World journal of methodology最新文献

{"title":"Utilization of online systems to promote youth participation in research: A methodological study.","authors":"Marie Salem,&nbsp;Lance Pollack,&nbsp;Alex Zepeda,&nbsp;Kathleen P Tebb","doi":"10.5662/wjm.v13.i4.210","DOIUrl":"https://doi.org/10.5662/wjm.v13.i4.210","url":null,"abstract":"<p><strong>Background: </strong>Online surveys can align with youth's increased use of the internet and can be a mechanism for expanding youth participation in research. This is particularly important during the coronavirus disease 2019 (COVID-19) pandemic, when in-person interactions are limited. However, the advantages and drawbacks of online systems used for research need to be carefully considered before utilizing such methodologies.</p><p><strong>Aim: </strong>To describe and discuss the strengths and limitations of an online system developed to recruit adolescent girls for a sexual health research study and conduct a three-month follow up survey.</p><p><strong>Methods: </strong>This methodology paper examines the use of an online system to recruit and follow participants three months after their medical visit to evaluate a mobile sexual and reproductive health application, <i>Health-E You/Salud iTu</i>^TM, for adolescent girls attending school-based health centers (SBHCs) across the United States. SBHC staff gave adolescent girls a web link to an online eligibility and consent survey. Participants were then asked to complete two online surveys (baseline and 3-month follow-up). Surveys, reminders, and incentives to complete them were distributed through short message service (SMS) text messages. Upon completing each survey, participants were also sent an email with a link to an electronic gift card as a thank-you for their participation. Barriers to implementing this system were discussed with clinicians and staff at each participating SBHC.</p><p><strong>Results: </strong>This online recruitment and retention system enabled participant recruitment at 26 different SBHCs in seven states across the United States. Between September 2021 and June 2022, 415 adolescent girls were screened using the Qualtrics online survey platform, and 182 were eligible to participate. Of those eligible, 78.0% (<i>n</i> = 142) completed the baseline survey. Participants were racially, geographically, and linguistically diverse. Most of the participants (89.4%) were non-White, and 40.8% spoke Spanish. A total of 62.0% (<i>n</i> = 88) completed the 3-month follow-up survey. Limitations of this system included reliance on internet access (<i>via</i> Wi-Fi or cell service), which was not universally available or reliable. In addition, an individual unrelated to the study obtained the survey link, filled out multiple surveys, and received multiple gift cards before the research team discovered and stopped this activity. As a result, additional security protocols were instituted.</p><p><strong>Conclusion: </strong>Online systems for health research can increase the reach and diversity of study participants, reduce costs for research personnel time and travel, allow for continued study operation when in-person visits are limited (such as during the COVID-19 pandemic), and connect youth with research using technology. However, there are challenges and limitation","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":"13 4","pages":"210-222"},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6d/5c/WJM-13-210.PMC10523248.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41159320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of carbon monoxide poisonings and carboxyhemoglobin levels with COVID-19 and clinical severity.","authors":"Abuzer Coskun,&nbsp;Burak Demirci,&nbsp;Kenan Ahmet Turkdogan","doi":"10.5662/wjm.v13.i4.248","DOIUrl":"https://doi.org/10.5662/wjm.v13.i4.248","url":null,"abstract":"<p><strong>Background: </strong>Coronavirus disease 2019 (COVID-19), which recently spread throughout the entire world, is still a significant health issue. Additionally, the most common cause of risky poisoning in emergency services is carbon monoxide (CO) poisoning. Both disorders seem to merit more research as they have an impact on all bodily systems <i>via</i> the lungs.</p><p><strong>Aim: </strong>To determine how arterial blood gas and carboxyhemoglobin (COHb) levels affect the clinical and prognostic results of individuals requiring emergency treatment who have both COVID-19 and CO poisoning.