment.","PeriodicalId":94289,"journal":{"name":"Singapore medical journal","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148427829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knowledge landscape and hotspots of scientific publications on myocarditis: a bibliometric analysis from 2000 to 2024. 心肌炎科学出版物的知识格局与热点：2000 - 2024年文献计量学分析

IF 1.9

Singapore medical journal Pub Date : 2026-07-10 DOI: 10.4103/singaporemedj.SMJ-2025-163

Xifeng Zheng, Yan He, Weiqin Lin, Ching-Hui Sia

{"title":"Knowledge landscape and hotspots of scientific publications on myocarditis: a bibliometric analysis from 2000 to 2024.","authors":"Xifeng Zheng, Yan He, Weiqin Lin, Ching-Hui Sia","doi":"10.4103/singaporemedj.SMJ-2025-163","DOIUrl":"10.4103/singaporemedj.SMJ-2025-163","url":null,"abstract":"Abstract: We performed a bibliometric analysis of myocarditis publications from 2000 to 2024, with the aim of synthesising current research and identifying emerging trends in the field. We retrieved scientific publications on myocarditis from the Web of Science (WOS) database spanning from January 2000 to December 2024. Only English-language original articles and reviews were included. Relevant information such as journal and publisher details, titles, authors, organisations, abstracts, keywords, publication dates and citation counts was extracted. We then conducted bibliometric analysis and visualised the results using R software and Microsoft Excel. The WOS database search yielded 15,387 records on myocarditis, comprising 12,566 articles and 2821 reviews. These publications were from 133 countries and regions, 12,490 research institutions and 64,899 scholars. The annual number of scientific publications on myocarditis increased at a rate of 6.75%. We further analysed the top ten contributing countries, research organisations, influential researchers, most cited articles and frequent keywords associated with myocarditis. Keyword trend analysis identified the most active research areas, including coronavirus disease 2019 and myocarditis, immune-related mechanisms and immunotherapy, myocarditis associated with immune checkpoint inhibitors, advanced diagnostic methods (e.g. endomyocardial biopsy and cardiac magnetic resonance imaging) and various fatal clinical complications. The results of the bibliometric analysis of publication trends in myocarditis from 2000 to 2024 provide deeper insights into the existing literature on myocarditis.","PeriodicalId":94289,"journal":{"name":"Singapore medical journal","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148427900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mpox post-exposure prophylaxis in Singapore: local experience. 新加坡的麻疹暴露后预防：当地经验。

IF 1.9

Singapore medical journal Pub Date : 2026-07-10 DOI: 10.4103/singaporemedj.SMJ-2025-209

Wilnard Yeong Tze Tan, Yijun Lin, Pream Raj, Zubaidah Said, Jasmine Shi Min Teo, Frank Kwang Kiat Ng, Imrana Banu, Vernon J Lee, Poh Lian Lim, Shawn Vasoo

引用次数: 0

Comparative efficacy of common thrombolytics in acute ischaemic stroke: a network meta-analysis. 常见溶栓药物治疗急性缺血性卒中的比较疗效：网络荟萃分析。

IF 1.9

Singapore medical journal Pub Date : 2026-07-10 DOI: 10.4103/singaporemedj.SMJ-2025-179

Kew Cheng Joon, Adam Bing Heng Cheng, Rui Kyi Ng, Rowena Kwan, Yong Yi Tan, Benjamin Yong Qiang Tan, Yimin Chen, Ching-Hui Sia, Leong Litt Leonard Yeo, Joshua Yeo

{"title":"Comparative efficacy of common thrombolytics in acute ischaemic stroke: a network meta-analysis.","authors":"Kew Cheng Joon, Adam Bing Heng Cheng, Rui Kyi Ng, Rowena Kwan, Yong Yi Tan, Benjamin Yong Qiang Tan, Yimin Chen, Ching-Hui Sia, Leong Litt Leonard Yeo, Joshua Yeo","doi":"10.4103/singaporemedj.SMJ-2025-179","DOIUrl":"10.4103/singaporemedj.SMJ-2025-179","url":null,"abstract":"Introduction: Thrombolytics are widely used for the treatment of ischaemic stroke. Alteplase is the most commonly used thrombolytic. Newer thrombolytics, particularly tenecteplase and reteplase, are currently available. As such, we performed a network meta-analysis to compare the efficacy of thrombolytic agents.Methods: A systematic search of PubMed MEDLINE, Embase, Scopus and the Cochrane Library was conducted from database inception to 31 August 2024 to identify studies evaluating the efficacy of different thrombolytic agents. Studies analysing thrombolytic effects in terms of mortality or modified Rankin Scale (mRS) in patients with acute ischaemic stroke were included. Comparative efficacy on the two main outcomes was then analysed using a random effects network meta-analysis.Results: Twenty-three studies were included with a pooled patient cohort of 25,379 patients. In patients with AIS, the network meta-analysis demonstrated no difference in terms of mortality outcomes across the thrombolytics. In terms of functional outcomes, reteplase was associated with a better functional outcome compared to alteplase (odds ratio [OR] 1.37, 95% confidence interval [CI] 1.06, 1.77) and urokinase (OR 1.54, 95% CI 1.14, 2.08). These results were analysed regardless of the duration of follow-up. Further sensitivity analysis based on 90-day follow-up showed no significant differences in terms of mortality outcomes, while reteplase showed similar functional outcomes compared to alteplase and tenecteplase.Conclusion: Reteplase appeared to be associated with better functional outcomes and had similar mortality rates compared to alteplase. Further head-to-head randomised controlled trials between the thrombolytic agents are needed to confirm these findings.","PeriodicalId":94289,"journal":{"name":"Singapore medical journal","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148427952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Singapore Advanced Cardiac Life Support Guidelines 2026. 新加坡高级心脏生命支持指南2026。

