Singapore medical journal最新文献_第3页

Current status of functional testing for upper gastrointestinal disorders: state-of-the-art review. 上消化道疾病功能检测的现状：最新进展综述。

IF 1.9

Singapore medical journal Pub Date : 2025-08-01 Epub Date: 2025-08-20 DOI: 10.4103/singaporemedj.SMJ-2025-106

Andrew Xia Huang Tan, Alex Yu Sen Soh, Jonathan Ziyang Kuang, Kewin Tien Ho Siah, Andrew Ming Liang Ong, Daphne Ang

{"title":"Current status of functional testing for upper gastrointestinal disorders: state-of-the-art review.","authors":"Andrew Xia Huang Tan, Alex Yu Sen Soh, Jonathan Ziyang Kuang, Kewin Tien Ho Siah, Andrew Ming Liang Ong, Daphne Ang","doi":"10.4103/singaporemedj.SMJ-2025-106","DOIUrl":"10.4103/singaporemedj.SMJ-2025-106","url":null,"abstract":"Abstract: Neurogastroenterology and motility disorders of the upper gastrointestinal (GI) tract represent a complex and heterogeneous group of conditions that involve the interaction between the GI tract and the central nervous system. They constitute a significant number of outpatient gastroenterology visits, resulting in a high healthcare burden. These disorders often occur in the absence of identifiable structural causes on routine endoscopy and radiological imaging. A more targeted approach in the assessment of functional GI disorders is increasingly being integrated into routine clinical practice, given the recent advancements in technology and physiologic testing. When used in the appropriate clinical context, these tests not only elucidate the physiological basis for the patient's symptoms, but also prevent inappropriate treatment and repeated investigations. This review aims to summarise the advances in clinically available diagnostic tools for the evaluation of upper GI functional disorders.","PeriodicalId":94289,"journal":{"name":"Singapore medical journal","volume":"66 8","pages":"431-438"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interventional endosonography comes of age: an update on endoscopic ultrasonography-guided drainage and anastomosis procedures. 介入超声技术的发展：超声内镜引导引流和吻合手术的最新进展。

IF 1.9

Singapore medical journal Pub Date : 2025-08-01 Epub Date: 2025-08-20 DOI: 10.4103/singaporemedj.SMJ-2025-169

Tiing Leong Ang, Christopher Jen Lock Khor

{"title":"Interventional endosonography comes of age: an update on endoscopic ultrasonography-guided drainage and anastomosis procedures.","authors":"Tiing Leong Ang, Christopher Jen Lock Khor","doi":"10.4103/singaporemedj.SMJ-2025-169","DOIUrl":"10.4103/singaporemedj.SMJ-2025-169","url":null,"abstract":"Abstract: Endoscopic ultrasonography (EUS) has progressed beyond diagnostic imaging to include EUS-guided tissue acquisition and EUS-directed therapies. This review provides an update on EUS-guided drainage and anastomotic procedures, and other therapeutic procedures. Today, EUS-guided drainage of symptomatic walled-off pancreatic fluid collections is the norm, with endoscopic necrosectomy as an adjunct. For high-risk surgical patients unsuitable for cholecystectomy, EUS-guided gallbladder drainage of acute cholecystitis is an option. Additionally, EUS-guided drainage of obstructed biliary and pancreatic ductal system can be performed as salvage procedures after unsuccessful endoscopic retrograde cholangiopancreatography (ERCP). Bariatric procedures such as Roux-en-Y gastric bypass alter the gastric anatomy, hindering access to the major papilla. This can be overcome by creating a conduit through the excluded stomach using EUS-directed transgastric ERCP. Gastric outlet obstruction and afferent loop syndrome can be treated using EUS-guided gastrojejunostomy. These therapeutic interventions are a major advancement in the field of interventional EUS, achieving significant clinical impact.","PeriodicalId":94289,"journal":{"name":"Singapore medical journal","volume":"66 8","pages":"420-425"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute gastroenteritis in adults. 成人急性肠胃炎。

IF 1.9

Singapore medical journal Pub Date : 2025-08-01 Epub Date: 2025-08-20 DOI: 10.4103/singaporemedj.SMJ-2022-161

Wei Ling Tay, Jaime Mei-Fong Chien, Vijo Poulose, Choon How How, Mark Chung Wai Ng

引用次数: 0

Recent advances in gastroenterology. 胃肠病学最新进展。

IF 1.9

Singapore medical journal Pub Date : 2025-08-01 Epub Date: 2025-08-20 DOI: 10.4103/singaporemedj.SMJ-2025-170

