Progress in cardiovascular diseases最新文献

{"title":"Transcatheter versus surgical pulmonary valve replacement in native RVOT: A 3-year propensity score-matched study.","authors":"Borja Rivero-Santana, Enrique Balbacid-Domingo, Santiago Jiménez-Valero, César Abelleira-Pardeiro, Miguel Ángel Martín-Arena, Jesús Saldaña-García, Pablo Merás-Colunga, José Ruiz-Cantador, Carlos Merino, Luz Polo, Jesús Blázquez, María Fernández-Velasco, Ángel Aroca, Raúl Moreno, Federico Gutiérrez-Larraya","doi":"10.1016/j.pcad.2026.08.002","DOIUrl":"10.1016/j.pcad.2026.08.002","url":null,"abstract":"<p><strong>Background: </strong>Surgical pulmonary valve replacement (SPVR) is the standard therapy for native or patched right ventricular outflow tract (nRVOT) dysfunction. Transcatheter pulmonary valve replacement (TPVR) has emerged as a less invasive alternative, but comparative data are lacking.</p><p><strong>Objectives: </strong>To compare clinical outcomes and valve performance between TPVR and SPVR in patients with nRVOT dysfunction.</p><p><strong>Methods: </strong>Patients with nRVOT dysfunction undergoing TPVR or SPVR were retrospectively identified. TPVR cases were propensity score-matched 1:2 to SPVR. The primary outcome was freedom from all-cause mortality, prosthetic valve endocarditis, or valve-related reintervention.</p><p><strong>Results: </strong>Among 176 patients, 123 (41 TPVR, 82 SPVR) were matched. At 3 years, freedom from the primary outcome was 95.2% for TPVR and 91.5% for SPVR (HR 0.68; 95% CI 0.14-3.29; p = 0.63). TPVR had fewer major in-hospital complications (4.9% vs 18.3%; p = 0.04) and shorter ICU and hospital stays (0.3 ± 0.8 vs 4.8 ± 6.9 days, and 3.1 ± 3.0 vs 12.9 ± 14.6 days; both p < 0.001). Mean gradients were consistently lower with TPVR post-procedure (8.0 vs 9.9 mmHg; p = 0.02), at 1 year (7.9 vs 10.6 mmHg; p = 0.02), and at 3 years (8.4 vs 11.0 mmHg; p = 0.03). Pulmonary regurgitation remained comparable, with most patients having none or mild regurgitation at 3 years (90.0% vs 94.5%; p = 0.22).</p><p><strong>Conclusions: </strong>In the first propensity score-matched comparison of TPVR and SPVR in nRVOT dysfunction, TPVR demonstrated comparable 3-year clinical outcomes, fewer major in-hospital complications, shorter hospital stay, and more favorable valve hemodynamic performance. These findings support TPVR as an effective, less invasive alternative, although longer-term outcomes warrant further study.</p>","PeriodicalId":94178,"journal":{"name":"Progress in cardiovascular diseases","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148690687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large language models in sports cardiology: Challenges, governance, and human-in-the-loop integration.","authors":"Stefano Palermi, Andrea Saglietto, Fabrizio D'Ascenzo, Gaetano Maria De Ferrari, Francesco Bruno, Gary Tse, Sevda Ece Kizilkiliç, Fleur Tjong, Samuel Ruiperez Campillo, Nurgul Keser, Stefan Busnatu, Maria Marketou, Florian A Wenzl, Marco Vecchiato, Joao Matteo Rampone","doi":"10.1016/j.pcad.2026.07.005","DOIUrl":"https://doi.org/10.1016/j.pcad.2026.07.005","url":null,"abstract":"<p><strong>Background: </strong>Large language models (LLMs) are increasingly integrated into clinical artificial intelligence (AI) workflows, with emerging applications in medical documentation, information synthesis, guideline retrieval, and patient communication. Recent advances in foundation models, including multimodal systems, have further expanded these capabilities. However, current evidence derives predominantly from examination-style benchmarks, retrospective vignettes, and hospital-based populations, limiting its direct applicability to athlete-centered cardiovascular care. Sports cardiology represents a uniquely challenging environment for AI because of low disease prevalence, physiological-pathological overlap, longitudinal uncertainty, and eligibility-driven decision-making.