Obesity (Silver Spring, Md.)最新文献_第5页

Efficacy and Safety of GLP-1 Receptor Agonists, Dual Agonists, and Retatrutide for Weight Loss in Adults With Overweight or Obesity: A Bayesian NMA. GLP-1受体激动剂、双重激动剂和利特鲁肽对超重或肥胖成人减肥的有效性和安全性：贝叶斯NMA

Obesity (Silver Spring, Md.) Pub Date : 2025-07-20 DOI: 10.1002/oby.24360

Binayak Sinha, Samit Ghosal

{"title":"Efficacy and Safety of GLP-1 Receptor Agonists, Dual Agonists, and Retatrutide for Weight Loss in Adults With Overweight or Obesity: A Bayesian NMA.","authors":"Binayak Sinha, Samit Ghosal","doi":"10.1002/oby.24360","DOIUrl":"https://doi.org/10.1002/oby.24360","url":null,"abstract":"Objective: To compare the efficacy and safety of GLP-1 receptor agonists (GLP-1RAs), dual agonists (GLP-1RAs/GIP or GCGR), and retatrutide (GLP-1/GIP/glucagon) for weight loss in adults with overweight or obesity.Methods: We conducted a systematic review and Bayesian network meta-analysis (NMA) of 19 randomized controlled trials (RCTs) including 29,506 adults (BMI ≥ 25 kg/m2), assessing liraglutide, semaglutide, survodutide, tirzepatide, retatrutide, and placebo. Outcomes included mean weight loss, achievement of ≥ 5%, ≥ 10%, and ≥ 15% weight loss, waist circumference (WC), BMI, and adverse events (AEs) at ≥ 36 weeks. Subgroup and meta-regression analyses evaluated the impact of diabetes status, sex, age, and BMI.Results: Retatrutide and dual agonists achieved equivalent mean weight loss (-11.0 kg), surpassing GLP-1RAs (-9.0 kg), with retatrutide excelling at achieving ≥ 15% weight loss (OR 54.6). Dual agonists and GLP-1RAs followed (OR 16.4 and 9.0, respectively). Retatrutide had the highest AE risk. Meta-regression showed type 2 diabetes mellitus (T2DM) reduced weight loss by 4.338 kg for GLP-1RAs and 5.016 kg for dual agonists, with enhanced outcomes in female-dominant or high-BMI cohorts.Conclusions: Retatrutide offers superior weight loss efficacy but with a higher AE risk. Dual agonists provide a favorable efficacy-safety balance. Personalized treatment selection based on patient characteristics is recommended.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144677090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of body composition trajectories with changes in cognitive performance in the Look AHEAD study. 展望研究中身体成分轨迹与认知表现变化的关联。

Obesity (Silver Spring, Md.) Pub Date : 2025-07-20 DOI: 10.1002/oby.24212

Morgana Mongraw-Chaffin, Joni K Evans, Heather M Shappell, Mark A Espeland, Kathleen M Hayden

{"title":"Association of body composition trajectories with changes in cognitive performance in the Look AHEAD study.","authors":"Morgana Mongraw-Chaffin, Joni K Evans, Heather M Shappell, Mark A Espeland, Kathleen M Hayden","doi":"10.1002/oby.24212","DOIUrl":"https://doi.org/10.1002/oby.24212","url":null,"abstract":"Objective: The objective of this study was to investigate the longitudinal association of total body fat and appendicular lean mass (ALM), as well as sarcopenia, with cognitive decline after weight loss intervention.Methods: Among 972 Look AHEAD-MIND participants with type 2 diabetes and overweight or obesity, we investigated the longitudinal association of dual-energy x-ray absorptiometry body composition trajectories with cognitive change. We identified three latent trajectories each for total body fat and ALM. Mixed linear regression models were adjusted for the following: repeated measures; order of cognitive test; years from randomization; randomization arm; age; sex; race and ethnicity; and education. We also investigated differences in cognitive score by sarcopenia and BMI categories.Results: A gradual decrease in total body fat and no decrease in ALM were significantly independently associated with higher cognitive scores compared with other trajectories. Differences in cognitive score were large for sarcopenia, but not for obesity. Full adjustment for demographic and socioeconomic factors substantially attenuated the estimates.Conclusions: Weight loss approaches that preserve ALM and function may lead to reduced cognitive decline compared with weight loss alone. The improved ability to target interventions toward those who are more resilient to aging-related body composition changes may prevent unintended consequences of weight loss.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144677088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic association of estradiol and body roundness index with accelerated biological aging in male individuals. 雌二醇和身体圆度指数与男性个体加速生物衰老的协同关联。

