The American journal of the medical sciences最新文献

{"title":"Grit and resilience among pulmonary and critical care physicians: A multi-institutional study.","authors":"Alan W Hu, Thomas J Beckman, Allison M LeMahieu, Helen M Keetley, Rosemary Adamson, Hitesh H Patel, Dustin C Krutsinger, Joshua L Denson, Sarah Dhannoon, David C Chu, Diana J Kelm","doi":"10.1016/j.amjms.2025.07.009","DOIUrl":"10.1016/j.amjms.2025.07.009","url":null,"abstract":"<p><strong>Background: </strong>Pulmonary and Critical Care Medicine (PCCM) physicians work in stressful environments and are at risk for burnout. Grit and resilience have been shown to protect against burnout in various medical specialties, but this relationship has not been explored among PCCM physicians. The purpose of this study was to determine associations between grit and resilience with burnout, academic productivity, and COVID-19-related clinical experiences in PCCM fellows and faculty.</p><p><strong>Methods: </strong>A cross-sectional, multi-institutional survey was conducted during the 2022-2023 academic year among PCCM fellows and faculty from six academic institutions. Measures included the Short Grit Scale, Connor-Davidson Resilience scale, single-item measures of emotional exhaustion and depersonalization, ICU-level COVID-19 experience, and academic productivity metrics. Mixed-effects proportional odds regression models assessed relationships between grit, resilience, burnout, and academic performance, considering clustering within institutions.</p><p><strong>Results: </strong>One hundred and thirty-one participants were surveyed with a response rate of 40.3 %. Median scores for grit, burnout, and resiliency were 3.8 (0-5), 4 (0-12), and 31 (0-40), respectively. Higher grit correlated with less burnout (OR=0.34, p < 0.001), fewer PubMed publications (OR = 0.57, p = 0.048), and more national or international presentations (OR = 1.99, p = 0.027). Higher resilience was associated with less burnout (OR = 0.90, p = 0.001).</p><p><strong>Conclusions: </strong>This is the first study to examine grit and resilience in the field of PCCM. Higher grit and resilience were associated with less burnout in PCCM physicians. Additionally, physicians with higher grit and resilience scores experienced more COVID-19 related deaths. Given the intense and emotionally taxing nature of PCCM, further research on interventions to optimize grit and resilience in PCCM physicians is needed.</p>","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcatheter edge-to-edge repair in patients with mitral annular calcification: A systematic review and meta-analysis.","authors":"Abiodun Idowu, Olayinka Adebolu, Bakhtawer Siraj, Phuuwadith Wattanachayakul, Omotola Balogun, Kevin Bryan Lo, Christian Witzke, Emmanuel Akintoye, Behnam Bozorgnia, Gregg Pressman","doi":"10.1016/j.amjms.2025.07.008","DOIUrl":"10.1016/j.amjms.2025.07.008","url":null,"abstract":"<p><strong>Background: </strong>Mitral annular calcification (MAC) is common in patients with functional mitral regurgitation undergoing transcatheter edge-to-edge mitral valve repair (TEER). However, the safety and effectiveness of TEER systems in patients with MAC is poorly understood.</p><p><strong>Methods: </strong>We systematically reviewed multiple online databases to identify studies that reported outcomes in patients undergoing TEER with underlying moderate/severe MAC versus those with no/mild MAC. Random-effect model meta-analysis at a 95 % confidence interval was done via Cochrane Review Manager 5.4.</p><p><strong>Results: </strong>A total of 6 studies with a pooled 2808 patients (no/mild MAC: 84.5 % vs moderate/severe MAC: 15.5 %) were included. Compared to those with no/mild MAC, patients undergoing TEER with moderate/severe MAC have an insignificant trend towards a lower immediate procedural success (OR: 0.62, 95 % CI: 0.37 - 1.04, p = 0.07). After one year of TEER, the two groups had similar rates of repeat mitral valve intervention or surgery (OR: 1.67, 95 %CI: 0.92 - 3.05, p = 0.09), sustained clinical improvement (NYHA ≤ 2) (OR: 0.86, 95 %CI: 0.64 - 1.15, p = 0.30), and heart failure re-admission (OR: 0.84, 95 %CI: 0.52 - 1.36, p = 0.48). All-cause mortality was, however, higher in the moderate/severe MAC patients (OR: 1.82, 95 %CI: 1.15 - 2.86, p = 0.01).