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Glucose-6-Phosphate Dehydrogenase Levels and Oxidative Stress Markers Among Cancer Patients in Jos, Nigeria 尼日利亚乔斯癌症患者的葡萄糖-6-磷酸脱氢酶水平和氧化应激标记物
Cancer Research Journal Pub Date : 2024-07-04 DOI: 10.11648/j.crj.20241203.11
B. Samuel, Amos Dangana, Taofeeq Oduola, Chinedu Onwuchekwa, Yinka Oyeniyi, M. Dansura, V. Gagari, Mercy Mobi, Ezeama Chika, A. Omoare, Muhammad Usman, Agwu Ojenya, N. Gyang, Chinwe N. Ugwu, Idris Abdullahi
{"title":"Glucose-6-Phosphate Dehydrogenase Levels and Oxidative Stress Markers Among Cancer Patients in Jos, Nigeria","authors":"B. Samuel, Amos Dangana, Taofeeq Oduola, Chinedu Onwuchekwa, Yinka Oyeniyi, M. Dansura, V. Gagari, Mercy Mobi, Ezeama Chika, A. Omoare, Muhammad Usman, Agwu Ojenya, N. Gyang, Chinwe N. Ugwu, Idris Abdullahi","doi":"10.11648/j.crj.20241203.11","DOIUrl":"https://doi.org/10.11648/j.crj.20241203.11","url":null,"abstract":"Glucose-6-phosphate dehydrogenase (G6PD) is a sensitive cytosolic antioxidant enzyme that could be associated with carcinogenesis. Hence, its plasma levels are a good indicator to monitor cancer-induced cellular stress. This study aimed to determine the correlation between Glucose-6-phosphate dehydrogenase and oxidative stress markers among cancer patients in Jos, Nigeria. This case-control study involved 100 subjects (60 cancer patients and 40 healthy control subjects). Their blood samples were collected to measure the levels of G6PD and oxidative stress markers (malondialdehyde, total plasma peroxide, total antioxidant potential, and oxidative stress indices). Twenty-four (40.0%) of the cancer patients were G6PD deficient. Of this, 13 (54.2%) were females G6PD. Of the G6PD deficient cancer patients, 11(45.8%) were male, conversely, 16 (44.4%) of the cancer subjects who had normal G6PD were males. Of the cancer patients, 26.7%; 13.3%, 11.7 % and 10% had prostate, breast cancer, chronic lymphocytic leukemia (CLL), and hepatocellular carcinoma (HCC), respectively were the most frequent. There was no significant association between G6PD deficiency and cancer (<I>X<sup>2</sup></I>=0.025, <i>p</i>=0.804). Among G6PD deficiency cancer patients, the oxidative stress markers were significantly (<i>p<</i>0.05) higher compared to the control group. These findings showed that relatively more of the cancer patients had normal G6PD status even in increased cellular oxidative stress which could be due to host genetic factors. This suggests the need for further experiments on molecular characterization of mechanisms responsible for the findings.\u0000","PeriodicalId":9422,"journal":{"name":"Cancer Research Journal","volume":" 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141680132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research Progress of Single-Cell Sequencing Technology in Giant Cell Tumor of Bone 骨巨细胞瘤单细胞测序技术的研究进展
Cancer Research Journal Pub Date : 2024-01-18 DOI: 10.11648/j.crj.20241201.12
Yiming Liu, Dongping Ye
{"title":"Research Progress of Single-Cell Sequencing Technology in Giant Cell Tumor of Bone","authors":"Yiming Liu, Dongping Ye","doi":"10.11648/j.crj.20241201.12","DOIUrl":"https://doi.org/10.11648/j.crj.20241201.12","url":null,"abstract":"","PeriodicalId":9422,"journal":{"name":"Cancer Research Journal","volume":"101 27","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139615892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meta-Analysis on Relation Between Helicobacter Infection and Primary Liver Carcinoma 螺旋杆菌感染与原发性肝癌关系的 Meta 分析
Cancer Research Journal Pub Date : 2024-01-11 DOI: 10.11648/j.crj.20241201.11
Xiaolong Liu, Changhe Cheng