Obesity (Silver Spring, Md.) Pub Date : 2025-07-16 DOI: 10.1002/oby.24326

Fan Dong, Yi Ma, Xiang-Feng Chen

{"title":"Synergistic association of estradiol and body roundness index with accelerated biological aging in male individuals.","authors":"Fan Dong, Yi Ma, Xiang-Feng Chen","doi":"10.1002/oby.24326","DOIUrl":"https://doi.org/10.1002/oby.24326","url":null,"abstract":"Objective: The objective of this study was to investigate the relationship of estradiol or body roundness index (BRI), respectively, or the coexistence of their changes with accelerated biological aging in male individuals.Methods: A cross-sectional study with 1818 male individuals aged 20 to 79 years who participated in the National Health and Nutrition Examination Survey 2015-2016 was conducted, in which positive phenotypic age acceleration value was defined as the occurrence of accelerated biological aging. Weighted multivariate logistic regression models were established to evaluate the independent and joint associations of estradiol and BRI with male accelerated biological aging. Restricted cubic spline models were used to explore whether a nonlinear relationship existed.Results: An independent association of either serum estradiol or BRI with male accelerated biological aging was significantly shown after adjusting for important covariates. For BRI, such an association was nonlinear, but estradiol did not exhibit a similar nonlinear correlation. Moreover, the coexistence of a high level of serum estradiol and a high level of BRI obviously strengthens such an association in adjusted models, suggesting the cooperative impact of estradiol with BRI.Conclusions: Both serum estradiol and BRI are significantly associated with accelerated biological aging in male individuals. Integrating high estradiol with high BRI might noticeably reinforce this association.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144651673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A geriatrician's approach to managing the complex older adult with obesity. 老年医学专家的方法来管理复杂的老年人肥胖。

Obesity (Silver Spring, Md.) Pub Date : 2025-07-08 DOI: 10.1002/oby.24267

Shenbagam Dewar

{"title":"A geriatrician's approach to managing the complex older adult with obesity.","authors":"Shenbagam Dewar","doi":"10.1002/oby.24267","DOIUrl":"https://doi.org/10.1002/oby.24267","url":null,"abstract":"The prevalence of obesity in older adults is rapidly increasing due to the demographic shift occurring globally. Older adults with obesity face health care challenges due to multimorbidity, functional dependency, and disability. This population often has prior history of struggles through weight-loss attempts during the middle years of life. Therefore, weight-loss intervention needs a personalized approach, taking into consideration weight-loss attempts, relapse, and life events, including bariatric surgery, functional limitations, psychosocial status, and current residential environment. Racial and ethnic and systemic disparities based on gender, sexual orientation, rurality, zip code, and income merit attention, as they are barriers to obesity management. Intensive lifestyle intervention with dietary changes and physical activity remains the cornerstone of obesity management, with pharmacotherapy and bariatric surgery as adjuncts in the armamentarium. With the revolutionary influx of antiobesity medications, geriatricians face the challenge to treat obesity with limited evidence-based interventions in older adults. The goal of this review is to guide geriatricians with current evidence of obesity management in older adults. This review highlights the need for a tailored weight-management approach to be delivered to this fast-growing segment of the population with complex needs, which is predicted to impact health care economics due to the related comorbidities and disabilities.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144593285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Variability in body weight and body composition and cognitive trajectories in older adults in the United States. 美国老年人体重、身体组成和认知轨迹的变异性。

