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Total-Body PET in Theranostics: Reshaping Treatment Planning and Follow-Up. 全身PET在治疗学中的应用：重塑治疗计划和随访。
PET clinics Pub Date : 2026-04-07 DOI: 10.1016/j.cpet.2026.02.001
Andrea Di Giorgio, Martina Di Franco, Riccardo Mei, Andrea Farolfi, Stefano Fanti
{"title":"Total-Body PET in Theranostics: Reshaping Treatment Planning and Follow-Up.","authors":"Andrea Di Giorgio, Martina Di Franco, Riccardo Mei, Andrea Farolfi, Stefano Fanti","doi":"10.1016/j.cpet.2026.02.001","DOIUrl":"https://doi.org/10.1016/j.cpet.2026.02.001","url":null,"abstract":"<p><p>The advent of total-body PET/computed tomography (TB PET) is revolutionizing the field of molecular imaging. The high photon collection efficiency of TB PET translates into superior sensitivity and signal-to-noise ratio compared to conventional scanners, enabling shorter acquisition times and lower administered doses while significantly enhancing diagnostic performance. In the era of precision medicine, patient selection for radioligand therapy and treatment response assessment are expected to benefit from accurate lesion detection, dual-tracer studies, the use of short- and long-lived radiopharmaceuticals, tracer kinetic analysis, and frequent follow-up monitoring. These advantages are made possible by long-axial field-of-view scanners and further maximized through TB PET/CT.</p>","PeriodicalId":94168,"journal":{"name":"PET clinics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147641053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel Theranostic Targets for Prostate Cancer Beyond Prostate-Specific Membrane Antigen. 前列腺特异性膜抗原以外的前列腺癌新治疗靶点。
PET clinics Pub Date : 2026-04-07 DOI: 10.1016/j.cpet.2026.02.003
Pedram Heidari, Hossein Jadvar, Bashar Kako, Shadi A Esfahani
{"title":"Novel Theranostic Targets for Prostate Cancer Beyond Prostate-Specific Membrane Antigen.","authors":"Pedram Heidari, Hossein Jadvar, Bashar Kako, Shadi A Esfahani","doi":"10.1016/j.cpet.2026.02.003","DOIUrl":"https://doi.org/10.1016/j.cpet.2026.02.003","url":null,"abstract":"<p><p>Prostate-specific membrane antigen (PSMA)-targeted theranostics have transformed prostate cancer management, but some tumors exhibit low or heterogeneous PSMA expression, limiting eligibility and efficacy for radiopharmaceutical therapy. This review explores emerging biomarkers that may complement or expand beyond PSMA, including gastrin-releasing peptide receptor, fibroblast activation protein, prostate stem cell antigen, CD46, delta-like ligand 3, glypican-3, B7-H3, 6-transmembrane epithelial antigen of the prostate-1, trophoblast cell surface antigen-2, CEACAM5, and vicrostatin. We review their molecular biology, preclinical validation, clinical translation, and ongoing trials. These biomarkers represent diverse biological compartments, broadening the scope of precision radiotheranostics for prostate cancer.</p>","PeriodicalId":94168,"journal":{"name":"PET clinics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147641122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PET-Computed Tomography in the Management of Sarcoma by Interventional Oncology. 介入肿瘤学治疗肉瘤的pet计算机断层扫描。
PET clinics Pub Date : 2025-07-01 Epub Date: 2025-09-13 DOI: 10.1016/j.cpet.2025.08.002
Fereshteh Yazdanpanah, Stephen J Hunt
{"title":"PET-Computed Tomography in the Management of Sarcoma by Interventional Oncology.","authors":"Fereshteh Yazdanpanah, Stephen J Hunt","doi":"10.1016/j.cpet.2025.08.002","DOIUrl":"10.1016/j.cpet.2025.08.002","url":null,"abstract":"<p><p>PET-computed tomography (CT) has become essential in sarcoma management, offering precise diagnosis, staging, and response assessment by combining metabolic and anatomic imaging. Its high accuracy in detecting primary, recurrent, and metastatic disease guides personalized treatment strategies and enhances interventional procedures like biopsies and ablations. Advances in novel radiotracers and hybrid imaging modalities further improve diagnostic specificity, especially in complex and pediatric cases. Integrating PET-CT with genomic data and artificial intelligence (AI)-driven tools promises to advance personalized medicine, enabling tailored therapies and better outcomes. As a cornerstone of multidisciplinary sarcoma care, PET-CT continues to transform diagnostic and therapeutic approaches in oncology.</p>","PeriodicalId":94168,"journal":{"name":"PET clinics","volume":" ","pages":"e17-e25"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145067088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of PET-computed Tomography for the Interventional Radiology Management of Fever of Unknown Origin and Infection. pet计算机断层扫描在不明原因发热和感染的介入放射学治疗中的作用。
