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The Monkeypox (Mpox) Dilemmas: What Is the Clinical and Histologic Presentation of the Bullae and Are They Infectious, and Why Is the Infection Dying Out So Quickly? 猴痘（Mpox）难题：囊泡的临床和组织学表现是什么，是否具有传染性，为什么感染很快就消失了？
Skinmed Pub Date : 2024-09-17 eCollection Date: 2024-01-01
W Clark Lambert, Michael Lavery, Muriel Lambert, Albert Alhatem, Robert A Schwartz, Rohan Shah, Claude E Gagna
{"title":"The Monkeypox (Mpox) Dilemmas: What Is the Clinical and Histologic Presentation of the Bullae and Are They Infectious, and Why Is the Infection Dying Out So Quickly?","authors":"W Clark Lambert, Michael Lavery, Muriel Lambert, Albert Alhatem, Robert A Schwartz, Rohan Shah, Claude E Gagna","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":94206,"journal":{"name":"Skinmed","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dermatology One Hundred Years Ago. 百年前的皮肤病学
Skinmed Pub Date : 2024-09-17 eCollection Date: 2024-01-01
Lawrence Charles Parish, W Clark Lambert
{"title":"Dermatology One Hundred Years Ago.","authors":"Lawrence Charles Parish, W Clark Lambert","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":94206,"journal":{"name":"Skinmed","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cannabidiol in Dermatology: Proposed Mechanism of Action and Potential Medication Interactions. 皮肤病学中的大麻二酚：拟议的作用机制和潜在的药物相互作用。
Skinmed Pub Date : 2024-09-17 eCollection Date: 2024-01-01
Brittany M Snyder, Shannon C Trotter
{"title":"Cannabidiol in Dermatology: Proposed Mechanism of Action and Potential Medication Interactions.","authors":"Brittany M Snyder, Shannon C Trotter","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In the setting of increasing patient-reported cannabidiol (CBD) usage in the dermatologic setting, it is of great importance that clinicians become aware of potential medication interactions that may arise from cannabidiol usage in order to ensure safe and efficacious medication therapy. This brief review aimed to bring awareness to the mechanism of CBD while highlighting potential interactions between CBD and medication therapy for commonly encountered dermatologic conditions, including acne, allergic contact dermatitis, atopic dermatitis, pruritus, skin aging, skin cancer, and psoriasis.</p>","PeriodicalId":94206,"journal":{"name":"Skinmed","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two Features of Annular Lichenoid Dermatitis of Youth (ALDY). 青年环状苔癣性皮炎（ALDY）的两个特征。
Skinmed Pub Date : 2024-09-17 eCollection Date: 2024-01-01
Elie Saliba, Amal Alawami, Ahmad Berjawi, Sara Yumeen, Zeina Tannous
{"title":"Two Features of Annular Lichenoid Dermatitis of Youth (ALDY).","authors":"Elie Saliba, Amal Alawami, Ahmad Berjawi, Sara Yumeen, Zeina Tannous","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A healthy 14-year-old boy presented with a 2-month history of two slowly expanding asymptomatic lesions on his right trunk. No etymology of any new medications, recent travel, or tick bites was reported. Physical examination demonstrated two 4.5×2.5- cm and 3.5×2-cm annular hyperpigmented plaques with slightly elicited red borders on the right lower abdomen and right inferior flank. No evidence of atrophy or sclerosis was noted (Figure 1A). A 4-mm punch biopsy revealed irregular epidermal hyperplasia with alteration of thinned and quadrangular rete ridges, a dense band-like lichenoid infiltrate in the papillary dermis admixed with numerous melanophages and occasional necrotic keratinocytes. No evidence of epidermotropism was observed (Figure 1B). The dermal infiltrate was predominantly composed of CD3+ T-lymphocytes admixed with rare CD20+ B-lymphocytes and increased CD8-CD4 ratio. The patient showed significant improvement following the application of a potent steroid ointment for several weeks.</p>","PeriodicalId":94206,"journal":{"name":"Skinmed","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Well-Demarcated Acral Scaly Pigmented Eruption. 界限分明的鳞状色素性溃疡
Skinmed Pub Date : 2024-09-17 eCollection Date: 2024-01-01
Anissa Zaouak, Oumayma Magdoud, Raja Jouini, Houda Hammami, Samy Fenniche
{"title":"A Well-Demarcated Acral Scaly Pigmented Eruption.","authors":"Anissa Zaouak, Oumayma Magdoud, Raja Jouini, Houda Hammami, Samy Fenniche","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":94206,"journal":{"name":"Skinmed","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
OpzeluraTM (Ruxolitinib) Cream 1.5. OpzeluraTM (Ruxolitinib) 乳霜 1.5。
Skinmed Pub Date : 2024-09-17 eCollection Date: 2024-01-01
William Abramovits, Akhil Abraham, Kimberly Dawn Vincent, Aditya K Gupta
{"title":"Opzelura<sup>TM</sup> (Ruxolitinib) Cream 1.5.","authors":"William Abramovits, Akhil Abraham, Kimberly Dawn Vincent, Aditya K Gupta","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Ruxolitinib cream 1.5% was first approved by the US Food and Drug Administration (FDA) in 2011. Opzelura™ cream was introduced by Incyte Dermatology in 2021 for the short-term and non-continuous chronic treatment of mild to moderate atopic dermatitis (AD) in non-immunocompromised patients aged ≥12 years, whose clinical manifestations are not controlled with prescribed topical therapies, such as topical corticosteroids, topical calcineurin inhibitors, or topical phosphodiesterase-4 ( PDE4) inhibitors, or when such therapies are not advisable. Ruxolitinib is a Janus kinase (JAK) inhibitor that addresses inflammation in AD. It selectively inhibits JAK1 and JAK2, blocking JAK and activating signal transducer and activator of transcription (STAT), thereby interrupting the cytokine pathways responsible for cutaneous inflammation. The targeted downstream cytokines include Interleukin- 4 (IL-4), IL-13, IL-31, and cytokine thymic stromal lymphopoietin (TSLP), which play pivotal roles in the itching and inflammation experienced by AD patients. Ruxolitinib cream is directly applied as a thin layer over AD lesions twice daily up to 20% body surface area (BSA) using no more than 60 g per week. It can be used for up to 8 weeks on delicate or thin skin surfaces.</p>","PeriodicalId":94206,"journal":{"name":"Skinmed","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patchy Alopecia in a Patient with Systemic Lupus Erythematosus: Think About Tinea Capitis. 系统性红斑狼疮患者的斑片状脱发：想想头癣
