Reumatologia clinica最新文献

{"title":"Comment on “Knowledge, intentions, and practices of breastfeeding among women with systemic lupus erythematosus: A cross-sectional survey”","authors":"Deepti M. Sati, Vanashri Dhananjay Shinde, Chhaya Agarwal","doi":"10.1016/j.reumae.2026.502223","DOIUrl":"10.1016/j.reumae.2026.502223","url":null,"abstract":"","PeriodicalId":94193,"journal":{"name":"Reumatologia clinica","volume":"22 7","pages":"Article 502223"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148915032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vogt–Koyanagi–Harada disease: Beyond ophthalmology, an important condition for the Latin American Rheumatology Community","authors":"Ignacio Javier Gandino, Ramiro Adrian Gómez, José Maximiliano Martínez Pérez, Cristhian A. Urzua","doi":"10.1016/j.reumae.2026.502166","DOIUrl":"10.1016/j.reumae.2026.502166","url":null,"abstract":"","PeriodicalId":94193,"journal":{"name":"Reumatologia clinica","volume":"22 7","pages":"Article 502166"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148915075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antisynthetase syndrome in Chile: Experience from a clinical cohort","authors":"Sebastián Campos Benavente,&nbsp;Sergio Prieto-González,&nbsp;Óscar Neira Quiroga,&nbsp;Verónica Wolff Cecchi","doi":"10.1016/j.reumae.2026.502216","DOIUrl":"10.1016/j.reumae.2026.502216","url":null,"abstract":"<div><h3>Background and objective</h3><div>Antisynthetase syndrome (ASS) is an autoimmune disease characterised by the presence of autoantibodies against aminoacyl-tRNA synthetases and a variable spectrum of clinical manifestations. Its clinical expression appears to depend on the predominant antibody subtype. In Latin America, and particularly in Chile, published data on this condition remain scarce. The aim of this study was to describe and compare the clinical, immunological, and therapeutic characteristics of patients with ASS according to antibody subtype in a Chilean cohort.</div></div><div><h3>Methods</h3><div>An analytical cross-sectional observational study was conducted, including patients with a clinical diagnosis of ASS and positivity for an antisynthetase antibody (Jo-1, PL-7, PL-12, EJ, or OJ) from Hospital del Salvador and Instituto Nacional del Tórax between June 2018 and June 2022. Clinical manifestations were compared between Jo-1 and non–Jo-1 groups. Fulfillment of classification criteria (Connors, Solomon, and CLASS), first-line treatment strategies, and fatal outcomes were also evaluated.</div></div><div><h3>Results</h3><div>A total of 60 patients was analyzed: 36.7% were anti–Jo-1 positive and 63.3% had other antisynthetase antibodies. Interstitial lung disease (ILD) was the most frequent manifestation (73.3%), predominating in the Jo-1 group (95.5% vs. 60.5%, <em>p</em> = 0.003). Myopathy and arthritis were more common in Jo-1 than in non–Jo-1 patients (<em>p</em> = 0.017 and <em>p</em> = 0.048, respectively). Patterns of clinical involvement differed significantly, with triple involvement (ILD, arthritis, and myopathy) observed in 52.4% of Jo-1 patients and 18.8% of non–Jo-1 patients (<em>p</em> = 0.0001). Only 56.6% of the cohort fulfilled Solomon criteria, whereas 80% fulfilled CLASS criteria, with lower fulfilment rates in the non–Jo-1 group. Mycophenolate mofetil was the most frequently used immunosuppressive therapy, particularly in patients with ILD, and methylprednisolone pulse therapy was associated with pulmonary involvement and more extensive clinical phenotypes. Ro52 positivity was associated with ILD (<em>p</em> = 0.002) and NSIP/OP patterns.</div></div><div><h3>Conclusion</h3><div>Antisynthetase syndrome in Chile demonstrated a heterogeneous clinical spectrum according to antibody subtype. Only one-third of patients were anti–Jo-1 positive, showing a more classic clinical phenotype, whereas non–Jo-1 patients tended to present with a more oligosymptomatic disease pattern. The high frequency of ILD and its association with Ro52 positivity highlight their clinical relevance. Current classification criteria appear insufficient for non–Jo-1 patients, emphasizing the need for validation studies in our region.</div></div>","PeriodicalId":94193,"journal":{"name":"Reumatologia clinica","volume":"22 7","pages":"Article 502216"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148633373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arachnodactyly and congenital contractures in a patient with nodular osteoarthritis: Suspicion of Beals syndrome","authors":"Julia Ulier Bellmunt,&nbsp;Yedra Usón Rodríguez,&nbsp;Pilar Martínez Vallés,&nbsp;Marina Soledad Moreno García","doi":"10.1016/j.reumae.2026.502206","DOIUrl":"10.1016/j.reumae.2026.502206","url":null,"abstract":"","PeriodicalId":94193,"journal":{"name":"Reumatologia clinica","volume":"22 7","pages":"Article 502206"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148633406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rheumatologic manifestations and diagnostic delay of nutritional rickets: Experience from a paediatric rheumatology unit","authors":"Adrián Mayo-Juanatey,&nbsp;Rosa Bou