{"title":"Meta-Analysis on Relation Between Helicobacter Infection and Primary Liver Carcinoma","authors":"Xiaolong Liu, Changhe Cheng","doi":"10.11648/j.crj.20241201.11","DOIUrl":"https://doi.org/10.11648/j.crj.20241201.11","url":null,"abstract":"","PeriodicalId":9422,"journal":{"name":"Cancer Research Journal","volume":"29 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139533431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognosis of Breast Cancer in Relation with Estrogen-Progesterone and HER-2 Receptor Status 乳腺癌预后与雌激素-孕激素和 HER-2 受体状态的关系
Cancer Research Journal Pub Date : 2023-12-14 DOI: 10.11648/j.crj.20231104.15
Shamsun Nahar, N. Mollah, Md Saidul Haque, Md Jamal Uddin, Sarwar Alam, Faruk Ahammad, Khursheda Akhter, Shejuti Sharmin, Afsana Sharmin Anika, N. Akhter
{"title":"Prognosis of Breast Cancer in Relation with Estrogen-Progesterone and HER-2 Receptor Status","authors":"Shamsun Nahar, N. Mollah, Md Saidul Haque, Md Jamal Uddin, Sarwar Alam, Faruk Ahammad, Khursheda Akhter, Shejuti Sharmin, Afsana Sharmin Anika, N. Akhter","doi":"10.11648/j.crj.20231104.15","DOIUrl":"https://doi.org/10.11648/j.crj.20231104.15","url":null,"abstract":"","PeriodicalId":9422,"journal":{"name":"Cancer Research Journal","volume":"181 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139002338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GATA3 rs3824662, IKZF1 (rs4132601& rs11978267), and ARID5B (rs10821936 & rs10994982) Gene Polymorphisms in Egyptian Adult Patients with Acute Leukemia 埃及成人急性白血病患者中的 GATA3 rs3824662、IKZF1 (rs4132601 & rs11978267) 和 ARID5B (rs10821936 & rs10994982) 基因多态性
Cancer Research Journal Pub Date : 2023-12-08 DOI: 10.11648/j.crj.20231104.14
Samy M Attallah, Youssef Mohammed Mosaad, Mona Mohamed Taalab, Noha Nasser Eisa, Amal Mahmoud Hammad, Iman Mohammed Fawzy, Nada Youssef, Ashraf Antar Elghzaly
{"title":"<I>GATA3</I> rs3824662<i>, IKZF1</i> (rs4132601& rs11978267), and <I>ARID5B</I> (rs10821936 & rs10994982) Gene Polymorphisms in Egyptian Adult Patients with Acute Leukemia","authors":"Samy M Attallah, Youssef Mohammed Mosaad, Mona Mohamed Taalab, Noha Nasser Eisa, Amal Mahmoud Hammad, Iman Mohammed Fawzy, Nada Youssef, Ashraf Antar Elghzaly","doi":"10.11648/j.crj.20231104.14","DOIUrl":"https://doi.org/10.11648/j.crj.20231104.14","url":null,"abstract":"","PeriodicalId":9422,"journal":{"name":"Cancer Research Journal","volume":"264 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139011200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Study of Symptom Experience of Hepatocellular Carcinoma Patients After Hepatic Arterial Infusion Chemotherapy Surgery 肝动脉灌注化疗手术后肝细胞癌患者症状体验研究
Cancer Research Journal Pub Date : 2023-12-08 DOI: 10.11648/j.crj.20231104.13
Deng Juan
{"title":"A Study of Symptom Experience of Hepatocellular Carcinoma Patients After Hepatic Arterial Infusion Chemotherapy Surgery","authors":"Deng Juan","doi":"10.11648/j.crj.20231104.13","DOIUrl":"https://doi.org/10.11648/j.crj.20231104.13","url":null,"abstract":"","PeriodicalId":9422,"journal":{"name":"Cancer Research Journal","volume":"258 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139011339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High Accuracy Classification of Populations with Breast Cancer: SVM Approach 乳腺癌人群的高精度分类:SVM方法
Cancer Research Journal Pub Date : 2023-08-15 DOI: 10.11648/j.crj.20231103.13
Philip de Melo, M. Davtyan