</p><p><strong>Main body: </strong>This narrative review critically examines the conceptual, technical, regulatory, and governance challenges associated with LLM deployment in sports cardiology. We argue that current evaluation paradigms inadequately capture the uncertainty-intensive nature of athlete cardiovascular assessment and propose the text-proxy paradigm, a governance-oriented framework in which LLMs operate as semantic integration layers that process clinician-verified and structured outputs generated by validated upstream systems rather than directly interpreting physiological signals. Within this architecture, LLMs may support documentation, longitudinal synthesis, guideline retrieval, contextual reasoning, and athlete communication under continuous human oversight. We further discuss uncertainty propagation across layered AI systems, workflow-oriented validation, regulatory implications, and a staged framework for responsible clinical implementation.</p><p><strong>Conclusion: </strong>Future progress will depend less on increasingly capable models than on trustworthy clinical ecosystems that prioritize governance, calibration, transparency, auditability, and clinician oversight. Rather than serving as an early adopter of autonomous AI, sports cardiology may provide a benchmark for the responsible integration of foundation models into high-stakes clinical medicine.</p>","PeriodicalId":94178,"journal":{"name":"Progress in cardiovascular diseases","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148611472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical activity, fitness, and longevity.","authors":"Fabian Sanchis-Gomar, Carl J Lavie, Fatima Rodriguez, Peter Kokkinos, Barry A Franklin","doi":"10.1016/j.pcad.2026.07.004","DOIUrl":"10.1016/j.pcad.2026.07.004","url":null,"abstract":"<p><p>Longevity is a relevant cardiovascular (CV) endpoint because survival integrates incident CV disease (CVD), competing non-CVD risks, and the physiological reserve that determines resilience to aging and chronic illness. Two related constructs, physical activity (PA; a modifiable behavior) and cardiorespiratory fitness (CRF; an integrative phenotype reflecting habitual PA, genetics, cardiopulmonary function, skeletal muscle oxidative capacity, and comorbidity), are consistently associated with lower all-cause and CVD mortality across diverse populations. In this invited narrative review, we synthesize evidence linking PA and CRF to longevity, highlight the dose-response nature of benefits and the importance of activity domain and intensity, and explain why CRF generally outperforms self-reported PA for risk prediction. We address challenges in causal inference, residual confounding variables, reverse causation, and selection/measurement bias, and emphasize approaches that strengthen inference, including device-based PA assessment (e.g., accelerometry), repeated measures, and triangulation with mechanistic and trial evidence. Mechanistic pathways plausibly linking PA and CRF to survival include favorable effects on blood pressure, glycemia and insulin sensitivity, adiposity and body composition, vascular reactivity, autonomic balance, inflammation and immune function, thrombosis, and preservation of skeletal muscle and mitochondrial reserve. We review evidence in particularly relevant subgroups and discuss the \"extreme exercise hypothesis\", distinguishing mortality from risks, such as atrial fibrillation and accelerated coronary calcification, in endurance athletes. We conclude with practical actions for clinicians and health systems, such as prescribing activities based on the frequency, intensity, time, and type (FITT) principles, incorporating resistance training, treating CRF as a vital sign, and addressing common implementation barriers.</p>","PeriodicalId":94178,"journal":{"name":"Progress in cardiovascular diseases","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148564213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of age at cardiometabolic disease diagnosis with mortality and life expectancy: 8.4 million person-years of observation.","authors":"Qing Wang, Lu Long, Lei Liu, Shanshan Zhang, Xingyao Li, Qian Shen, Siyue Wang, Pengcheng Liu, Huan Liu, Chenhui Zhang, Xiangli Chen, Ying Qu, Mengjie Huang, Jie Tang, Rong Zhong","doi":"10.1016/j.pcad.2026.07.006","DOIUrl":"10.1016/j.pcad.2026.07.006","url":null,"abstract":"<p><strong>Background: </strong>Cardiometabolic disease (CMD) and cardiometabolic multimorbidity (CMM) are increasing rapidly, particularly among younger adults. This study aimed to quantify associations of age at CMD/CMM diagnosis with mortality risk and life expectancy.