Virology最新文献_第5页

Role of Interferon Regulatory Factor 1 in acute and chronic virus infections. 干扰素调节因子1在急慢性病毒感染中的作用

Virology Pub Date : 2024-12-30 DOI: 10.1016/j.virol.2024.110386

Cade R Rahlf, Vera L Tarakanova

引用次数: 0

Avian circoviruses and hepadnaviruses identified in tissue samples of various waterfowl. 在各种水禽组织样本中鉴定出的禽圆环病毒和肝病毒。

Virology Pub Date : 2024-12-26 DOI: 10.1016/j.virol.2024.110381

Diego A Olivo, Simona Kraberger, Elliott S Chiu, Joy M Custer, Danny Jackson, Melanie Regney, Michael C Lund, Rohan A Bandoo, Victor Aguiar de Souza Penha, Dean Drake, Kevin J McGraw, Arvind Varsani

{"title":"Avian circoviruses and hepadnaviruses identified in tissue samples of various waterfowl.","authors":"Diego A Olivo, Simona Kraberger, Elliott S Chiu, Joy M Custer, Danny Jackson, Melanie Regney, Michael C Lund, Rohan A Bandoo, Victor Aguiar de Souza Penha, Dean Drake, Kevin J McGraw, Arvind Varsani","doi":"10.1016/j.virol.2024.110381","DOIUrl":"https://doi.org/10.1016/j.virol.2024.110381","url":null,"abstract":"North America is home to over 40 species of migratory waterfowl. Utilizing tissue and cloacal-swab sampling from hunter-harvested carcasses in 2021-2023, we identified circular DNA viruses associated with 116 waterfowl samples from nine species (American wigeons, Mexican ducks, northern shovelers, northern pintails, canvasbacks, mallards, American black ducks, gadwalls, and green-winged teals). We determined the genome sequences of viruses in the families Circoviridae (n = 18) and Hepadnaviridae (n = 2) from the 13 virus-infected birds. The 18 circoviruses can be classified into four circovirus lineages: duck circovirus, wigfec circovirus 1, and two new lineages, marcaroli circovirus and spata circovirus. The new circovirus lineages identified are most closely related to waterfowl circoviruses based on the pairwise identities and phylogenetic analyses of full genomes, replication-associated protein, and capsid protein sequences. The two identified hepadnavirus genomes are part of the duck hepatitis B virus lineage sharing >89% identity with known ones.","PeriodicalId":94266,"journal":{"name":"Virology","volume":"603 ","pages":"110381"},"PeriodicalIF":0.0,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early evolution of mumps-HCV chimeric viruses in Vero cells induces loss of HCV gene expression and promotes accumulation of substitutions uncharacteristic of mumps strains. 在Vero细胞中，腮腺炎-丙型肝炎病毒嵌合病毒的早期进化诱导了丙型肝炎病毒基因表达的缺失，并促进了非腮腺炎毒株特征的取代的积累。

Virology Pub Date : 2024-12-25 DOI: 10.1016/j.virol.2024.110379

Dorotea Pali, Dubravko Forčić, Maja Jagušić, Tanja Košutić Gulija, Mirna Jurković, Marko Babić, Daniela Kalafatovic, Jelena Ivančić-Jelečki

引用次数: 0

Insights into the different mechanisms of Autophagy and Apoptosis mediated by Morbilliviruses. 深入了解由变形病毒介导的自噬和凋亡的不同机制。

Virology Pub Date : 2024-12-24 DOI: 10.1016/j.virol.2024.110371

Rashmi Singh, Sharad Kumar Gaur, Rakhi Nagar, Rajeev Kaul

引用次数: 0

The UP1 domain is essential for the facilitation effect of HnRNP A1 on PRRSV-2 replication. UP1结构域对于HnRNP A1对PRRSV-2复制的促进作用至关重要。

Virology Pub Date : 2024-12-24 DOI: 10.1016/j.virol.2024.110378

Huiyuan Jing, Ying Liu, Zhifeng Peng, Erzhen Duan, Jie Liu, Yujin Lv, Yanting Sun, Wang Dong, Xianghui Li, Jinhe Wang, Sufang Cao, Haihua Wang, Yan Zhang, Huawei Li