</p><p><strong>Methods: </strong>Between January 2018 and December 2021, 479 CO-poisoning patients participated in this single-center, retrospective study. Patients were primarily divided into two groups for analysis: Pre-pandemic and pandemic periods. Additionally, the pandemic era was divided into categories based on the presence of COVID-19 and, if present, the clinical severity of the infection. The hospital information system was used to extract patient demographic, clinical, arterial blood gas, COVID-19 polymerase chain reaction, and other laboratory data.</p><p><strong>Results: </strong>The mean age of the 479 patients was 54.93 ± 11.51 years, and 187 (39%) were female. 226 (47%) patients were in the pandemic group and 143 (30%) of them had a history of COVID-19. While the mean potential of hydrogen (pH) in arterial blood gas of all patients was 7.28 ± 0.15, it was 7.35 ± 0.10 in the pre-pandemic group and 7.05 ± 0.16 in the severe group during the pandemic period (<i>P</i> < 0.001). COHb was 23.98 ± 4.19% in the outpatients and 45.26% ± 3.19% in the mortality group (<i>P</i> < 0.001). Partial arterial oxygen pressure (PaO₂) was 89.63 ± 7.62 mmHg in the pre-pandemic group, and 79.50 ± 7.18 mmHg in the severe group during the pandemic period (<i>P</i> < 0.001). Despite the fact that mortality occurred in 35 (7%) of all cases, pandemic cases accounted for 30 of these deaths (85.7%) (<i>P</i> <0.001). The association between COHb, troponin, lactate, partial arterial pressure of carbon dioxide, HCO₃, calcium, glucose, age, pH, PaO₂, potassium, sodium, and base excess levels in the pre-pandemic and pandemic groups was statistically significant in univariate linear analysis.</p><p><strong>Conclusion: </strong>Air exchange barrier disruption caused by COVID-19 may have pulmonary consequences. In patients with a history of pandemic COVID-19, clinical results and survival are considerably unfavorable in cases of CO poisoning.</p>","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":"13 4","pages":"248-258"},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0f/d7/WJM-13-248.PMC10523238.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41160328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of the phase angle in the prognosis of the cirrhotic patient: 15 years of follow-up.","authors":"Letícia Pereira Pinto,&nbsp;Claudio Augusto Marroni,&nbsp;Juliana Czermainski,&nbsp;Maria Luiza Fernandes Dahlem,&nbsp;Randhall B Carteri,&nbsp;Sabrina Alves Fernandes","doi":"10.5662/wjm.v13.i4.238","DOIUrl":"https://doi.org/10.5662/wjm.v13.i4.238","url":null,"abstract":"<p><strong>Background: </strong>In 2019, cirrhosis accounted for 2.4% of global deaths. The projection for 2030 is an increase in this index. In recent years, hospitalization costs have escalated by 36% for compensated cirrhosis and 24% for decompensated cirrhosis. Therefore, it is necessary to identify a tool capable of predicting the mortality of these patients according to their clinical condition and consequently extending their survival time. Different studies have shown that the phase angle (PA) can be a feasible method in clinical practice, with the potential to guide assertive patient management in the therapeutic of chronic liver disease.</p><p><strong>Aim: </strong>To evaluate the prognostic role of PA in cirrhotic patients over a 15-year follow-up period.</p><p><strong>Methods: </strong>Retrospective cohort study with 129 cirrhotic patients of both sexes over 18 years old. Diagnosis of cirrhosis by liver biopsy. The first year of data collection was 2007, and data regarding outcomes was collected in 2023. Data were gathered from medical records, such as esophageal varices (EV), EV bleeding, ascites, spontaneous bacterial peritonitis (SBP), encephalopathy, laboratory findings and PA. The cut-off value for the PA was 5.4°, a value described in 2012 by Fernandes <i>et al</i> for 129 patients evaluated in this study and the cut-off points for the Brazilian population presented in percentiles (P), as described by Mattiello <i>et al</i>. The mortality was assessed using the PA percentile through Kaplan-Meier curves and multivariate binary logistic regression models.