The Canadian journal of hospital pharmacy最新文献

{"title":"Unsolicited Email and Predatory Solicitations: A Retrospective Case Study of a Canadian Hospital Pharmacist and the Tip of a Larger Iceberg.","authors":"Juliette Mutin, Victor El-Jammal, Armand Lebel, Jean-François Bussières","doi":"10.4212/cjhp.3863","DOIUrl":"https://doi.org/10.4212/cjhp.3863","url":null,"abstract":"<p><strong>Background: </strong>Open access publishing has broadened research dissemination, but it has also enabled the rise of predatory journals and conferences, posing challenges for health care professionals, including pharmacists.</p><p><strong>Objectives: </strong>To analyze unsolicited professional emails received by a hospital pharmacist and to characterize potentially predatory solicitations.</p><p><strong>Methods: </strong>All email messages received over a 31-day period in 2024 by a senior Canadian hospital pharmacist involved in research were reviewed and assessed according to 12 indicators of predation, including false impact factors, suggestion to submit manuscript by email, flattery, solicitation for an unrelated field, and short deadlines.</p><p><strong>Results: </strong>Of 1228 emails received over the study period, 453 (37%) contained at least one predatory indicator, with a total of 494 distinct solicitations: 347 (70%) for manuscript submission, 116 (24%) for conference attendance, 15 (3%) for republication of a previously published article, 11 (2%) for peer review, and 5 (1%) for webinar participation. The emails contained an average of 3.6 (standard deviation 1.7) indicators.</p><p><strong>Conclusions: </strong>One-third of the emails received were predatory in nature, highlighting the scale of the phenomenon.</p>","PeriodicalId":94225,"journal":{"name":"The Canadian journal of hospital pharmacy","volume":"79 2","pages":"e3863"},"PeriodicalIF":0.0,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13048768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial Administration Delays for Patients with Suspected Sepsis in a Canadian Emergency Department: Prevalence and Risk Factors.","authors":"Kristin Kaupp, Sarah Smit, Sarah Burgess, Emily Black, Osama Loubani, Meghan MacKenzie","doi":"10.4212/cjhp.3830","DOIUrl":"https://doi.org/10.4212/cjhp.3830","url":null,"abstract":"<p><strong>Background: </strong>For patients with sepsis, timely administration of antimicrobials is imperative, with evidence demonstrating that delays may be associated with an increase in mortality.</p><p><strong>Objective: </strong>To determine whether antimicrobial administration is delayed among patients with sepsis admitted through the Queen Elizabeth II Health Sciences Centre Emergency Department (QEII-HSC-ED) in Halifax, Nova Scotia.</p><p><strong>Methods: </strong>A single-centre, retrospective health records review was conducted for adult patients with sepsis admitted through the QEII-HSC-ED between January 1, 2021, and December 31, 2022. Differences between groups with and without antimicrobial administration delays were compared by univariate analysis, and an adjusted multivariate regression was completed to examine associations between risk factors and significant delays.</p><p><strong>Results: </strong>A total of 275 patient encounters were included in the analysis, accounting for a total of 1208 antimicrobial doses: 275 first doses and 933 subsequent doses. Of the 275 patient encounters, 216 (78.5%) had at least one significant dose delay; 135 (49.1%) of the encounters had delay of the first dose, and 169 (61.5%) had delay of a subsequent dose. Of the 933 subsequent doses administered, 276 (29.6%) had a significant delay. Relative to patients admitted to a medicine service, surgical patients had reduced odds of experiencing significant delay of a subsequent dose (odds ratio 0.25, 95% confidence interval 0.08-0.77).</p><p><strong>Conclusions: </strong>Many patients with sepsis admitted through the QEII-HSC-ED experienced significant delays in administration of first and/or subsequent doses of antimicrobial therapy, which may have increased their risk of negative outcomes. These results can be used to develop future initiatives aimed at improving time to administration of antimicrobials for patients with sepsis admitted to the study institution.</p>","PeriodicalId":94225,"journal":{"name":"The Canadian journal of hospital pharmacy","volume":"79 2","pages":"e3830"},"PeriodicalIF":0.0,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13048766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypomagnesemia Associated with Omeprazole Use in Patients Treated with Platinum Derivatives: An Exploratory Randomized Placebo-Controlled Clinical Trial.","authors":"Ney Moura Lemos Pereira, Rand Randall Martins, Telma Maria Araújo Moura Lemos, Andréa Carla Pinto Fernandes, Andréa Juliana Pereira Gomes, Marcos Dias Leão, Priscilla Karilline do Vale Bezerra, Antonio Gouveia Oliveira, Fernanda Nervo Raffin","doi":"10.4212/cjhp.3600","DOIUrl":"https://doi.org/10.4212/cjhp.3600","url":null,"abstract":"<p><strong>Background: </strong>Hypomagnesemia, characterized by decreased levels of magnesium in the blood, is common among patients with cancer and may be related to the administration of proton pump inhibitors (PPIs) and/or platinum derivatives.