</p><p><strong>Conclusions: </strong>TEER appears safe and effective in carefully selected patients with significant MAC. A standardized selection algorithm is needed to identify MAC patients that would benefit most from TEER.</p>","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COPET study findings regarding the clinical relevance of biomass exposure as an etiotype in COPD.","authors":"Prof Dr Esra Ertan Yazar, Prof Dr Nilgün Demirci, Assc Prof Dr Burcu Arpınar Yiğitbaş, Prof Dr Mukadder Çalıkoğlu, Prof Dr Gazi Gülbaş, Prof Dr Muzaffer Onur Turan, Assc Prof Dr Hülya Şahin, Prof Dr Nurhan Sarıoğlu, Assc Prof Dr Nevin Taci Hoca, Prof Dr Fulsen Bozkuş, Assc Prof Dr Seda Tural, Prof Dr Nihal Arzu Mirici, Assc Prof Nalan Ogan, Assc Prof Dr Burcu Yormaz, Assc Prof Dr Ayperi Öztürk, Prof Dr Filiz Koşar, Prof Dr Evrim Eylem Akpınar, Prof Dr Gülşah Günlüoğlu, Assc Prof Burak Mete, Prof Dr Can Öztürk, Prof Dr Mecit Süerdem","doi":"10.1016/j.amjms.2025.07.001","DOIUrl":"https://doi.org/10.1016/j.amjms.2025.07.001","url":null,"abstract":"<p><strong>Purpose: </strong>The finding that COPD can also develop in non-smokers has led to further investigations of etiologic causes other than smoking. This study evaluated the relationship between tobacco smoking and/or biomass-burning smoke exposure (BBS) and the demographic, clinical, and prognostic characteristics of individuals with COPD.</p><p><strong>Methods: </strong>A total of 1129 stable COPD patients from the COPET study were retrospectively analyzed. The patients were divided into three groups: the COPD-B group (n = 52), which included patients who were solely BBS; the COPD-C group (n = 634), which included patients who exclusively tobacco smoking; and the COPD-BC group (n = 443), which included patients with both BBS and tobacco smoking.</p><p><strong>Results: </strong>The average age of the patients was 65.8 ± 9.1 years, and 87.4% of them were men. In the COPD-B group, the following factors were significantly greater compared to the COPD-C and COPD-BC groups: age (p = 0.001), BMI (p = 0.001), percentage of female patients (p < 0.001), FEV1/FVC ratio (p = 0.014), eosinophil count (p < 0.001), ADO score (p < 0.001), and the proportion of patients with frequent exacerbations (p = 0.013). Thorax CT scans showed that the COPD-BC group had a greater incidence of bronchiectasis and emphysema than the COPD-B and COPD-C groups (p< 0.001).</p><p><strong>Conclusion: </strong>This study highlights significant clinical and radiological differences among COPD patients based on tobacco smoking and BBS, which may substantially impact COPD outcomes, including exacerbations and prognosis.</p>","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intranasal administration of stem cell therapy: A promising approach for early Alzheimer's disease intervention.","authors":"Eeshal Fatima, Anoushey Fatima","doi":"10.1016/j.amjms.2025.07.002","DOIUrl":"10.1016/j.amjms.2025.07.002","url":null,"abstract":"","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost analysis of mechanical thrombectomy vs catheter-directed thrombolysis vs anticoagulation alone for pulmonary embolism.","authors":"Zein Kattih, Simon Meredith, Vincent Dong, Victoria Roselli, Daniel Mina, Dimitre Stefanov, Shankar Thampi, Arber Kodra, Chad Kliger, Bushra Mina","doi":"10.1016/j.amjms.2025.06.011","DOIUrl":"10.1016/j.amjms.2025.06.011","url":null,"abstract":"<p><strong>Introduction: </strong>Pulmonary embolism is the third most common cause of cardiovascular death in the US with a high financial burden. Data on cost-analysis is limited in comparing advanced treatment modalities.