Obesity (Silver Spring, Md.) Pub Date : 2025-07-03 DOI: 10.1002/oby.24309

Ashley C Flores, Alexandra M Wennberg, Cindy W Leung, Muzi Na

{"title":"Variability in body weight and body composition and cognitive trajectories in older adults in the United States.","authors":"Ashley C Flores, Alexandra M Wennberg, Cindy W Leung, Muzi Na","doi":"10.1002/oby.24309","DOIUrl":"https://doi.org/10.1002/oby.24309","url":null,"abstract":"Objective: This study examined the associations of variability and patterns in BMI, body weight (BW), and waist circumference (WC) with cognitive decline.Methods: A total of 4304 participants (aged ≥65 years) from the National Health and Aging Trends Study between 2011 around 2021 were analyzed. Adjusted mixed-effect models assessed BW and body composition variability metrics linked to cognitive function z scores over 11 years, including standard deviation (SD), coefficient of variation (CV), root mean square error, last-to-first assessment change groups, and overall pattern over the follow-up.Results: Participants in the highest SD variability quartile had the fastest cognitive decline (β = -0.036 [95% CI: -0.044 to -0.028] z scores per year) compared with the lowest variability BMI quartile (β = -0.019 [95% CI: -0.027 to -0.010] z scores per year, p values for interaction, < 0.001). Similar trends were observed for BMI CV and root mean square error, BW SD and CV, and WC CV. Compared with the stable or gain group, participants with ≥5% loss in BMI and BW had the fastest cognitive decline (both p values for interaction, < 0.0002). The cognitive decline rates among the stable, loss, gain and cycling patterns in BMI, BW, or WC were not significantly different.Conclusions: Greater variability and loss in BW and body composition were linked to accelerated cognitive decline in older adults.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic and environmental contributions to the associations between midlife personality and late-life metabolic health. 遗传和环境因素对中年人格和晚年代谢健康之间关系的影响。

Obesity (Silver Spring, Md.) Pub Date : 2025-05-01 DOI: 10.1002/oby.24268

Colin D Freilich, Jacob J Kunkel, Keely A Dugan, Elise J Vomacka, Adolfo G Cuevas, Kristian Markon, Matt McGue, Glenn I Roisman, Robert F Krueger

{"title":"Genetic and environmental contributions to the associations between midlife personality and late-life metabolic health.","authors":"Colin D Freilich, Jacob J Kunkel, Keely A Dugan, Elise J Vomacka, Adolfo G Cuevas, Kristian Markon, Matt McGue, Glenn I Roisman, Robert F Krueger","doi":"10.1002/oby.24268","DOIUrl":"10.1002/oby.24268","url":null,"abstract":"Objective: Personality traits such as conscientiousness and emotional stability are consistently linked with better metabolic health, but there is limited evidence on the etiology of these associations and their robustness across the life-span.Methods: Therefore, we estimated phenotypic, genetic, and unique environmental associations of traits indexed by the Multidimensional Personality Questionnaire in early-to-middle adulthood (mean age = 38.3 years) with BMI, waist circumference, high-density lipoprotein cholesterol, C-reactive protein, triglycerides, and glycated hemoglobin in older adulthood (mean age = 70.4 years) using the Minnesota Twin Registry sample (n = 950).Results: Traits that indexed emotional instability in midlife, such as alienation and stress reactivity, were significant predictors of several metabolic outcomes late in life (bivariate |r| ≤ 0.22), whereas negative associations with traits related to conscientiousness (e.g., control, constraint, achievement) tended to be more modest. For most traits that were phenotypically associated, we observed significant genetic correlations. Additionally, alienation and stress reactivity had weak-to-moderate unique environmental correlations with BMI, waist circumference, and C-reactive protein (re = 0.10-0.29).Conclusions: These results are consistent with an etiology of declining metabolic health into old age involving the propensity toward negative affective experiences decades prior, further validating the health relevance of individual differences in personality.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12353325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of lifestyle-based weight loss in older adults with obesity on muscle and bone health: a balancing act. 老年肥胖患者以生活方式为基础的减肥对肌肉和骨骼健康的影响：一种平衡行为。