PET clinics Pub Date : 2025-07-01 Epub Date: 2025-09-13 DOI: 10.1016/j.cpet.2025.08.001
Fereshteh Yazdanpanah, Stephen J Hunt
{"title":"The Role of PET-computed Tomography for the Interventional Radiology Management of Fever of Unknown Origin and Infection.","authors":"Fereshteh Yazdanpanah, Stephen J Hunt","doi":"10.1016/j.cpet.2025.08.001","DOIUrl":"10.1016/j.cpet.2025.08.001","url":null,"abstract":"<p><p>This article highlights the pivotal role of PET-computed tomography (PET-CT) in diagnosing and managing fever of unknown origin and infectious diseases. Its high sensitivity in detecting metabolically active lesions allows precise localization of occult infections, guiding interventional radiology (IR) procedures such as biopsies and drainages. PET-CT also enhances assessment of treatment efficacy and facilitates early detection of residual or recurrent infections. Advances in infection-specific radiotracers and hybrid imaging technologies promise further improvements in diagnostic accuracy and procedural planning. Effective integration of PET-CT into IR workflows, supported by standardized protocols, can significantly improve patient outcomes through targeted, minimally invasive interventions.</p>","PeriodicalId":94168,"journal":{"name":"PET clinics","volume":" ","pages":"e1-e15"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145067103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PET-CT in the Management of Metastatic Neuroendocrine Tumors by Interventional Oncology. 介入肿瘤学治疗转移性神经内分泌肿瘤的PET-CT研究。
PET clinics Pub Date : 2025-07-01 Epub Date: 2025-09-13 DOI: 10.1016/j.cpet.2025.08.003
Arsalan Seyedi, Fereshteh Yazdanpanah, Stephen J Hunt
{"title":"PET-CT in the Management of Metastatic Neuroendocrine Tumors by Interventional Oncology.","authors":"Arsalan Seyedi, Fereshteh Yazdanpanah, Stephen J Hunt","doi":"10.1016/j.cpet.2025.08.003","DOIUrl":"10.1016/j.cpet.2025.08.003","url":null,"abstract":"<p><p>This article highlights the role of PET-computed tomography (CT) imaging in diagnosing and managing metastatic neuroendocrine tumors (mNETs). PET-CT, particularly with Gallium-68-DOTATATE, allows earlier and more precise detection of lesions compared to conventional imaging. It identifies somatostatin receptor-positive tumors, aiding in staging, interventional procedures, and guiding peptide receptor radionuclide therapy. The complementary use of fluorodeoxyglucose-PET for predicting tumor biology and managing aggressive, poorly differentiated tumors, helps provide a comprehensive framework for personalized mNETs management. Finally, PET-CT's role in patient diagnosis, staging, surveillance, and management by the interventional oncologist is outlined in detail.</p>","PeriodicalId":94168,"journal":{"name":"PET clinics","volume":" ","pages":"e27-e34"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145067133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PET in Cerebrovascular Disease. PET在脑血管疾病中的应用
PET clinics Pub Date : 2010-01-01 DOI: 10.1016/j.cpet.2009.12.007
William J Powers, Allyson R Zazulia
{"title":"PET in Cerebrovascular Disease.","authors":"William J Powers, Allyson R Zazulia","doi":"10.1016/j.cpet.2009.12.007","DOIUrl":"https://doi.org/10.1016/j.cpet.2009.12.007","url":null,"abstract":"<p><p>Investigation of the interplay between the cerebral circulation and brain cellular function is fundamental to understanding both the pathophysiology and treatment of stroke. Currently, PET is the only technique that provides accurate, quantitative in vivo regional measurements of both cerebral circulation and cellular metabolism in human subjects. We review normal human cerebral blood flow and metabolism and human PET studies of ischemic stroke, carotid artery disease, vascular dementia, intracerebral hemorrhage and aneurysmal subarachnoid hemorrhage and discuss how these studies have added to our understanding of the pathophysiology of human cerebrovascular disease.</p>","PeriodicalId":94168,"journal":{"name":"PET clinics","volume":"5 1","pages":"83106"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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