Somatosensory & motor research最新文献

{"title":"Transcriptomic mechanisms of lumbar sympathectomy improving cold allodynia of nerve injury in rat.","authors":"Mengjiao Chen, Ping Xu, Wenli Ren, Yinan Zhang, Yong Fei, Wenping Zhang","doi":"10.1080/08990220.2026.2696803","DOIUrl":"10.1080/08990220.2026.2696803","url":null,"abstract":"<p><strong>Background: </strong>Neuropathic Pain (NP) is a chronic pain caused by damage to the nervous system, often manifested as spontaneous pain, pain allergy and abnormal pain. Cold abnormal pain is one of the common manifestations of neuropathic pain, which seriously affects the quality of life of patients. Lumbar sympathetic nerve resection has been widely used to treat lower limb pain, but its specific mechanism in cold abnormal pain is not yet clear.</p><p><strong>Materials: </strong>A chronic constriction injury (CCI) of the sciatic nerve model and a lumbar sympathectomy (LS) model were established to investigate the effect of LS on abnormal cold pain in CCI rats and its molecular mechanism. The effect of LS on cold allodynia in CCI rats was observed through behavioral tests, including the measurement of mechanical pain threshold, the acetone cold stimulation test, and the cold plate test. The changes in the levels of differentially expressed genes in CCI rats after LS were further observed by transcriptome sequencing (bulk RNA-seq).</p><p><strong>Result: </strong>Through behavioural experiments and transcriptome sequencing (bulk RNA-Seq) analysis, we found that lumbar sympathectomy (LS) significantly alleviated cold allodynia, cold-evoked allodynia and cold pain sensitivity in CCI rats, and changed the spinal cord transcriptome, including pathways related to inflammatory signal transduction and tissue remodelling. The functional enrichment analysis of differential expression genes (DEGs) revealed a number of signalling pathways associated with pain regulation. This study provides a new molecular biological basis for the application of LS in alleviating cold abnormal pain.</p>","PeriodicalId":94211,"journal":{"name":"Somatosensory & motor research","volume":" ","pages":"1-14"},"PeriodicalIF":1.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148371612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posture dependent changes in perceptual threshold during light touch foot sole stimulation.","authors":"Justin Watts, Fraser MacRae, Sue Peters","doi":"10.1080/08990220.2026.2696806","DOIUrl":"https://doi.org/10.1080/08990220.2026.2696806","url":null,"abstract":"<p><strong>Objective: </strong>Light touch sensitivity of the foot sole is typically measured when individuals are seated or lying down; yet, a critical function of the foot sole is to support cutaneous feedback during standing and walking activities. The objective of this study was to evaluate how individuals perceive light touch stimulation across the foot sole while in different postures including standing.</p><p><strong>Methods: </strong>We measured light touch perceptual threshold (LTPT) in standing, seated, and supine postures in 19 volunteers (10 females, 9 males), using Semmes-Weinstein Monofilaments. Perceptual thresholds were calculated at three foot sole locations (1st metatarsal, lateral arch, and heel) in each posture.</p><p><strong>Results: </strong>Perceptual thresholds were significantly higher in the standing condition compared to the seated and supine conditions across all foot locations; perceptual thresholds were significantly higher while seated compared to supine only at the heel and not at the lateral arch or 1st metatarsal. Our results demonstrate that postural changes significantly influence sensitivity across the foot sole.</p><p><strong>Conclusion: </strong>Performing perceptual threshold assessments of the foot sole while standing may offer more relevant insights into the capacity of foot sole cutaneous afferents to convey light touch information in conditions where such feedback plays a vital role in maintaining balance.</p>","PeriodicalId":94211,"journal":{"name":"Somatosensory & motor research","volume":" ","pages":"1-11"},"PeriodicalIF":1.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148371554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing physical activity and balance challenges in children with obstetric brachial plexus palsy.","authors":"Büşra Gül, Güleser Güney Yılmaz, Burcu Semin Akel","doi":"10.1080/08990220.2026.2683795","DOIUrl":"https://doi.org/10.1080/08990220.2026.2683795","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate physical activity and balance in children with OBPP (Obstetric Brachial Plexus Palsy) and investigate the relationship between these variables.</p><p><strong>Participants and setting: </strong>The study included 58 children with OBPP and 58 healthy controls aged 7-12 years.</p><p><strong>Methods: </strong>Physical activity was measured using the Physical Activity Questionnaire for Children (PAQ-C). Dynamic balance was evaluated with the Y Balance Test (YBT), and static balance was assessed using the One-Leg Standing (OLS) test. Outcome measures included scores from these assessments and group comparisons.