Scars, burns & healing最新文献

{"title":"Wound healing activity of crude extract and solvent fractions of <i>Salvia nilotica</i> leaves in excision and incision wounds in mice.","authors":"Aschalew Mulatu Tefera, Helen Bitew, Gebretsadkan Hintsa Tekulu, Mebrahtom Gebrelibanos Hiben","doi":"10.1177/20595131261480435","DOIUrl":"10.1177/20595131261480435","url":null,"abstract":"<p><strong>Purpose: </strong>Juice from <i>Salvia nilotica</i> fresh leaves is traditionally used for the treatment of wounds in Ethiopia; yet, such a claim has not been scientifically verified so far. Therefore, this study aimed to evaluate the wound-healing properties of <i>S. nilotica</i> leaf extract and solvent fractions using excision and incision wound models in mice.</p><p><strong>Methods: </strong>About 80% methanolic crude extract and its solvent fractions (chloroform, butanol, and aqueous) were formulated as an ointment. Incision and excision models were used to assess the wound-healing effect of the crude extract, whereas the solvent fractions were tested in the excision model. In the excision model, wound contraction, epithelialization, and histopathological changes were measured, whereas tensile strength was measured in the incision model.</p><p><strong>Results: </strong>The crude extract of <i>S. nilotica</i> significantly promoted wound healing (<i>P</i> < 0.05), which was evident with increased wound contraction, enhanced tensile strength, and reduced epithelialization period when compared with the negative control groups<i>.</i> All solvent fractions have also enhanced the wound-healing process similarly. The histopathological examination results also confirmed the positive effects of the plant extract on wound healing as the extract has increased collagen deposition, fibroblast proliferation, and vascularization of the wound site<i>.</i></p><p><strong>Conclusion: </strong>The findings of this study showed the wound-healing potential of <i>S. nilotica</i> leaf extracts, which in turn may partly justify the traditional use of the plant material for wound-healing purposes.</p>","PeriodicalId":94205,"journal":{"name":"Scars, burns & healing","volume":"12 ","pages":"20595131261480435"},"PeriodicalIF":0.0,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13542533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148898399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body appreciation and psychosocial indicators in patients with keloids, hypertrophic scars, and burn scars.","authors":"Luciana Nacif da Costa Valle, Vanessa Borges Mendes, Ana Paula Melchiors Stahlschmidt, Fernando Ribeiro Andrade, Marcio Roberto Silva, Gisele Viana de Oliveira","doi":"10.1177/20595131261468100","DOIUrl":"10.1177/20595131261468100","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Scars present repercussions beyond physical appearance, affecting emotional well-being and social interactions. Few studies have compared how different scar types, including keloids (K), hypertrophic scars (HS), and post-burn scars (BS), relate to psychosocial outcomes.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Assess body appreciation and screening indicators of anxiety and depression in patients with scars of different etiologies.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;We conducted an exploratory cross-sectional study including 42 patients with scars allocated to three groups: K, HS, and BS. Body image perception was measured using the Body Appreciation Scale (BAS), and anxiety and depression were assessed using the Hospital Anxiety and Depression Scale (HADS). Mean BAS and HADS scores were compared across groups, and associations with clinical features were explored.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The combined prevalence of anxiety and depression symptoms increased descriptively from HS (0%) to K (5.9%) to BS (20%) (&lt;i&gt;p&lt;/i&gt; = 0.11). Higher odds of combined anxiety and depression symptoms were associated with facial involvement (&lt;i&gt;p&lt;/i&gt; = 0.017; OR = 19.8, 95% CI 1.70-229.65), and functional impairment (&lt;i&gt;p&lt;/i&gt; = 0.039; OR = 18.0, 95% CI 1.59-202.95) features more frequent among burn patients, although confidence intervals were wide. BAS scores did not differ significantly among groups (&lt;i&gt;p&lt;/i&gt; = 0.78), indicating moderate-to-high body appreciation across scar types (mean BAS: 3.68 burns, 3.77 hypertrophic, 3.85 keloids). Anxiety (&lt;i&gt;p&lt;/i&gt; = 0.57) and depression (&lt;i&gt;p&lt;/i&gt; = 0.43) scores were similar.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Different scar types were associated with broadly similar psychosocial outcomes. Emotional vulnerability among patients with burn scars appears more closely related to scar-related features, such as facial location and functional impairment, than to scar etiology alone. Findings should be interpreted cautiously and regarded as hypothesis-generating.