Progress in cardiovascular diseases最新文献

Advancing familial hypercholesterolaemia management: real-world evidence for inclisiran's impact on LDL-C and arterial stiffness. 推进家族性高胆固醇血症管理：inclisiran对LDL-C和动脉硬度影响的真实证据

IF 7.6

Progress in cardiovascular diseases Pub Date : 2025-07-31 DOI: 10.1016/j.pcad.2025.07.010

Amany Elshorbagy, Kausik Ray

引用次数: 0

Transthyretin amyloid cardiomyopathy: Evolving therapies, expanding hope. 转甲状腺素淀粉样心肌病：不断发展的疗法，扩大的希望。

IF 7.6

Progress in cardiovascular diseases Pub Date : 2025-07-26 DOI: 10.1016/j.pcad.2025.07.011

Juan Pablo Costabel, Leonardo Lucas Suarez, Yogita Rochlani, Ahmad Masri, Leandro Slipczuk, Enrique Berrios

{"title":"Transthyretin amyloid cardiomyopathy: Evolving therapies, expanding hope.","authors":"Juan Pablo Costabel, Leonardo Lucas Suarez, Yogita Rochlani, Ahmad Masri, Leandro Slipczuk, Enrique Berrios","doi":"10.1016/j.pcad.2025.07.011","DOIUrl":"https://doi.org/10.1016/j.pcad.2025.07.011","url":null,"abstract":"Transthyretin amyloid cardiomyopathy (ATTR-CM) is a progressive and life-threatening condition characterized by the deposition of misfolded transthyretin (TTR) protein in the myocardium, leading to restrictive cardiomyopathy and heart failure. Given its high mortality rate and historically limited therapeutic options, there is a growing need for effective treatments. Current therapeutic strategies focus on reducing the production of TTR using RNA-targeted therapies and stabilizing the native TTR tetramer to prevent misfolding and aggregation. In recent years, emerging therapies-including monoclonal antibodies aimed at promoting amyloid clearance and gene-editing techniques designed to eliminate pathogenic TTR expression-have demonstrated encouraging results in early-phase studies. However, several challenges persist, including delays in diagnosis, variability in clinical response, and limited long-term outcome data. Early detection, timely initiation of treatment, and a personalized approach based on disease stage and genotype are critical to improving prognosis. Ongoing clinical trials are expected to provide further insight into the durability, safety, and broader applicability of these novel therapies, potentially reshaping the treatment landscape for ATTR-CM.","PeriodicalId":94178,"journal":{"name":"Progress in cardiovascular diseases","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144736395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atherogenic dyslipidemia: A marker of cardiovascular risk in treated hypertension. 动脉粥样硬化性血脂异常：高血压治疗后心血管风险的标志。

IF 7.6

Progress in cardiovascular diseases Pub Date : 2025-07-23 DOI: 10.1016/j.pcad.2025.07.008

Waqas A Malick, Omar Al Dhaybi, Deepak L Bhatt

引用次数: 0

Catheter ablation as first line therapy for atrial fibrillation. 导管消融作为房颤的一线治疗。

Progress in cardiovascular diseases Pub Date : 2025-07-22 DOI: 10.1016/j.pcad.2025.07.009

Maham F Karatela, Hugh Calkins

引用次数: 0

Rethinking coronary artery metal implants. 重新思考冠状动脉金属植入。

IF 7.6

Progress in cardiovascular diseases Pub Date : 2025-07-17 DOI: 10.1016/j.pcad.2025.07.005

Pier Pasquale Leone, Mauro Gitto, Chao Gao, Jorge Sanz Sánchez, Azeem Latib, Antonio Colombo

引用次数: 0

Fat, fib, and forgetfulness: The interplay between adiposity, atrial fibrillation, and dementia. 脂肪、心房纤颤和健忘：肥胖、心房纤颤和痴呆之间的相互作用。

IF 7.6

Progress in cardiovascular diseases Pub Date : 2025-07-17 DOI: 10.1016/j.pcad.2025.07.006

Tyson S Burnham, Ravi Ranjan, Klitos Konstantinidis, Benjamin A Steinberg, T Jared Bunch

引用次数: 0

How to facilitate smoking cessation. 如何促进戒烟。

Progress in cardiovascular diseases Pub Date : 2025-07-16 DOI: 10.1016/j.pcad.2025.07.007

Furio Colivicchi, Stefania Angela Di Fusco, Vered Gil Ad, Silvia Castelletti, Luigi Pollarolo, Maria Laura Canale, Simona Giubilato, Roberta Rossini, Stefano Oliva, Andrea Tedeschi, Alessandra Greco, Myriam Rita Intravaia, Francesco Antonio Veneziano, Piero Clavario, Claudio Bilato, Marco Corda, Giovanna Geraci, Attilio Iacovoni, Alessandro Navazio, Federico Nardi, Domenico Gabrielli, Massimo Grimaldi, Fabrizio Oliva

引用次数: 0

Left atrial size trajectories and outcome over a 35-year follow-up in patients with hypertrophic cardiomyopathy. 肥厚性心肌病患者35年随访的左心房大小轨迹和结果。

Progress in cardiovascular diseases Pub Date : 2025-07-11 DOI: 10.1016/j.pcad.2025.07.004