Torrent,&nbsp;Joan Calzada-Hernández,&nbsp;Silvia Marín del Barrio,&nbsp;María Navallas Irujo,&nbsp;Jordi Antón","doi":"10.1016/j.reumae.2026.502161","DOIUrl":"10.1016/j.reumae.2026.502161","url":null,"abstract":"","PeriodicalId":94193,"journal":{"name":"Reumatologia clinica","volume":"22 7","pages":"Article 502161"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148633377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Update to the Sociedad Española de Reumatología Guidelines on the Use of Biological Therapy in Systemic Lupus Erythematosus","authors":"Íñigo Rúa-Figueroa,&nbsp;Noé Brito García,&nbsp;María Galindo Izquierdo,&nbsp;Jaime Calvo Alén,&nbsp;Irene Altabás González,&nbsp;Beatriz Tejera Segura,&nbsp;Tarek Carlos Salman Monte,&nbsp;José María Pego-Reigosa,&nbsp;Enrique Morales Ruiz,&nbsp;Ignacio García Doval,&nbsp;Julio Suarez Cuba,&nbsp;Leyre Riancho Zarrabeitia,&nbsp;Ariadna Auladell Rispau,&nbsp;Janet Puñal Riobóo","doi":"10.1016/j.reumae.2026.502201","DOIUrl":"10.1016/j.reumae.2026.502201","url":null,"abstract":"<div><div>The significant growth of information in the field of biological therapies (BT) for the treatment of systemic lupus erythematosus (SLE) has made it necessary to update the previous SER recommendation document. Three BTs have been approved for use in SLE. The first BT available was belimumab, with an already abundant and solid body of evidence regarding its efficacy and safety. More recently, anifrolumab was added, also backed by a robust body of evidence but with less experience of practical application. Finally, the emergence of obinutuzumab, a second-generation anti-CD20 monoclonal antibody that is more effective than rituximab and has demonstrated efficacy in lupus nephritis, has revitalised ablative therapy in SLE, although more safety data is needed before it can widely replace rituximab. Despite the lack of direct comparisons between the various biological agents available, certain differences regarding their efficacy across different disease domains, as well as in the speed of action and safety-related aspects, must be taken into account when tailoring treatment decisions. Overall, biologics have been increasingly incorporated into the treatment algorithm at earlier stages of SLE, based on their ability to improve outcomes compared to standard therapy, and are now first-line treatments for certain manifestations such as lupus nephritis.</div></div>","PeriodicalId":94193,"journal":{"name":"Reumatologia clinica","volume":"22 7","pages":"Article 502201"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148702740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence literacy in fibromyalgia: The inverse gap between informed patients and unprepared clinicians","authors":"Juan Sebastián Therán-León,&nbsp;Andrés Felipe Otero-Rueda","doi":"10.1016/j.reumae.2026.502154","DOIUrl":"10.1016/j.reumae.2026.502154","url":null,"abstract":"","PeriodicalId":94193,"journal":{"name":"Reumatologia clinica","volume":"22 6","pages":"Article 502154"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148261280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Capillaroscopic alterations characterization in patients with primary systemic vasculitis","authors":"Everardo Álvarez-Hernández,&nbsp;Mariana Berenice Colli-Cortés","doi":"10.1016/j.reumae.2026.502168","DOIUrl":"10.1016/j.reumae.2026.502168","url":null,"abstract":"<div><h3>Background</h3><div>Clinical manifestations in systemic vasculitis may be due to decreased arterial and venous flow because inflammation. There are few studies characterizing the changes in microcirculation in these diseases. Capillaroscopy can help detect changes in the microvasculature.</div></div><div><h3>Objective</h3><div>Characterize capillaroscopy alterations in primary systemic vasculitis’s patients and associated factors.</div></div><div><h3>Patients</h3><div>Cross-sectional, observational, and comparative study. Thirty-two patients with systemic vasculitis (PGA <em>n</em> = 17, PAM <em>n</em> = 4, AT <em>n</em> = 4, PHS n = 3, PAN <em>n</em> = 2, and others <em>n</em> = 2) and 32 controls matched for age and sex were included. All participants underwent capillaroscopy of eight fingers (2nd to 5th finger of each hand), obtaining at least two images of each finger studied for analysis.</div></div><div><h3>Results</h3><div>No characteristic pattern was found, only nonspecific changes. Avascular areas (84.4% vs. 59.4%, <em>p</em> = .026), microhemorrhages (34.4% vs. 6.3%, <em>p</em> &lt; .005), and neoangiogenesis (34.4% vs. 0%, <em>p</em> &lt; .001) were more frequent in the vasculitis group compared to the control group. The duration of the disease had moderate correlation with capillary density (<em>r</em> = −.31, <em>p</em> = .010) and avascular areas (<em>r</em> = .40, <em>p</em> = .001).</div><div>VDI had moderate correlation (<em>r</em> = .50, <em>p</em> = .050) with capillary density. Capillary neoangiogenesis correlated with the diagnosis of vasculitis (<em>r</em> = −.40, <em>p</em> = .001) and ischemic lesions (<em>r</em> = .371, <em>p</em> = .003). The factors associated with capillaroscopic changes were: disease activity (BVAS3), cumulative damage (VDI) and presence of ischemic lesions.