Skinmed Pub Date : 2024-09-17 eCollection Date: 2024-01-01
Anissa Zaouak, Meriem Cherif, Amal Chamli, Refka Frioui, Houda Hammami, Samy Fenniche
{"title":"Patchy Alopecia in a Patient with Systemic Lupus Erythematosus: Think About Tinea Capitis.","authors":"Anissa Zaouak, Meriem Cherif, Amal Chamli, Refka Frioui, Houda Hammami, Samy Fenniche","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":94206,"journal":{"name":"Skinmed","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidermodysplasia Verruciformis (Lewandowsky and Lutz's Dysplasia). 疣状表皮增生症（Lewandowsky 和 Lutz's疣）。
Skinmed Pub Date : 2024-09-17 eCollection Date: 2024-01-01
Avita Dhiman, Naveen Kumar Kansal, Pakesh Baishya
{"title":"Epidermodysplasia Verruciformis (Lewandowsky and Lutz's Dysplasia).","authors":"Avita Dhiman, Naveen Kumar Kansal, Pakesh Baishya","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A woman in her twenties, with a non-consanguineous marriage, presented to the dermatology clinic with asymptomatic lesions on her face, neck, trunk, and extremities for the past 12 years. The general physical and systemic examination was unremarkable. Cutaneous examination revealed multiple hypopigmented to a few hyperpigmented, slightly scaly tinea versicolor-like macules distributed predominantly on the neck, upper portion of the back, and distal parts of the extremities (Figures 1-5). There were muultiple, slightly erythematous to violaceous flat-topped wart-like papules and plaques were discovered on the arms (Figures 1 and 2), with seborrheic keratosis-like lesions on the face (Figure 5). Baseline investigations, such as complete blood count (CBC), liver function test (LFT), kidney function test (KFT), and plasma glucose levels, were normal. Serologic tests conducted for human immunodeficiency virus (HIV)-1 and HIV-2, and hepatitis B and C were nonreactive. Skin lesion potassium hydroxide (KOH) examination from tinea versicolor-like lesions was negative for fungal elements. Skin biopsies were performed from tinea versicolor-like macules present on the upper portion of the back, flat wart-like plaque on the dorsum of the left hand, and hyperpigmented scaly plaque in the extensor area of the left leg. Histopathologic examination revealed parakeratosis, hyperkeratosis, and acanthosis with swollen keratinocytes, bluish-gray cytoplasm, and rounded nuclei with prominent nucleoli. No dysplastic changes/atypia or mitotic figures (Figures 6 and 7), plus occasional perinuclear halo (a vacuolated area that surrounds the nucleus), were observed. Following clinicopathologic correlation, the patient was diagnosed with epidermodysplasia verruciformis (EV, or Lewandowsky and Lutz's dysplasia).</p>","PeriodicalId":94206,"journal":{"name":"Skinmed","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thermal Signature of Pigmented Lesions as Observed by Digital Infrared Thermal Imaging. 通过数字红外热成像观察色素病变的热特征。
Skinmed Pub Date : 2024-09-17 eCollection Date: 2024-01-01
Ariel Berl, Ofir Shir-Az, Murat Charyev, Avshalom Shalom
{"title":"Thermal Signature of Pigmented Lesions as Observed by Digital Infrared Thermal Imaging.","authors":"Ariel Berl, Ofir Shir-Az, Murat Charyev, Avshalom Shalom","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study examined the thermal signature of pigmented lesions observed by digital infrared thermal imaging as a possible adjunct to physician diagnosis. Thermal images of pigmented lesions were compared to clinical examination by a plastic surgeon interested in skin diseases, dermatoscopy, and histopathology. A total of 35 patients with 55 pigmented skin lesions were considered. We found that all lesions emitting a dark signal on thermal imaging, compared to the nearby skin, were benign, while only one of all benign lesions (1.9%) had a bright \"warm\" signal. Benign lesions with papule/nodular morphology were dark in 87.5% of patients. All lesions diagnosed as malignant melanoma, both dermatoscopically and histologically, had plaque morphology; yet, only half demonstrated some signals on thermal imaging. Based on these results, we concluded that thermal imaging could be used as an adjunct to diagnosis when examining skin lesions. This study provided an introduction to using thermal imaging for spotting skin lesions.</p>","PeriodicalId":94206,"journal":{"name":"Skinmed","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Amlodipine-Induced Gum Hypertrophy in a Hypertensive Patient. 氨氯地平诱发高血压患者牙龈肥厚。
Skinmed Pub Date : 2024-09-17 eCollection Date: 2024-01-01
Manju Daroach, Avita Dhiman, Darwin Kaushal, Payal Chauhan
{"title":"Amlodipine-Induced Gum Hypertrophy in a Hypertensive Patient.","authors":"Manju Daroach, Avita Dhiman, Darwin Kaushal, Payal Chauhan","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":94206,"journal":{"name":"Skinmed","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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