Nephrologie & therapeutique最新文献_第8页

Difelikefalin and treatment of severe pruritus associated with chronic kidney disease Real-life retrospective study in a dialysis center Difelikefalin与慢性肾病相关的严重瘙痒的治疗在透析中心的现实回顾性研究

Nephrologie & therapeutique Pub Date : 2024-08-01 Epub Date: 2024-06-14 DOI: 10.1684/ndt.2024.78

Rémi Brasme, Claire Cartery, Marlène Goubet, Marie-Flore Hennino, Nathalie Maisonneuve

{"title":"Difelikefalin and treatment of severe pruritus associated with chronic kidney disease Real-life retrospective study in a dialysis center","authors":"Rémi Brasme, Claire Cartery, Marlène Goubet, Marie-Flore Hennino, Nathalie Maisonneuve","doi":"10.1684/ndt.2024.78","DOIUrl":"10.1684/ndt.2024.78","url":null,"abstract":"Introduction: Difelikefalin is to date the first and only specific treatment to be approved for the treatment of moderate-to-severe chronic kidney disease-associated pruritus (CKD-aP) in adult patients on hemodialysis.Patients and methods: This was a retrospective, single-center, real-life study in hemodialysis patients with CKD-aP treated with difelikefalin. The primary objective was to evaluate the evolution of the intensity of pruritus during treatment with difelikefalin using the Worst Itch Intensity-Numerical Rating Scale (WI-NRS). Adult patients were included if they had been on hemodialysis for at least 3 months and were suffering from moderate to severe CKD-aP (objectified by the WI-NRS score) for which difelikefalin had been prescribed.Results: 11 patients (7 men and 4 women; mean age, 63.8 years) with a mean (SD) weekly dialysis time of 13 h (2.4) were included. The mean hemodialysis duration was 5 (3.6) years and the mean pruritus duration was 4.3 (3.2) years. At inclusion, on-going treatments of CKD-aP were emollients in all patients and antihistamines in 9 patients. The mean WI-NRS score was 7.4 (1.1) at initiation of difelikefalin. At last assessment after a median follow-up of 9.0 months, the mean change of WI-NRS score was -5.1 (2.9) and 82% of patients had a decrease ≥ 3 points. Mild to moderate adverse reactions to difelikefalin were reported in 4 patients, all of whom recovered without sequelae.Conclusion: These results show that difelikefalin, prescribed according to its therapeutic indication, is effective in the treatment of CKD-aP under real-life conditions, outside the controlled conditions of a clinical trial.","PeriodicalId":94153,"journal":{"name":"Nephrologie & therapeutique","volume":"20 4","pages":"251-259"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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French translation and adaptation of the KDIGO nomenclature for kidney function and disease 肾功能和疾病的KDIGO命名法的法语翻译和改编

Nephrologie & therapeutique Pub Date : 2024-08-01 DOI: 10.1684/ndt.2024.86

Olivier Bonny, Ibtissam Arbaoui, Denis Fouque, Aghiles Hamroun, Michel Jadoul, Bénédicte Stengel, François Babinet, Isabelle Binet, Pascaline Faure, Luc Frimat, François Kaze, Hélène Lazareth, Yves Poulin, Daniel Schiltz, Anne Stinat, Cécile Vandevivère, Serge Quérin

{"title":"French translation and adaptation of the KDIGO nomenclature for kidney function and disease","authors":"Olivier Bonny, Ibtissam Arbaoui, Denis Fouque, Aghiles Hamroun, Michel Jadoul, Bénédicte Stengel, François Babinet, Isabelle Binet, Pascaline Faure, Luc Frimat, François Kaze, Hélène Lazareth, Yves Poulin, Daniel Schiltz, Anne Stinat, Cécile Vandevivère, Serge Quérin","doi":"10.1684/ndt.2024.86","DOIUrl":"10.1684/ndt.2024.86","url":null,"abstract":"A harmonized medical nomenclature that is accessible to the lay people is crucial to raising awareness of insidious health problems such as chronic kidney disease and facilitating communication between healthcare professionals. This article presents the proposals of a French-speaking working group for the translation and adaptation into French of the nomenclature for renal function and disease that resulted from a KDIGO consensus conference published in English in 2020. In particular, the working group recommends abandoning terms that used to correspond in French to “chronic renal failure”, “acute renal failure”, “end-stage renal failure”, “uremia”, “cadaveric donor” and “microalbuminuria”, in favor of French equivalents of “chronic renal disease”, “acute kidney injury”, “renal failure”, “uremic syndrome”, “deceased donor” and “albuminuria”. Arguments against the former and in favor of the latter are presented. Other equivalents of English terms from the KDIGO nomenclature are presented in a Table, and an Appendix presents equivalents proposed in German and Spanish by other authors. We hope that our proposals will be well received by healthcare professionals as well as by their patients and the public.","PeriodicalId":94153,"journal":{"name":"Nephrologie & therapeutique","volume":"20 4","pages":"285-300"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent data on atypical hemolytic uremic syndrome associated with pregnancy, kidney transplantation or hypertensive emergency 与妊娠、肾移植或高血压急症有关的非典型溶血性尿毒症的最新数据

Nephrologie & therapeutique Pub Date : 2024-08-01 DOI: 10.1684/ndt.2024.83

Khalil El Karoui

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Recent data on atypical hemolytic uremic syndrome associated with pregnancy, kidney transplantation or hypertensive emergency 妊娠、肾移植或高血压急症相关的非典型溶血性尿毒症综合征的最新资料

