Progress in cardiovascular diseases最新文献

{"title":"First presentation of atherosclerotic cardiovascular disease in previously healthy individuals: The multi-ethnic study of atherosclerosis.","authors":"Jonathan Kermanshahchi, Andrew S Kao, Charlotte C Ellberg, Edward Duran, Michael H Criqui, Michael D Shapiro, Harpreet S Bhatia","doi":"10.1016/j.pcad.2025.05.004","DOIUrl":"https://doi.org/10.1016/j.pcad.2025.05.004","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the first presentation of atherosclerotic cardiovascular disease (ASCVD) in individuals without known ASCVD.</p><p><strong>Methods: </strong>Distribution of first ASCVD events (angina, stroke, myocardial infarction [MI], or death/resuscitated cardiac arrest [RCA]), and the association between traditional risk factors, coronary artery calcium (CAC) and lipoprotein(a) [Lp(a)] with these events in Cox proportional hazards models were evaluated in 6779 participants in the Multi-Ethnic Study of Atherosclerosis. Risk prediction improvement with addition of CAC to the pooled cohort equations (PCE) was evaluated using net reclassification improvement (NRI).</p><p><strong>Results: </strong>The mean age was 62.1 ± 10.2 years and 1037 participants (15.3 %) experienced an ASCVD event over a median of 15.8 years. The most common first presentation was cardiovascular death/RCA (n = 287;27.7 %). Among those with events, Black (35.6 %, p = 0.001)) individuals more often presented with death/RCA, Hispanic (29.3 %, p = 0.037) individuals more often presented with stroke compared to White individuals (24.8 % and 21.7 %, respectively). Compared to men, women more frequently presented with stroke (29.5 vs. 20.7 %, p = 0.002) and death/RCA (29.8 vs 26.3 %, p = 0.243) though this did not meet statistical significance. CAC score was significantly associated with first presentation of all events, including death/RCA (HR 1.13, 95 % CI 1.07-1.19) and improved risk prediction when added to the PCE (continuous NRI 0.6081, 95 % CI 0.4971-0.7141). Lp(a) was significantly associated with MI only (HR 1.15 per SD, 95 % CI 1.02-1.29).</p><p><strong>Conclusions: </strong>In previously asymptomatic individuals, the most common initial presentation of ASCVD was death/resuscitated cardiac arrest, particularly among women, minorities, and those with CAC. CAC scoring may identify individuals at risk for death/resuscitated cardiac arrest as a first presentation of ASCVD.</p>","PeriodicalId":94178,"journal":{"name":"Progress in cardiovascular diseases","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac implantable electronic devices in pediatric and congenital populations.","authors":"Douglas Y Mah, John K Triedman","doi":"10.1016/j.pcad.2025.05.005","DOIUrl":"https://doi.org/10.1016/j.pcad.2025.05.005","url":null,"abstract":"<p><p>Pediatric patients and children and adults with congenital heart disease often will require implantation of cardiac implantable electronic devices (CIEDs) for management of a variety of cardiac rhythm pathologies. The safe and effective use of CIEDs in these patients requires an awareness of important differences between this special population and the adult populations for whom these devices were primarily developed and in whom they have been most thoroughly studied. These include issues of body size and growth, anticipated lifespan, anatomical issues related to implantation and the epidemiology of underlying rhythm issues. In this paper, we discuss these issues in the context of the current state of the art in pediatric and congenital heart disease patients with respect to implant and lead extraction strategies, physiological cardiac pacing and resynchronization, ICD indications and use of transvenous and subcutaneous devices, and the use of implantable monitoring devices.</p>","PeriodicalId":94178,"journal":{"name":"Progress in cardiovascular diseases","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A social ecological perspective on interventions to address short sleep duration in adults with coronary heart disease.","authors":"Codie R Rouleau, Sheila N Garland","doi":"10.1016/j.pcad.2025.05.003","DOIUrl":"https://doi.org/10.1016/j.pcad.2025.05.003","url":null,"abstract":"<p><strong>Background: </strong>Short sleep duration (<7 h/day) affects one-third of the population, is implicated in morbidity and mortality from coronary heart disease (CHD), and is driven by an interplay of individual, social, and societal factors.