</p><p><strong>Results: </strong>Patients were divided into two groups according to the PA 5.4th (PA > 5.4°, <i>n</i> = 40; PA ≤ 5.4°, <i>n</i> = 89) PA percentile (< P50, <i>n</i> = 56; ≥ P50 <i>n</i> = 73). The percentile classification was more accurate in identifying long-term deaths than the 5.4º PA. Patients with < P50 had a higher number of relevant complications such as ascites, SBP, liver encephalopathy and HCC. PA is strongly correlated with serum albumin (<i>P</i> < 0.001), International Normalized Ratio (<i>P</i> = 0.01), total bilirubin (<i>P</i> = 0.02) and direct bilirubin (<i>P</i> = 0.003). PA is correlated with survival time (<i>P</i> < 0.001) and length of stay (<i>P</i> = 0.02). Logistic regression analysis shows that an increase of 1° in PA enlarges the cirrhotic patient's chance of survival by 17.7%.</p><p><strong>Conclusion: </strong>PA is a good predictor of morbidity and mortality for cirrhotic patients. The PA by percentile showed greater sensitivity in predicting mortality compared to the cut-off point of 5.4º.</p>","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":"13 4","pages":"238-247"},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cb/cb/WJM-13-238.PMC10523241.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41174904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physician-scientists or celebrities? Kardashian-index of gastroenterologists.","authors":"Onyinye Ugonabo,&nbsp;Saad Ullah Malik,&nbsp;Usman Ali Akbar,&nbsp;Zarlakhta Zamani,&nbsp;Wesam Frandah","doi":"10.5662/wjm.v13.i4.337","DOIUrl":"https://doi.org/10.5662/wjm.v13.i4.337","url":null,"abstract":"<p><strong>Background: </strong>The coronavirus disease 2019 pandemic unleashed a flood of untrustworthy information on social media platforms, resulting in the unfortunate consequence of expert scientists' opinions getting lost amidst the chaotic sea of misinformation. The question of how much influence these esteemed scientists hold on social media platforms remains elusive. To address this scientific quandary, we sought to explore the concept of the Kardashian index (K-index), a term introduced by Hall in 2014. This metric provides a rudimentary means of evaluating whether a physician scientist's popularity on social media aligns with their significant scientific contributions.</p><p><strong>Aim: </strong>To evaluate if a Gastroenterologist physician's popularity on social media is at par with their scientific contributions (research articles and publications).</p><p><strong>Methods: </strong>We conducted an extensive search to identify all gastroenterologists actively practicing and associated with the top 100 hospitals as reported by the United States News. We collected specific data on a sub-group including their names, affiliations, degrees, and sub-specializations. To gauge their social media popularity, we utilized the K-index calculation which is determined by dividing the actual number of Twitter followers by the number of researcher's citations. The expected number of followers (F) is calculated using the formula F = 43.3 C ^ 0.32, where C represents the number of citations.</p><p><strong>Results: </strong>Physicians affiliated with the Mayo Clinic emerged as the most prominent presence on Twitter, constituting 16% of the total. They were followed closely by physicians from Mount Sinai Hospital (9%) and the University of Michigan Hospital (9%). Surprisingly, 76% of the physicians evaluated exhibited a low K-index, falling within the range of 0 to less than 2. This suggests that a significant number of highly influential physician-scientists are not receiving due recognition, as indicated by their relatively low number of followers. On the other hand, 24% of the physicians had an inflated K-index, exceeding 5, which positioned them as the \"Kardashians\". These individuals enjoyed greater social media popularity than their actual scientific contributions. Interestingly, our analysis revealed no discernible association between sex and K-index (<i>P</i> value of 0.92).</p><p><strong>Conclusion: </strong>In the gastroenterology field, our study estimated that a majority (76%) of highly researched physicians are undervalued despite their significant scientific contributions.</p>","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":"13 4","pages":"337-344"},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9b/5e/WJM-13-337.PMC10523252.