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Lay summary: &lt;/strong&gt;This study examined how different types of scars, including burns, hypertrophic scars, and keloids, may affect emotional well-being and body image. Adults with these scars completed questionnaires assessing body appreciation, anxiety, and depression. Overall, levels of body appreciation were similar across groups, suggesting that many people can adapt to visible or symptomatic scars over time.Participants with burn scars showed a tendency toward higher levels of anxiety and depressive symptoms. However, these emotional difficulties were more strongly associated with features such as facial involvement and functional limitations than with the type of scar itself. This highlights the importance of considering the broader clinical and social context in which scars occur.As this was an initial study with a relatively small number of participants, the findings should be interpreted as exploratory rather than defini","PeriodicalId":94205,"journal":{"name":"Scars, burns & healing","volume":"12 ","pages":"20595131261468100"},"PeriodicalIF":0.0,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13400918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148595367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NovoSorb® Biodegradable Temporising Matrix (BTM) for reconstruction of paediatric acute ischaemic limb injuries secondary to sepsis: A literature review and case series.","authors":"Eva Nagy, Abigail V Shaw, Jessica Steele","doi":"10.1177/20595131261449046","DOIUrl":"10.1177/20595131261449046","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;NovoSorb® Biodegradable Temporising Matrix (BTM) is a synthetic polyurethane bilayer matrix, used in trauma and burns reconstruction. However, there is little evidence of its use for paediatric limb ischaemia. We present a review of literature and three paediatric cases of sepsis-induced ischaemic limb injuries, reconstructed using BTM.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Data were collected on demographics, management and outcomes of three patients cared for by the senior author and plastic surgery service. The operative regimen and challenges faced are discussed.Three children, aged 1-8 years, were managed between 2022 and 2024. The first case had an immune-mediated reaction after bronchiolitis, and two cases had group A streptococcus sepsis. The first case required debridement of both lower limbs, covered with BTM, to improve scar quality and limb length. The second child had bilateral upper limb ischaemia, necessitating left below-elbow and right trans-metacarpal amputations, with BTM applied bilaterally to optimise residual limb length and stump quality. The third child underwent a right above-knee amputation and had significant soft tissue necrosis from the plantar surface of the left foot to the knee; BTM was applied to the left leg as a limb-salvage strategy.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;All cases required multiple surgical debridements, followed by early BTM application and subsequent split-thickness skin grafting. Follow-up of 1 year showed good outcomes in scar quality and preservation of limb length.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;BTM has not been reported in wounds of this aetiology in the paediatric population. These cases demonstrate BTM as a valuable adjunct in reconstruction of complex wounds secondary to sepsis-induced critical limb ischaemia.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Lay summary: &lt;/strong&gt;Occasionally, serious infections in children can severely reduce blood flow to parts of the arms or legs. This can cause tissue damage, often leading to amputations. Treating these injuries is difficult, especially when the aim is to save as much of the limb as possible. NovoSorb® Biodegradable Temporising Matrix (BTM) is a man-made dressing that helps the body form and organise new tissue before a skin graft is applied. It is already used for burns and other injuries, but its use in children with infection-related limb damage has been rarely reported.&lt;b&gt;Question:&lt;/b&gt; Can BTM help rebuild and maintain residual length in children's limbs after severe infection causes loss of blood supply?&lt;b&gt;Work conducted:&lt;/b&gt; This study reported three children, aged 1-8 years, treated between 2022 and 2024.&lt;b&gt;What we did:&lt;/b&gt; Each child had life-threatening infections that damaged parts of their arms or legs. Surgeons removed the dead tissue in stages, utilised BTM early to protect the wounds and help new tissue organise, then later added thin skin grafts. After at least one year, all children had good scar quality and movement of the l","PeriodicalId":94205,"journal":{"name":"Scars, burns & healing","volume":"12 ","pages":"20595131261449046"},"PeriodicalIF":0.0,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13376533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148581885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of role of rhomboid flap and double Z-plasty in post-burn contractures: A prospective case series in Iraq.","authors":"Mohammed Alaa Jameel, Wameth Alaa Jamel, Riyam Amer Hammood Alkhuzaie, Noor Saleh Hady, Alaa Jameel Hasan","doi":"10.1177/20595131261462299","DOIUrl":"10.1177/20595131261462299","url":null,"abstract":"<p><strong>Background and aim: </strong>Numerous reconstructive options are used to address post-burn scar contractures, including skin grafting, geometric relaxation techniques, local flaps, and free flaps. This study aimed to evaluate the functional and cosmetic outcomes of a combined rhomboid flap and double Z-plasty technique for wide and long post-burn contractures crossing joints in various body parts.