World journal of methodology最新文献

{"title":"Adolescent varicocele, a Gordian knot: A comprehensive review of clinical perspectives and future directions.","authors":"Nakul Baban Aher, Pradhyumna Koushik Thothala Prabhakar, Subash Kaushik Thirukonda Govarthanam, Sriram Krishnamoorthy","doi":"10.5662/wjm.v16.i1.108384","DOIUrl":"10.5662/wjm.v16.i1.108384","url":null,"abstract":"<p><p>The abnormal dilatation of the spermatic veins, or varicocele, affects 14%-20% of teenagers, a proportion similar to that of adults, which peaks in late adolescence (15-19 years old). It is more common in metropolitan and developed areas, possibly due to increased access to medical attention and diagnostic resources. Treatment myths and beliefs about adolescent varicocele (AV) persist, making it a highly disputable condition to address. Concerns include whether surgical intervention is necessary for teenage varicocele and whether it enhances seminal parameters after varicocelectomy. Inadequate or delayed management may contribute to future infertility, imposing a significant public health and economic burden due to the costs associated with assisted reproductive technologies and psychosocial impacts. This minireview addresses common misconceptions about teenage varicocele and clarifies the clinical assessment, treatment, and long-term effects of varicocele in adolescents. This minireview examines and provides information on essential topics, including etiopathogenesis, evaluation, and groups of patients at risk of infertility, emphasizing the importance of testicular volume asymmetry (greater than 20%) and semen parameters in predicting future subfertility. Principles of management, indications, and choice of intervention (follow-up, surgical, and adjunctive treatment) are explored, along with treatment outcomes, to address this challenging situation. A balance between intervention and cautious follow-up is emphasized in the evidence-based suggestions for treatment strategies, which depend on the clinical examination, scrotal Doppler, and semen parameter findings. Based on testicular asymmetry, semen parameters, and symptomatology, management strategies range from conservative surveillance to surgical varicocelectomy and minimally invasive procedures like embolization. AV is a complex condition. If untreated, it can cause oligospermia, infertility, and irreparable testicular damage. Timely intervention, such as subinguinal microsurgical varicocelectomy, is essential after an early diagnosis is made by clinical examination supported by Doppler ultrasound and semen analysis for symptomatic, bilateral palpable, or asymptomatic unilateral varicoceles with testicular asymmetry greater than 20% and abnormal semen parameters in Tanner V boys. Long-term data indicate that patients who have had surgery have better testicular growth and semen characteristics; nevertheless, the effect on future fertility is still being studied, indicating the need for individualized treatment plans. Testicular health, with preserved reproductive potential, is maintained through proactive evaluation and care. AV can affect quality of life in addition to causing physical discomfort; worries about fertility, body image, and social stigma call for comprehensive, patient-centered care.</p>","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":"16 1","pages":"108384"},"PeriodicalIF":0.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12968759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147438735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative effectiveness of amitriptyline <i>vs</i> duloxetine in the treatment of chronic low back pain: An observational study.","authors":"Nityananda Sardar, Raktim Swarnakar, Soumyadipta Ghosh, Pankaj Kumar Mandal","doi":"10.5662/wjm.v16.i1.107203","DOIUrl":"10.5662/wjm.v16.i1.107203","url":null,"abstract":"<p><strong>Background: </strong>Chronic nonspecific low back pain is defined as pain that persists for greater than 12 weeks and mainly occurs in the lower back with no evidence of associated underlying serious conditions [like malignancy, inflammation (like ankylosing spondylitis) or infection, vertebral fracture, <i>etc.</i>].</p><p><strong>Aim: </strong>To compare the efficacy and safety of amitriptyline with duloxetine in treating chronic low back pain (CLBP).</p><p><strong>Methods: </strong>The present study was a two-arm observational study conducted over 18 months in a tertiary rehabilitation setting. A total of 254 patients were included in the study.