</p><p><strong>Objective: </strong>To review observational and experimental studies that have tested interventions to address short sleep in various clinical presentations (sleep disorders, behaviorally induced short sleep, lack of sleep opportunity) and describe considerations needed for CHD populations.</p><p><strong>Conclusions: </strong>Few existing interventions have a primary aim to increase sleep duration in individuals with insufficient sleep, and none specifically target individuals with established CHD. Short sleep duration may be modifiable via treatment of insomnia, behavioral sleep extension, and system-level changes to healthcare settings, workplace policies, and communities. With further research on interventions that address diverse phenotypes of short sleep-while assessing long-term cardiometabolic outcomes, patient preferences, and mechanisms-of-action-sleep health could become an important component of CHD secondary prevention.</p>","PeriodicalId":94178,"journal":{"name":"Progress in cardiovascular diseases","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No second chances: Cardiovascular death is the most frequent incident event among patients with coronary artery calcium.","authors":"Peter P Toth, Maciej Banach","doi":"10.1016/j.pcad.2025.05.002","DOIUrl":"10.1016/j.pcad.2025.05.002","url":null,"abstract":"","PeriodicalId":94178,"journal":{"name":"Progress in cardiovascular diseases","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CTA in roadmapping post-CABG evaluation.","authors":"Ilana S Golub, Angela Misic, Srikanth Krishnan, Logan Hubbard, Dhananjay Chatterjee, Rosa Lopez, Travis Benzing, Sina Kianoush, Keishi Ichikawa, Jairo Aldana-Bitar, Matthew J Budoff","doi":"10.1016/j.pcad.2025.04.009","DOIUrl":"https://doi.org/10.1016/j.pcad.2025.04.009","url":null,"abstract":"<p><p>Although coronary artery bypass grafting (CABG) outcomes are typically highly successful, outpatient evaluation of bypass grafts is an important step. Moreover, the return of myocardial ischemia and acute coronary syndrome (ACS) events after bypass is not uncommon. Whether due to failure of prior bypass grafts or progression of underlying arteriosclerosis in native coronaries, regularly evaluating if a patient requires intervention (and assessing graft patency vs. closure) is essential. Imaging via cardiac computed tomography angiography (CTA) offers a gold standard anatomical map to facilitate efficiency and accuracy in later invasive coronary angiography (ICA) or surgical re-CABG intervention. This review discusses the utility of CTA as a safe pre and post CABG evaluation tool, in guiding outpatient evaluation of graft patency and roadmapping subsequent reintervention if needed. We seek to ameliorate clinical uncertainties and synthesize growing amounts of research, to help encourage a homogenous approach to post-CABG evaluation. This comprehensive review paper introduces the indications for bypass grafting surgery and transcatheter PCI approaches, details techniques and strategies for bypass surgery, discusses CTA in evaluating post-CABG graft patency, and consolidates research surrounding pre-reintervention CTA in post-CABG patients. Last, this review explores future directions in standardizing post-CABG evaluation guidelines.</p>","PeriodicalId":94178,"journal":{"name":"Progress in cardiovascular diseases","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging the adherence gap in ASCVD: Aligning patient and provider perspectives on lipid-lowering therapy.","authors":"Vita N Jaspan, Michael D Shapiro","doi":"10.1016/j.pcad.2025.04.011","DOIUrl":"https://doi.org/10.1016/j.pcad.2025.04.011","url":null,"abstract":"","PeriodicalId":94178,"journal":{"name":"Progress in cardiovascular diseases","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of ventricular tachycardia in patients with advanced heart failure.","authors":"Ioan Liuba, Jakub Sroubek, Pasquale Santangeli","doi":"10.1016/j.pcad.2025.04.006","DOIUrl":"https://doi.org/10.1016/j.pcad.2025.04.006","url":null,"abstract":"<p><p>Ventricular arrhythmias (VAs) are highly prevalent