</p><p><strong>Material and methods: </strong>This prospective case series involved 100 patients with post-burn scar contractures in different body areas who underwent surgery using rhomboid flap and double Z-plasty at Al-Wasity Teaching Hospital between January 2020 and July 2024. Patient data, including age, sex, duration of contracture, preoperative and postoperative contracture band length, and improvement in joint range of motion, were recorded.</p><p><strong>Results: </strong>Of the 100 patients included in this study, 98 experienced a significant increase in their joint range of motion and achieved full movement after release using our technique. There were no major flap losses or necrosis, although three patients experienced partial superficial epidermal sloughing, which did not affect the overall results. Only two patients had less than full-range shoulder abduction.</p><p><strong>Conclusion: </strong>The rhomboid flap combined with double Z-plasty is a reliable technique that serves as a valuable option in the reconstructive surgeon's armamentarium for managing wide and long chronic post-burn contractures over joints. This treatment offers the advantages of effective lengthening, excellent postoperative function, and acceptable cosmetic outcomes, while requiring less postoperative splinting and resulting in a low observed incidence of contracture recurrence during short-term follow-up in this series.</p>","PeriodicalId":94205,"journal":{"name":"Scars, burns & healing","volume":"12 ","pages":"20595131261462299"},"PeriodicalIF":0.0,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13329057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148392929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case series to evaluate burn therapy practices after application of Biodegradable Temporising Matrix (BTM).","authors":"Bradley Schmitt, Kathryn Heath, Marcus Wagstaff","doi":"10.1177/20595131261449383","DOIUrl":"10.1177/20595131261449383","url":null,"abstract":"<p><strong>Objective: </strong>Evolution in the use of Biodegradable Temporising Matrix (BTM) in our adult burn service prompted an evaluation of our therapy guidelines.</p><p><strong>Method: </strong>We conducted a retrospective case note review of adult burn patients who received BTM between March 2022 and September 2024. Data collected included commencement timing of range of motion (ROM) and ambulation after BTM application, burn and BTM total body surface area (%TBSA) and reason for any BTM loss.</p><p><strong>Results: </strong>The study included 22 patients (23 procedures). Overall, median burn TBSA was 30% with median BTM TBSA of 22% (BTM range 0.1%-70% TBSA). All patients had BTM crossing at least one upper limb (UL) or lower limb (LL) joint. Median time to ROM initiation after BTM was 4.5 days for UL and 2.0 days for LL. Median time to ambulation was 1.0 day overall. Among LL BTM patients intubated for < 7 days, ambulation commenced at a median of 1.5 days. Larger LL BTM areas (>10% TBSA) were slower to mobilise than smaller (<10% TBSA) areas (median 2.5 vs 1.0 days). Partial BTM loss occurred in six cases (26%), though none were attributed to therapy interventions.</p><p><strong>Conclusion: </strong>Therapy guidelines in our burns unit now recommend initiating gentle ROM within 3-5 days after BTM application, and ambulation from day 2-3, even in patients with large LL BTM areas, without negatively impacting BTM integration or timing to SSG.</p>","PeriodicalId":94205,"journal":{"name":"Scars, burns & healing","volume":"12 ","pages":"20595131261449383"},"PeriodicalIF":0.0,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13180123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147978068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A mixed methods study investigating patient's initial experiences after acquiring a surgical scar, burn injury, and/or amputation.","authors":"Philippa Tollow, Georgia Mouhlen, Maia Thornton","doi":"10.1177/20595131251387481","DOIUrl":"10.1177/20595131251387481","url":null,"abstract":"<p><strong>Introduction: </strong>Experiences of seeing an altered appearance for the first time can have an important influence on an individual's psychological wellbeing, their body image and their adjustment. Existing research has explored this experience in individuals with breast cancer and facial burns, but limited research has been conducted in other appearance altering conditions. The aim of this study was to explore patient's initial experiences viewing themselves after acquiring an appearance altering condition, including distress, preparedness and social support.</p><p><strong>Methods: </strong>Participants (<i>n</i> <i>=</i> 64) with a surgical scar, burn injury or amputation completed a mixed methods online survey. This survey included questions about practical elements of the experience, the support they received, their expectations, distress, and preparedness; as well as open questions regarding participant's feelings, fears, support and suggested improvements to the experience. Data analysis included statistical analysis and inductive content analysis.</p><p><strong>Discussion: </strong>Participants reported a variety of initial experiences. Some felt adequately prepared and supported, whilst others felt this could have improved. A strong correlation was found between perceived support and distress (r_s = -.66, <i>p</i> = <.001) and preparedness and distress (r_s = -.66, <i>p</i> = <.001). No significant differences in preparedness, distress or support were found according to gender, age, or condition.