</p><p><strong>Results: </strong>The mean age was significantly higher in the amitriptyline group (34.78 ± 8.22 years) compared with the duloxetine group (29.98 ± 7.28 years, <i>P</i> < 0.0001). Baseline visual analog scale (VAS) scores were also significantly different between groups (amitriptyline: 7.92 ± 0.56; duloxetine: 8.46 ± 0.79; <i>P</i> < 0.0001). Within-group analysis showed a significant reduction in VAS scores over time in both groups (<i>P</i> < 0.001). At 12 weeks the duloxetine group showed significantly lower VAS scores (0.92 ± 0.78) compared with the amitriptyline group (1.87 ± 1.71; <i>P</i> < 0.0001). Analysis of variance, adjusting for age and baseline VAS, confirmed a significant group effect on pain reduction at 12 weeks (<i>P</i> < 0.001), favoring duloxetine. Side effects were generally mild. The most common in the amitriptyline group were dry mouth (17.3%) and drowsiness (7.9%) while in the duloxetine group, dry mouth (15.7%) and constipation (2.4%) were most reported.</p><p><strong>Conclusion: </strong>Amitriptyline and duloxetine effectively treat CLBP; however, considering side effects and more sustained pain relief, duloxetine appears to be the better option. Nonetheless, treatment choice should consider individual patient profiles.</p>","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":"16 1","pages":"107203"},"PeriodicalIF":0.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12968736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147438795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Apparent diffusion coefficient of kidneys with non-contrast magnetic resonance angiography for functional and anatomical assessment in renal artery stenosis.","authors":"Hira Lal, Surabhi Agarwal, Kaushik Ponmalai, Raghunandan Prasad, Dharmendra S Bhadauria, Sanjay Gambhir, Swagata Mandal, Sandeep Kumar, Priyank Yadav, Pinky Jowel","doi":"10.5662/wjm.v16.i1.107927","DOIUrl":"10.5662/wjm.v16.i1.107927","url":null,"abstract":"<p><strong>Background: </strong>Renal artery stenosis (RAS) is a vascular disorder linked to secondary hypertension, chronic kidney disease, and renal failure due to interstitial fibrosis. Early diagnosis is crucial as RAS-induced hypertension responds well to angioplasty. Non-invasive imaging techniques, including non-contrast magnetic resonance angiography (NC-MRA), help assess RAS without contrast-related risks. Diffusion-weighted MR imaging (DW-MRI) has emerged as a promising method for evaluating kidney function by measuring the apparent diffusion coefficient (ADC), which correlates with renal pathology.</p><p><strong>Aim: </strong>To compare ADC values in hypertensive, RAS, and healthy kidneys, assess the correlation between ADC and stenosis severity, and evaluate its relationship with split glomerular filtration rate (GFR).</p><p><strong>Methods: </strong>This prospective observational study which included 86 patients with suspected RAS and twenty normal healthy controls underwent NC-MRA on a 3T-MR-Scanner followed by DW-MRI at b values of 0 and 1000 seconds/mm² in the transverse plane. ADC maps were created using Functool. ADC values were measured in the cortex and medulla of each kidney's upper, middle, and lower pole, and the average ADC (ADCavg) for cortex and medulla calculated. In patients with RAS, degree of stenosis (DOS) was calculated on NC-MRA. The ADC of 212 kidneys was compared, and the relationship between DOS and ADC was established. In addition, split GFR was calculated in 30 kidneys using 99mTc-DTPA, and correlated with ADC value. The ADC values of kidneys with and without RAS were compared using the Student's <i>t</i>-test. The correlation between ADC and stenosis severity was assessed by Spearman's test, while the relationship between ADC and split GFR was evaluated using Pearson's test. A <i>P</i> value < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>RAS was detected in 58 of 86 (67.44%) hypertensive patients (81 of 172 kidneys), and the ADCavg (<i>P</i> = 0.044) was significantly lower in RAS kidneys than in kidneys with normal arteries and essential hypertension and healthy controls.</p><p><strong>Conclusion: </strong>DW-MRI can be a useful non-invasive technique to estimate the kidney's functional status in RAS patients. It can be used as a complementary assessment tool with NC-MRA to triage patients in need of interventional management.</p>","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":"16 1","pages":"107927"},"PeriodicalIF":0.