{"title":"High Accuracy Classification of Populations with Breast Cancer: SVM Approach","authors":"Philip de Melo, M. Davtyan","doi":"10.11648/j.crj.20231103.13","DOIUrl":"https://doi.org/10.11648/j.crj.20231103.13","url":null,"abstract":": Breast cancer is one of the most common cancers diagnosed in the United States. Breast cancer can occur in both men and women. The number of deaths associated with this disease is steadily declining, largely due to factors such as earlier detection and a new personalized approach to treatment. In this article, we offer a highly accurate and reliable classification approach based on feature engineering and an improved support vector machine (SVM) classifier. We examine a dataset with 30 features and use in-depth data analytics and visualization to pinpoint the top nine features that have a significant impact on classification accuracy. The SVM classification outperformed other classifiers, including kernel extensions, with a high accuracy of 99.12%. The study stresses the value of machine learning in medical diagnosis, notably in the early detection of breast cancer","PeriodicalId":9422,"journal":{"name":"Cancer Research Journal","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89552072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gastric Cancers: Surgical Management and Prognostic Factors in the General Surgery Department of the National Ignace Deen Hospital, Conakry (Guinea) 科纳克里(几内亚)国立依尼亚斯迪恩医院普通外科胃癌的外科治疗和预后因素
Cancer Research Journal Pub Date : 2023-07-17 DOI: 10.11648/j.crj.20231103.12
Conde Ansoumane, F. Naby, Soumaoro Labilé Togba, Kondano Saa Yawo, F. Houssein, T. Aboubacar
{"title":"Gastric Cancers: Surgical Management and Prognostic Factors in the General Surgery Department of the National Ignace Deen Hospital, Conakry (Guinea)","authors":"Conde Ansoumane, F. Naby, Soumaoro Labilé Togba, Kondano Saa Yawo, F. Houssein, T. Aboubacar","doi":"10.11648/j.crj.20231103.12","DOIUrl":"https://doi.org/10.11648/j.crj.20231103.12","url":null,"abstract":"","PeriodicalId":9422,"journal":{"name":"Cancer Research Journal","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77633272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lentivirus-Mediated Overexpression of miR-218-5p Inhibits Metastasis by Targeting CDH2 in Colorectal Cancer 慢病毒介导的miR-218-5p过表达通过靶向CDH2抑制结直肠癌转移
Cancer Research Journal Pub Date : 2023-07-06 DOI: 10.11648/j.crj.20231103.11
Hailong Zhu, Xuyou Zhu, Xiaoli Li, R. Cui
{"title":"Lentivirus-Mediated Overexpression of miR-218-5p Inhibits Metastasis by Targeting CDH2 in Colorectal Cancer","authors":"Hailong Zhu, Xuyou Zhu, Xiaoli Li, R. Cui","doi":"10.11648/j.crj.20231103.11","DOIUrl":"https://doi.org/10.11648/j.crj.20231103.11","url":null,"abstract":"","PeriodicalId":9422,"journal":{"name":"Cancer Research Journal","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82547595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Knowledge, Sexual Behaviors on Human Papillomavirus Infections and Associated Factors: Survey Among Female Adolescents and Adults in the Republic of Congo 人乳头瘤病毒感染的知识、性行为及其相关因素:刚果共和国女性青少年和成年人的调查
Cancer Research Journal Pub Date : 2023-05-29 DOI: 10.11648/j.crj.20231102.14
Roch Bredin Bissala Nkounkou, Estelle Géraldine Essangui Same, Loic Pradel Kojom Foko, Parfait Christy Nganga, Paola Candyse Tsimba Lemba, Austin Mas Ngoulou Ntsiba, Luc Magloire Anicet Boumba, Fabien Roch Niama, Carole Else Eboumbou Moukoko
{"title":"Knowledge, Sexual Behaviors on Human Papillomavirus Infections and Associated Factors: Survey Among Female Adolescents and Adults in the Republic of Congo","authors":"Roch Bredin Bissala Nkounkou, Estelle Géraldine Essangui Same, Loic Pradel Kojom Foko, Parfait Christy Nganga, Paola Candyse Tsimba Lemba, Austin Mas Ngoulou Ntsiba, Luc Magloire Anicet Boumba, Fabien Roch Niama, Carole Else Eboumbou Moukoko","doi":"10.11648/j.crj.20231102.14","DOIUrl":"https://doi.org/10.11648/j.crj.20231102.14","url":null,"abstract":"","PeriodicalId":9422,"journal":{"name":"Cancer Research Journal","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85528334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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