Thomas J Perry, Bryan Cass, Ryan Ellis, Ali Khalifeh
{"title":"Heparin-Induced Thrombocytopenia With a False Negative Anti-PF4 Assay.","authors":"Thomas J Perry, Bryan Cass, Ryan Ellis, Ali Khalifeh","doi":"10.1177/15385744251395139","DOIUrl":"10.1177/15385744251395139","url":null,"abstract":"<p><p><b>Background:</b> Heparin-induced thrombocytopenia (HIT) is an acquired prothrombotic state from anti-heparin platelet-factor 4 (PF4) mediated activation of platelets. Anti-PF4 assay is used to screen for HIT due to high sensitivity and negative predictive value. <b>Case Report:</b> We present a 74-year-old male that had clinical HIT with false negative anti-PF4 and subsequently positive serotonin release assay (SRA). Delay in cessation of heparin led to recurrent limb thrombosis in the setting of multiple revascularization attempts with a poor outcome. <b>Conclusion:</b> We re-emphasize the importance of clinical presentation in management of patients with suspected HIT.</p>","PeriodicalId":94265,"journal":{"name":"Vascular and endovascular surgery","volume":" ","pages":"358-360"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145454502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Camila Esquetini-Vernon, Houssam Farres, Camilo Polania-Sandoval, Yetzali Claudio-Medina, Hennessy Morales-Arroyo, Charles Ritchie, Christopher Jacobs, Ricardo Paz-Fumagalli, Beau Toskich, Jonathan Vandenberg, Biraaj Mahajan, Young Erben
{"title":"Higher Risk for Morbidity and Non-Aortic Related Mortality in Type 2 Endoleak Patients Treated Outside of Instructions for Use.","authors":"Camila Esquetini-Vernon, Houssam Farres, Camilo Polania-Sandoval, Yetzali Claudio-Medina, Hennessy Morales-Arroyo, Charles Ritchie, Christopher Jacobs, Ricardo Paz-Fumagalli, Beau Toskich, Jonathan Vandenberg, Biraaj Mahajan, Young Erben","doi":"10.1177/15385744251395118","DOIUrl":"10.1177/15385744251395118","url":null,"abstract":"<p><p>ObjectiveTo evaluate outcomes in patients with type 2 endoleak (T2E) and the impact of treatment outside the device instructions for use (IFU).MethodsThis retrospective single-center study included abdominal aortic aneurysms (AAA) patients who underwent EVAR (2011- 2024). Primary outcomes were 30-day and mid-term complications, reintervention, and mortality by T2E status. Propensity score matching was applied and secondary analysis stratified outcomes by IFU compliance, comparing within (<sub>in</sub>IFU) or outside(<sub>out</sub>IFU) IFU in each T2E group.ResultsAmong 154 EVAR patients (137 men (89.1%) and 17 women (11.0%); mean age 77.5 ± 7.6 years), 77 were T2E(-), and 77 were T2E(+). Baseline characteristics were similar. Thirty-day complications were comparable (T2E(-): 5, 6.4% vs T2E(+): 2, 2.56%, <i>P</i> = 0.72). The mean follow-up duration was 2.7 ± 2.4 years. Sac diameter change (Δ) decreased in the T2E(-) (7.7 ± 8.4 mm) and enlarged in the T2E(+) (1.79 ± 12.5 mm; <i>P</i> < 0.01). Mid-term graft-related complications (T2E(-): 3, 3.8% vs T2E(+): 49, 62.8%, <i>P</i> < 0.01) and reinterventions (T2E(-): 3, 3.8%, vs T2E(+): 20, 25.6% <i>P</i> < 0.01) were higher in the T2E(+) with no difference in mortality (<i>P</i> = 1.00). These findings remained after excluding type 1 endoleaks. Among the T2E(+), those treated <sub>out</sub>IFU had longer hospital stays (<sub>out</sub>IFU: 3.0 ± 2.8 days vs <sub>in</sub>IFU: 1.8 ± 2.0 days, <i>P</i> = 0.03), higher T1E (<sub>out</sub>IFU: 3, 33.3% vs <sub>in</sub>IFU: 1, 4.34%, <i>P</i> < 0.01), higher rates of reintervention (<sub>out</sub>IFU: 9, 100.0% vs <sub>in</sub>IFU:17; 24.6%, <i>P</i> < 0.01) and higher all-cause mortality than those within IFU criteria (<sub>out</sub>IFU: 5, 55.0% vs <sub>in</sub>IFU: 13, 18.8%, <i>P</i> < 0.01). IFU status did not significantly affect outcomes in T2E(-) patients.ConclusionsT2E is associated with sac growth and increased reinterventions, but not higher mortality. On subgroup analysis, those T2E(+) treated <sub>out</sub>IFU had longer hospitalizations, higher T1E rates, more reinterventions, and higher all-cause; but not aneurysmal-related mortality.