</p><p><strong>Results: </strong>Children with OBPP showed significant deficits in dynamic balance, particularly in the posterolateral direction (<i>p</i> < 0.05), while static balance and physical activity levels did not differ significantly between groups (<i>p</i> > 0.05). Logistic regression identified the left posterolateral balance score as a significant positive predictor for group classification (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>Children with OBPP experience significant impairments in dynamic balance, emphasizing the need for targeted interventions to address postural control and lateral stability. Comprehensive assessments incorporating physical activity and balance measures are crucial for developing effective rehabilitation strategies.</p>","PeriodicalId":94211,"journal":{"name":"Somatosensory & motor research","volume":" ","pages":"1-6"},"PeriodicalIF":1.1,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148145958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling ten novel SETX mutations: implications for ALS pathogenesis and clinical diversity.","authors":"Xuecai Chen, Xiaodan Chen, Xiangyu Lin, Weiwei Zhou, Hailiang Hu, Haishan Jiang","doi":"10.1080/08990220.2025.2500940","DOIUrl":"10.1080/08990220.2025.2500940","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the relationship between newly identified senataxin (<i>SETX)</i> gene mutations and the clinical manifestation of Amyotrophic Lateral Sclerosis (ALS), enhancing understanding of the genetic underpinnings associated with this disorder.</p><p><strong>Methods: </strong>A cohort study was conducted at Nanfang Hospital, involving comprehensive genetic sequencing of ALS patients to identify novel <i>SETX</i> mutations. Homology modelling and structural analysis were employed to predict the functional impacts of these mutations on the senataxin protein. Clinical assessments, including symptom evaluation, age of onset, and progression rate, were integrated with electrophysiological studies to establish correlations between genetic variants and clinical outcomes.</p><p><strong>Results: </strong>Ten novel <i>SETX</i> mutations were identified, expanding the genetic landscape of ALS. These mutations exhibited diverse impacts on clinical presentations, with patients showing variability in onset age, symptom severity, and progression rates. Computational modelling suggested that certain mutations cause significant structural changes in senataxin, potentially affecting its RNA/DNA helicase function. Electrophysiological findings consistently revealed nerve conduction abnormalities, indicating that these mutations may influence neuronal excitability and contribute to ALS pathogenesis.</p><p><strong>Conclusion: </strong>The discovery of novel <i>SETX</i> mutations provides valuable insights into the genetic and clinical complexity of ALS. This study underscores the importance of genetic screening for <i>SETX</i> mutations and suggests potential personalised therapeutic approaches targeting senataxin dysfunction. By elucidating genotype-phenotype correlations, these findings contribute to the broader understanding of ALS and offer pathways for developing targeted interventions to address the challenges posed by this disabling disease.</p>","PeriodicalId":94211,"journal":{"name":"Somatosensory & motor research","volume":" ","pages":"107-114"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upper extremity function assessment test using virtual environment technique in stroke survivors.","authors":"Gizem Murat, Mert Doğan, Özge Onursal Kılınç, Sibel Aksu Yıldırım, Muhammed Kılınç","doi":"10.1080/08990220.2025.2500941","DOIUrl":"10.1080/08990220.2025.2500941","url":null,"abstract":"<p><strong>Purpose: </strong>The objective assessment of the upper limbs of stroke survivors is challenging. Serious game-based assessments may allow for an objective assessment of this population. The present work aims to investigate the validity of the metrics provided by the Upper Extremity Smart Exercises-Innovative Treatment (USE-IT) assessment method for upper limb rehabilitation.</p><p><strong>Materials and methods: </strong>Thirty-three stroke survivors were included in this study. We assessed the stroke survivors using The Fugl-Meyer Upper Extremity Scale (FM-UE), The Wolf Motor Function Test (WMFT), The Action Research Arm Test (ARAT), ABILHAND, ACTIVLIM, and the USE-IT. Validity was assessed by examining the correlation of the USE-IT metrics with the clinical scales.</p><p><strong>Results: </strong>All clinical scales and the Global Reaching Map total score, one of the two outputs of the USE-IT assessment method, were found to be moderately correlated (|r| = 0.52-0.69) (<i>p</i> < .05). The other outputs of the USE-IT assessment method, the Local Reaching Map total score, showed a correlation with the Fugl-Meyer Assessment Upper Arm (FM-UA), The Action Research Arm Test (ARAT) Grip, and the Wolf Motor Function Test (WMFT) parameters (|r| = 0.34-0.38) (<i>p</i> < .05).</p><p><strong>Conclusions: </strong>This study showed that the USE-IT assessment is well correlated with commonly used clinical scales for the upper limb motor function in stroke survivors. Therefore, the USE-IT is a valid game-based system for assessing upper limb impairment in stroke survivors.