</p><p><strong>Objective: </strong>To evaluate the safety and potential impact on serum magnesium levels of concomitant use of the PPI omeprazole in patients receiving a platinum derivative.</p><p><strong>Methods: </strong>This prospective, randomized, double-blind, single-dose, placebo-controlled study involved fixed doses of PPI administered on an outpatient basis. It spanned 4 cycles of platinum-based combination chemotherapy (21 days per cycle), and entailed a screening period (14 days before chemotherapy), 2 PPI treatment periods (total of 60 days), and a follow-up period (1 cycle). Patients recruited between May 2019 and March 2020 at 3 hospitals in Brazil were randomly assigned to receive placebo or PPI in a 1:1 ratio. Data analysis employed a linear mixed-effects model and Kaplan-Meier analysis.</p><p><strong>Results: </strong>A total of 164 patients were included in the study, 83 in the placebo group and 81 in the PPI group. Blood magnesium levels showed a modest decrease over time (by approximately 20%) across all patients. A correlation was observed between treatment duration and decrease in serum magnesium in the total sample (β = -0.035, 95% confidence interval [CI] -0.048 to -0.0021; <i>p</i> < 0.001). Compared with the placebo group, the PPI group showed a slightly greater decline (β = -0.121, 95% CI -0.231 to -0.011; <i>p</i> = 0.031). Additionally, no differences were noted between groups regarding the occurrence of neuropathy (<i>p</i> = 0.77), anorexia (<i>p</i> = 0.77), diarrhea (<i>p</i> = 0.34), or constipation (<i>p</i> = 0.39). Omeprazole use was associated with a lower incidence of nausea and vomiting (<i>p</i> = 0.005).</p><p><strong>Conclusion: </strong>These exploratory findings suggest that the concomitant use of omeprazole with platinum derivatives may be associated with a slightly faster rate of serum magnesium depletion than occurs with chemotherapy alone, but without clinical relevance or occurrence of frank hypomagnesemia.</p><p><strong>Clinical trial registration: </strong>Brazilian Registry of Clinical Trials (ReBEC) RBR-8vsb7k2.</p>","PeriodicalId":94225,"journal":{"name":"The Canadian journal of hospital pharmacy","volume":"79 2","pages":"e3600"},"PeriodicalIF":0.0,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13048769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Medication Errors after Implementation of an Electronic Health Record System in a Canadian Community Hospital.","authors":"Lidia Yrigoyen-DaCruz, Antoinette Duronio, Eric Dinunzio","doi":"10.4212/cjhp.3798","DOIUrl":"https://doi.org/10.4212/cjhp.3798","url":null,"abstract":"<p><strong>Background: </strong>The introduction of electronic health records (EHRs) and computerized physician order entry has been associated with a reduction in medication errors due to the safety features of these systems.</p><p><strong>Objectives: </strong>To identify changes in medication errors-specifically related to the types and severity of errors documented and the numbers and types of errors by clinical program-before and after implementation of an EHR system and to identify medication safety initiatives.</p><p><strong>Methods: </strong>This retrospective observational study was conducted at a 2-campus, 500-bed Canadian community hospital before (April 10, 2019, to April 10, 2021) and after (April 11, 2021, to April 11, 2023) implementation of an EHR system. Data were categorized according to event type to ascertain changes in types of errors before and after EHR implementation by clinical program. Data were also collected to determine changes in the severity of errors, as well as changes in categories and changes in frequency of event types (e.g., barcode scanning, medications not ordered, incorrect orders).</p><p><strong>Results: </strong>Totals of 1379 and 1269 medication errors were reported before and after EHR implementation, respectively. The reduction in frequency of errors was statistically significant (<i>z</i> score = 2.14). Overall, statistically significant reductions were observed for errors that did not reach the patient and for errors that reached the patient and necessitated increased monitoring. There were statistically significant decreases in errors secondary to medication(s) not being ordered (197 before vs 121 after EHR implementation) and medications being administered to the incorrect patient (58 vs 20, respectively).