</p>","PeriodicalId":94265,"journal":{"name":"Vascular and endovascular surgery","volume":" ","pages":"297-308"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145423812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Second-Generation Hydrogel Coils for Transcatheter Arterial Embolization of Acute Arterial Bleeding in the Body Trunk.","authors":"Masashi Shimohira, Shuji Ikeda, Shinichi Ozaki, Toshinobu Saga, Yuta Nakano, Kyohei Takahata, Yuki Maruchi, Akiko Narita, Hiroaki Okada, Takahiro Yamamoto, Nozomu Matsunaga, Kojiro Suzuki","doi":"10.1177/15385744251409969","DOIUrl":"10.1177/15385744251409969","url":null,"abstract":"<p><p>IntroductionFirst-generation hydrogel coils have been shown to reduce the risk of recanalization due to their expansion properties. However, their clinical use has been limited by coil stiffness and time constraints for deployment. Recently developed second-generation hydrogel coils are softer and offer improved deliverability. This study aimed to evaluate their feasibility and effectiveness in transcatheter arterial embolization (TAE) for acute arterial bleeding in the body trunk.MethodsThis retrospective study included 24 TAE procedures performed in 23 patients (15 men, 8 women; median age, 72 years; range, 14-88 years) between March 2019 and November 2024. Indications for TAE included iatrogenic injury (n = 7), gastrointestinal bleeding (n = 5), trauma (n = 3), aneurysm rupture (n = 3), tumor invasion (n = 3), and others (n = 3). Second-generation hydrogel coils were used in all cases, comprising a median of 78% (range, 13-100%) of the total coil length. Technical success was defined as complete occlusion of the target artery on digital subtraction angiography. Clinical success was defined as the absence of rebleeding within 24 h of embolization.ResultsAnemia, hemorrhagic shock, and coagulopathy were present before TAE in 92% (22/24), 21% (5/24), and 25% (6/24) of procedures, respectively. The mean total coil length was 40 cm (range, 4-127 cm), and the mean procedure time was 111 min (range, 58-207 min). Both technical and clinical success rates were 100% (24/24). One complication (4%) occurred: transient liver dysfunction in a patient treated for hepatic artery bleeding.ConclusionsTAE using second-generation hydrogel coils showed high technical and clinical success rates, indicating that these coils may be a feasible and effective option for managing acute arterial hemorrhage in the body trunk.</p>","PeriodicalId":94265,"journal":{"name":"Vascular and endovascular surgery","volume":" ","pages":"376-381"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145795878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ye In Christopher Kwon, David T Zhu, S Ayesha Farooq, Robert Larson
{"title":"Primary Retroperitoneal Tumors Presenting as Ruptured Aneurysms.","authors":"Ye In Christopher Kwon, David T Zhu, S Ayesha Farooq, Robert Larson","doi":"10.1177/15385744251409950","DOIUrl":"10.1177/15385744251409950","url":null,"abstract":"<p><p>BackgroundRetroperitoneal tumors represent a variety of rare lesions that can arise either from solid organs (kidney, pancreas, adrenals) or less commonly the mesenchymal soft tissue. Depending on histologic subtype, these malignancies often have a variable clinical presentation and prognosis.Case presentationIn the current series, we present 2 cases: first, a patient with Stage 3 retroperitoneal sarcoma eroding the para-visceral aorta causing rupture; second, a kidney transplant recipient with non-Hodgkin's lymphoma presenting as a ruptured right hypogastric arterial aneurysm.ConclusionWe discuss the caveats and pitfalls in diagnosing and treating these complex tumors including clinical and radiographic presentation.</p>","PeriodicalId":94265,"journal":{"name":"Vascular and endovascular surgery","volume":" ","pages":"370-375"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145807040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Devrat Shah, Ioannis Tsouknidas, Kimberly M Feeney, Ricky T Tong, Henry Hirsch