</p>","PeriodicalId":94211,"journal":{"name":"Somatosensory & motor research","volume":" ","pages":"115-122"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Approaches to sensory-motor symptoms in neurological diseases.","authors":"Fatih Özden, Mehmet Özkeskin, Miray Baser","doi":"10.1080/08990220.2025.2585799","DOIUrl":"10.1080/08990220.2025.2585799","url":null,"abstract":"<p><p>Often, somatosensory and motor symptoms frequently co-occur in individuals with neurological conditions. These two systems exert reciprocal influences on one another; thus, an effective neurological rehabilitation protocol in clinical practice should concurrently address both motor and sensory assessment and training procedures. Although neurological rehabilitation guidelines emphasize the motor and sensory systems, it is valuable to examine contemporary approaches to their assessment and rehabilitation separately and in detail. In this review, we synthesize current neurological rehabilitation strategies for Stroke, Multiple Sclerosis, and Parkinson's Disease. In addition to outlining the clinical presentation of these pathologies, we provide a comprehensive overview of motor and sensory assessment methods as well as current rehabilitation approaches.</p>","PeriodicalId":94211,"journal":{"name":"Somatosensory & motor research","volume":" ","pages":"133-145"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145497828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disappearing hemispheric lateralization in tactile habituation: an electrophysiological approach.","authors":"Çağdaş Güdücü, Güliz Akın Öztürk, Semai Bek, Adile Öniz","doi":"10.1080/08990220.2025.2600494","DOIUrl":"10.1080/08990220.2025.2600494","url":null,"abstract":"<p><strong>Aim: </strong>Hemispheric asymmetry is well established in tactile processing, with higher cortical responses observed on the contralateral side of the stimulation area. However, the effect of the interstimulus interval on lateralization is poorly understood. In this context, we aimed to reveal the effects of repeated non-painful tactile stimuli on brain responses and hemispheric lateralization <i>via</i> static ISIs.</p><p><strong>Methods: </strong>Twenty-six healthy participants (13 females; mean age 22.2 ± 3.30 years) participated in the study. Tactile stimuli were delivered to the index fingertip of the right hand <i>via</i> a pneumatic stimulator with static ISIs (2s, 4s, and 8s applied as separate sessions). Electroencephalography was performed throughout the procedure. We determined the ROI and primarily analysed nine electrodes (Fz, Cz, Pz, F3, C3, P3, F4, C4, and P4). We measured the peak-to-peak maximum amplitudes (PP_maxN2P3) between N₂₀₀ and P₃₀₀, labelling N₂₀₀ as N₂ and P₃₀₀ as P₃.</p><p><strong>Results: </strong>The results revealed no significant differences in the amplitudes of PP_maxN2P3 between the ipsilateral and contralateral hemispheres. Constant ISI manipulation altered the laterality of non-painful tactile stimuli. Furthermore, the amplitude of the brain responses would be higher in both the ipsilateral and contralateral hemispheres when the ISI increased. The evaluation of the duration of PP_maxN2P3 was prolonged in the frontal, central, and parietal areas.</p><p><strong>Conclusion: </strong>The results indicate that manipulation of the interstimulus interval (ISI) can potentially negate the traditional contralateral advantage observed in tactile processing.</p>","PeriodicalId":94211,"journal":{"name":"Somatosensory & motor research","volume":" ","pages":"162-173"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145759132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Textured foot orthotics and proprioception: augmenting cutaneous feedback to improve joint position sense accuracy.","authors":"Kelly A Robb, Daniel Schmidt, Stephen D Perry, Andresa M C Germano","doi":"10.1080/08990220.2025.2600492","DOIUrl":"10.1080/08990220.2025.2600492","url":null,"abstract":"<p><p>The maintenance of proprioception in upright standing posture and joint position sense accuracy (JPSA), is contingent on the coordination of sensory inputs made available to individuals during the task. Adding texture to augment cutaneous feedback on neuromuscular control of the ankle joint has yet to be studied in JPSA, thus motivating the purpose of this research to investigate the changes in ankle joint proprioception when wearing textured (FOTs) and non-textured orthoses (FOs) during a passive ankle joint position reproduction task in healthy young and middle-aged individuals (<i>n</i> = 48; 31 under 30 years, 17 over 30 years). Error accuracy, tibialis anterior and medial gastrocnemius muscle activity, and centre of pressure displacement were recorded from 48 participants while completing four ankle JPSA replication tasks (5°, 10° plantarflexion, 5°, 10° dorsiflexion) in stance. When the middle-aged participants (over 30 years) completed the dorsiflexion 5° JPSA task, a 31% error reduction was observed standing in FOTs compared to FOs. These results provide evidence supporting the effectiveness of adding cutaneous feedback to improve proprioception in middle-aged individuals.