</p><p><strong>Conclusion: </strong>Implementation of the EHR system was associated with a reduction in overall medication incidents at the study institution. Findings from this study allowed the medication safety committee to identify targeted medication safety initiatives focused on barcode scanning (of both medications and patient identification) to reduce the frequency of patients receiving incorrect medications.</p>","PeriodicalId":94225,"journal":{"name":"The Canadian journal of hospital pharmacy","volume":"79 2","pages":"e3798"},"PeriodicalIF":0.0,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13048767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Challenge of Generative Artificial Intelligence for Journals.","authors":"Cynthia A Jackevicius","doi":"10.4212/cjhp.3979","DOIUrl":"https://doi.org/10.4212/cjhp.3979","url":null,"abstract":"","PeriodicalId":94225,"journal":{"name":"The Canadian journal of hospital pharmacy","volume":"79 1","pages":"e3979"},"PeriodicalIF":0.0,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12956287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147358495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prescribing and Dispensing Delayed Antibiotics for Pediatric Patients with Otitis Media and Pharyngitis.","authors":"Shobhitha Balasubramaniam, Melanie MacInnis, Katrina Hurley, Eleanor Fitzpatrick, Katelyn Zwicker, Emily Black","doi":"10.4212/cjhp.3876","DOIUrl":"https://doi.org/10.4212/cjhp.3876","url":null,"abstract":"<p><strong>Background: </strong>Providing patients with a delayed prescription for antibiotics to treat acute otitis media (AOM) or pharyngitis may result in decreased antibiotic use.</p><p><strong>Objectives: </strong>To characterize antibiotic prescribing for patients discharged from a pediatric emergency department (PED) with AOM or pharyngitis and to determine the percentage of delayed antibiotic prescriptions dispensed prematurely by a community pharmacy.</p><p><strong>Methods: </strong>This study was completed by linking provincial administrative data on prescriptions dispensed from community pharmacies and a retrospective chart review at a single PED. The study included any pediatric patient who was seen in the PED between March 2019 and February 2021, given a diagnosis of AOM or pharyngitis, and discharged with a prescription for an antibiotic. Patient data were collected from scanned medical records. The chart review was linked to records for dispensed antibiotics in the provincial drug information system. Results were summarized and reported descriptively.</p><p><strong>Results: </strong>A total of 1569 (53.3%) of the 2945 patients seen in the PED with the diagnoses of interest received a prescription for an antibiotic. Delayed prescriptions were given in 21.2% (332/1569) of these encounters. An antibiotic was dispensed within 7 days of the PED visit for fewer than half of the patients (40.4%, 134/332) who received a delayed prescription. About a third of caregivers filled delayed prescriptions within 48 hours (30.1%, 100/332), and 16.9% (43/254) did so earlier than advised.</p><p><strong>Conclusion: </strong>Caregivers who were given a discharge prescription for a delayed antibiotic generally adhered to guidance provided by prescribers and waited to fill the prescription. This strategy may reduce overuse of antibiotics.</p>","PeriodicalId":94225,"journal":{"name":"The Canadian journal of hospital pharmacy","volume":"79 1","pages":"e3876"},"PeriodicalIF":0.0,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12956290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147358453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Le défi de l’intelligence artificielle générative pour les revues scientifiques.","authors":"Cynthia A Jackevicius","doi":"10.4212/cjhp.3991","DOIUrl":"https://doi.org/10.4212/cjhp.3991","url":null,"abstract":"","PeriodicalId":94225,"journal":{"name":"The Canadian journal of hospital pharmacy","volume":"79 1","pages":"e3991"},"PeriodicalIF":0.0,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12956289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147358455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Status Epilepticus in Children before and after Implementation of a Treatment Algorithm.","authors":"Anne-Sophie Bard, Noémie Savard, Isabelle Laverdière, Karine Cloutier, Geneviève Laflamme, Christian Héroux","doi":"10.4212/cjhp.3811","DOIUrl":"https://doi.org/10.4212/cjhp.3811","url":null,"abstract":"<p><strong>Background: </strong>Pharmacological management of status epilepticus (SE) in children must be rapid and optimal to limit morbidity and mortality.