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12968772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147438759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of lifestyle modifications in glaucoma: A systematic review.","authors":"Sarita Aggarwal, Arvind Kumar Morya, Rajwinder Kaur, Bharat Gurnani, Kirandeep Kaur","doi":"10.5662/wjm.v16.i1.110410","DOIUrl":"10.5662/wjm.v16.i1.110410","url":null,"abstract":"<p><strong>Background: </strong>Glaucoma is a group of eye diseases that lead to irreversible damage to the optic nerve and gradual vision loss. Although it can occur at any age, it is most commonly seen in people over 40. Globally, around 60.5 million people are currently affected, and this number is expected to rise to over 110 million by 2040. Often called the \"silent thief of sight\", glaucoma typically progresses without noticeable symptoms until significant vision has already been lost, making it a major cause of visual disability worldwide. Despite advancements in research, lowering intraocular pressure (IOP) remains the only proven way to slow or halt disease progression.</p><p><strong>Aim: </strong>To explore the potential role of lifestyle modifications in the prevention and management of glaucoma, particularly as complementary strategies alongside traditional IOP-lowering treatments.</p><p><strong>Methods: </strong>An extensive review of existing literature was carried out to examine the effects of various lifestyle factors-including diet, physical activity, yoga practices, sleep posture, and the use of nutritional supplements-on the development and progression of glaucoma.</p><p><strong>Results: </strong>Several studies suggest that lifestyle changes may have a positive impact on glaucoma outcomes. Regular physical exercise, balanced nutrition, certain yoga postures, and proper sleep positioning have been associated with benefits for eye health. Additionally, some supplements may support the optic nerve and contribute to slowing disease progression. These approaches, which are already recognized in the management of other chronic conditions like diabetes and hypertension, show promise in glaucoma care as well.</p><p><strong>Conclusion: </strong>While lowering IOP remains the cornerstone of glaucoma treatment, there is growing interest in the role of lifestyle choices in influencing disease progression. Adopting healthier habits may serve as a valuable addition to existing treatment plans. More clinical research is needed to better understand these connections and to guide practical recommendations for patients and clinicians alike.</p>","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":"16 1","pages":"110410"},"PeriodicalIF":0.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12968758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147438681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence in mobile health applications: A comprehensive review of its role in diabetes care.","authors":"Wen-Jie Li, Lin-Ze Li","doi":"10.5662/wjm.v16.i1.107488","DOIUrl":"10.5662/wjm.v16.i1.107488","url":null,"abstract":"<p><p>This review explores the integration of artificial intelligence (AI) in mobile health applications for diabetes care. It focuses on key AI methodologies - machine learning, deep learning, and natural language processing - and their roles in glucose monitoring, personalized self-management, risk prediction, and clinical decision support. Drawing on recent literature (2018-2024), the study outlines the benefits of AI in improving accuracy, engagement, and precision in diabetes treatment. Challenges such as data privacy, algorithmic bias, and regulatory barriers are also examined. A new section discusses when AI technologies may become burdensome, especially in low-resource settings or for users with limited digital literacy. The review concludes with directions for enhancing model explainability and integrating AI with wearable and Internet of Things devices, emphasizing the need for ethical and equitable implementation in future diabetes management strategies.</p>","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":"16 1","pages":"107488"},"PeriodicalIF":0.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12968744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147438749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are iris masses in lung carcinoma always a metastasis: Two case reports.","authors":"Bhagabat Nayak, Prasanta Raghab Mohapatra, Koyel Chakraborty, Jayadev Nanda, Shri Haripriya, Satya Padmaja Mantha, Madhusmita Sethy, Bijnya Birajita Panda","doi":"10.5662/wjm.v16.i1.112458","DOIUrl":"10.5662/wjm.v16.i1.112458","url":null,"abstract":"<p><strong>Background: </strong>Small cell lung cancer (SCLC) constitutes about 15% of lung cancers and is an aggressive disease with uveal metastasis. An isolated iris lesion in such patients may or may not be a manifestation of disseminated disease. We report two cases - one patient with SCLC and another with non-small cell lung cancer, each with varied presentation.