in patients with advanced heart failure (AHF), a condition characterized by severe signs and symptoms despite conventional HF therapy. The management of VAs in this setting remains challenging. Antiarrhythmic drug therapy options are limited and only amiodarone has demonstrated effectiveness in suppressing VA, albeit this agent is associated with a substantial risk of cardiac and noncardiac adverse effects. Catheter ablation is effective for the reduction of VAs in patients with AHF. Identification of patients at high risk for periprocedural hemodynamic decompensation has important implications in terms of procedural planning and improving patient safety and procedural outcomes. Herein, we review the current state of scientific evidence for the management of VA in patients with AHF.</p>","PeriodicalId":94178,"journal":{"name":"Progress in cardiovascular diseases","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of cardiac rehabilitation participation on functional capacity in patients with hypertrophic obstructive cardiomyopathy following septal myectomy surgery.","authors":"Gizem Cifci, Katherine R Malterer, Elizabeth C Arendt, Tedy Sawma, Steve R Ommen, Hartzell V Schaff, Ray W Squires, Amanda R Bonikowske, Joshua R Smith","doi":"10.1016/j.pcad.2025.04.008","DOIUrl":"https://doi.org/10.1016/j.pcad.2025.04.008","url":null,"abstract":"","PeriodicalId":94178,"journal":{"name":"Progress in cardiovascular diseases","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular magnetic resonance in pulmonary hypertension: Keeping it simple.","authors":"Daniel Lorenzatti, Manish Motwani","doi":"10.1016/j.pcad.2025.04.010","DOIUrl":"https://doi.org/10.1016/j.pcad.2025.04.010","url":null,"abstract":"","PeriodicalId":94178,"journal":{"name":"Progress in cardiovascular diseases","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preprocedural CT angiography and machine learning for mortality prediction after transcatheter aortic valve replacement.","authors":"Jacek Kwiecinski, Kajetan Grodecki, Konrad Pieszko, Maciej Dabrowski, Zbigniew Chmielak, Wojciech Wojakowski, Julia Niemierko, Jadwiga Fijalkowska, Dariusz Jagielak, Philipp Ruile, Simon Schoechlin, Hesham Elzomor, Piotr Slomka, Adam Witkowski, Damini Dey","doi":"10.1016/j.pcad.2025.04.007","DOIUrl":"https://doi.org/10.1016/j.pcad.2025.04.007","url":null,"abstract":"<p><p>Prediction of outcomes following transcatheter aortic valve replacement (TAVR) is challenging. Considering that in aortic stenosis outcomes are governed by both valve degeneration and myocardial adverse remodeling, we aimed to evaluate machine-learning leveraging pre-procedural computed tomography (CT) for the prediction of 1-year mortality following TAVR. The analysis included data of consecutive patients who underwent TAVR at a high-volume center between January 2017 and January 2022 and was externally validated on unseen data from 3 international sites. Machine learning by extreme gradient boosting was trained and tested using clinical variables, CT-derived volumetric measurements including myocardial mass, and quantitative fibrocalcific aortic valve characteristics measured using standardized software. The EuroScore II and a separate machine learning risk score based exclusively on baseline clinical characteristics served as comparators. The derivation cohort included 631 consecutive patients (48 % men, 80 ± 8 years old, EuroSCORE II 6.5 [4.6-10.3] %). Machine learning was externally validated on data of 596 patients (48 % men, 81 ± 8 years old, EuroSCORE II 5.4 [4.7-8.1] %). In external validation, the machine learning prognostic risk score had an area under the receiver operator curve of 0.79 (0.74-0.84) which was superior to the EuroSCORE 0.59 (0.53-0.66), and the machine learning risk based on clinical data alone 0.64 (0.59-0.69), p < 0.001 for difference. Machine-learning integrating clinical data and CT-derived imaging characteristics was found to predict 1-year all-cause mortality following TAVR significantly better than clinical variables or clinical risk scores alone; and can help identify patients at higher prognostic risk prior to the procedure.</p>","PeriodicalId":94178,"journal":{"name":"Progress in cardiovascular diseases","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}