</p><p><strong>Methods: </strong>A total of 684,218 participants from six cohorts (UK Biobank, US NHANES, SHARE, CHARLS, CMEC, and ELSA) were included. CMD was defined as the presence of cardiovascular disease (CVD), hypertension, or diabetes. Cox proportional hazard models were used to estimate hazard ratios (HRs) for all-cause and cause-specific mortality according to age at CMD diagnosis. Life expectancy reduction were further evaluated by age of diagnosis.</p><p><strong>Results: </strong>Earlier CMD diagnosis showed a clear dose-response association with higher mortality across cohorts. In the UK Biobank, the HR (95% CI) for all-cause mortality was 5.91 (4.95-7.06) for diagnosis before age 40, declining to 1.37 (1.33-1.41) at ≥70 years. Similar trends were observed in other cohorts. Earlier CMD diagnosis were also associated with greater life expectancy reduction. For instance, among 60-year-olds in the UK Biobank, those diagnosed before age 40, at 40-49, and at 50-59 years lost approximately 9.3, 5.4, and 3.2 years, respectively. For multimorbidity, mortality risk and years of life lost increased with the number of CMDs. Participants with coexisting CVD and hypertension diagnosed before age 40 had the highest mortality risk [7.36 (5.09-10.63)] and lost about 9.6 years of life at age 60.</p><p><strong>Conclusions: </strong>Earlier diagnosis of CMD and CMM is strongly associated with elevated mortality and substantial reductions in life expectancy. These findings underscore the importance of early preventive intervention strategies to delay disease onset and mitigate premature mortality.</p>","PeriodicalId":94178,"journal":{"name":"Progress in cardiovascular diseases","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148551932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronary CT angiography for risk stratification among young adults: Prevalence of atherosclerosis and long-term outcomes.","authors":"Arthur Shiyovich, Daniel M Huck, Rhanderson Cardoso, Adam N Berman, Stephanie A Besser, David W Biery, Avinainder Singh, Milena Petranovic, Brittany N Weber, Jon Hainer, Camila V Blair, Ludovic Trinquart, Nandini Meyersohn, Vinit Baliyan, Cian P McCarthy, Michael T Lu, Leandro Slipczuk, Khurram Nasir, Michael Steigner, Ayaz Aghayev, Sandeep Hedgire, Marcelo Di Carli, Brian Ghoshhajra, Ron Blankstein","doi":"10.1016/j.pcad.2026.07.003","DOIUrl":"10.1016/j.pcad.2026.07.003","url":null,"abstract":"<p><strong>Aims: </strong>The prevalence and long-term prognostic significance of coronary atherosclerosis detected by coronary computed tomography angiography (CCTA) in young adults remain insufficiently defined. We aimed to evaluate the prevalence of coronary atherosclerosis and its association with long-term cardiovascular outcomes among young adults undergoing clinically indicated CCTA.</p><p><strong>Methods and results: </strong>We performed a retrospective cohort study of consecutive patients undergoing CCTA at two academic centres between 2006 and 2021. Patients with prior coronary artery disease, end-stage renal disease, or malignancy were excluded. Young adults were defined as men ≤50 years and women ≤60 years. Coronary artery disease (CAD) was classified as no CAD, non-obstructive plaque (1-49% stenosis), or obstructive CAD (≥50% stenosis). The primary outcome was a composite of cardiovascular death, non-fatal myocardial infarction, or ischaemic stroke. Associations between CAD severity and outcomes were assessed using cause-specific proportional hazards models with multivariable adjustment. Among 10,247 young adults (median age 47 years; 56% women), 29.0% had non-obstructive plaque and 8.7% had obstructive CAD. Over a median follow-up of 6.7 years (interquartile range 4.2-10.4), the risk of the primary outcome increased with increasing CAD severity. Compared with no CAD, obstructive CAD was associated with a more than two-fold higher risk of events [adjusted hazard ratio (HR) 2.6, 95% confidence interval (CI) 1.9-3.6], while non-obstructive CAD was associated with a modest, non-significant increase in risk (adjHR 1.2, 95% CI 0.9-1.7). Among patients with non-obstructive CAD, event rates increased with greater plaque extent.