{"title":"Blunt Abdominal Aortic Injury Managed Successfully With Endovascular Stent Graft.","authors":"Devrat Shah, Ioannis Tsouknidas, Kimberly M Feeney, Ricky T Tong, Henry Hirsch","doi":"10.1177/15385744251387575","DOIUrl":"10.1177/15385744251387575","url":null,"abstract":"<p><p>Blunt abdominal aortic injury has a low incidence and accounts for only 4-6% of aortic injuries. Both prognosis and management depend on the type and the severity of injury.A 23 year-old female patient presented after a high speed motor vehicle collision, with a focal dissection and a near complete occlusion of the distal aorta leading to acute limb ischemia, an unstable L1-L2 spinal fracture and a grade 3 liver laceration. An endovascular repair with an aortobiiliac stent graft was performed with resolution of her ischemic lower extremity pain. At 18 months follow-up visit, the aortoiliac axis was widely patent and the stent was intact.</p>","PeriodicalId":94265,"journal":{"name":"Vascular and endovascular surgery","volume":" ","pages":"283-287"},"PeriodicalIF":0.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of the Safety and Efficacy of Three Techniques for Coil Embolization of Splenic Artery Aneurysms: A Retrospective Single-Center Study.","authors":"Yekai Weng, Dehai Lang","doi":"10.1177/15385744251387768","DOIUrl":"10.1177/15385744251387768","url":null,"abstract":"<p><p>ObjectiveThe coil embolization is the most common endovascular intervention used to treat splenic artery aneurysms (SAAs) and this study aimed to analyze the safety and efficacy of 3 different coil embolization techniques.MethodsA retrospective study was conducted on 60 patients with SAAs who underwent endovascular intervention at Ningbo NO. 2 Hospital from November 2020 to November 2023. The coil embolization technique included Sac embolization (SE, <i>n</i> = 25), the isolation technique (IT, <i>n</i> = 23) and Stent-assisted coil embolization (SACE, <i>n</i> = 12). Perioperative and follow-up data were collected. The primary outcomes assessed were technical success and 30 day, 12 months, and 24 months survival rates. Secondary outcomes included major complications, early or later re-intervention, Post-embolization syndrome (PES) and freedom from end-organ ischemia.ResultsThe SAAs diameter in the SE group, the IT group and the SACE group were 21 mm (16-35), 21 mm (15-70) and 22.4 ± 2.4 mm, respectively. The technical success rate in the SE and SACE groups was 100%, while in the IT group was 95.7% (22/23). There were no significant differences between the 3 groups in terms of major complication (2/25 SE group, 2/23 IT group, 2/12 SACE group, <i>P</i> = 0.733), PES (4/25 SE group, 8/23 IT group, 1/12 SACE group, <i>P</i> = 0.178), or early re-intervention rates (1/25 SE group, 0/23 IT group, 1/12 SACE group, <i>P</i> = 0.675). The mean follow-up times for the 3 groups were 27.7 ± 10.5 months (SE group), 29.7 ± 9.1 months (IT group) and 22.8 ± 6.4 months (SACE group), respectively. Compared to the SE group, the risk of splenic infarction was higher in the IT group (0% vs 17.4%, <i>P</i> = 0.046). No splenic abscesses, Splenectomy, and late re-intervention occured in the cohort. The 30-day, 12-month, and 24-month mortality rates were 0. During the follow-up, 1 non-aneurysm-related death occured in the IT group (4.3%, 1/23) at 37 months postoperatively.ConclusionAll 3 coil embolization techniques, including the SE, the IT and the SACE, have a favorable safety and efficacy. The IT may have a higher risk of splenic infarction. For SAAs with different anatomical features, the preferred coil embolization technique may be different.</p>","PeriodicalId":94265,"journal":{"name":"Vascular and endovascular surgery","volume":" ","pages":"234-243"},"PeriodicalIF":0.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145350881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Louise Koskas, Steeve Doizi, Mohammad Zagzoog, Jean-Michel Davaine, Fabien Koskas
{"title":"Early and Mid-term Results From a Tertiary Care Center for Total Aortic Arch Replacement Using the Thoraflex Hybrid Graft.","authors":"Louise Koskas, Steeve Doizi, Mohammad Zagzoog, Jean-Michel Davaine, Fabien Koskas","doi":"10.1177/15385744251387766","DOIUrl":"10.1177/15385744251387766","url":null,"abstract":"<p><p>ObjectiveTo report the outcomes of the frozen elephant trunk (FET) technique for patients with chronic aortic dissection and thoracic aortic aneurysm.MethodsPatients undergoing the FET technique using the Vascutek Thoraflex hybrid graft for chronic aortic dissection and thoracic aortic aneurysm from 2013 to 2021 were included. Outcomes included mortality rates, peri-operative complications and aortic related re-interventions. Patients