World journal of methodology最新文献

{"title":"External validation of the Moroccan Arabic version of the European Organization for Research and Treatment of Cancer colorectal (CR29) module: Monocentric study.","authors":"Houda Bachri,&nbsp;Hajar Essangri,&nbsp;Nezha El Bahaoui,&nbsp;Amine Benkabbou,&nbsp;Raouf Mohsine,&nbsp;Anass Mohammed Majbar,&nbsp;Amine Souadka","doi":"10.5662/wjm.v13.i4.259","DOIUrl":"https://doi.org/10.5662/wjm.v13.i4.259","url":null,"abstract":"<p><strong>Background: </strong>Quality of life (QoL) outcomes are a focal endpoint of cancer treatment strategies.</p><p><strong>Aim: </strong>To externally validate the Moroccan Arabic version of the European Organization for Research and Treatment of Cancer (EORTC) QoL Questionnaire (QLQ) for colorectal cancer (CRC) patients (CR29).</p><p><strong>Methods: </strong>Both Moroccan Arabic modules of QLQ-CR29 and QLQ-C30 were administered to Moroccan CRC. Psychometric properties were retested by measuring Cronbach's alpha coefficient for reliability and Intraclass correlation coefficient (ICC) to examine test-retest reproducibility. The multitrait-scaling analysis was performed to demonstrate the validity of the instrument and known-groups comparison was used to test the score's ability to discriminate between different groups of patients.</p><p><strong>Results: </strong>In total, 221 patients were included in our study and 34 patients completed the questionnaire twice. The Urinary Frequency scale and Stool Frequency scale had good internal consistency with alpha Cronbach coefficients of 0.79 and 0.83 respectively, while the same coefficients were moderately lower for the Blood and Mucus in Stool scale (0.61) and the Body Image scale (0.67). The ICCs ranged from 0.88 to 1 indicating good to excellent reproducibility. In multitrait scaling analyses, the criterion for item convergent and divergent validity was satisfactory. The known-group comparison showed statistically significant differences between patients according to age, gender, stoma status, tumor location, and radiotherapy.</p><p><strong>Conclusion: </strong>The Moroccan Arabic version of the EORTC QLQ-CR29 is a valid and reliable tool that can be used safely for research and clinical purposes in Moroccan CRC patients.</p>","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/91/07/WJM-13-259.PMC10523244.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41161041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compensated liver cirrhosis: Natural course and disease-modifying strategies.","authors":"Ramesh Kumar,&nbsp;Sudhir Kumar,&nbsp;Sabbu Surya Prakash","doi":"10.5662/wjm.v13.i4.179","DOIUrl":"https://doi.org/10.5662/wjm.v13.i4.179","url":null,"abstract":"<p><p>Compensated liver cirrhosis (CLC) is defined as cirrhosis with one or more decompensating events, such as ascites, variceal haemorrhage, or hepatic encephalopathy. Patients with CLC are largely asymptomatic with preserved hepatic function. The transition from CLC to decompensated cirrhosis occurs as a result of a complex interaction between multiple predisposing and precipitating factors. The first decompensation event in CLC patients is considered a significant turning point in the progression of cirrhosis, as it signals a drastic decline in median survival rates from 10-12 years to only 1-2 years. Furthermore, early cirrhosis has the potential to regress as liver fibrosis is a dynamic condition. With the advent of effective non-invasive tools for detecting hepatic fibrosis, more and more patients with CLC are currently being recognised. This offers clinicians a unique opportunity to properly manage such patients in order to achieve cirrhosis regression or, at the very least, prevent its progression. There are numerous emerging approaches for preventing or delaying decompensation in CLC patients. A growing body of evidence indicates that treating the underlying cause can lead to cirrhosis regression, and the use of non-selective beta-blockers can prevent decompensation by lowering portal hypertension. Additionally, addressing various cofactors (such as obesity, diabetes, dyslipidaemia, and alcoholism) and precipitating factors (such as infection, viral hepatitis, and hepatotoxic drugs) that have a detrimental impact on the natural course of cirrhosis may benefit patients with CLC. However, high-quality data must be generated through well-designed and adequately powered randomised clinical trials to validate these disease-modifying techniques for CLC patients. This article discussed the natural history of CLC, risk factors for its progression, and therapeutic approaches that could alter the trajectory of CLC evolution and improve outcomes.