</p><p><strong>Conclusion: </strong>In routine clinical practice, approximately 40% of young adults undergoing CCTA demonstrate coronary atherosclerosis, which is independently associated with adverse long-term cardiovascular outcomes. These findings support the role of CCTA in early risk stratification and targeted preventive strategies among younger individuals.</p>","PeriodicalId":94178,"journal":{"name":"Progress in cardiovascular diseases","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148538026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caution: very high HDL-cholesterol.","authors":"Sultana Monira Hussain, Andrew M Tonkin, John J McNeil","doi":"10.1016/j.pcad.2026.07.001","DOIUrl":"10.1016/j.pcad.2026.07.001","url":null,"abstract":"","PeriodicalId":94178,"journal":{"name":"Progress in cardiovascular diseases","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148407594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socioeconomic inequalities in the association between diet quality and incident cardiovascular diseases: A prospective study in the Netherlands.","authors":"Ming-Jie Duan, Maartje P Poelman, Eva Corpeleijn, Sander Biesbroek","doi":"10.1016/j.pcad.2026.07.002","DOIUrl":"10.1016/j.pcad.2026.07.002","url":null,"abstract":"<p><strong>Aims: </strong>Lower socioeconomic position (SEP) groups have higher risks of cardiovascular diseases (CVD), with diet quality being a crucial risk factor. However, whether the association between diet quality and incident CVD differs across SEP (education and income) groups is unclear, which was examined in this study.</p><p><strong>Methods: </strong>This study included participants aged 30-80 years, free of CVD at baseline, from the Dutch Lifelines cohort. The Lifelines Diet Score, a diet quality indicator based on Dutch dietary guidelines, was calculated with data assessed by a 110-item food frequency questionnaire. Cox proportional hazards models were used to assess the association between diet quality and incident CVD (the first non-fatal major cardiovascular event), and whether this association was modified by SEP, adjusted for age, sex, energy intake, alcohol intake, smoking, TV watching time, moderate-to-vigorous physical activity, sleep duration, social/hobby clubs participation, chronic stress, family history of CVD, and BMI.</p><p><strong>Results: </strong>Of 82,360 participants included, 2827 incident CVD cases were identified (median follow-up 7.4 years, incidence rate 4.7 per 1000 person-years). Education modified the association between diet quality and incident CVD (P-interaction = 0.033). Comparing the poorest to the best diet quality quartiles, hazard ratios (95%CI) were 1.27 (1.06, 1.51) in low, 1.28 (1.06, 1.54) in middle, and 0.98 (0.76, 1.27) in high education group.</p><p><strong>Conclusions: </strong>For low- and middle-education groups, poor diet quality was associated with disproportionately higher risks of incident CVD. Improving diet quality may therefore have the potential to be a core entry point for lowering CVD health inequalities. To address persistent health inequalities, health policies should tackle broader environmental, social, and structural factors of diet and health equity.