</p><p><strong>Methods: </strong>A cohort of patients were selected from a PERT registry database from cases at a tertiary center in a metropolitan area between 2016 and 2023. Patients were treated with either anticoagulation alone, CDT, or MT. The primary outcome was revenue-per-case.</p><p><strong>Results: </strong>MT had the highest revenue-per-case, with a median (IQR) of $59,058 ($42,827-$86,950) (p < 0.0001). CDT had a median (IQR) revenue-per-case of $19,007 ($14,062-$34,651). Anticoagulation alone had a median (IQR) revenue-per-case of $16,171 ($12,666-$31,473). Margin-per-case closely paralleled the primary outcome. While hospital length of stay, survival at discharge, and 90-day readmission were not different among the groups, ICU utilization was 20 % in anticoagulation patients, 100 % in CDT patients, and 24 % in MT patients (p < 0.0001). CTEPH was identified in 12 % of the anticoagulation group, 12 % of the CDT patients, and none of the MT patients (p = 0.04).</p><p><strong>Discussion: </strong>MT has a significantly higher revenue-per-case compared with anticoagulation alone and CDT. ICU utilization of mechanical thrombectomy was lower than catheter-directed thrombolysis and near the ICU utilization with anticoagulation alone. Institution policies and device choice may impact these outcomes, which may vary by center.</p><p><strong>Conclusions: </strong>Advanced therapies that can prevent the downstream sequalae of PE have higher cost but may be more advantageous, and further research is required to evaluate long term benefits.</p>","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An analysis of studies comparing myocarditis and pericarditis in COVID-19 vaccinated and SARS-CoV-2 infected individuals.","authors":"Whitney Bowyer, Alyson Haslam, Vinay Prasad","doi":"10.1016/j.amjms.2025.06.012","DOIUrl":"10.1016/j.amjms.2025.06.012","url":null,"abstract":"<p><p>We sought to identify studies that examined myocarditis and pericarditis after both COVID-19 vaccination and SARS-CoV-2 infection. A literature search was conducted, and retrospective cohort studies examining incidence rates for myocarditis and pericarditis after both COVID-19 vaccination and SARS-CoV-2 infection were included. The methodologies and conclusions of each study was assessed, and a risk of bias was determined. We found 6 articles that utilized cohorts of both vaccinated and infected populations. Of the included articles, all of them had risk of bias concerns, with 50 % having a poor-quality rating and 50 % having a fair quality rating. Methodological biases, including reliance on electronic health record data, inadequate observational periods, and failure to account for baseline characteristics between the two cohorts, were observed across studies. Ultimately, these methodological limitations lead to hyperinflated myocarditis rates in the infection cohorts and a lack of meaningful comparisons between the infection and vaccination cohorts.</p>","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of genetic liability to migraines on spontaneous coronary artery dissection and fibromuscular dysplasia.","authors":"Yun-Hu Chen, Fang Yan","doi":"10.1016/j.amjms.2025.06.007","DOIUrl":"10.1016/j.amjms.2025.06.007","url":null,"abstract":"<p><strong>Background: </strong>Associations among migraines, spontaneous coronary artery dissection (SCAD), and fibromuscular dysplasia (FMD) have been reported; however, their causality is inconclusive.</p><p><strong>Methods: </strong>We inferred a causal relation between exposure (migraines) and outcomes (SCAD and FMD) using two-sample MR analysis. Mediation analysis was performed using reverse and multivariate MR analysis methods. Finally, using two-sample MR analysis, we explored whether the currently perceived potential risk factors for SCAD and FMD mediate the aforementioned causal association.