</p>","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/eb/49/WJM-13-179.PMC10523240.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41174903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical, imaging, arthroscopic, and histologic features of bilateral anteromedial meniscofemoral ligament: A case report.","authors":"Juan Bautista Luco,&nbsp;Damian Di Memmo,&nbsp;Valentina Gomez Sicre,&nbsp;Tomas Ignacio Nicolino,&nbsp;Matias Costa-Paz,&nbsp;Juan Astoul,&nbsp;Ignacio Garcia-Mansilla","doi":"10.5662/wjm.v13.i4.359","DOIUrl":"https://doi.org/10.5662/wjm.v13.i4.359","url":null,"abstract":"<p><strong>Background: </strong>The anteromedial meniscofemoral ligament (AMMFL) is a very rare entity, commonly unrecognized and underreported. Although it was not proved to be a cause of anterior knee pain, concerns have been raised on the relationship between the presence of this structure and medial meniscus injury secondary to its abnormal motion. Regarding histologic examination, some studies have shown meniscus-like fibrocartilage, while others have identified it as ligament-like collagenous fibrous connective tissue.</p><p><strong>Case summary: </strong>We report the case of a 34-year-old ballerina with an AMMFL associated with a torn medial meniscus of both knees. Surgery was performed to treat the meniscal injury and two biopsies of each AMMFL were taken in different locations to define the histopathological composition. Histologic examination revealed fibrocartilaginous tissue compatible with meniscus. Follow-up evaluation one year after surgery evidenced full remission of symptoms and the patient had resumed her athletic activities.</p><p><strong>Conclusion: </strong>Clinical, magnetic resonance imaging, arthroscopic, and histological features have been carefully described to better characterize the AMMFL.</p>","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/91/c0/WJM-13-359.PMC10523243.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41176527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sclerotic marginal zone lymphoma: A case report.","authors":"Zade Moureiden,&nbsp;Hammad Tashkandi,&nbsp;Mohammad Omar Hussaini","doi":"10.5662/wjm.v13.i4.366","DOIUrl":"https://doi.org/10.5662/wjm.v13.i4.366","url":null,"abstract":"<p><strong>Background: </strong>Marginal zone lymphoma (MZL) is an indolent non-Hodgkin B cell lymphoma with various architectural pattern including perifollicular, follicular colonization, nodular, micronodular, and diffuse patterns. A sclerotic variant has not been previously reported and represents a diagnostic pitfall.</p><p><strong>Case summary: </strong>A 66-year-old male developed left upper extremity swelling. Chest computed tomography (CT) in September 2020 showed 14 cm mass in left axilla. Needle core biopsy of axillary lymph node showed sclerotic tissue with atypical B lymphoid infiltrate but was non-diagnostic. Excisional biopsy was performed for diagnosis and showed extensive fibrosis and minor component of infiltrating B cells. Flow cytometry showed a small population of CD5-, CD10-, kappa restricted B cells. Monoclonal immunoglobulin heavy chain and light chain gene rearrangement were identified. Upon being diagnosed with MZL, patient was treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone and achieved complete remission by positron emission tomography/CT.</p><p><strong>Conclusion: </strong>This is an important case report because by morphology this case could have easily been overlooked as non-specific fibrosis with chronic inflammation representing a significant diagnostic pitfall. Moreover, this constitutes a new architectural pattern. While sclerotic lymphomas have rarely been described (often misdiagnosed as retroperitoneal fibrosis), we do not know of any cases describing this architectural presentation of MZL.</p>","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d4/96/WJM-13-366.PMC10523246.