</p>","PeriodicalId":94178,"journal":{"name":"Progress in cardiovascular diseases","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148400220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative associations of LDL-C, Lp(a), hsCRP, and IL-6 with cardiovascular risk: Insights from the United Kingdom (UK) biobank and the multi-ethnic study of atherosclerosis (MESA).","authors":"James McParland, Rishi Rikhi, Harpreet S Bhatia, Alexander C Razavi, Parag Chevli, Saeid Mirzai, Jared A Spitz, Garima Sharma, Shahzeb Khan, Leandro Slipczuk, Mayank Dalakoti, Michael J Blaha, Roger S Blumenthal, Michael D Shapiro","doi":"10.1016/j.pcad.2026.05.005","DOIUrl":"https://doi.org/10.1016/j.pcad.2026.05.005","url":null,"abstract":"<p><strong>Introduction: </strong>Low-density lipoprotein-cholesterol (LDL-C) is a well-established causal risk factor for atherosclerosis and remains the cornerstone of primary prevention. Lipoprotein(a) [Lp(a)] and high-sensitivity C-reactive protein (hsCRP) are considered risk-enhancing factors in current guidelines. Interleukin-6 (IL-6), a pro-inflammatory cytokine upstream of CRP, has recently emerged as a potential therapeutic target. We sought to compare the longitudinal associations of LDL-C, Lp(a), hsCRP, and IL-6, both individually and in relation to one another, with atherosclerotic cardiovascular disease (ASCVD) events in two large, contemporary primary prevention cohorts.</p><p><strong>Methods: </strong>Participants with baseline measurements of LDL-C, Lp(a), hsCRP, and IL-6 from the United Kingdom (UK) Biobank and the Multi-Ethnic Study of Atherosclerosis (MESA) were included in this study. The primary endpoint was incident ASCVD (defined as composite of myocardial infarction, stroke, or cardiovascular death). Cox proportional hazards models were used to calculate hazard ratios across biomarker quartiles, adjusting for traditional risk factors and other biomarkers.</p><p><strong>Results: </strong>The mean age (SD) was 56.8 (8.1) years in UK Biobank and 62.2 (10.2) years in MESA. In fully adjusted models including all covariates, the HRs for ASCVD comparing top vs bottom quartiles in UK Biobank were: LDL-C 1.10 (95% CI: 0.97-1.25), Lp(a) 1.15 (1.03-1.29), hsCRP 1.19 (1.04-1.37), and IL-6 1.67 (1.44-1.93). In MESA, corresponding HRs were: LDL-C 1.26 (1.02-1.56), Lp(a) 1.23 (0.99-1.53), hsCRP 1.13 (0.88-1.44), and IL-6 1.60 (1.24-2.07).</p><p><strong>Conclusion: </strong>In two large primary prevention cohorts, IL-6 demonstrated the strongest association with ASCVD, independent of LDL-C, Lp(a), and hsCRP when mutually adjusted. These data suggest that IL-6 may be a key driver of ASCVD, with potential implications for risk prediction and therapeutic targeting for prevention of ASCVD.</p>","PeriodicalId":94178,"journal":{"name":"Progress in cardiovascular diseases","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148007486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovations in cardiac computed tomography: Imaging in coronary artery disease.","authors":"Venkat Sanjay Manubolu, Keishi Ichikawa, Matthew J Budoff","doi":"10.1016/j.pcad.2024.05.005","DOIUrl":"10.1016/j.pcad.2024.05.005","url":null,"abstract":"<p><p>Coronary computed tomography angiography (CCTA) has emerged as a pivotal tool in the non-invasive evaluation of coronary artery disease (CAD). Recent advancements in imaging techniques, quantitative plaque assessment methods, assessment of coronary physiology, and perivascular coronary inflammation have propelled CCTA to the forefront of CAD management, enabling precise risk stratification, disease monitoring, and evaluation of treatment response. However, challenges persist, including the need for cardiovascular outcomes data for therapy modifications based on CCTA findings and the lack of standardized quantitative plaque assessment techniques to establish universal guidelines for treatment strategies. This review explores the current utilization of CCTA in clinical practice, highlighting its clinical impact and discussing challenges and opportunities for future development. By addressing these nuances, CCTA holds promise for revolutionizing coronary imaging and improving CAD management in the years to come. Ultimately, the goal is to provide precise risk stratification, optimize medical therapy, and improve cardiovascular outcomes while ensuring cost-effectiveness for healthcare systems.</p>","PeriodicalId":94178,"journal":{"name":"Progress in cardiovascular diseases","volume":" ","pages":"51-59"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}