The International journal of periodontics & restorative dentistry最新文献

{"title":"Exosome-Mediated Alveolar Ridge Augmentation: A First Human Case Report with Histology.","authors":"Nathan Estrin, Nima Farshidfar, Paras Ahmad, Scott Froum, Marco Antonio Castro Pinto, Yufeng Zhang, Richard J Miron","doi":"10.11607/prd.7567","DOIUrl":"https://doi.org/10.11607/prd.7567","url":null,"abstract":"<p><p>Exosomes, the smallest subset of extracellular vesicles, play a crucial role in cell signaling and communication throughout the body. Their regenerative potential has sparked tremendous interest, with over 5,000 articles on exosomes being published yearly, primarily focused on invitro and pre-clinical studies. However, to date, no study has investigated their use in humans for dental applications. In this first case report, horizontal ridge augmentation was performed utilizing a novel combination of bone allografts, platelet-rich fibrin (PRF), and a specialized subset of exosomes (Periosomes). Implants were placed at 3 months post-surgery, during which a core biopsy was taken for histological analysis. Additionally, cone-beam computed tomography (CBCT) scans were obtained at 1, 2, 3, and 6 months, revealing marked and progressive bone growth. To our knowledge, this study represents the first documented use of exosomes in human alveolar bone regeneration. This case highlights the promising potential of exosomes in regenerative dentistry, opening new avenues for their application in guided bone regeneration procedures.</p>","PeriodicalId":94231,"journal":{"name":"The International journal of periodontics & restorative dentistry","volume":"0 0","pages":"1-20"},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143576083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of External Cervical Resorption via Surgical Crown Lengthening and Concomitant Placement of a Resin Modified Glass Ionomer Restoration: A Case Series a 1-4 Year Follow Up.","authors":"Adam S Goldberg, David A Goldberg, Paul S Rosen","doi":"10.11607/prd.7452","DOIUrl":"https://doi.org/10.11607/prd.7452","url":null,"abstract":"<p><p>External cervical resorption is a disease entity with an idiopathic etiology by which osteoclastic invasion cavitates teeth near the cemento-enamel junction. The lesion, if left untreated, has the potential to progress and compromise tooth maintainability. Treatment of these lesions requires access, often surgical, removal of the affected tissue, and placement of a restorative material. This case series documents 10 external cervical resorption lesions that were treated by surgical crown lengthening with concurrent placement of a resin modified glass ionomer restoration and followed for a period ranging from July 2020 to July 2024. This case series offers evidence that external cervical resorption can be treated with a high expectancty of tooth survival. Longer term follow-up will be needed to see if this treatment remains stable and predictable.</p>","PeriodicalId":94231,"journal":{"name":"The International journal of periodontics & restorative dentistry","volume":"0 0","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143576086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D-Printed Surgical Template 'Mucoguide' to Increase Predictability in Mucogingival Surgery: Technical Note and Case Report.","authors":"Federico Rivara, Luca Toselli","doi":"10.11607/prd.7453","DOIUrl":"https://doi.org/10.11607/prd.7453","url":null,"abstract":"<p><strong>Background: </strong>Mucogingival surgery is reliable technique to treat both functional and esthetic issues on teeth. In particular, the treatment success of gingival recessions depends on flap design. An inaccurate flap design could lead to surgical failure. For this reason, a new software-guided tool to design and perform mucogingival incisions was proposed.</p><p><strong>Methods: </strong>After the definition of the flap design according to the mucogingival technique, a template is designed to allow the clinician to guide the mucogingival flap in terms of position of the incision lines and blade inclination. The guide also incorporated the palatal box collect a connective tissue graft. The printed guide is stabilized teeth support and the 45-degree inclination of the edges allows to realize a beveled incision following the flap design. Afterwards the guide is removed and the surgery is completed with papillae de-epithelialization, connective tissue grafting and flap closure.</p><p><strong>Results: </strong>At 12 months both sites resulted in successful coverage according to the planning.</p><p><strong>Conclusions: </strong>In order to minimize surgical failures related to a poor flap design, a new digital tool was proposed to transfer flap design from the screen to the surgical field reducing surgical time and mistakes that could lead to a negative outcome.