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41144799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilization of online systems to promote youth participation in research: A methodological study.","authors":"Marie Salem,&nbsp;Lance Pollack,&nbsp;Alex Zepeda,&nbsp;Kathleen P Tebb","doi":"10.5662/wjm.v13.i4.210","DOIUrl":"https://doi.org/10.5662/wjm.v13.i4.210","url":null,"abstract":"<p><strong>Background: </strong>Online surveys can align with youth's increased use of the internet and can be a mechanism for expanding youth participation in research. This is particularly important during the coronavirus disease 2019 (COVID-19) pandemic, when in-person interactions are limited. However, the advantages and drawbacks of online systems used for research need to be carefully considered before utilizing such methodologies.</p><p><strong>Aim: </strong>To describe and discuss the strengths and limitations of an online system developed to recruit adolescent girls for a sexual health research study and conduct a three-month follow up survey.</p><p><strong>Methods: </strong>This methodology paper examines the use of an online system to recruit and follow participants three months after their medical visit to evaluate a mobile sexual and reproductive health application, <i>Health-E You/Salud iTu</i>^TM, for adolescent girls attending school-based health centers (SBHCs) across the United States. SBHC staff gave adolescent girls a web link to an online eligibility and consent survey. Participants were then asked to complete two online surveys (baseline and 3-month follow-up). Surveys, reminders, and incentives to complete them were distributed through short message service (SMS) text messages. Upon completing each survey, participants were also sent an email with a link to an electronic gift card as a thank-you for their participation. Barriers to implementing this system were discussed with clinicians and staff at each participating SBHC.</p><p><strong>Results: </strong>This online recruitment and retention system enabled participant recruitment at 26 different SBHCs in seven states across the United States. Between September 2021 and June 2022, 415 adolescent girls were screened using the Qualtrics online survey platform, and 182 were eligible to participate. Of those eligible, 78.0% (<i>n</i> = 142) completed the baseline survey. Participants were racially, geographically, and linguistically diverse. Most of the participants (89.4%) were non-White, and 40.8% spoke Spanish. A total of 62.0% (<i>n</i> = 88) completed the 3-month follow-up survey. Limitations of this system included reliance on internet access (<i>via</i> Wi-Fi or cell service), which was not universally available or reliable. In addition, an individual unrelated to the study obtained the survey link, filled out multiple surveys, and received multiple gift cards before the research team discovered and stopped this activity. As a result, additional security protocols were instituted.</p><p><strong>Conclusion: </strong>Online systems for health research can increase the reach and diversity of study participants, reduce costs for research personnel time and travel, allow for continued study operation when in-person visits are limited (such as during the COVID-19 pandemic), and connect youth with research using technology. However, there are challenges and limitation","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6d/5c/WJM-13-210.PMC10523248.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41159320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of carbon monoxide poisonings and carboxyhemoglobin levels with COVID-19 and clinical severity.","authors":"Abuzer Coskun,&nbsp;Burak Demirci,&nbsp;Kenan Ahmet Turkdogan","doi":"10.5662/wjm.v13.i4.248","DOIUrl":"https://doi.org/10.5662/wjm.v13.i4.248","url":null,"abstract":"<p><strong>Background: </strong>Coronavirus disease 2019 (COVID-19), which recently spread throughout the entire world, is still a significant health issue. Additionally, the most common cause of risky poisoning in emergency services is carbon monoxide (CO) poisoning. Both disorders seem to merit more research as they have an impact on all bodily systems <i>via</i> the lungs.</p><p><strong>Aim: </strong>To determine how arterial blood gas and carboxyhemoglobin (COHb) levels affect the clinical and prognostic results of individuals requiring emergency treatment who have both COVID-19 and CO poisoning.</p><p><strong>Methods: </strong>Between January 2018 and December 2021, 479 CO-poisoning patients participated in this single-center, retrospective study. Patients were primarily divided into two groups for analysis: Pre-pandemic and pandemic periods. Additionally, the pandemic era was divided into categories based on the presence of COVID-19 and, if present, the clinical severity of the infection. The hospital information system was used to extract patient demographic, clinical, arterial blood gas, COVID-19 polymerase chain reaction, and other laboratory data.