</p><p><strong>Results: </strong>Inverse Variance Weighted (IVW) analysis showed that migraines increased the risk of developing SCAD and FMD. SCAD increases the risk of developing FMD. Reverse causality or pleiotropy was not observed. Multivariate random IVW analysis showed that the effect of migraine on FMD was no longer significant in the multivariate model, whereas the effect of SCAD remained significant. SCAD mediated the causal association between migraine and FMD, with a mediating effect of 0.119 and a proportion of 18.30 %. IVW analyses did not find direct evidence that these associations were consistently related to other potential pathogenic factors of SCAD or FMD.</p><p><strong>Conclusions: </strong>Migraines are a risk factor for both SCAD and FMD, whereas SCAD is an incomplete mediator of the causal relation between migraine and FMD. However, mechanistic studies are warranted to investigate this link.</p>","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic efficacy of scopoletin on oxidative stress and cardiac dysfunction in streptozotocin-induced diabetic rats.","authors":"Abdelrahim Alqudah, Esam Qnais, Omar Gammoh, Yousra Bseiso, Mohammed Wedyan, Sireen Abdul Rahim Shilbayeh, Rawan Abudalo, Muna Oqal, Alaa A A Aljabali","doi":"10.1016/j.amjms.2025.06.010","DOIUrl":"10.1016/j.amjms.2025.06.010","url":null,"abstract":"<p><strong>Background: </strong>Cardiac dysfunction associated with diabetes often arises as a serious condition, primarily driven by persistent oxidative imbalance and chronic inflammation. There are few treatments for such complication and therefore, there is considerable interest in natural compounds such as scopoletin has antioxidative and anti-inflammatory activities. This study investigates how scopoletin may influence disease progression in a rat model of diabetic cardiomyopathy induced by streptozotocin (STZ).</p><p><strong>Methods: </strong>Thirty-two male Wistar rats were evenly distributed into four study groups using a randomization protocol: a non-diabetic control, an untreated diabetic group, a diabetic group administered scopoletin, and a diabetic group treated with metformin (Glucophage) as a reference therapy. Post-diabetes induction by streptozotocin, treatments were administered for three weeks, subsequently, malondialdehyde (MDA) concentrations were measured along with, the enzymatic activities of key cardiac antioxidants-superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx)-were evaluated to assess oxidative defense status. ATPase activities, gene expression (p53 and VCAM-1), and histopathological examinations of heart tissues.</p><p><strong>Results: </strong>Scopoletin treatment significantly reduced MDA levels by up to 35 %, with p < 0.01 compared to the diabetic control. Antioxidant enzyme activities were notably enhanced, with increases in SOD, CAT, and GPx activities by approximately 50 % (p < 0.01). Cardiac ATPase activities showed marked improvement (p < 0.05), and the expression of p53 and VCAM-1 was effectively downregulated (p < 0.01). Histopathological analysis revealed substantial reductions in myocardial damage, vacuolation, and tissue congestion in scopoletin-treated groups, with the high-dose effects comparable to those observed with metformin (Glucophage).</p><p><strong>Conclusions: </strong>Scopoletin demonstrates significant potential in treating diabetic cardiomyopathy. These results encourage further clinical trials to explore scopoletin as a complementary therapy for cardiac complications in diabetic patients.</p>","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of inhaler treatments on respiratory functions and exacerbation frequency in non-cystic fibrosis bronchiectasis.","authors":"Uğur Fidan, Deniz Kızılırmak, Ayşın Şakar Coşkun","doi":"10.1016/j.amjms.2025.06.008","DOIUrl":"10.1016/j.amjms.2025.06.008","url":null,"abstract":"<p><strong>Background: </strong>Bronchiectasis is a chronic airway disease caused by abnormal and permanent dilation of the airways. This study aimed to evaluate the effects of inhaler therapy use on respiratory functions and clinical outcomes in patients with non-cystic fibrosis bronchiectasis.