were categorised into aortic dissection and thoracic aortic aneurysm groups.Results39 patients were identified, of whom 56% (n = 22) had a thoracic aortic aneurysm and 44% (n = 17) chronic aortic dissection. Patients with aneurysm had a significantly higher rate of peripheral artery disease at baseline. A significant difference was found in in-hospital mortality rate (27% in patients presenting with aneurysm (n = 6) vs 0% (n = 0) in patients with dissection). Peri-operative complications were 2 (5%) post-operative strokes, 1 (3%) symptomatic spinal cord ischemia, 2 (5%) lower limb ischemia and 4 (10%) ischemic colitis. The median follow-up was 14.8 (2.9-46.5) months. During follow up, mortality from all cause was 18% (n = 7), and aortic re-intervention rate 18% (n = 7) after 39.4 (19.8-45.5) months.ConclusionsThe FET technique is a good therapeutic option for aortic disease of the aortic arch and proximal descending aorta. While the postoperative outcome was acceptable given the high mortality rates of such disease and their treatment, outcomes were better among patients presenting with aortic dissection, particularly in terms of peri-operative mortality.</p>","PeriodicalId":94265,"journal":{"name":"Vascular and endovascular surgery","volume":" ","pages":"224-233"},"PeriodicalIF":0.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145294748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kishan Karia, Ahmad Al-Rekabi, Melanie Suseeharan, Rahul Bahl, Mohamad Hamady
{"title":"The Use of Pressure Indices, Such as Fractional Flow Reserve, in Peripheral Arterial Disease-A Review of Current Literature and Potential Prospects.","authors":"Kishan Karia, Ahmad Al-Rekabi, Melanie Suseeharan, Rahul Bahl, Mohamad Hamady","doi":"10.1177/15385744251394835","DOIUrl":"10.1177/15385744251394835","url":null,"abstract":"<p><p>PurposeTo assess the evidence in the current literature, identify the knowledge gaps and propose future standards for the use of pressure indices in peripheral arterial disease (PAD).MethodsA search of all medical databases was performed to identify studies performed between 01/01/2000 and 31/12/2024, looking at the use of FFR or IFR in the management of PAD. The Newcastle-Ottawa scale was used to assess the quality of the papers. A comparison of the studies was performed using various parameters including; study design, cohort demographics, aim, lesions treated, hyperaemic agent used/pressure indices utilised, FFR endpoint and clinical outcomes.Results136 studies were found in initial search. Only studies investigating FFR were identified, none looked at IFR. Following the application of the exclusion criteria, 8 relevant studies with a total of 247 patients were included in the final analyses. No randomised controlled or prospective trials were found. Significant heterogeneity was observed in the methodology and data collection among the included papers. Despite this, the analysis demonstrated initial evidence showing the potential of pressure measurements to revolutionise diagnostic, intra-procedural and prognostic decisions in PAD, akin to the data that already exists in coronary artery disease.ConclusionsFurther standardised research of FFR is needed in peripheral vascular disease to improve objective understanding of physiological parameters pre and post-treatment. To this end, a standardisation tool has been proposed to homogenise and aid future research in drawing more robust conclusions for the use of pressure indices in PAD.</p>","PeriodicalId":94265,"journal":{"name":"Vascular and endovascular surgery","volume":" ","pages":"271-282"},"PeriodicalIF":0.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12916854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145558839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Prathyusha Nagineti, James Walmsley, Thawwab Mohideen, Matthew Allen, Daniel Manners, Devender Mittapalli