Tiing Leong Ang

引用次数: 0

Sarcopenia and sarcopenic obesity in cardiovascular disease: a comprehensive review. 心血管疾病中的肌肉减少症和肌肉减少性肥胖：一项综合综述。

IF 1.9

Singapore medical journal Pub Date : 2025-08-01 DOI: 10.4103/singaporemedj.SMJ-2024-233

Li Feng Tan, Ching Hui Sia, Reshma Aziz Merchant

引用次数: 0

Early predictors of rescue therapy and colectomy in acute severe ulcerative colitis. 急性严重溃疡性结肠炎抢救治疗和结肠切除术的早期预测因素。

IF 1.9

Singapore medical journal Pub Date : 2025-08-01 Epub Date: 2025-08-20 DOI: 10.4103/singaporemedj.SMJ-2024-242

Samuel Jun Ming Lim, Kaina Chen, Yi Yuan Tan, Shu Wen Tay, Thomson Chong Teik Lim, Ennaliza Salazar, Webber Pak-Wo Chan, Malcolm Teck Kiang Tan

{"title":"Early predictors of rescue therapy and colectomy in acute severe ulcerative colitis.","authors":"Samuel Jun Ming Lim, Kaina Chen, Yi Yuan Tan, Shu Wen Tay, Thomson Chong Teik Lim, Ennaliza Salazar, Webber Pak-Wo Chan, Malcolm Teck Kiang Tan","doi":"10.4103/singaporemedj.SMJ-2024-242","DOIUrl":"10.4103/singaporemedj.SMJ-2024-242","url":null,"abstract":"Introduction: Acute severe ulcerative colitis (ASUC) is a significant cause of disease morbidity. One-third of patients with ASUC are steroid refractory. Rescue therapy may not successfully induce remission, necessitating colectomy. We aimed to identify predictors of rescue therapy and colectomy in ASUC assessed within 24 h of admission for early risk stratification.Methods: We conducted a retrospective cohort study of 58 admissions for ASUC among 47 patients from August 2002 to January 2022. Serum biomarkers assessed were measured on admission. Primary outcomes were the need for rescue therapy during the same admission and colectomy within 1 year of admission.Results: Rescue therapy (all with infliximab) was given in 20 (34.5%) of the admissions. Colectomy was done within 1 year for nine (15.5%) of the admissions. An elevated C-reactive protein (CRP) of >30 mg/L (relative risk [RR] 1.63), a CRP-albumin ratio of >0.85 (RR 1.63), and a composite factor of both CRP > 30 mg/L and age ≥60 years (RR 2.37) were significantly associated with the need for rescue therapy. Hypoalbuminaemia ≤ 25 g/L (RR 4.35) and the use of biologics at presentation (RR 1.54) were significantly associated with colectomy within 1 year of admission, while a CRP of ≥ 80 mg/L was a significant protective factor (RR 0.70).Conclusion: Patients with ASUC who have elevated CRP or CRP-albumin ratio on admission should be considered at risk for steroid-refractory disease. Those with hypoalbuminaemia on admission and using biologics at presentation are more likely to require colectomy in the first year after admission for ASUC.","PeriodicalId":94289,"journal":{"name":"Singapore medical journal","volume":"66 8","pages":"449-456"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pictorial review of ascariasis in acute abdomen. 急腹症蛔虫病的影像回顾。

IF 1.9

Singapore medical journal Pub Date : 2025-08-01 Epub Date: 2025-08-20 DOI: 10.4103/singaporemedj.SMJ-2022-181

Kelvin Kay Nguan Koh, Maaz Mohammad Salah, Chi Long Ho

引用次数: 0

Recent advances in bariatric endoscopy for obesity management: expanding the therapeutic spectrum. 肥胖症内窥镜治疗的最新进展：扩大治疗范围。

IF 1.9

Singapore medical journal Pub Date : 2025-08-01 Epub Date: 2025-08-20 DOI: 10.4103/singaporemedj.SMJ-2025-121

Ravishankar Asokkumar

引用次数: 0

Lumbar endoscopic discectomy versus minimally invasive microdiscectomy: a retrospective cost-effectiveness study. 腰椎内窥镜椎间盘切除术与微创显微椎间盘切除术：回顾性成本-效果研究。

IF 1.9

Singapore medical journal Pub Date : 2025-08-01 DOI: 10.4103/singaporemedj.SMJ-2024-070

