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The Ulster medical journal最新文献

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First use of Bedaquiline, Linezolid, and Pretomanid (BPaL) in a family cluster of multi-drug resistant (MDR) TB infection. 贝达喹啉、利奈唑胺和普雷托马尼（BPaL）在多药耐药（MDR）结核感染家庭聚集性病例中的首次使用。
The Ulster medical journal Pub Date : 2024-12-01 Epub Date: 2024-12-11
Marcus Pratt, Mark McNicol, Michael Hunter, Martin Dedicoat
{"title":"First use of Bedaquiline, Linezolid, and Pretomanid (BPaL) in a family cluster of multi-drug resistant (MDR) TB infection.","authors":"Marcus Pratt, Mark McNicol, Michael Hunter, Martin Dedicoat","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":94250,"journal":{"name":"The Ulster medical journal","volume":"93 2","pages":"55-57"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Northern Ireland Healthcare Crisis. 北爱尔兰医疗保健危机。
The Ulster medical journal Pub Date : 2024-12-01 Epub Date: 2024-12-11
{"title":"Northern Ireland Healthcare Crisis.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":94250,"journal":{"name":"The Ulster medical journal","volume":"93 2","pages":"47"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633311/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
WHAT'S IN A NAME? DECIPHERING THE TAXONOMY OF BACTERIA, FUNGI AND PARASITES CAUSING INFECTION. 名字里有什么？破译引起感染的细菌、真菌和寄生虫的分类。
The Ulster medical journal Pub Date : 2024-12-01 Epub Date: 2024-12-11
J E Moore, B C Millar
{"title":"WHAT'S IN A NAME? DECIPHERING THE TAXONOMY OF BACTERIA, FUNGI AND PARASITES CAUSING INFECTION.","authors":"J E Moore, B C Millar","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":94250,"journal":{"name":"The Ulster medical journal","volume":"93 2","pages":"96"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ethics - A matter of principle? 伦理——原则问题？
The Ulster medical journal Pub Date : 2024-12-01 Epub Date: 2024-12-11
Michael Trimble
{"title":"Ethics - A matter of principle?","authors":"Michael Trimble","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Discussion of bioethical issues using the four principles approach proposed by Beauchamp and Childress is now standard practice in the UK. This paper first documents the history of principlism before considering its impact and reviewing some criticisms of the approach. A future paper will examine some of the philosophical difficulties arising from principlism in greater depth.</p>","PeriodicalId":94250,"journal":{"name":"The Ulster medical journal","volume":"93 2","pages":"83-86"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ethics - A matter of principle?Part 2: Rationality, ends, and the levels of moral discourse. 道德--原则问题？第 2 部分：理性、目的和道德论述的层次。
The Ulster medical journal Pub Date : 2024-11-01 Epub Date: 2024-11-26
Michael Trimble
{"title":"Ethics - A matter of principle?Part 2: Rationality, ends, and the levels of moral discourse.","authors":"Michael Trimble","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Discussion of bioethical issues using four principles approach proposed by Beauchamp and Childress is now standard practice in the UK. An earlier paper documented the history of principlism before considering its impact and reviewing some criticisms of the approach. This paper will examine some of the philosophical difficulties in greater depth. A particular concern is that principlism leads to <i>thin</i> debate with consideration of means without due concern regarding their intended ends.</p>","PeriodicalId":94250,"journal":{"name":"The Ulster medical journal","volume":"93 3","pages":"127-130"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11591212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quaerere Verum. Quaerere Verum.
The Ulster medical journal Pub Date : 2024-11-01 Epub Date: 2024-11-26
David J Armstrong
{"title":"Quaerere Verum.","authors":"David J Armstrong","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":94250,"journal":{"name":"The Ulster medical journal","volume":"93 3","pages":"97-99"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11591217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integration of genomic medicine to mainstream patient care within the UK National Health Service. 将基因组医学纳入英国国民健康服务的病人护理主流。
The Ulster medical journal Pub Date : 2024-11-01 Epub Date: 2024-11-26
Anhukrisha Karthikeyan, Shane McKee, Gareth J McKay
{"title":"Integration of genomic medicine to mainstream patient care within the UK National Health Service.","authors":"Anhukrisha Karthikeyan, Shane McKee, Gareth J McKay","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The integration of genomic medicine within mainstream patient care promises advances in healthcare and potential benefits for disease prediction and personalised treatment approaches. This paper explores the challenges of integrating genomic medicine within the UK's National Health Service (NHS) and potential solutions for alignment with the NHS's proposed long-term plan and Genome UK strategy. Critical challenges and knowledge gaps have been identified, including a referral-dependent system, unclear eligibility criteria, lack of policies and guidelines, gaps in clinical genomic competence, genomic sequencing costs, equity issues for genomic testing access across the UK, and data management and patient privacy concerns. Proposed solutions and future directions include extending genetic test ordering authority to include mainstream clinicians and establishing unambiguous eligibility criteria, policies and guidelines through a developing trained workforce and appropriate patient engagement. Moreover, expanded Whole Genome Sequencing (WGS) and pharmacogenomic testing approaches through up-scaling genomic sequencing capacity and standardising genetic testing across the UK will lower consumable costs. Leveraging artificial intelligence (AI) and data warehousing approaches will improve data management, particularly in the context of integration within electronic health records. In summary, the successful integration of genomic medicine within mainstream patient care holds transformative potential for healthcare provision. By recognising the challenges identified and embracing the proposed solutions, healthcare systems can revolutionise patient outcomes, advancing precision medicine and shaping the future of genomic-driven healthcare.