</p><p><strong>Results: </strong>The mean age of the 479 patients was 54.93 ± 11.51 years, and 187 (39%) were female. 226 (47%) patients were in the pandemic group and 143 (30%) of them had a history of COVID-19. While the mean potential of hydrogen (pH) in arterial blood gas of all patients was 7.28 ± 0.15, it was 7.35 ± 0.10 in the pre-pandemic group and 7.05 ± 0.16 in the severe group during the pandemic period (<i>P</i> < 0.001). COHb was 23.98 ± 4.19% in the outpatients and 45.26% ± 3.19% in the mortality group (<i>P</i> < 0.001). Partial arterial oxygen pressure (PaO₂) was 89.63 ± 7.62 mmHg in the pre-pandemic group, and 79.50 ± 7.18 mmHg in the severe group during the pandemic period (<i>P</i> < 0.001). Despite the fact that mortality occurred in 35 (7%) of all cases, pandemic cases accounted for 30 of these deaths (85.7%) (<i>P</i> <0.001). The association between COHb, troponin, lactate, partial arterial pressure of carbon dioxide, HCO₃, calcium, glucose, age, pH, PaO₂, potassium, sodium, and base excess levels in the pre-pandemic and pandemic groups was statistically significant in univariate linear analysis.</p><p><strong>Conclusion: </strong>Air exchange barrier disruption caused by COVID-19 may have pulmonary consequences. In patients with a history of pandemic COVID-19, clinical results and survival are considerably unfavorable in cases of CO poisoning.</p>","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0f/d7/WJM-13-248.PMC10523238.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41160328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of the phase angle in the prognosis of the cirrhotic patient: 15 years of follow-up.","authors":"Letícia Pereira Pinto,&nbsp;Claudio Augusto Marroni,&nbsp;Juliana Czermainski,&nbsp;Maria Luiza Fernandes Dahlem,&nbsp;Randhall B Carteri,&nbsp;Sabrina Alves Fernandes","doi":"10.5662/wjm.v13.i4.238","DOIUrl":"https://doi.org/10.5662/wjm.v13.i4.238","url":null,"abstract":"<p><strong>Background: </strong>In 2019, cirrhosis accounted for 2.4% of global deaths. The projection for 2030 is an increase in this index. In recent years, hospitalization costs have escalated by 36% for compensated cirrhosis and 24% for decompensated cirrhosis. Therefore, it is necessary to identify a tool capable of predicting the mortality of these patients according to their clinical condition and consequently extending their survival time. Different studies have shown that the phase angle (PA) can be a feasible method in clinical practice, with the potential to guide assertive patient management in the therapeutic of chronic liver disease.</p><p><strong>Aim: </strong>To evaluate the prognostic role of PA in cirrhotic patients over a 15-year follow-up period.</p><p><strong>Methods: </strong>Retrospective cohort study with 129 cirrhotic patients of both sexes over 18 years old. Diagnosis of cirrhosis by liver biopsy. The first year of data collection was 2007, and data regarding outcomes was collected in 2023. Data were gathered from medical records, such as esophageal varices (EV), EV bleeding, ascites, spontaneous bacterial peritonitis (SBP), encephalopathy, laboratory findings and PA. The cut-off value for the PA was 5.4°, a value described in 2012 by Fernandes <i>et al</i> for 129 patients evaluated in this study and the cut-off points for the Brazilian population presented in percentiles (P), as described by Mattiello <i>et al</i>. The mortality was assessed using the PA percentile through Kaplan-Meier curves and multivariate binary logistic regression models.</p><p><strong>Results: </strong>Patients were divided into two groups according to the PA 5.4th (PA > 5.4°, <i>n</i> = 40; PA ≤ 5.4°, <i>n</i> = 89) PA percentile (< P50, <i>n</i> = 56; ≥ P50 <i>n</i> = 73). The percentile classification was more accurate in identifying long-term deaths than the 5.4º PA. Patients with < P50 had a higher number of relevant complications such as ascites, SBP, liver encephalopathy and HCC. PA is strongly correlated with serum albumin (<i>P</i> < 0.001), International Normalized Ratio (<i>P</i> = 0.01), total bilirubin (<i>P</i> = 0.02) and direct bilirubin (<i>P</i> = 0.003). PA is correlated with survival time (<i>P</i> < 0.001) and length of stay (<i>P</i> = 0.02). Logistic regression analysis shows that an increase of 1° in PA enlarges the cirrhotic patient's chance of survival by 17.7%.