{"title":"The UP1 domain is essential for the facilitation effect of HnRNP A1 on PRRSV-2 replication.","authors":"Huiyuan Jing, Ying Liu, Zhifeng Peng, Erzhen Duan, Jie Liu, Yujin Lv, Yanting Sun, Wang Dong, Xianghui Li, Jinhe Wang, Sufang Cao, Haihua Wang, Yan Zhang, Huawei Li","doi":"10.1016/j.virol.2024.110378","DOIUrl":"https://doi.org/10.1016/j.virol.2024.110378","url":null,"abstract":"Porcine reproductive and respiratory syndrome virus (PRRSV) infection causes reproductive failure and respiratory distress and is a serious threat to the swine industry, given its continuous and rapid emergence. The knowledge of viral-host interaction could facilitate anti-PRRSV drug development. HnRNP A1 is an abundantly expressed protein which associates with RNA metabolic processes and plays multifarious roles during the reproduction cycle of multiple viruses. However, the function of porcine HnRNP A1 in PRRSV-2 replication is still unknown. Herein, HnRNP A1 was identified as a nucleocapsid (N)-binding protein for PRRSV-2. Overexpression of porcine HnRNP A1 promoted the expression of viral RNA, and viral proteins, corresponding to enhanced virus titers. While deletion of the UP1 domain abolished the HnRNP A1-mediated enhancement of PRRSV-2 replication. In addition, HnRNP A1-silencing confirmed its pro-viral effect on PRRSV-2 infectivity in porcine alveolar macrophages (PAMs). RNA pull-down and RNA immunoprecipitation verification confirmed that the UP1 domain is important for the recognition of the guanine-rich sequence (GRS) in PRRSV-2 negative RNA. Eventually, supplementation with TMPyP4, a G4 ligand, efficiently provokes the release of HnRNP A1 from GRS, thereby limiting PRRSV-2 replication. Together, these findings help to inform the mechanism by which HnRNP A1 accelerates PRRSV-2 replication, and facilitate antiviral drug design.","PeriodicalId":94266,"journal":{"name":"Virology","volume":"603 ","pages":"110378"},"PeriodicalIF":0.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Triticum mosaic virus: An overview of biology, functional genomics, gene expression vector, and management strategies. 小麦花叶病毒：生物学、功能基因组学、基因表达载体和管理策略综述。

Virology Pub Date : 2024-12-24 DOI: 10.1016/j.virol.2024.110377

Satyanarayana Tatineni, Shaonpius Mondal, Stephen N Wegulo, Gary L Hein

{"title":"Triticum mosaic virus: An overview of biology, functional genomics, gene expression vector, and management strategies.","authors":"Satyanarayana Tatineni, Shaonpius Mondal, Stephen N Wegulo, Gary L Hein","doi":"10.1016/j.virol.2024.110377","DOIUrl":"https://doi.org/10.1016/j.virol.2024.110377","url":null,"abstract":"Triticum mosaic virus (TriMV; Poacevirus tritici) is the founding member of the genus Poacevirus within the family Potyviridae. TriMV is one of the components of the wheat streak mosaic disease (WSMD) complex, an economically significant wheat disease in the Great Plains region of the USA. TriMV contains a single-stranded positive-sense RNA genome of 10,266 nts with an unusually long 5'-nontranslated region of 739 nts. TriMV is transmitted only by the Type-2 genotype of wheat curl mites (Aceria tosichella Keifer) and is mostly found as a co-infection with another wheat curl mite-transmitted wheat streak mosaic virus (WSMV). TriMV and WSMV synergistically interact in co-infected wheat with exacerbated disease symptoms. The development of an infectious cDNA clone and GFP or RFP-tagged stable expression vectors has advanced the functional genomics of TriMV, including virus-virus and virus-host interactions. NIa-Pro and CP, and P1 and NIa-Pro cistrons of TriMV are identified as elicitors of superinfection exclusion and determinants of synergistic interaction with WSMV, respectively. TriMV stably maintained P1 (1083 nts) plus NIa (1305 nts) cistrons of WSMV for more than 28 days postinoculation, suggesting that TriMV can be used as a stable gene expression vector in wheat. Because of the synchrony of the mites and viruses in this disease complex, primary management efforts should focus on the timing and presence of vector hosts. Importantly, an enhanced understanding of TriMV biology and its interactions with plants, mites, and WSMV will facilitate the development of effective tools to improve the sustainable management of the wheat-mite-virus complex.","PeriodicalId":94266,"journal":{"name":"Virology","volume":"603 ","pages":"110377"},"PeriodicalIF":0.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Respiratory viruses affecting health and performance in equine athletes. 影响马运动员健康和表现的呼吸道病毒。

Virology Pub Date : 2024-12-24 DOI: 10.1016/j.virol.2024.110372

Thibault Frippiat, Linda van den Wollenberg, Emmanuelle van Erck-Westergren, Kees van Maanen, Dominique-Marie Votion