Salvatore Di Napoli, Daniela Pacella, Leopoldo Ordine, Grazia Canciello, Felice Borrelli, Lorenzo Moscano, Raffaele Martorano, Roberto Polizzi, Brigida Napolitano, Alessandra Spinelli, Raffaella Lombardi, Giovanni Esposito, Maria Angela Losi

{"title":"Left atrial size trajectories and outcome over a 35-year follow-up in patients with hypertrophic cardiomyopathy.","authors":"Salvatore Di Napoli, Daniela Pacella, Leopoldo Ordine, Grazia Canciello, Felice Borrelli, Lorenzo Moscano, Raffaele Martorano, Roberto Polizzi, Brigida Napolitano, Alessandra Spinelli, Raffaella Lombardi, Giovanni Esposito, Maria Angela Losi","doi":"10.1016/j.pcad.2025.07.004","DOIUrl":"10.1016/j.pcad.2025.07.004","url":null,"abstract":"Background: In Hypertrophic cardiomyopathy (HCM) increasing evidence suggests left atrial (LA) remodelling plays a critical role in disease progression. Traditional static LA size measurements, while established as risk markers, do not reflect the dynamic nature of LA changes over time.Objectives: This study aimed to define long-term LA remodelling trajectories in HCM and assess their prognostic value for predicting atrial fibrillation (AF), sudden cardiac death (SCD), and heart failure (HF) death.Methods: A cohort of 210 HCM patients with at least 5 LA measurements (36 % women, mean age 45 ± 17 years) was followed over a 35-year period. Group-based trajectory modelling identified distinct longitudinal patterns of LA size. Clinical endpoints included incident AF, SCD, and a composite of heart failure-related death or transplantation. Cox regression analyses compared the predictive value of these trajectories against static baseline LA measurements.Results: Three LA remodelling trajectories were identified. Over a mean follow-up of 21.8 ± 7.8 years, 73 patients developed AF, 25 experienced SCD, and 9 died from HF. Moderate (Cluster B) and severe (Cluster C) remodelling trajectories were associated with significantly increased AF risk (log-rank p < 0.001), with Cluster C showing a markedly elevated adjusted hazard ratio (aHR 9.30 vs. 5.03 for baseline size). Cluster C was also significantly associated with higher risk of SCD (aHR 3.61, p = 0.031) and HF death (p = 0.028).Conclusions: Longitudinal LA remodelling patterns offer superior prognostic value over static measurements in HCM, enabling improved risk stratification and personalized care.","PeriodicalId":94178,"journal":{"name":"Progress in cardiovascular diseases","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of contact force and pulsed field ablation parameters on myocardial lesion formation during pulsed field ablation: A systematic review of pre-clinical studies. 接触力和脉冲场消融参数对脉冲场消融过程中心肌病变形成的影响：临床前研究的系统回顾。

Progress in cardiovascular diseases Pub Date : 2025-07-09 DOI: 10.1016/j.pcad.2025.07.001

Jacopo Marazzato, Fengwei Zou, Marco Schiavone, Vincenzo Mirco La Fazia, Giovanni Forleo, Sanghamitra Mohanty, Aung Lin, Domingo Ynoa Garcia, Andrea Natale, Xiaodong Zhang, Luigi Di Biase

{"title":"Impact of contact force and pulsed field ablation parameters on myocardial lesion formation during pulsed field ablation: A systematic review of pre-clinical studies.","authors":"Jacopo Marazzato, Fengwei Zou, Marco Schiavone, Vincenzo Mirco La Fazia, Giovanni Forleo, Sanghamitra Mohanty, Aung Lin, Domingo Ynoa Garcia, Andrea Natale, Xiaodong Zhang, Luigi Di Biase","doi":"10.1016/j.pcad.2025.07.001","DOIUrl":"10.1016/j.pcad.2025.07.001","url":null,"abstract":"Pulsed field ablation (PFA) is a novel and minimally thermal energy source that exploits the biophysics of irreversible electroporation (IRE) to cause cell death. Differently from radiofrequency ablation (RFA) where adequate catheter-tissue contact proved paramount in lesion formation, the additional role of contact force (CF) during PFA is under debate due to the inherent myocardial selectivity and the customizable nature of IRE. In fact, it is not clear whether the amount of contact exerted during PFA delivery is as pivotal in achieving optimal lesion size as during RFA. Moreover, the variety of PFA catheters and the myriads of IRE ablation settings available would further potentially limit the role of CF in this scenario. However, beyond CF, specific ablation parameters, such as the PFA dose, number of pulses, catheter tip orientation and specific PFA workflows, proved to act in synergy with CF in achieving wide and deep ablation lesions even during PFA delivery. Therefore, the aim of this systematic review is to provide a better understanding on which ablation parameters - CF included - can help to obtain effective lesion formation during PFA.","PeriodicalId":94178,"journal":{"name":"Progress in cardiovascular diseases","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RSV in cardiovascular care: When the lungs speak to the heart. 呼吸道合胞病毒在心血管护理中的作用：当肺部与心脏对话时。

Progress in cardiovascular diseases Pub Date : 2025-07-09 DOI: 10.1016/j.pcad.2025.07.003

Paul Loubet, François Roubille

引用次数: 0