</p><p><strong>Conclusion: </strong>PA is a good predictor of morbidity and mortality for cirrhotic patients. The PA by percentile showed greater sensitivity in predicting mortality compared to the cut-off point of 5.4º.</p>","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cb/cb/WJM-13-238.PMC10523241.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41174904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physician-scientists or celebrities? Kardashian-index of gastroenterologists.","authors":"Onyinye Ugonabo,&nbsp;Saad Ullah Malik,&nbsp;Usman Ali Akbar,&nbsp;Zarlakhta Zamani,&nbsp;Wesam Frandah","doi":"10.5662/wjm.v13.i4.337","DOIUrl":"https://doi.org/10.5662/wjm.v13.i4.337","url":null,"abstract":"<p><strong>Background: </strong>The coronavirus disease 2019 pandemic unleashed a flood of untrustworthy information on social media platforms, resulting in the unfortunate consequence of expert scientists' opinions getting lost amidst the chaotic sea of misinformation. The question of how much influence these esteemed scientists hold on social media platforms remains elusive. To address this scientific quandary, we sought to explore the concept of the Kardashian index (K-index), a term introduced by Hall in 2014. This metric provides a rudimentary means of evaluating whether a physician scientist's popularity on social media aligns with their significant scientific contributions.</p><p><strong>Aim: </strong>To evaluate if a Gastroenterologist physician's popularity on social media is at par with their scientific contributions (research articles and publications).</p><p><strong>Methods: </strong>We conducted an extensive search to identify all gastroenterologists actively practicing and associated with the top 100 hospitals as reported by the United States News. We collected specific data on a sub-group including their names, affiliations, degrees, and sub-specializations. To gauge their social media popularity, we utilized the K-index calculation which is determined by dividing the actual number of Twitter followers by the number of researcher's citations. The expected number of followers (F) is calculated using the formula F = 43.3 C ^ 0.32, where C represents the number of citations.</p><p><strong>Results: </strong>Physicians affiliated with the Mayo Clinic emerged as the most prominent presence on Twitter, constituting 16% of the total. They were followed closely by physicians from Mount Sinai Hospital (9%) and the University of Michigan Hospital (9%). Surprisingly, 76% of the physicians evaluated exhibited a low K-index, falling within the range of 0 to less than 2. This suggests that a significant number of highly influential physician-scientists are not receiving due recognition, as indicated by their relatively low number of followers. On the other hand, 24% of the physicians had an inflated K-index, exceeding 5, which positioned them as the \"Kardashians\". These individuals enjoyed greater social media popularity than their actual scientific contributions. Interestingly, our analysis revealed no discernible association between sex and K-index (<i>P</i> value of 0.92).</p><p><strong>Conclusion: </strong>In the gastroenterology field, our study estimated that a majority (76%) of highly researched physicians are undervalued despite their significant scientific contributions.</p>","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9b/5e/WJM-13-337.PMC10523252.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41144798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ChatGPT in action: Harnessing artificial intelligence potential and addressing ethical challenges in medicine, education, and scientific research.","authors":"Madhan Jeyaraman,&nbsp;Swaminathan Ramasubramanian,&nbsp;Sangeetha Balaji,&nbsp;Naveen Jeyaraman,&nbsp;Arulkumar Nallakumarasamy,&nbsp;Shilpa Sharma","doi":"10.5662/wjm.v13.i4.170","DOIUrl":"https://doi.org/10.5662/wjm.v13.i4.170","url":null,"abstract":"<p><p>Artificial intelligence (AI) tools, like OpenAI's Chat Generative Pre-trained Transformer (ChatGPT), hold considerable potential in healthcare, academia, and diverse industries. Evidence demonstrates its capability at a medical student level in standardized tests, suggesting utility in medical education, radiology reporting, genetics research, data optimization, and