{"title":"Respiratory viruses affecting health and performance in equine athletes.","authors":"Thibault Frippiat, Linda van den Wollenberg, Emmanuelle van Erck-Westergren, Kees van Maanen, Dominique-Marie Votion","doi":"10.1016/j.virol.2024.110372","DOIUrl":"https://doi.org/10.1016/j.virol.2024.110372","url":null,"abstract":"Some respiratory viruses can affect equine athletes, with acute respiratory clinical signs leading to a reduced ability to perform. The direct association between equine respiratory viruses and athletic performance is unclear in subclinically affected horses. This narrative review summarises the current evidence on respiratory viruses most commonly detected in performing horses, including equine herpesviruses, equine influenza virus, equine rhinitis viruses, equine arteritis virus, and equine adenovirus 1. It covers their virology, clinical manifestations, epidemiology, pathogenesis, diagnosis, and control measures, with a focus on their impact on performance. Molecular diagnostics on nasopharyngeal swabs are the preferred method for detecting equine respiratory viruses nowadays. Studies highlighted in this review reveal a high prevalence of equine herpesviruses -particularly gammaherpesviruses- in the airways of both healthy and diseased horses. In contrast, equine rhinitis A virus, equine arteritis virus, and equine adenovirus 1 are the least common viruses. Transportation contributes to spreading equine infectious diseases across countries and can temporarily weaken the immune system, increasing the risk of respiratory viral infections and reactivation of latent equine herpesviruses. Moreover, respiratory viral infections are frequently observed in young horses starting their training. Although there is limited evidence on the specific impact of equine respiratory viruses on performance, this review emphasises that vaccination and care management are essential strategies for limiting the spread and severity of outbreaks in sport horses.","PeriodicalId":94266,"journal":{"name":"Virology","volume":"603 ","pages":"110372"},"PeriodicalIF":0.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunogenicity of a multivalent protein subunit vaccine based on non-glycosylated RBD antigens of SARS-cov-2 and its variants. 基于SARS-cov-2及其变体非糖基化RBD抗原的多价蛋白亚单位疫苗的免疫原性

Virology Pub Date : 2024-12-24 DOI: 10.1016/j.virol.2024.110380

Berenice Calderón-Pérez, Leandro Alberto Núñez-Muñoz, Lady Laura Trejo-Ayala, Víctor Hugo Rosales-García, Benjamín Emmanuel Chávez-Álvarez, Brenda Yazmín Vargas-Hernández, José Abrahán Ramírez-Pool, Roberto Ruiz-Medrano, Beatriz Xoconostle-Cázares

{"title":"Immunogenicity of a multivalent protein subunit vaccine based on non-glycosylated RBD antigens of SARS-cov-2 and its variants.","authors":"Berenice Calderón-Pérez, Leandro Alberto Núñez-Muñoz, Lady Laura Trejo-Ayala, Víctor Hugo Rosales-García, Benjamín Emmanuel Chávez-Álvarez, Brenda Yazmín Vargas-Hernández, José Abrahán Ramírez-Pool, Roberto Ruiz-Medrano, Beatriz Xoconostle-Cázares","doi":"10.1016/j.virol.2024.110380","DOIUrl":"https://doi.org/10.1016/j.virol.2024.110380","url":null,"abstract":"COVID-19 infections continue due to accessibility barriers to vaccines and the emergence of SARS-CoV-2 variants. An effective, safe, accessible, and broad-spectrum vaccine is still needed to control the disease. We developed a multivalent protein subunit vaccine comprising antigens designed from a non-N-glycosylated region of the receptor-binding domain of the spike protein of SARS-CoV-2. We combined a previously developed antigen based on the Wuhan original viral strain, and a site-mutated antigen based on several variants including Alpha, Beta, Gamma, Eta, Iota, Theta, Zeta, Mu and Omicron. The recombinant antigens were expressed in a prokaryotic system and the immunogenicity of the multivalent vaccine was tested in a mouse model. The evaluation of the subunit vaccine candidate, incorporating different variant-based multivalent recombinant antigens from non-glycosylated regions of the RBD, demonstrated a favorable safety profile, significant immunogenicity, and potent neutralizing activity, collectively supporting its potential efficacy and safety for further development.","PeriodicalId":94266,"journal":{"name":"Virology","volume":"603 ","pages":"110380"},"PeriodicalIF":0.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting CCR5: A central approach to HIV treatment and cure strategies. 靶向CCR5：艾滋病毒治疗和治愈策略的核心方法。

Virology Pub Date : 2024-12-24 DOI: 10.1016/j.virol.2024.110375

Yunus Yukselten, Hanan Wishah, Jessica A Li, Richard E Sutton

引用次数: 0

N6-methyladenosine (m6A) modification: Emerging regulators in plant-virus interactions. N6-甲基腺苷（m6A）修饰：植物与病毒相互作用的新调节因子。

Virology Pub Date : 2024-12-24 DOI: 10.1016/j.virol.2024.110373

Yanjun Li, Jianping Chen, Zongtao Sun

引用次数: 0