</p><p><strong>Conclusions: </strong>Whilst many participants reported satisfaction with viewing their appearance for the first time, some participants reported significant distress and a need for further support around this experience. This suggests an important role for healthcare providers in discussing expectations and providing appropriate patient support following injury or treatment.</p>","PeriodicalId":94205,"journal":{"name":"Scars, burns & healing","volume":"11 ","pages":"20595131251387481"},"PeriodicalIF":0.0,"publicationDate":"2025-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12572712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145433649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Examining the role of post-traumatic stress disorder, chronic pain and opioid use in burn patients: A multi-cohort analysis\".","authors":"","doi":"10.1177/20595131251376836","DOIUrl":"https://doi.org/10.1177/20595131251376836","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1177/20595131241288298.].</p>","PeriodicalId":94205,"journal":{"name":"Scars, burns & healing","volume":"11 ","pages":"20595131251376836"},"PeriodicalIF":0.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12461071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145188163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geographic distribution and trends of small-area burn claims in Japan: An analysis using NDB open data from 2014 to 2021.","authors":"Takeshi Utsunomiya, Takahiro Ueda","doi":"10.1177/20595131251371009","DOIUrl":"10.1177/20595131251371009","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Burns are a major global health issue, causing approximately 180,000 deaths annually and leading to high morbidity rates. The Japan Trauma Data Bank Report 2022 recorded 1749 burn cases, with a mortality rate of 17.6%. However, comprehensive national data regarding non-fatal burns and regional differences in Japan are lacking. This study aimed to analyze the distribution of small-area burns among patients across Japanese prefectures using the National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;We utilized NDB Open Data from fiscal years 2014 to 2021 to investigate medical claims for small-area burns. The number of claims was normalized to the population of each prefecture using demographic data obtained from eStat, and the correlation between the number of claims and per capita income in each prefecture was assessed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The highest number of small-area burn claims was observed among children aged 0-5 years and individuals aged &gt;65 years. Women aged 15-64 years submit approximately twice as many claims as men in the same age group. Significant geographic variations were observed, with more claims in Kochi, Saga, Kumamoto, and Kagoshima and fewer claims in Okinawa, Hokkaido, and Chiba. The number of claims decreased annually, with Saga Prefecture exhibiting the most substantial reduction. There is a significant negative correlation between the number of claims and per capita income.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The annual decrease in claims corresponds with previous reports of a decreased incidence of burn injuries. Regional differences suggest an influence of local factors on burn incidence. Further research is necessary to explore these regional disparities and to identify effective burn prevention strategies.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Lay summary: &lt;/strong&gt;Burns are a major global health problem, causing many injuries and deaths each year. In Japan, severe burns are well-documented, but there is little information about small-area burns that do not require hospitalization. Understanding how often and where these small-area burns occur can help create better prevention strategies. This study aims to understand the frequency and distribution of small-area burns across different regions in Japan and among various age and gender groups. We want to identify which areas have higher or lower rates of small-area burns and observe any trends over time. We used data from Japan's National Database of Health Insurance Claims, covering 2014 to 2021. This database includes information on medical treatments paid for by health insurance. We calculated the number of small-area burns per 1000 people for each prefecture (region) in Japan and analyzed differences based on age and gender. We found small-area burns are most common among young children (aged 0-5) and older adults (over 65). Women aged 15-64 had about twice as many small-area b","PeriodicalId":94205,"journal":{"name":"Scars, burns & healing","volume":"11 ","pages":"20595131251371009"},"PeriodicalIF":0.0,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12368327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic role of mesenchymal stem cells in second-degree burn wound repair: Integration with split-thickness skin grafts.","authors":"Carl I Schulman, Divya Aickara, Luis Rodriguez-Menocal, Nicholas Namias, Louis Pizano, Wellington Guzman, Ambar Candanedo, Evangelos V Badiavas","doi":"10.1177/20595131251357442","DOIUrl":"10.1177/20595131251357442","url":null,"abstract":"<p><strong>Background: </strong>Mesenchymal stem cells (MSCs) have shown significant potential in a variety of clinical applications for repairing and regenerating damaged tissues. MSCs can stimulate cellular processes such as fibroblast proliferation, migration, and endothelial angiogenesis, as well as modulate the host's immune response to favor more optimal wound healing. Therefore, the application of mesenchymal stem cell (MSC) therapy to severe burn wounds holds promise as a potential avenue for improved outcomes, especially in cases where alternative therapies may be limited.