IF 1.9

Singapore medical journal Pub Date : 2026-07-01 Epub Date: 2026-07-27 DOI: 10.4103/singaporemedj.SMJ-2026-280

Jonathan Wei Sheng Ong, Benjamin Sieu-Hon Leong, Yew Woon Chia, Daniel Thuan Tee Chong, Wee Kim Fong, David Chee Guan Foo, Andrew Fu Wah Ho, Janice Hui Hong Oh, Eillyne Seow, Duu Wen Sewa, Swee Han Lim, Chi Keong Ching

{"title":"Singapore Advanced Cardiac Life Support Guidelines 2026.","authors":"Jonathan Wei Sheng Ong, Benjamin Sieu-Hon Leong, Yew Woon Chia, Daniel Thuan Tee Chong, Wee Kim Fong, David Chee Guan Foo, Andrew Fu Wah Ho, Janice Hui Hong Oh, Eillyne Seow, Duu Wen Sewa, Swee Han Lim, Chi Keong Ching","doi":"10.4103/singaporemedj.SMJ-2026-280","DOIUrl":"10.4103/singaporemedj.SMJ-2026-280","url":null,"abstract":"Abstract: Advanced cardiovascular life support (ACLS) provides a structured approach to the management of cardiac arrest and life-threatening arrhythmias, building on early recognition, high-quality cardiopulmonary resuscitation (CPR), and timely defibrillation. The 2026 Singapore ACLS guidelines present updated, evidence-based recommendations informed by the latest guidance from the American Heart Association and the European Resuscitation Council. Key updates include optimisation of CPR quality, integration of point-of-care ultrasonography, and refined use of pharmacological and electrical therapies during resuscitation. The role of extracorporeal CPR as a rescue strategy in selected patients and the importance of organised post-resuscitation care in improving neurological outcomes are emphasised. Management of tachyarrhythmias and bradyarrhythmias is also addressed. Special circumstances, including pulmonary embolism, drowning and cardiac arrest during pregnancy, are discussed. These guidelines aim to standardise practice and improve survival and functional outcomes following cardiac arrest in Singapore.","PeriodicalId":94289,"journal":{"name":"Singapore medical journal","volume":"67 7","pages":"414-426"},"PeriodicalIF":1.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13515999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148595473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

2026 Updates to Singapore Resuscitation and First Aid Guidelines. 2026年新加坡复苏和急救指南的更新。

IF 1.9

Singapore medical journal Pub Date : 2026-07-01 Epub Date: 2026-07-27 DOI: 10.4103/singaporemedj.SMJ-2026-379

Swee Han Lim, Kee Chong Ng, Jonathan Wei Sheng Ong, Gene Yong-Kwang Ong, Bin Huey Quek, Andrew Fu Wah Ho, Yew Woon Chia, Benjamin Sieu-Hon Leong

引用次数: 0

Singapore Neonatal Resuscitation Guidelines 2026. 新加坡新生儿复苏指南2026。

IF 1.9

Singapore medical journal Pub Date : 2026-07-01 Epub Date: 2026-07-27 DOI: 10.4103/singaporemedj.SMJ-2026-278

Juin Yee Kong, Khadijah Binti Abdul Kader, Vijayendra Ranjan Baral, Sridhar Arunachalam, Santosi Buvaneswarran, Amutha Chinnadurai, Wing Yee Tong, Wai Yan Yip, Kenny Teong Tai Ee, Cheo Lian Yeo, Agnihotri Biswas, Selina Kah Ying Ho, Bin Huey Quek