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41144798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ChatGPT in action: Harnessing artificial intelligence potential and addressing ethical challenges in medicine, education, and scientific research.","authors":"Madhan Jeyaraman,&nbsp;Swaminathan Ramasubramanian,&nbsp;Sangeetha Balaji,&nbsp;Naveen Jeyaraman,&nbsp;Arulkumar Nallakumarasamy,&nbsp;Shilpa Sharma","doi":"10.5662/wjm.v13.i4.170","DOIUrl":"https://doi.org/10.5662/wjm.v13.i4.170","url":null,"abstract":"<p><p>Artificial intelligence (AI) tools, like OpenAI's Chat Generative Pre-trained Transformer (ChatGPT), hold considerable potential in healthcare, academia, and diverse industries. Evidence demonstrates its capability at a medical student level in standardized tests, suggesting utility in medical education, radiology reporting, genetics research, data optimization, and drafting repetitive texts such as discharge summaries. Nevertheless, these tools should augment, not supplant, human expertise. Despite promising applications, ChatGPT confronts limitations, including critical thinking tasks and generating false references, necessitating stringent cross-verification. Ensuing concerns, such as potential misuse, bias, blind trust, and privacy, underscore the need for transparency, accountability, and clear policies. Evaluations of AI-generated content and preservation of academic integrity are critical. With responsible use, AI can significantly improve healthcare, academia, and industry without compromising integrity and research quality. For effective and ethical AI deployment, collaboration amongst AI developers, researchers, educators, and policymakers is vital. The development of domain-specific tools, guidelines, regulations, and the facilitation of public dialogue must underpin these endeavors to responsibly harness AI's potential.</p>","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":"13 4","pages":"170-178"},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4b/d4/WJM-13-170.PMC10523250.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41171170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biliary fistula and late recurrence of liver hydatid cyst: Role of cysto-biliary communication: A prospective multicenter study.","authors":"Tamer A A M Habeeb,&nbsp;Mauro Podda,&nbsp;Boris Tadic,&nbsp;Vishal G Shelat,&nbsp;Yaman Tokat,&nbsp;Mohamed Ibrahim Abo Alsaad,&nbsp;Abd-Elfattah Kalmoush,&nbsp;Mohammed Shaaban Nassar,&nbsp;Fawzy Metwally Mustafa,&nbsp;Mahmoud Hassib Morsi Badawy,&nbsp;Mohamed Sobhy Shaaban,&nbsp;Tarek Zaghloul Mohamed,&nbsp;Mohammed Ibrahim El Sayed Henish,&nbsp;Hamdi Elbelkasi,&nbsp;Mahmoud Abdou Yassin,&nbsp;Abdelshafy Mostafa,&nbsp;Amr Ibrahim,&nbsp;Waleed A-Abdelhady,&nbsp;Tamer Mohamed Elshahidy,&nbsp;Mohamed Ibrahim Mansour,&nbsp;Adel Mahmoud Moursi,&nbsp;Mohamed Abdallah Zaitoun,&nbsp;Ehab Shehata Abd-Allah,&nbsp;Ashraf Abdelmonem Elsayed,&nbsp;Rasha S Elsayed,&nbsp;Ahmed M Yehia,&nbsp;Amr Abdelghani,&nbsp;Mohamed Negm,&nbsp;Heba Alhussein Abo-Alella,&nbsp;Mostafa M Elaidy","doi":"10.5662/wjm.v13.i4.272","DOIUrl":"https://doi.org/10.5662/wjm.v13.i4.272","url":null,"abstract":"<p><strong>Background: </strong>Hydatid cyst disease (HCD) is common in certain locations. Surgery is associated with postoperative biliary fistula (POBF) and recurrence. The primary aim of this study was to identify whether occult cysto-biliary communication (CBC) can predict recurrent HCD. The secondary aim was to assess the role of cystic fluid bilirubin and alkaline phosphatase (ALP) levels in predicting POBF and recurrent HCD.</p><p><strong>Aim: </strong>To identify whether occult CBC can predict recurrent HCD. The secondary aim was to assess the role of cystic fluid bilirubin and ALP levels in predicting POBF and recurrent HCD.</p><p><strong>Methods: </strong>From September 2010 to September 2016, a prospective multicenter study was undertaken involving 244 patients with solitary primary superficial stage cystic echinococcosis 2 and cystic echinococcosis 3b HCD who underwent laparoscopic partial cystectomy with omentoplasty. Univariable logistic regression analysis assessed independent factors determining biliary complications and recurrence.