</p><p><strong>Case summary: </strong>The first case was a 49-year-old female who presented with redness in the left eye. She was a known case of SCLC with multi-organ involvement. The best corrected visual acuity (BCVA) was 20/100. Slit-lamp bio-microscopy showed an iris mass with neovascularization. Cytology from anterior chamber paracentesis was suggestive of malignancy. Subsequently she received whole-brain radiotherapy followed by six cycles of platinum doublet chemotherapy. On follow-up, the iris lesion subsided with BCVA of 20/50. The second case was a 54-year-old female with lung adenocarcinoma and brain metastasis. She presented with pain and redness in the right eye (BCVA 20/200). Slit lamp bio-microscopy showed multiple iris nodules in the affected eye. Trabeculectomy was done due to raised intraocular pressure (IOP). Aqueous tap and tissue biopsy for cytology and histopathology respectively, were negative for secondaries. Postoperatively, BCVA improved to 20/70, with an IOP of 12 mmHg and resolution of the nodules.</p><p><strong>Conclusion: </strong>Iris lesions in lung carcinoma patients may not necessarily be metastases. Sometimes they can be reactive nodules mimicking secondaries.</p>","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":"16 1","pages":"112458"},"PeriodicalIF":0.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12968780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147438799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"White blood cells and neutrophil-to-high density lipoprotein ratio as predictive markers of left ventricular dysfunction in heart failure.","authors":"Pradeep Kumar Dabla, Dharmsheel Shrivastav, Vimal Mehta, Swati Singh, Rashid Mir","doi":"10.5662/wjm.v16.i1.108178","DOIUrl":"10.5662/wjm.v16.i1.108178","url":null,"abstract":"<p><strong>Background: </strong>Systemic inflammation, especially of white blood cells (WBCs), is being increasingly accepted as a central mechanism underlying the pathogenesis and development of heart failure (HF). Few studies have assessed their effectiveness as accessible and cost-efficient biomarkers for the early detection of left ventricular dysfunction, as well as their potential predictive value in patients with coronary artery disease (CAD).</p><p><strong>Aim: </strong>To explore the correlation between WBC parameters and low left ventricular ejection fraction (LVEF) in HF patients and to evaluate its predictive potential.</p><p><strong>Methods: </strong>Two-hundred patients with angiographically proven CAD were enrolled in the study. Lymphocyte and neutrophil counts were measured in an automated analyzer. The number of neutrophils was divided by serum level of high density lipoprotein (HDL) to obtain the neutrophil-to-HDL ratio (NHR). Regression analysis was used to examine correlations, and receiver operating characteristic curve analysis was employed to identify predictive value of these hematological markers.</p><p><strong>Results: </strong>WBC, neutrophils, lymphocytes, and NHR are significantly higher among HF patients with low LVEF. Regression analysis revealed a negative association between LVEF and WBC (<i>r</i> ² = 0.007), neutrophils (<i>r</i> ² = 0.019), lymphocytes (<i>r</i> ² = 0.089), and the NHR (<i>r</i> ² = 0.013). ROC analysis revealed that the AUC for WBC was 0.61, with a sensitivity of 72% and specificity of 60%, while neutrophils showed the same AUC (0.61) but with 56% sensitivity and 60% specificity. Lymphocytes showed a higher AUC of 0.68 (72% sensitivity, 60% specificity), while NHR had the lowest AUC at 0.59 (65% sensitivity, 52% specificity).</p><p><strong>Conclusion: </strong>These data indicate that parameters of WBCs, notably lymphocytes, neutrophils, and NHR, can act as useful biomarkers for detection of decreased LVEF in patients with HF. These findings suggest that neutrophils, lymphocytes, and NHR are not only routinely available and cost-effective markers but may also serve as early predictors of reduced LVEF in CAD patients, offering potential utility in clinical risk stratification and management. Further research is needed to validate these findings and explore their potential as clinical risk markers and therapeutic targets in CAD with HF.</p>","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":"16 1","pages":"108178"},"PeriodicalIF":0.