{"title":"Cerament® Bone Void Filler in Vascular Patients With Calcaneal Osteomyelitis: Outcomes From a Prospective Case Series.","authors":"Prathyusha Nagineti, James Walmsley, Thawwab Mohideen, Matthew Allen, Daniel Manners, Devender Mittapalli","doi":"10.1177/15385744251387555","DOIUrl":"10.1177/15385744251387555","url":null,"abstract":"<p><p>ObjectiveCerament® bone void filler combined with an antimicrobial agent has been shown to be effective in both reducing post operative infections and the treatment of osteomyelitis in orthopaedic surgery. Patients under the care of vascular surgery have significant co-morbidities with a mixture of lower limb arterial insufficiency and poor wound healing secondary to diabetes. Conventional management for heel ulcers relies on the improvement of distal blood flow, debridement of infected tissue and antibiotic therapy, though many patients fail to improve with these measures. The purpose of this case series was to report the outcomes of Cerament® G and V in vascular patients who have not responded to conventional treatments.MethodsConsecutive patients with heel ulceration and osteomyelitis secondary to peripheral vascular disease and/or diabetic complications were included and followed up for a median duration of 8 months. Patients underwent a single application of Cerament® G or V to the calcaneal body and debridement. Outcomes included improvement in ulceration, repeat surgical intervention, amputation rate, further anti-microbial therapy, and impact on mobility.ResultsAfter exclusion of two patients due to death and major limb amputation during index admission, 20 patients were included in the study with a median age of 76 years (range 49-87), of which 70% were males. 14 patients (70%) had improvement in their ulcer appearance at follow up. 4 patients (20%) required repeat Cerament® and 4 patients (20%) required lower limb amputation. 3 (15.0%) patients required further course of anti-microbial treatment. Mobility was improved in 5 patients (25%, <i>P</i> < 0.01).ConclusionIn this case series of high-risk vascular patients, single-stage application of Cerament® for heel ulcers with calcaneal osteomyelitis was associated with improvement of ulcer healing, limb preservation, and improved mobility. Further randomized, controlled studies are needed to confirm efficacy in comparison to standard therapy.</p>","PeriodicalId":94265,"journal":{"name":"Vascular and endovascular surgery","volume":" ","pages":"209-215"},"PeriodicalIF":0.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145369385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lauren Carmon, Ashley A Peters, Nora Laban, Kelly Langert, Kristopher G Maier, Vivian Gahtan
{"title":"Part I: Acute Lower Limb Ischemia-Reperfusion Injury: Pathophysiology and Experimental Interventions.","authors":"Lauren Carmon, Ashley A Peters, Nora Laban, Kelly Langert, Kristopher G Maier, Vivian Gahtan","doi":"10.1177/15385744251387771","DOIUrl":"10.1177/15385744251387771","url":null,"abstract":"<p><p><b>Background:</b> Ischemia-reperfusion injury (IRI) secondary to acute limb ischemia is a complex clinical phenomenon induced by a variety of pathologies, including arterial embolization, arterial thrombosis, vascular trauma, advanced peripheral vascular disease, traumatic crush injuries, and/or prolonged tourniquet application. The restoration of blood flow and oxygen to the limb after an ischemic period, while necessary, is ultimately the driving force of IRI. The exaggerated inflammation, oxidative stress, and tissue damage caused by IRI often lead to limb dysfunction, limb loss, multi-organ failure, and/or death. While no gold-standard therapy currently exists, various in vitro and in vivo models have been developed to explore potential therapeutic strategies. Currently, pharmacological agents with anti-inflammatory and/or antioxidant properties, as well as non-pharmacological strategies, have been investigated, and some agents show promise in mitigating the effects of lower extremity ischemia-reperfusion injury (IRI). <b>Purpose:</b> In this review article, we provide a comprehensive overview of the pathophysiology of IRI, discuss the local and systemic effects of IRI, and examine the experimental models used to investigate IRI. We also outline the current in vitro and in vivo pharmacological and non-pharmacological interventions studied to reduce IRI.</p>","PeriodicalId":94265,"journal":{"name":"Vascular and endovascular surgery","volume":" ","pages":"255-270"},"PeriodicalIF":0.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145370556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}