</p><p><strong>Results: </strong>There was a highly statistically significant association (<i>P</i> ≤ 0.001) between cystic fluid biochemical indices and the development of biliary complications (of 16 patients with POBF, 15 patients had high cyst fluid bilirubin and ALP levels), where patients with high bilirubin-ALP levels were 3405 times more likely to have biliary complications. There was a highly statistically significant association (<i>P</i> ≤ 0.001) between biliary complications, biochemical indices, and the occurrence of recurrent HCD (of 30 patients with recurrent HCD, 15 patients had high cyst fluid bilirubin and ALP; all 16 patients who had POBF later developed recurrent HCD), where patients who developed biliary complications and high bilirubin-ALP were 244.6 and 214 times more likely to have recurrent hydatid cysts, respectively.</p><p><strong>Conclusion: </strong>Occult CBC can predict recurrent HCD. Elevated cyst fluid bilirubin and ALP levels predicted POBF and recurrent HCD.</p>","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":"13 4","pages":"272-286"},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6c/22/WJM-13-272.PMC10523247.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41180834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential long-term neurological and gastrointestinal effects of COVID-19: A review of adult cohorts.","authors":"Zaki A Sherif,&nbsp;Mrinalini Deverapalli,&nbsp;Suryanarayana Reddy Challa,&nbsp;Zara Martirosyan,&nbsp;Peter Whitesell,&nbsp;Antonio Machado Pizuorno,&nbsp;Zainab Naqvi,&nbsp;Ingrid K Tulloch,&nbsp;Gholamreza Oskrochi,&nbsp;Hassan Brim,&nbsp;Hassan Ashktorab","doi":"10.5662/wjm.v13.i4.323","DOIUrl":"https://doi.org/10.5662/wjm.v13.i4.323","url":null,"abstract":"<p><strong>Background: </strong>The respiratory infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved into a multi-organ disorder, with long-term effects known as post-acute sequelae of SARS-CoV-2 infection or long coronavirus disease (COVID).</p><p><strong>Aim: </strong>To examine the current knowledge and outcomes of long-term neurological and gastrointestinal (GI) symptoms in adult cohorts, including United States minority populations.</p><p><strong>Methods: </strong>PubMed and Google Scholar were searched using relevant terms, and data from five studies were analyzed, comprising 27383 patients with persistent neurological and GI sequelae.</p><p><strong>Results: </strong>The main symptoms included anxiety, depression, dysphagia, headache, vomiting, nausea, gastroesophageal reflux, fatigue, and abdominal pain. Patients with comorbidities and metabolic syndromes were at higher risk for long COVID. While most patients were European Americans, there was a need for further study on African Americans.</p><p><strong>Conclusion: </strong>The underlying causes of these symptoms remain unclear, warranting more investigation into the long-term impact of the SARS-CoV-2 on different populations.</p>","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":"13 4","pages":"323-336"},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0f/80/WJM-13-323.PMC10523249.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41158052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-COVID-19 cholangiopathy: Systematic review.","authors":"Mazen Abdalla Rasheed,&nbsp;Vinícius Remus Ballotin,&nbsp;Lucas Goldmann Bigarella,&nbsp;Jonathan Soldera","doi":"10.5662/wjm.v13.i4.296","DOIUrl":"https://doi.org/10.5662/wjm.v13.i4.296","url":null,"abstract":"<p><strong>Background: </strong>The coronavirus disease 2019 (COVID-19) pandemic has had a profound impact on global health, primarily characterized by severe respiratory illness. However, emerging evidence suggests that COVID-19 can also lead to secondary sclerosing cholangitis (SC), referred to as post-COVID-19 cholangiopathy.</p><p><strong>Aim: </strong>To synthesize currently reported cases to assess the current state of knowledge on post-COVID-19 cholangiopathy.</p><p><strong>Methods: </strong>Medical Subject Headings and Health Sciences Descriptors were used to retrieve relevant studies, which were combined using Boolean operators. Searches were conducted on electronic databases including Scopus, Web of Science, and MEDLINE (PubMed). Studies published in English, Spanish, or Portuguese were included, with no restrictions on the publication date. Additionally, the reference lists of retrieved studies were manually searched. Simple descriptive analyses were used to summarize the results. Then the data were extracted and assessed based on Reference Citation Analysis (https://www.referencecitationanalysis.com/).