</p>","PeriodicalId":94250,"journal":{"name":"The Ulster medical journal","volume":"93 3","pages":"111-118"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11591220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Ten Year Review Of Management And Outcomes Of Retroperitoneal Sarcoma: A Retrospective Cohort Study. 腹膜后肉瘤管理与疗效十年回顾：回顾性队列研究
The Ulster medical journal Pub Date : 2024-11-01 Epub Date: 2024-11-26
Nicola McKinley, Rebekah Wilson, Ryan Huddleston, Ray Kennedy, Julie Reid
{"title":"A Ten Year Review Of Management And Outcomes Of Retroperitoneal Sarcoma: A Retrospective Cohort Study.","authors":"Nicola McKinley, Rebekah Wilson, Ryan Huddleston, Ray Kennedy, Julie Reid","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Retroperitoneal sarcomas (RPS) are a heterogeneous group of rare tumours that require complex surgical management with outcomes tightly correlated to quality of surgery.This study aimed to examine the determine patient demographics, treatment approaches and outcomes for patients with primary RPS in this single center during the period 2010-2021.</p><p><strong>Methods: </strong>All patients diagnosed with RPS from 2010 to 2021 that underwent surgical resection in a single trust in Northern Ireland were identified. Data was collated using histopathology records, electronic care records and retrospective chart review.</p><p><strong>Results: </strong>Fifty-four resections were performed for RPS in a 10 year period. 30 day mortality rate was 3.7%, in-hospital mortality was 1.9% and 90 day mortality was 7.4%. 11.1% of patients were recorded as having a severe postoperative adverse event. 90.4% patients achieved an R0/R1 resection. The 1, 3, and 5-year overall survival were 80% [95% confidence interval (CI) 67-89), 69% (95% CI 53-79), and 62% (95% CI 48-75). The 1 and 5-year crude-cumulative-incidence (CCI) for local recurrence were 32% (95%CI 20, 46) and 55% (95%CI 32,77). 1 and 5-year CCI for distant metastases were 11% (95%CI 4, 23) and 35% (95%CI 15,59). Median overall survival was 6.3 years (IQR 5.0-7.6).</p><p><strong>Conclusion: </strong>Survival outcomes in this LVH are similar to those reported by a number of HVHs worldwide, with an additional low rate of severe postoperative complication. Given that there are only between 250 and 300 new diagnoses of retroperitoneal sarcoma (RPS) in the UK each year prospective data collection and participation in multi-institution studies, specifically a UK collaboration, is critical to expand upon current knowledge and further improve management, outcomes and follow-up of patients with this rare and complex surgical disease.</p>","PeriodicalId":94250,"journal":{"name":"The Ulster medical journal","volume":"93 3","pages":"100-104"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11591214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ulster Medical Society Lecture Programme 2024-2025. 阿尔斯特医学会 2024-2025 年讲座计划。
The Ulster medical journal Pub Date : 2024-11-01 Epub Date: 2024-11-26
Mark Vignesha Roberts
{"title":"Ulster Medical Society Lecture Programme 2024-2025.","authors":"Mark Vignesha Roberts","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":94250,"journal":{"name":"The Ulster medical journal","volume":"93 3","pages":"99"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11591216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simulate to stimulate? A systematic review of stress, learning, and performance in healthcare simulation. 模拟刺激？对医疗模拟中的压力、学习和表现进行系统回顾。
The Ulster medical journal Pub Date : 2024-11-01 Epub Date: 2024-11-26
Aaron Vage, Andrew D Spence, Gary McKeown, Gerard J Gormley, Paul K Hamilton
{"title":"Simulate to stimulate? A systematic review of stress, learning, and performance in healthcare simulation.","authors":"Aaron Vage, Andrew D Spence, Gary McKeown, Gerard J Gormley, Paul K Hamilton","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In recent years, simulation has come to prominence as an educational method within the healthcare professions, aiming to shield learners from real-world consequences. However, the associated risks of this educational method have largely remained unaddressed. One of the most potent risks of simulation is felt to be the experience of psychological stress. Over the last two decades, researchers have suggested that an increase in simulation-related stress goes hand-in-hand with diminishing performance, but the evidence base for this claim is lacking. A medical educator thus has no robust scientific steering on which to gauge how 'hard to push' a trainee in a simulation environment to best assist their learning. In this review we systematically analyse the literature to further understand the impact of simulation-related stress on learner performance and report that inducing a high-stress environment during simulation is generally associated with impaired performance.</p>","PeriodicalId":94250,"journal":{"name":"The Ulster medical journal","volume":"93 3","pages":"119-126"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11591218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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