</p>","PeriodicalId":94231,"journal":{"name":"The International journal of periodontics & restorative dentistry","volume":"0 0","pages":"1-17"},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143576082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timing of Implant Placement in Esthetic Area: Diagnostic Algorithm for Clinical Decision Making.","authors":"Matteo Antonio Deflorian, Fabio Galli, Riccardo Scaini, Enrico Maria Strappa, Tiziano Testori","doi":"10.11607/prd.7541","DOIUrl":"https://doi.org/10.11607/prd.7541","url":null,"abstract":"<p><p>Immediate implant placement in esthetic area is a challenging surgical procedure. In the anterior maxilla, the esthetic outcome and the tissues stability over time is highly emphasized. A thorough preoperative analysis of the local site anatomy is essential to choose the most suitable surgical and prosthetic protocol. Due to the heterogenous data from the literature, a diagnostic algorithm was developed to assist the clinician in the decision-making process for single-tooth implant rehabilitation in the anterior maxilla. The treatment options were based on the predictability of implant primary stability, integrity of the buccal bone wall, gingival phenotype, and absence or presence of gingival recessions. Within its limitations, this approach may reduce the incidence of complications and failures.</p>","PeriodicalId":94231,"journal":{"name":"The International journal of periodontics & restorative dentistry","volume":"0 0","pages":"1-35"},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143576085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Stable and Successfully Treated Periodontitis Subjects-A Service Evaluation of a Single Hospital Centre.","authors":"Varkha Rattu, Luigi Nibali","doi":"10.11607/prd.7565","DOIUrl":"https://doi.org/10.11607/prd.7565","url":null,"abstract":"<p><strong>Aims: </strong>To identify the 1) prevalence of meeting the endpoints of 'stable periodontitis' (probing pocket depth (PPD) ≤4mm, bleeding on probing (BoP) <10%, no BoP at 4mm sites), 'endpoints of therapy' (no PPD >4mm with BoP, no PPD ≥6mm), 'controlled periodontitis' (≤4 sites with PPD ≥5mm), 'PPD <5mm' and 'PPD <6mm' at the start of supportive periodontal care (SPC) and 2) identify any variables which may affect endpoint achievement.</p><p><strong>Materials and methods: </strong>This service evaluation evaluated consecutive patients entering SPC between 2020 and 2022 at Guy's Hospital, London. Data collected included periodontal parameters (PPD, FMPS, FMBS) at baseline and their final active periodontal treatment (APT) visit and were analysed using SPSS 29.0 for descriptive and quantitative statistics. Logistic regressions utilised univariable and multivariable models to examine associations between clinical variables and outcomes.</p><p><strong>Results: </strong>This analysis included 141 subjects (mean age 45.4 ± 1.1 years; 64.5% female; 58.9% Caucasian). Most subjects had generalised Stage III/IV periodontitis (93.6%). At SPC entry, 12.77% of subjects exhibited stable periodontitis, and 48.23% met the endpoints of therapy. Relative percentage changes from baseline to end of APT in achieving stable periodontitis/ endpoints of therapy in teeth were as follows: all teeth (66.25% / 90.97%), anteriors (81.75% / 97.12%), premolars (74.20% / 94.69%), and molars (52.40% / 86.01%). Regression analyses confirmed associations between age and disease extent with endpoints but explained limited variance (R² ≤ 0.267).</p><p><strong>Conclusions: </strong>Periodontal treatment significantly improved clinical parameters at site and tooth-level, though molars demonstrated lower endpoint achievement highlighting localised treatment challenges. Age and disease extent influenced outcomes, but predictor variables explained only modest variance, highlighting the complexity of achieving therapeutic success in periodontitis management.</p>","PeriodicalId":94231,"journal":{"name":"The International journal of periodontics & restorative dentistry","volume":"0 0","pages":"1-23"},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143576084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Xenograft Combined with a Mixture of Polynucleotides and Hyaluronic Acid (PN-HA) for Horizontal Alveolar Bone Regeneration: Clinical and Histologic Assessments in a Case Series.","authors":"Mario Beretta, Mattia Manfredini, Claudia Paola Bruna Dellavia, Gaia Pellegrini, Carlo Maiorana, Pier Paolo Poli","doi":"10.11607/prd.7042","DOIUrl":"10.11607/prd.7042","url":null,"abstract":"<p><p>The present case series aims to investigate the use of polynucleotides mixed with hyaluronic acid (PN-HA) in a gel form to promote bone regeneration in horizontal alveolar defects. Overall, six adult patients underwent localized horizontal guided bone regeneration by means of xenogeneic bone substitute and a resorbable barrier with a staged approach. The graft was a mixture of deproteinized bovine bone mineral (DBBM) particles and PN-HA gel in a 3:1 ratio, respectively. The material was covered by a resorbable collagen membrane fixed with pins to the underlying bone. Implant placement was performed after 5 months. Healing proceeded uneventfully, and, upon reentry, the graft appeared well vascularized and firmly attached to the recipient bone. Histologically, the regenerated bone appeared highly mineralized and well-organized in lamellae, and the residual biomaterial granules were completely embedded. Histomorphometric evaluations revealed that newly formed boneoccupied an average of 41.2% ± 12.4% of the analyzed samples. Linear measurements performed on CBCT scans yielded an overall linear horizontal bone gain of 4.91 ± 0.88 mm. These data suggest that a mixture of DBBM and PN-HA can be safely used to promote bone regeneration in cases of horizontal alveolar defects.