Obesity (Silver Spring, Md.) Pub Date : 2025-03-10 DOI: 10.1002/oby.24229

Tiffany M Cortes, Kacey Chae, Colleen M Foy, Denise K Houston, Kristen M Beavers

{"title":"The impact of lifestyle-based weight loss in older adults with obesity on muscle and bone health: a balancing act.","authors":"Tiffany M Cortes, Kacey Chae, Colleen M Foy, Denise K Houston, Kristen M Beavers","doi":"10.1002/oby.24229","DOIUrl":"10.1002/oby.24229","url":null,"abstract":"Despite adverse metabolic and functional consequences of obesity (BMI ≥30 kg/m2), clinical recommendations for weight loss (WL) in older adults (65+ years) with obesity remain controversial. Reluctance stems partly from epidemiologic data demonstrating musculoskeletal tissue loss with WL and increased risk of disability and osteoporotic fracture. Randomized controlled trials in older adults complement and extend knowledge in this area showing: (1) lifestyle-based WL interventions often yield clinically meaningful (~8%-10%) WL in older adults; (2) lean mass loss is significant, although fat mass loss is preferential and physical performance is often improved, particularly when combined with aerobic and resistance training (RT); (3) bone loss is also significant, with some evidence that RT can attenuate WL-associated bone loss; and (4) fat mass regain after intervention cessation is common, yet physical performance gains appear to be maintained. Best practices for treating older adults with obesity include comprehensive assessment of baseline musculoskeletal health; patient-centered goal setting; moderate (i.e., -500 kcal/day) caloric restriction ensuring protein (1-1.2 g/kg/day), calcium (1000-1200 mg/day), and vitamin D (800-1000 IU/day) needs are met; incorporation of RT (≥2 days/week) and moderate-intensity weight-bearing aerobic training (≥150 min/week); and delivery of care by a multidisciplinary team.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12353011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BMI-for-age percentile curves for older adults. 老年人的bmi年龄百分位数曲线。

Obesity (Silver Spring, Md.) Pub Date : 2025-03-10 DOI: 10.1002/oby.24189

Hailey R Banack, Christopher D Kim, Claire E Cook, Alexandra Wasser, Jay S Kaufman, Steven D Stovitz

{"title":"BMI-for-age percentile curves for older adults.","authors":"Hailey R Banack, Christopher D Kim, Claire E Cook, Alexandra Wasser, Jay S Kaufman, Steven D Stovitz","doi":"10.1002/oby.24189","DOIUrl":"10.1002/oby.24189","url":null,"abstract":"Objective: The objective of this manuscript is to present BMI-for-age percentile curves for men and women aged 45 to 90 years.Methods: Weighted empirical percentile estimates were calculated using data from the Canadian Longitudinal Study on Aging (CLSA) comprehensive cohort (2011-2018) according to age and sex. Statistical smoothing procedures were used to generate smoothed curves for the percentile values. Overweight and obesity were defined as BMI greater than the 85th and 95th percentile for age and sex, respectively.Results: In order to create BMI-for-age percentile curves, n = 56,705 observations were used (n = 29,961 individuals at baseline and n = 26,744 individuals at the first follow-up visit). In men, absolute values for BMI percentiles are lower than those in women, and the decline in BMI begins earlier (i.e., at a younger age). In women, the 95th percentile threshold for BMI is highest between ages 59 and 67 years (i.e., 41 kg/m2), and in men, the 95th percentile threshold for BMI is highest between ages 51 and 62 years (i.e., 39 kg/m2).Conclusions: BMI-for-age percentile curves demonstrate how an individual's BMI value compares with values from a reference population comprising individuals of the same age and sex. This approach has widespread utility to determine eligibility for interventions and as a tool to incorporate into clinical models of care for obesity management in an aging population.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Musculoskeletal characteristics in older adults with overweight or obesity: INVEST in Bone Health trial baseline analysis. 超重或肥胖老年人的肌肉骨骼特征：INVEST in Bone Health试验基线分析

Obesity (Silver Spring, Md.) Pub Date : 2025-03-06 DOI: 10.1002/oby.24243

S Delanie Lynch, Marjorie Howard, Daniel P Beavers, Leon Lenchik, Ryan Barnard, Joshua R Stapleton, Erica Lawrence, Peggy M Cawthon, Fang-Chi Hsu, Kristen M Beavers, Ashley A Weaver