</p><p><strong>Methods: </strong>One hundred forty-six patients with non-cystic fibrosis bronchiectasis aged over 18 years, diagnosed using high-resolution computed tomography, were included in the study. Age, sex, body mass index, smoking status, additional diseases, known etiologic factors, and vaccination status of the patients included in the retrospectively designed study were recorded as sociodemographic data. Respiratory functions, disease severity, and clinical outcomes of patients with bronchiectasis who did and did not receive inhaled anticholinergic and steroid treatments were compared.</p><p><strong>Results: </strong>Ninety (61.6 %) of the 146 patients included in the study were women. The mean age was 56.14 ± 16.22 years. The etiology of bronchiectasis was unknown in 78 (53.4 %) patients. The most prevalent comorbidity was asthma. According to modified Reiff scoring, 91 (62.3 %) patients were classified as having mild bronchiectasis. Twenty-six (17.8 %) patients had airway obstruction. There were 93 (63.7 %) patients using inhaled corticosteroids and 32 (21.9 %) using inhaled anticholinergics.</p><p><strong>Conclusions: </strong>It was determined that patients using inhaler anticholinergics or inhaled steroids were in the more severe group. However, inhaler anticholinergic and inhaler steroid treatments had no effect on hospital admissions and exacerbation frequency in patients with bronchiectasis. Hospitalizations were more frequent among patients with bronchiectasis using inhaled steroids.</p>","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of hepatitis B virus infection and helicobacter pylori co-infection with gastric disorders and cancer.","authors":"Xiaoying Wu, Jianhua Yu, Xi Luo, Yuntong Lan","doi":"10.1016/j.amjms.2025.06.009","DOIUrl":"10.1016/j.amjms.2025.06.009","url":null,"abstract":"<p><strong>Background and aims: </strong>The relationship between hepatitis B virus (HBV) and gastric disorders remains elusive. This study aimed to assess the associations between HBV infection and three gastric disorders. To our knowledge, this is among the first studies to report a synergistic association between HBV and HP co-infection and gastric cancer risk.</p><p><strong>Methods: </strong>HBV-positive patients (n = 352) and HBV-negative controls (n = 520) were recruited from June 2018 to May 2020 at the People's Hospital of Qijiang District. All patients were examined with gastroscopy and histopathological analysis was performed on gastric specimens. HBV DNA and hepatitis B virus surface antigen (HBsAg) were detected by qPCR and the enzyme-linked immunosorbent assay (ELISA), respectively. The relationship of HBV infection with gastric disorders was evaluated by logistic regression analysis. Survival and relapse rates of HBV gastric cancer (GC) cases were estimated using the Kaplan-Meier survival curve and Cox proportional hazard regression model.</p><p><strong>Results: </strong>Gastric mucosal lesions were more serious in the HBV-positive group than in the HBV- negative groups (P < 0.05). HBV DNA and HBsAg levels were strongly correlated with the manifestation of gastritis, gastric ulcer, and GC, and were the highest in GC patients. HBV and Helicobacter Pylori (HP) infections were identified as risk factors for GC (P < 0.05). HBV was significantly associated with gastric ulcer (OR = 10.51, 95 % CI = 5.66-19.52, p < 0.01) and gastric cancer (OR = 2.21, 95 % CI = 1.21-3.47, p = 0.037), while co-infection with HP further increased GC risk (OR = 3.39, 95 % CI = 1.71-6.12, p < 0.01).</p><p><strong>Conclusions: </strong>HBV infection was correlated with some gastric lesions. HBV infection alone might be a risk factor of GC. HBV infection potently increases the risk of GC in HP-positive patients.</p>","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}