</p>","PeriodicalId":94231,"journal":{"name":"The International journal of periodontics & restorative dentistry","volume":"0 0","pages":"209-219"},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139743029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Risks Behind Fixed Retainers After Orthodontic Treatment.","authors":"Rafi Romano, Lihi Keren","doi":"10.11607/prd.7083","DOIUrl":"10.11607/prd.7083","url":null,"abstract":"<p><p>Bonded fixed retainers are frequently used nowadays as the main-and often the only-retention protocol after orthodontic treatment. The expectations for long-lasting lifetime stability of the occlusion led orthodontists to seek the ultimate retention protocol with minimal patient compliance, including fixed retainers. However, fixed retainers have many disadvantages and risks that should be considered in advance. Different failures of fixed retainers are described and categorized, and the workflow for the retreatment of poor occlusion after relapse, despite the fixed retainers, is described. Three case presentations (open bite, root movement, and maxillomandibular protrusion) are described, and all received clear aligner treatment. A revised retention protocol is suggested.</p>","PeriodicalId":94231,"journal":{"name":"The International journal of periodontics & restorative dentistry","volume":"0 0","pages":"263-275"},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141185074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immediate Implant Placement in the Esthetic Area Using an Inverted Body-Shift Design: A Prospective Clinical Pilot Study.","authors":"Andrea Galve-Huertas, Erika Brancacci, Susana García-González, Octavi Ortíz-Puigpelat, Federico Hernández-Alfaro, Samir Aboul-Hosn Centenero","doi":"10.11607/prd.7109","DOIUrl":"10.11607/prd.7109","url":null,"abstract":"<p><p>A prospective clinical pilot study was carried out to evaluate a novel macroimplant design with a 12-degree angled platform. Twelve patients were enrolled in an immediate implant placement procedure with immediate esthetic rehabilitation to replace an anterior maxillary tooth and were treated with implants having an inverted body-shift design with a 12-degree angled neck. Only type I sockets (according to the Elian classification) were considered eligible for the study. The implant was placed at the center of the socket to optimize the alveolar bone and idealize the prosthetic emergence profile. There were no implant failures after 1 year of loading. Regarding the horizontal and vertical hard tissue changes, there was a statistically significant median overall horizontal change of -0.99 mm at 1 mm and -0.61 mm at 3 mm. On the other hand, outcomes were stable at 5 mm, and there was no statistical significance. The median pink esthetic score at the 1-year follow-up was 11.5. This implant may be useful in immediate tooth replacement at maxillary anterior postextraction sockets. Nevertheless, comparative studies with conventional implants should be performed.</p>","PeriodicalId":94231,"journal":{"name":"The International journal of periodontics & restorative dentistry","volume":"0 0","pages":"221-237"},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140878311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"25 Years of Minimally Invasive Surgery and Biologics in Regenerative Periodontal Therapy.","authors":"Giulio Rasperini, Gustavo Avila-Ortiz, Giorgio Pagni, William V Giannobile","doi":"10.11607/prd.2025.2.c","DOIUrl":"https://doi.org/10.11607/prd.2025.2.c","url":null,"abstract":"","PeriodicalId":94231,"journal":{"name":"The International journal of periodontics & restorative dentistry","volume":"45 2","pages":"146-151"},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrolytic Surface Decontamination in the Reconstructive Therapy of Peri-implantitis: Single-Center Outcomes.","authors":"Alberto Monje, Ramón Pons, Pedro Peña","doi":"10.11607/prd.7151","DOIUrl":"10.11607/prd.7151","url":null,"abstract":"<p><p>Surface decontamination in the reconstructive therapy of peri-implantitis is of paramount importance to achieve favorable outcomes. The objective of this single-center study, derived from a large multicenter clinical trial, was to analyze the electrolytic method (EM) as an adjunct to mechanical decontamination and compare it to hydrogen peroxide (HP), also used as an adjunct to mechanical decontamination, in the reconstructive therapy of peri-implantitis. At the 12-month follow-up (T2), 19 patients (n = 23 implants) completed the study. None of the tested modalities demonstrated superiority in the assessed clinical parameters. Only mucosal recession showed higher stability in the EM group. Similarly, radiographic marginal bone level gain and defect angle changes at T2 did not differ between the evaluated strategies. Notably, disease resolution was ~16% higher for the EM group; however, differences were not statistically significant. Additionally, it was demonstrated that pocket depth and the intrabony component depth at baseline were predictors of disease resolution. EM combined with mechanical instrumentation results in a safe and effective surface decontamination modality in the reconstructive therapy of peri-implantitis. This strategy resulted in a disease resolution rate of ~91%.</p>","PeriodicalId":94231,"journal":{"name":"The International journal of periodontics & restorative dentistry","volume":"0 0","pages":"185-198"},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141185065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}