Jon Yin Joseph Wan, Yong Yao Tan, Li Yun Ryan Koh, Zhihong Chew, Hong Lee Terry Teo

{"title":"Lumbar endoscopic discectomy versus minimally invasive microdiscectomy: a retrospective cost-effectiveness study.","authors":"Jon Yin Joseph Wan, Yong Yao Tan, Li Yun Ryan Koh, Zhihong Chew, Hong Lee Terry Teo","doi":"10.4103/singaporemedj.SMJ-2024-070","DOIUrl":"https://doi.org/10.4103/singaporemedj.SMJ-2024-070","url":null,"abstract":"Introduction: Lumbar endoscopic discectomy (LED) is an increasingly common minimally invasive procedure used in treating lumbar disc herniation and decompressing spinal nerves. Various techniques have been described, each offering improved intraoperative visualisation and safety profile yet maintaining smaller incisions, resulting in better surgical outcomes and shorter hospital stay, as compared to minimally invasive microdiscectomy (MISD). This study aimed to investigate the cost-effectiveness of LED (uniportal and biportal approaches) against conventional MISD.Methods: This is a single-centre, multi-surgeon, retrospective case cohort study of 24 and 18 patients who underwent elective single-level uniportal LED and biportal LED, respectively. In addition, an age-matched group of 42 patients who underwent single-level MISD was included. Patient demographics (age, gender, body mass index, Charlson Comorbidity Index and Functional Independence Measure), 6-month postoperative complications and inpatient hospitalisation costs were compared.Results: Both uniportal and biportal endoscopic discectomy groups had significantly higher operation durations but maintained comparable hospital length of stay, and intra- and postoperative complication rates. The uniportal group had significantly higher overall inpatient hospitalisation bill compared to the biportal and MISD groups due to the rental fee for specialised endoscopic equipment.Conclusion: The biportal endoscopic approach - due to its equipment versality - has lower equipment costs than uniportal endoscopic discectomy. For the biportal approach to potentially become a cost-effective and safe alternative to conventional MISD, a learning curve remains for surgeons and institutions to overcome in order to achieve shorter hospital stays and operative durations.","PeriodicalId":94289,"journal":{"name":"Singapore medical journal","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144786332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Public knowledge, awareness and perception of gut microbiome and faecal microbiota transplantation in Singapore: a survey study. 新加坡公众对肠道菌群和粪便菌群移植的知识、意识和感知：一项调查研究。

IF 1.9

Singapore medical journal Pub Date : 2025-08-01 Epub Date: 2025-06-06 DOI: 10.4103/singaporemedj.SMJ-2024-076

Lydia Wan Zhen Lim, Kai Yee Toh, Alex Richard Cook, Jonathan Wei Jie Lee, Jeremy Fung Yen Lim

{"title":"Public knowledge, awareness and perception of gut microbiome and faecal microbiota transplantation in Singapore: a survey study.","authors":"Lydia Wan Zhen Lim, Kai Yee Toh, Alex Richard Cook, Jonathan Wei Jie Lee, Jeremy Fung Yen Lim","doi":"10.4103/singaporemedj.SMJ-2024-076","DOIUrl":"10.4103/singaporemedj.SMJ-2024-076","url":null,"abstract":"Introduction: Despite the exponential increase in microbiome research, knowledge and beliefs about the gut microbiome and faecal microbiota transplantation (FMT) remain unclear. The aim of this study was to identify the extent of knowledge, awareness and perception among the general public regarding the gut microbiome and FMT.Methods: An online questionnaire on knowledge and beliefs about the gut microbiome and FMT was administered to 1831 participants. Data analysis software was used to generate descriptive statistics and explore associations between knowledge and sociodemographic variables.Results: Even though only 33% of participants had heard of the gut microbiome, more than 92% had consumed probiotic drinks or supplements. While 85% had not heard of the FMT procedure, 72% of respondents would consider having FMT to treat Clostridioides difficile infection (CDI). Willingness to receive FMT depended mainly on recommendation from healthcare providers (77%). Knowledge and awareness regarding the gut microbiome and FMT were relatively low, despite most participants having prior gut health-related behaviours.Conclusion: This study identified the public's perceptions of FMT and the potential barriers to its uptake. Insights from the study highlight the need for health education to enhance acceptance of FMT and the importance of using information supported by medical professionals to immunise the public against poorly validated science.","PeriodicalId":94289,"journal":{"name":"Singapore medical journal","volume":" ","pages":"439-448"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0