{"title":"Singapore Neonatal Resuscitation Guidelines 2026.","authors":"Juin Yee Kong, Khadijah Binti Abdul Kader, Vijayendra Ranjan Baral, Sridhar Arunachalam, Santosi Buvaneswarran, Amutha Chinnadurai, Wing Yee Tong, Wai Yan Yip, Kenny Teong Tai Ee, Cheo Lian Yeo, Agnihotri Biswas, Selina Kah Ying Ho, Bin Huey Quek","doi":"10.4103/singaporemedj.SMJ-2026-278","DOIUrl":"10.4103/singaporemedj.SMJ-2026-278","url":null,"abstract":"Abstract: Effective neonatal resuscitation demands coordinated teamwork following standardised algorithms and guidelines to ensure successful transition to extrauterine life. As guidelines evolve with emerging evidence, regular review and adherence to updated recommendations are crucial for optimal patient outcomes. We present the revised Singapore Neonatal Resuscitation Guidelines 2026. The recent 2025 recommendations from the International Liaison Committee on Resuscitation Neonatal Task Force's Consensus on Science and Treatment Recommendations, together with guidelines from the American Heart Association and the European Resuscitation Council, were compared with the existing guidelines. The recommendations of the Neonatal Subgroup of the Singapore Resuscitation and First Aid Council were formulated following the workgroup's critical discussion and appraisal of the currently available evidence, with careful consideration of its relevance and applicability to local clinical practice.","PeriodicalId":94289,"journal":{"name":"Singapore medical journal","volume":"67 7","pages":"453-465"},"PeriodicalIF":1.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13516002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148595444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Singapore Basic Cardiac Life Support and Automated External Defibrillation Guidelines 2026. 新加坡基本心脏生命支持和自动体外除颤指南2026。

IF 1.9

Singapore medical journal Pub Date : 2026-07-01 Epub Date: 2026-07-27 DOI: 10.4103/singaporemedj.SMJ-2026-319

Swee Han Lim, Benjamin Sieu-Hon Leong, Jun Hao Loke, Kee Chong Ng

{"title":"Singapore Basic Cardiac Life Support and Automated External Defibrillation Guidelines 2026.","authors":"Swee Han Lim, Benjamin Sieu-Hon Leong, Jun Hao Loke, Kee Chong Ng","doi":"10.4103/singaporemedj.SMJ-2026-319","DOIUrl":"10.4103/singaporemedj.SMJ-2026-319","url":null,"abstract":"Abstract: Basic cardiac life support and automated external defibrillation refer to the skills required for resuscitation of a cardiac arrest casualty. On recognising cardiac arrest, the rescuer should call '995' for an ambulance and start cardiopulmonary resuscitation. High-quality chest compressions are performed with the arms extended, elbows locked, shoulders directly perpendicular over the casualty's chest and the heel of the palm placed on the lower half of the sternum. The rescuer compresses to a depth of 4-6 cm for adults, at a rate of 100-120 compressions per minute, allowing complete chest recoil after each compression. Two quick ventilations of 400-600 mL each are delivered via a bag-valve-mask (or mouth-to-mouth or mouth-to-mask if trained and able) after 30 chest compressions (or 15 chest compressions for casualties under 12 years of age). Cardiopulmonary resuscitation should be stopped when the casualty regains consciousness, the emergency team takes over care, or when an automated external defibrillator analyses the heart rhythm or delivers a shock.","PeriodicalId":94289,"journal":{"name":"Singapore medical journal","volume":"67 7","pages":"406-413"},"PeriodicalIF":1.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13515997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148595491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Foreword. 前言。

IF 1.9

Singapore medical journal Pub Date : 2026-07-01 Epub Date: 2026-07-27 DOI: 10.4103/singaporemedj.SMJ-2026-431

引用次数: 0

Singapore Post-cardiac Arrest Care Guidelines 2026. 新加坡心脏骤停后护理指南2026。

IF 1.9

Singapore medical journal Pub Date : 2026-07-01 Epub Date: 2026-07-27 DOI: 10.4103/singaporemedj.SMJ-2026-279

Yew Woon Chia, Sohil Pothiawala, Julian Kenrick Loh, Carrie Kah-Lai Leong, Shir Lynn Lim, Ruth Weixian Chen, Ying Hao Christopher Seet, Zhi-Yan Valerie Ng, Benjamin Sieu-Hon Leong

{"title":"Singapore Post-cardiac Arrest Care Guidelines 2026.","authors":"Yew Woon Chia, Sohil Pothiawala, Julian Kenrick Loh, Carrie Kah-Lai Leong, Shir Lynn Lim, Ruth Weixian Chen, Ying Hao Christopher Seet, Zhi-Yan Valerie Ng, Benjamin Sieu-Hon Leong","doi":"10.4103/singaporemedj.SMJ-2026-279","DOIUrl":"10.4103/singaporemedj.SMJ-2026-279","url":null,"abstract":"Abstract: A robust chain of survival is important for achieving positive outcomes following out-of-hospital cardiac arrest, which continues to pose a substantial public health challenge in Singapore. Although improvements have been made in prehospital resuscitation and survival to hospital admission, further progress is required for survival to hospital discharge and neurological recovery. This underscores the urgent need to strengthen post-cardiac arrest care-the sixth link in the chain of survival-to optimise outcomes for patients admitted to the intensive care unit after return of spontaneous circulation. This review builds on earlier recommendations of the National Targeted Temperature Management Workgroup (2017) and the National Post-Cardiac Arrest and Survivorship Workgroup (2021), providing an updated summary of post-cardiac arrest management and practical guidance for clinicians treating resuscitated cardiac arrest patients in the intensive care unit.","PeriodicalId":94289,"journal":{"name":"Singapore medical journal","volume":"67 7","pages":"427-441"},"PeriodicalIF":1.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13516017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148595466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0