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12968738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147438652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of rosuvastatin treatment and other statins on burn wound healing.","authors":"Alexandra G Marneri, Efstathios T Pavlidis, Kalliopi E Stavrati, Christina Mouratidou, Serafeim-Chrysovalantis Kotoulas, Konstantinos D Ballas, Theodoros E Pavlidis","doi":"10.5662/wjm.v16.i1.112686","DOIUrl":"10.5662/wjm.v16.i1.112686","url":null,"abstract":"<p><p>Burn injuries represent a significant global public health concern and can result in severe complications. The process of burn wound recovery is intricate, dynamic and involves a series of synchronized events, such as hemostasis, inflammation, proliferation, revascularization, and remodeling. Obstacles in the healing of burn wounds are widespread, both in community and hospital settings. The correlation between the delay in wound-healing of burn injuries with increased mortality rates has led numerous investigators to devise novel therapeutic approaches aimed at accelerating the recovery of burn wounds. Statins, recognized for their varied pleiotropic impacts, have been proposed to enhance wound healing. Insights drawn from studies involving both animals and humans show that statins can speed up wound recovery. Rosuvastatin is one of the most recently studied statins. It promotes wound healing due to its hydrophilic characteristics, in combination with high hepatoselectivity and long half-life, which enable targeted action on the endothelium, improving microcirculation and promoting angiogenesis. Despite the encouraging preliminary results, it has not been widely used, resulting in limited data and heterogeneity. However, further high-quality, evidence-based research is urgently needed to identify whether rosuvastatin may present clinical advantages and improve burn wound recovery through angiogenesis, lymph-angiogenesis and microvascular function. Thus, rosuvastatin could be a potential alternative therapeutic approach for treating burn wounds.</p>","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":"16 1","pages":"112686"},"PeriodicalIF":0.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12968781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147438819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of older and newer sedation agents in bronchoscopy.","authors":"Shikha Upreti, Darrin Lowe, Salim Surani, Dhaval Patel","doi":"10.5662/wjm.v16.i1.108379","DOIUrl":"10.5662/wjm.v16.i1.108379","url":null,"abstract":"<p><p>Flexible bronchoscopy is an important diagnostic and therapeutic modality in pulmonary medicine. Appropriate sedation is essential for patient safety and comfort. Several agents, such as benzodiazepine and opiates (fentanyl, Midazolam, and morphine), have been used for conscious sedation and anxiolytics. Lately, there has been an influx of newer sedation agents that have been valuable in bronchoscopy because of their beneficial properties. For example, Ketamine, a dissociative anesthetic, has been used during bronchoscopic procedures as an alternative to conventional sedatives or as an adjunct to them. Its bronchodilatory effects, minimal respiratory depression, sympathomimetic effect leading to hemodynamic stability, and analgesic properties make it particularly valuable in high-risk populations, including patients with respiratory compromise. Besides Ketamine, Esketamine, Dexmedetomidine, and other agents are also being used. This minireview explores the role of older and newer agents in bronchoscopy, highlighting their efficacy, safety profile, and potential advantages.</p>","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":"16 1","pages":"108379"},"PeriodicalIF":0.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12968769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147438747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Considering mental function for successful total knee arthroplasty in older people.","authors":"Takahiko Nagamine","doi":"10.5662/wjm.v16.i1.107921","DOIUrl":"10.5662/wjm.v16.i1.107921","url":null,"abstract":"<p><p>Many older individuals suffer from chronic knee joint pain due to osteoarthritis, a degenerative joint disease. Total knee arthroplasty (TKA), also known as total knee replacement, is a surgical procedure designed to replace a damaged knee joint with artificial implants. TKA can significantly reduce or eliminate this pain. However, depression or cognitive decline may affect the therapeutic outcome of TKA in older individuals. When performing TKA in older people, it is necessary to screen for and address mental function.</p>","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":"16 1","pages":"107921"},"PeriodicalIF":0.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12968763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147438826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}