</p><p><strong>Results: </strong>The initial search yielded a total of 192 articles. After screening, 85 articles were excluded due to duplication, leaving 107 articles for further review. Of these, 63 full-length articles met the inclusion criteria and were included in the analyses. Most of the patients were male and exhibited elevated liver function tests (93.8%). Magnetic resonance imaging revealed duct thickening with contrast enhancement (47.7%), as well as beading of the intrahepatic ducts (45.7%) with peribiliary contrast enhancement on diffusion (28.7%). Liver biopsy results confirmed SC in most cases (74.4%). Sixteen patients underwent liver transplantation, with three experiencing successful outcomes.</p><p><strong>Conclusion: </strong>Post-COVID-19 cholangiopathy is a serious condition that is expected to become increasingly concerning in the coming years, particularly considering long COVID syndromes. Although liver transplantation has been proposed as a potential treatment option, more research is necessary to establish its efficacy and explore other potential treatments.</p>","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":"13 4","pages":"296-322"},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0f/7c/WJM-13-296.PMC10523251.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41169370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive analysis of cell-extracellular matrix protein Ras suppressor-1 in function and prognosis of gastrointestinal cancers.","authors":"Ya Xu,&nbsp;Yan-Yu Hou,&nbsp;Zheng Wu,&nbsp;Ze-Xuan Fang,&nbsp;Hua-Tao Wu,&nbsp;Jing Liu","doi":"10.5662/wjm.v13.i4.223","DOIUrl":"https://doi.org/10.5662/wjm.v13.i4.223","url":null,"abstract":"<p><strong>Background: </strong>Ras suppressor 1 (RSU1), a highly conserved protein, plays an important role in actin cytoskeleton remodeling and cell-extracellular matrix adhesion. Aberration of RSU1 activity can cause changes in cell adhesion and migration, thereby enhancing tumor proliferation and metastasis. However, the correlation between RSU1 and gastrointestinal cancers (GICs), as well as its prognostic role related to tumor-infiltrating immune cells (TIICs) remains unclear.</p><p><strong>Aim: </strong>To shows RSU1 plays a potential promoting role in facilitating tumor immune escape in GIC.</p><p><strong>Methods: </strong>Differential expression of RSU1 in different tumors and their corresponding normal tissues was evaluated by exploring the Gene Expression Profiling Interactive Analysis (GEPIA) dataset. The correlation between RSU1 expression and prognosis of GIC cancer patients was evaluated by Kaplan-Meier plotter. Then, RSU1-correlated genes were screened and functionally characterized <i>via</i> enrichment analysis. The correlation between RSU1 and TIICs was further characterized using the Tumor Immune Estimation Resource (TIMER). In addition, the correlation between RSU1 and immune cell surface molecules was also analyzed by TIMER.</p><p><strong>Results: </strong>High RSU1 expression was associated with poor overall survival of gastric cancer patients, exhibiting a hazard ratio (HR) = 1.36, first progression HR = 1.53, and post progression survival HR = 1.6. Specifically, high RSU1 Levels were associated with prognosis of gastric cancer in females, T4 and N3 stages, and Her-2-negative subtypes. Regarding immune-infiltrating cells, RSU1 expression level was positively correlated with infiltration of CD4+ T cells, macrophages, neutrophils, and dendritic cells (DCs) in colorectal adenocarcinoma and stomach adenocarcinoma. RSU1 expression was also predicted to be strongly correlated with immune marker sets in M2 macrophage, DCs and T cell exhaustion in GICs.</p><p><strong>Conclusion: </strong>In gastrointestinal cancers, RSU1 is increased in tumor tissues, and predicts poor survival of patients. Increased RSU1 may be involved in promoting macrophage polarization, DC infiltration, and T cell exhaustion, inducing tumor immune escape and the development of tumors in GICs. We suggest that RSU1 is a promising prognostic biomarker reflecting immune infiltration level of GICs, as well as a potential therapeutic target for precision treatment through improving the immune response.</p>","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":"13 4","pages":"223-237"},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/53/33/WJM-13-223.PMC10523239.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41161649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}