</div></div><div><h3>Discussion and conclusions</h3><div>The search for capillaroscopic abnormalities in patients with systemic vasculitis may be useful in patients with a history of ischemic lesions and longer disease duration.</div></div>","PeriodicalId":94193,"journal":{"name":"Reumatologia clinica","volume":"22 6","pages":"Article 502168"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148261272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical validation of video DASH for upper limb disorders in rheumatic patients","authors":"David Vega-Morales,&nbsp;Talia Dinora Galván-Lara,&nbsp;Jorge Medina-Castillo,&nbsp;Pablo Herrera-Sandate,&nbsp;Luis Antonio Chavez-Alvarez,&nbsp;Paulina Valdés Torres,&nbsp;Ana Karen Vazquez-Bañuelos","doi":"10.1016/j.reumae.2026.502192","DOIUrl":"10.1016/j.reumae.2026.502192","url":null,"abstract":"<div><h3>Introduction</h3><div>The Disabilities of the Arm, Shoulder and Hand (DASH) is a widely validated 30-item self-administered instrument used to quantify upper limb disability. In rheumatoid arthritis, limitations in construct validity have been reported in certain subgroups; therefore, a multimedia version (video-DASH), incorporating illustrative videos for each item, may improve comprehension and response consistency.</div></div><div><h3>Objective</h3><div>To evaluate the psychometric properties and acceptability of the video-DASH in patients with rheumatological diseases affecting the upper limb.</div></div><div><h3>Materials and methods</h3><div>A prospective methodological validation study including 28 participants (≥18 years) with a confirmed rheumatological diagnosis involving the upper limb. Exclusion criteria were severe cognitive impairment, visual or hearing limitations precluding interaction with the multimedia version, and surgery or acute upper limb injury within the previous 3 months. The questionnaire was administered at three time points. Internal consistency (Cronbach's <em>α</em>), test–retest reliability (intraclass correlation coefficient, ICC), longitudinal comparisons (Wilcoxon test with Holm correction), and agreement (Bland–Altman analysis) were assessed. A comprehension and satisfaction survey was also administered.</div></div><div><h3>Results</h3><div>Mean age was 55.5<!--> <!-->±<!--> <!-->9.06 years (34–72), and the predominant diagnosis was rheumatoid arthritis (92.9%). Mean scores decreased from 31.93 to 26.53 and 23.08, with significant differences across comparisons. Internal consistency was high (<em>α</em> <!-->=<!--> <!-->0.961, 0.979, and 0.987), and reliability was adequate (ICC<!--> <!-->=<!--> <!-->0.785–0.940). Bland–Altman analysis showed minimal bias. All participants reported adequate comprehension and positive satisfaction.</div></div><div><h3>Conclusion</h3><div>The video-DASH demonstrates good reliability and acceptability, supporting its use as a tool to assess upper limb function in patients with rheumatic disease.</div></div>","PeriodicalId":94193,"journal":{"name":"Reumatologia clinica","volume":"22 6","pages":"Article 502192"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148321077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coexistence of systemic lupus erythematosus and sarcoidosis: A case-based review","authors":"Dilara Bulut Gökten,&nbsp;Meltem Öznur,&nbsp;Rıdvan Mercan","doi":"10.1016/j.reumae.2026.502169","DOIUrl":"10.1016/j.reumae.2026.502169","url":null,"abstract":"<div><div>Sarcoidosis and systemic lupus erythematosus (SLE) are chronic multisystem inflammatory diseases with distinct pathogenetic mechanisms but overlapping clinical and immunological features. Their coexistence is exceedingly rare and may result in diagnostic delay or misinterpretation of disease activity. A 50-year-old woman presented with photosensitive facial rash, oral ulcers, constitutional symptoms, cytopenia, hypocomplementemia, and markedly elevated anti-double-stranded DNA titers, fulfilling the 2019 ACR/EULAR classification criteria for SLE. During follow-up, atypical cutaneous lesions involving the external auditory canal were identified. Histopathological examination revealed non-caseating granulomatous inflammation. Further evaluation with thoracic imaging and endobronchial ultrasound-guided biopsy demonstrated bilateral hilar and mediastinal lymphadenopathy with granulomatous inflammation, confirming the diagnosis of sarcoidosis. Treatment with hydroxychloroquine, systemic corticosteroids, and methotrexate led to significant clinical and laboratory improvement over a six-month follow-up period. This case highlights the importance of considering a coexisting diagnosis when atypical clinical or histopathological findings emerge in patients with established autoimmune disease, with histological confirmation playing a central role in accurate diagnosis.</div></div>","PeriodicalId":94193,"journal":{"name":"Reumatologia clinica","volume":"22 6","pages":"Article 502169"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148321120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}