</p><p><strong>Case presentation: </strong>We present the results of a specific case excluded from our previously reported phase I Clinical Trial, examining the safety of allogeneic bone marrow-derived stem cell therapy for deep 2nd-degree burn wounds. This patient had been discontinued from the trial as a clinical decision was made that the patient would best be served by subsequent split-thickness skin grafting, an exclusion criterion for the trial.</p><p><strong>Conclusion: </strong>We report the benefits of local allogenic MSC therapy followed by an early split-thickness skin graft. We observed a reduction in scar formation with improved sensation to touch using MSC therapy. No adverse events or evidence of rejection were seen. Our case report provides evidence supporting the notion that employing stem cell therapy preceding grafting represents a promising and synergistic therapeutic strategy for effectively treating burn injuries.</p><p><strong>Lay summary: </strong>Hypertrophic scarring is a common issue in burn wounds, despite surgery or non-surgical treatments, and it often leads to tight, restrictive scars that can cause significant discomfort and complications for patients. This report explores the safety of using bone marrow-derived mesenchymal stem cells (BM-MSCs) as a potential treatment for burn wounds, applied either directly to the skin or beneath the surface.To date, no adverse side effects have been reported with these methods. The report details the case of a patient who first received stem cells under the skin, followed by a topical application, and later had a skin graft to treat a large, deep second-degree burn. The stem cells used were from a young healthy adult donor. The patient's progress was monitored for six months.The findings suggest that combining donor stem cells with skin grafting could be a helpful way to treat burn injuries, particularly in cases of deep second-degree burns. This approach appears to enhance wound healing, facilitate faster recovery, and reduce complications like infections, which could lead to shorter hospital stays.</p>","PeriodicalId":94205,"journal":{"name":"Scars, burns & healing","volume":"11 ","pages":"20595131251357442"},"PeriodicalIF":0.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144736400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare scrotal burn from post-circumcision cetrimide-chlorhexidine (savlon) dressing: Case report and literature review.","authors":"Mahamudu Ayamba Ali, Mawuenyo Attawa Oyortey, Frank Obeng, Kekeli Kodjo Adanu, William Rehoboth Nyanator","doi":"10.1177/20595131251347495","DOIUrl":"10.1177/20595131251347495","url":null,"abstract":"<p><strong>Introduction: </strong>Scrotal burns resulting from wound care are a rare but preventable injury compared to the wide spectrum of post-circumcisions related complications documented. We report an inadvertent cetrimide-chlorhexidine antiseptic scrotal burns due to post-circumcision dressing and review the literature on genital chemical burns.</p><p><strong>Case presentation: </strong>A 6-week-old baby presented with a 3-days history of worsening scrotal burns following smearing of undiluted cetrimide-chlorhexidine as dressing post-circumcision. Examination revealed a healthy baby with non-tender non-specific multiple ulcers and pan-erythematous scrotum. Wound swab isolated Klebsiella and Pseudomonas spp.</p><p><strong>Discussions: </strong>Although there was no clinical complication during procedure, the wrongful post-operative care resulted in scrotal burns. The isolated uropathogens did not result in sepsis or Fournier's gangrene, we believe this preventable burn was eventually reported due to the worsening progression over the period, albeit with minor adverse effects.</p><p><strong>Conclusion: </strong>Post-circumcision instruction for cetrimide-chlorhexidine use by caregiver must be understood to avoid scrotal burns.</p><p><strong>Lay summary: </strong>Scrotal skin burns from chemical agent: Isolated scrotal skin burns are not common and even rarer when they are caused by prescribed medical solution. A neonate was brought in by the parents with complain of developing watery containing swellings on the scrotum that later bust and leads to peeling of the scrotal skin. The mother noticed this after applying dressing solution as part of the measures to prevent circumcision wound infection. Even though the child looked well, the large scrotal surface without skin cover could become a common point for bacteria entry into the body and its consequences. Even though our test isolated 2 different types of disease-causing bacteria from the scrotal wound, this child was managed well and the wounds healed without any further problem. The lessons: 1. circumcision is the commonest surgical procedure performed. 2. This incidence may only be the tip of the iceberg. 3. The parents brought him because it was getting worse. 4. It is a preventable injury by just using the agent in accordance with recommendations.</p>","PeriodicalId":94205,"journal":{"name":"Scars, burns & healing","volume":"11 ","pages":"20595131251347495"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}