</p>","PeriodicalId":94211,"journal":{"name":"Somatosensory & motor research","volume":" ","pages":"146-161"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145746306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prolongation of peripheral nerve block by Marmara Propolis: an experimental rat study.","authors":"Sefa Bulut, Melike Korkmaz Toker, Osman Bulut, Umut Furkan Demirkol, Ali Ihsan Uysal, Sinan Pektaş, Ali Sorucu, Bakiye Ugur","doi":"10.1080/08990220.2025.2575488","DOIUrl":"10.1080/08990220.2025.2575488","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the effects of Marmara propolis on the duration of sensory, deep sensory, and motor block recovery when used alone or in combination with bupivacaine in a rat sciatic nerve block model.</p><p><strong>Materials and methods: </strong>Thirty-two Wistar-Albino rats were randomly divided into four groups (<i>n</i> = 8): Group Bupivacaine (Group B) received 0.2 mL of 0.5% bupivacaine perineurally; Group Propolis (Group P) received 30 mg/kg of Marmara propolis (0.2 ml) perineurally; Group Bupivacaine + Propolis (Group BP) received a combination of 0.2 mL bupivacaine and 30 mg/kg propolis perineurally; Group Bupivacaine + Propolis intraperitoneally (Group BPip) received 0.2 mL bupivacaine perineurally and 30 mg/kg propolis intraperitoneally. Sensory, deep sensory, and motor function recoveries were assessed every 5 min until full recovery.</p><p><strong>Results: </strong>Group BP showed significantly longer recovery times for all three modalities compared to all other groups (<i>p</i> < 0.001). Group BPip also demonstrated prolonged deep sensory and motor recovery times compared to Groups B and P (<i>p</i> < 0.001). Group P exhibited the shortest recovery times across all measurements.</p><p><strong>Conclusions: </strong>Marmara propolis, particularly when used in combination with bupivacaine, prolongs sensory, deep sensory, and motor block durations. These findings suggest that propolis may have both local and systemic adjuvant effects in regional anaesthesia applications.HIGHLIGHTS OF THE STUDYMarmara propolis significantly prolonged sensory, deep sensory, and motor block durations when administered perineurally in a rat sciatic nerve block model.Intraperitoneal administration of propolis also resulted in prolonged deep sensory and motor block recovery, indicating systemic analgesic activity.The combination of bupivacaine and propolis produced the longest block durations, suggesting a synergistic or adjuvant effect.This is the first study to investigate both local and systemic applications of propolis as an adjunct to regional anaesthesia.Findings support the potential use of propolis as a natural, plant-based adjuvant in peripheral nerve blocks.</p>","PeriodicalId":94211,"journal":{"name":"Somatosensory & motor research","volume":" ","pages":"123-132"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145294912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristic differences in somatosensory gating between adolescents and adults.","authors":"Aoi Mase, Masako Nakagawa, Manabu Shibasaki, Hiroki Nakata","doi":"10.1080/08990220.2026.2637442","DOIUrl":"10.1080/08990220.2026.2637442","url":null,"abstract":"<p><p><b>Aim of the study</b>: To characterize differences in somatosensory gating associated with maturation, we compared the amplitude ratio of responses to the second stimulus (S2) over the first stimulus (S1) between adolescents and young adults using a paired-pulse stimulation paradigm while recording somatosensory-evoked potentials (SEPs). <b>Methods:</b> Thirteen right-handed adolescent males (14.1 ± 0.3 yrs) and twenty-four adult males (21.2 ± 1.2 yrs) participated. We focused on SEP components at Fz and C3', and sensory gating for each component was quantified as the S2/S1 amplitude. Components showing significant gating were identified within each group. Subsequently, S2/S1 amplitude ratios between groups and bivariate correlations among gated components were examined. <b>Results:</b> Adolescents showed significant gating for N30 at Fz and P22 and P45 at C3', and adults showed significant gating for N30 at Fz and P22 and N60 at C3'. The S2/S1 amplitude ratios for N30 at Fz and P45 at C3' were significantly smaller in adolescents than adults, whereas other components did not differ. Correlations among S2/S1 amplitude ratios were not significant in either group, suggesting component-specific mechanisms. <b>Conclusions:</b> Adolescents showed stronger frontal N30 gating and a different centroparietal pattern relative to adults, suggesting immature and region-specific inhibitory processes. The absence of correlations among S2/S1 ratios supports the presence of partially independent generator and neurochemical mechanisms across SEP components. These findings provide a developmental profile of somatosensory gating.</p>","PeriodicalId":94211,"journal":{"name":"Somatosensory & motor research","volume":" ","pages":"174-183"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147291686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}