drafting repetitive texts such as discharge summaries. Nevertheless, these tools should augment, not supplant, human expertise. Despite promising applications, ChatGPT confronts limitations, including critical thinking tasks and generating false references, necessitating stringent cross-verification. Ensuing concerns, such as potential misuse, bias, blind trust, and privacy, underscore the need for transparency, accountability, and clear policies. Evaluations of AI-generated content and preservation of academic integrity are critical. With responsible use, AI can significantly improve healthcare, academia, and industry without compromising integrity and research quality. For effective and ethical AI deployment, collaboration amongst AI developers, researchers, educators, and policymakers is vital. The development of domain-specific tools, guidelines, regulations, and the facilitation of public dialogue must underpin these endeavors to responsibly harness AI's potential.</p>","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4b/d4/WJM-13-170.PMC10523250.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41171170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biliary fistula and late recurrence of liver hydatid cyst: Role of cysto-biliary communication: A prospective multicenter study.","authors":"Tamer A A M Habeeb,&nbsp;Mauro Podda,&nbsp;Boris Tadic,&nbsp;Vishal G Shelat,&nbsp;Yaman Tokat,&nbsp;Mohamed Ibrahim Abo Alsaad,&nbsp;Abd-Elfattah Kalmoush,&nbsp;Mohammed Shaaban Nassar,&nbsp;Fawzy Metwally Mustafa,&nbsp;Mahmoud Hassib Morsi Badawy,&nbsp;Mohamed Sobhy Shaaban,&nbsp;Tarek Zaghloul Mohamed,&nbsp;Mohammed Ibrahim El Sayed Henish,&nbsp;Hamdi Elbelkasi,&nbsp;Mahmoud Abdou Yassin,&nbsp;Abdelshafy Mostafa,&nbsp;Amr Ibrahim,&nbsp;Waleed A-Abdelhady,&nbsp;Tamer Mohamed Elshahidy,&nbsp;Mohamed Ibrahim Mansour,&nbsp;Adel Mahmoud Moursi,&nbsp;Mohamed Abdallah Zaitoun,&nbsp;Ehab Shehata Abd-Allah,&nbsp;Ashraf Abdelmonem Elsayed,&nbsp;Rasha S Elsayed,&nbsp;Ahmed M Yehia,&nbsp;Amr Abdelghani,&nbsp;Mohamed Negm,&nbsp;Heba Alhussein Abo-Alella,&nbsp;Mostafa M Elaidy","doi":"10.5662/wjm.v13.i4.272","DOIUrl":"https://doi.org/10.5662/wjm.v13.i4.272","url":null,"abstract":"<p><strong>Background: </strong>Hydatid cyst disease (HCD) is common in certain locations. Surgery is associated with postoperative biliary fistula (POBF) and recurrence. The primary aim of this study was to identify whether occult cysto-biliary communication (CBC) can predict recurrent HCD. The secondary aim was to assess the role of cystic fluid bilirubin and alkaline phosphatase (ALP) levels in predicting POBF and recurrent HCD.</p><p><strong>Aim: </strong>To identify whether occult CBC can predict recurrent HCD. The secondary aim was to assess the role of cystic fluid bilirubin and ALP levels in predicting POBF and recurrent HCD.</p><p><strong>Methods: </strong>From September 2010 to September 2016, a prospective multicenter study was undertaken involving 244 patients with solitary primary superficial stage cystic echinococcosis 2 and cystic echinococcosis 3b HCD who underwent laparoscopic partial cystectomy with omentoplasty. Univariable logistic regression analysis assessed independent factors determining biliary complications and recurrence.</p><p><strong>Results: </strong>There was a highly statistically significant association (<i>P</i> ≤ 0.001) between cystic fluid biochemical indices and the development of biliary complications (of 16 patients with POBF, 15 patients had high cyst fluid bilirubin and ALP levels), where patients with high bilirubin-ALP levels were 3405 times more likely to have biliary complications. There was a highly statistically significant association (<i>P</i> ≤ 0.001) between biliary complications, biochemical indices, and the occurrence of recurrent HCD (of 30 patients with recurrent HCD, 15 patients had high cyst fluid bilirubin and ALP; all 16 patients who had POBF later developed recurrent HCD), where patients who developed biliary complications and high bilirubin-ALP were 244.6 and 214 times more likely to have recurrent hydatid cysts, respectively.</p><p><strong>Conclusion: </strong>Occult CBC can predict recurrent HCD. Elevated cyst fluid bilirubin and ALP levels predicted POBF and recurrent HCD.</p>","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6c/22/WJM-13-272.PMC10523247.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41180834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}