{"title":"Musculoskeletal characteristics in older adults with overweight or obesity: INVEST in Bone Health trial baseline analysis.","authors":"S Delanie Lynch, Marjorie Howard, Daniel P Beavers, Leon Lenchik, Ryan Barnard, Joshua R Stapleton, Erica Lawrence, Peggy M Cawthon, Fang-Chi Hsu, Kristen M Beavers, Ashley A Weaver","doi":"10.1002/oby.24243","DOIUrl":"10.1002/oby.24243","url":null,"abstract":"Objective: The objective of this study was to examine associations of computed tomography (CT)-derived musculoskeletal measures with demographics and traditional musculoskeletal characteristics.Methods: The Incorporating Nutrition, Vests, Education, and Strength Training (INVEST) in Bone Health trial (NCT04076618) acquired a battery of musculoskeletal measures in 150 older-aged adults living with overweight or obesity. At baseline, CT (i.e., volumetric bone mineral density, cortical thickness, muscle radiomics, and muscle/intermuscular adipose tissue [IMAT] area and density), dual-energy x-ray absorptiometry (DXA; i.e., areal bone mineral density, total body fat mass, appendicular lean mass, and lean body mass), and strength assessments (i.e., grip and knee extensor strength) were collected, along with demographic and clinical characteristics. Analyses employed linear regression and mixed-effects models along with factor analysis for dimensionality reduction of the radiomics data.Results: Participants were older-aged (mean [SD] age: 66 [5] years), mostly female (75%), and were living with overweight or obesity (mean [SD] BMI: 33.6 [3.3] kg/m2). Age was not significantly associated with most CT-derived bone, IMAT, or muscle measures. BMI was significantly associated with DXA and CT-derived muscle and IMAT measures, which were higher in male than female individuals (all p < 0.01). For the midthigh, muscle size was significantly related to grip and knee extensor strength (both p < 0.01).Conclusions: Machine learning-derived CT metrics correlated strongly with DXA and muscle strength, with higher BMI linked to greater IMAT and poorer muscle quality.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12353373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of antiobesity medications for weight reduction in older adults: a systematic review. 抗肥胖药物对老年人减肥的疗效：一项系统综述。

Obesity (Silver Spring, Md.) Pub Date : 2024-12-26 DOI: 10.1002/oby.24160

Alissa S Chen, Alexandra M Hajduk, Alyssa A Grimshaw, Terri R Fried, Ania M Jastreboff, Kasia J Lipska

{"title":"Efficacy of antiobesity medications for weight reduction in older adults: a systematic review.","authors":"Alissa S Chen, Alexandra M Hajduk, Alyssa A Grimshaw, Terri R Fried, Ania M Jastreboff, Kasia J Lipska","doi":"10.1002/oby.24160","DOIUrl":"10.1002/oby.24160","url":null,"abstract":"Objective: The objective of this study was to examine weight reduction and adverse events associated with use of antiobesity medications (AOMs) in older adults ages ≥65 years.Methods: Seven databases were searched for studies evaluating weight reduction of Food and Drug Administration (FDA)-approved AOMs. Studies had to include adults ages ≥65 years with obesity (BMI ≥ 30 kg/m2 or ≥27 kg/m2 with one weight-related condition), with independent analysis of weight reduction for adults ages ≥65 years. Two coauthors extracted and evaluated studies for risk of bias using standardized forms.Results: Six experimental studies (five secondary analyses of randomized clinical trial data and one single-arm trial) and two observational studies met inclusion criteria. Seven medications were studied. Sample size of older adults ranged from 13 to 6728. Experimental studies predominantly included patients with concurrent prediabetes or cardiovascular disease. All studies found statistically significant weight reduction between intervention and placebo groups or compared with baseline weight. Few studies reported on adverse events.Conclusions: Limited evidence suggests weight reduction of AOMs in older adults, with the best current evidence for the use of semaglutide in older adults with obesity and cardiovascular disease. Larger, more inclusive studies of older adults are needed to guide clinical care and determine the tolerability of AOMs for older adults.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0