</p><p><strong>Objectives: </strong>The primary objective was to compare SE management in children before and after the implementation of a drug treatment algorithm. The secondary objective was to describe the compliance of SE management with the algorithm following its implementation.</p><p><strong>Methods: </strong>This evaluative cross-sectional population study with retrospective chart review was performed in a 5-site teaching hospital, which included a tertiary pediatric hospital. Eligible patients were between 1 month and under 18 years of age, had a diagnosis of SE, and received antiseizure medication (ASM) between January 1, 2019, and April 1, 2023.</p><p><strong>Results: </strong>The study involved 108 patients, 60 treated before algorithm implementation and 48 treated after implementation. In both groups, most patients received a benzodiazepine (BZD) as first-line treatment (96% [52/54] and 100% [44/44], respectively). For second-line treatment, the proportion of patients receiving a BZD was greater before than after implementation (36% [10/28] and 26% [6/23], respectively). For first-line treatment, the mean lorazepam dose for patients weighing 40 kg or less was suboptimal (0.08 [standard deviation 0.03] mg/kg in both groups). Median time from hospital arrival to treatment was 7 minutes before and 6 minutes after implementation of the algorithm. For first-line treatment, the choice of ASM and the doses were compliant with the algorithm for 98% (43/44) and 53% (23/43) of patients, respectively.</p><p><strong>Conclusions: </strong>Implementation of the drug treatment algorithm brought limited changes at the study hospital. More specifically, choice of ASM and time between seizure onset and administration of ASM were similar before and after implementation. Weight-based doses of lorazepam remained suboptimal. Additional training should be given to clinicians.</p>","PeriodicalId":94225,"journal":{"name":"The Canadian journal of hospital pharmacy","volume":"79 1","pages":"e3811"},"PeriodicalIF":0.0,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12956291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147358483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tribute to the Reviewers of the <i>Canadian Journal of Hospital Pharmacy</i>.","authors":"","doi":"10.4212/cjhp.3982","DOIUrl":"https://doi.org/10.4212/cjhp.3982","url":null,"abstract":"","PeriodicalId":94225,"journal":{"name":"The Canadian journal of hospital pharmacy","volume":"79 1","pages":"e3982"},"PeriodicalIF":0.0,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12956288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147358405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Processus de préparation des cytotoxiques injectables : gestion des risques par l’application de la méthode d’analyse des modes de défaillance, de leurs effets et de leur criticité.","authors":"Wiem Ben Ayed, Azza Ben Haddada, Azza Ben Said, Imen Toukabri, Imen Limayem","doi":"10.4212/cjhp.3851","DOIUrl":"https://doi.org/10.4212/cjhp.3851","url":null,"abstract":"<p><strong>Background: </strong>The preparation of injectable chemotherapy drugs is a critical process, given their toxicity and the large number of stakeholders involved. As such, systematic and proactive risk assessment is required.</p><p><strong>Objective: </strong>To analyze the risks associated with the cytotoxic drug preparation process using the failure mode, effects, and criticality analysis (FMECA) method within a centralized cytotoxic drug preparation unit (CCDPU).</p><p><strong>Methods: </strong>An analytical study was conducted in a CCDPU over a 6-month period. The risk analysis was performed using the FMECA method. An action plan was developed to address critical scenarios. A second FMECA cycle was conducted to evaluate the effectiveness of the implemented actions.</p><p><strong>Results: </strong>A total of 189 failure modes were identified, of which 2% were deemed unacceptable and 30% were tolerable when controlled. An action plan was developed based on training, double visual inspection, and the implementation of analytical control. During the follow-up FMECA, a reduction of 23% in the overall criticality index was observed, with a significant improvement in criticality levels. Of the 60 actions, 73% were completed, and an updated action plan was proposed.</p><p><strong>Conclusion: </strong>These results demonstrate the CCDPU team's genuine commitment to risk management and the usefulness of the FMECA method in a continuous improvement approach to the cytotoxic preparation circuit.</p>","PeriodicalId":94225,"journal":{"name":"The Canadian journal of hospital pharmacy","volume":"79 1","pages":"e3851"},"PeriodicalIF":0.0,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12867534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146121481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}