Nephrologie & therapeutique Pub Date : 2024-08-01 DOI: 10.1684/ndt.2024.83

Khalil El Karoui

引用次数: 0

Management of immunosuppressive therapy after functional renal graft failure: results of a practice survey of French-speaking nephrologists 功能性肾移植失败后的免疫抑制治疗管理：法语区肾病专家的实践调查结果

Nephrologie & therapeutique Pub Date : 2024-06-26 DOI: 10.1684/ndt.2024.79

Cyril Garrouste, Marine Freist, Mathilde Prezelin-Reydit, Antoine Bouquegneau, Thomas Fournier, Betoul Schvartz, Antoine Thierry, Virginie Paumier Sanson, Valentin Mayet, Bruno Pereira, Christophe Mariat

{"title":"Management of immunosuppressive therapy after functional renal graft failure: results of a practice survey of French-speaking nephrologists","authors":"Cyril Garrouste, Marine Freist, Mathilde Prezelin-Reydit, Antoine Bouquegneau, Thomas Fournier, Betoul Schvartz, Antoine Thierry, Virginie Paumier Sanson, Valentin Mayet, Bruno Pereira, Christophe Mariat","doi":"10.1684/ndt.2024.79","DOIUrl":"10.1684/ndt.2024.79","url":null,"abstract":"The management of patients with kidney transplant failure (KTF) remains a complex process involving multiple stakeholders. A working group of the Transplantation Commission of the French-speaking Society of Nephrology, Dialysis and Transplantation (SFNDT) conducted a survey on the management of immunosuppressants (IS) after KTF among nephrologists at transplant centres and general nephrologists in France, Switzerland and Belgium between March and June 2023.\u0000We analysed 232 replies from 58 nephrologists at transplant centres and 174 general nephrologists, aged 43.6 (+10.6) years. In the first three months following KTF, nephrologists reported discontinuing antimetabolite, calcineurin inhibitor (CNI) and corticosteroid treatment in 83%, 39.9% and 25.8% of cases respectively. Conversely, some nephrologists reported that they were continuing to use CNI (14%) and corticosteroids (19.1%) on a long-term basis. The patient’s comorbidities associated with the discontinuation of IS treatment are cancer and opportunistic infections as KT’s complications and presence of diabetes mellitus at KTF, whereas humoral rejection encourages the IS to be maintained. Transplantectomy is proposed by nephrologists most often for graft intolerance syndrome (86.5%), more rarely to discontinue IS (17.6%) or in the absence of plans of new transplantation (9.3%). In multivariate analyses, the presence of a protocol in the centre facilitated the management of IS by the general nephrologists.\u0000The management of IS after AFG by French-speaking nephrologists is heterogeneous. Specific prospective studies are needed to establish new best practice recommendations, based on more robust evidence, which could encourage better adherence by nephrologists.","PeriodicalId":94153,"journal":{"name":"Nephrologie & therapeutique","volume":"20 3","pages":"193-202"},"PeriodicalIF":0.0,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141452544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Nurse-assisted arterio-venous fistula cannulation during home hemodialysis: first results of the DIADIDEAL study 家庭血液透析期间护士协助动静脉瘘插管：DIADIDEAL 研究的初步结果

Nephrologie & therapeutique Pub Date : 2024-06-26 DOI: 10.1684/ndt.2024.82

Laurence Pautret, Anne-Céline Galle, Anne Radiguet, Catherine Thibault, Ludivine Videloup, Sonia Guillouët, Thierry Lobbedez, Patrick Henri, Maxence Ficheux, Clémence Béchade

{"title":"Nurse-assisted arterio-venous fistula cannulation during home hemodialysis: first results of the DIADIDEAL study","authors":"Laurence Pautret, Anne-Céline Galle, Anne Radiguet, Catherine Thibault, Ludivine Videloup, Sonia Guillouët, Thierry Lobbedez, Patrick Henri, Maxence Ficheux, Clémence Béchade","doi":"10.1684/ndt.2024.82","DOIUrl":"10.1684/ndt.2024.82","url":null,"abstract":"Introduction: We have launched a pilot study, called DIADIDEAL, to propose nurse-assistance at home for arterio-venous fistula (AVF) cannulation in home hemodialysis (HHD) patients. The aim of the present study was to describe enrollment of the patients and their nurses.Materials: All prevalent HD patients on 30th November 2018 with no medical contraindication to HDD treatment and all incident patients on dialysis from the 30th November 2018 to the 21st April 2023 were eligible.Results: Among 155 prevalent HD patients, 4 patients were included. Among the 276 incident patients on dialysis during the study period, 6 were included. We have phoned 23 nurse centers during the recruitment period. Eight of them agreed to learn in our unit how to cannulate AVF; 27 private nurses were enrolled.Discussion: The results of the DIADIDEAL study will be available in 2024; we hope it will lead to a reimbursement of nurse-AVF cannulation at home in HDD.","PeriodicalId":94153,"journal":{"name":"Nephrologie & therapeutique","volume":"20 3","pages":"185-192"},"PeriodicalIF":0.0,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141452545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Withholding or withdrawing life support in nephrology: a perspective in the French-speaking background 肾脏病学中暂停或撤消生命支持：法语背景下的视角

Nephrologie & therapeutique Pub Date : 2024-06-26 DOI: 10.1684/ndt.2024.81

引用次数: 0

Prevalence of stages 3-5 chronic kidney disease in New Caledonia 新喀里多尼亚慢性肾病 3-5 期的发病率

Nephrologie & therapeutique Pub Date : 2024-06-26 DOI: 10.1684/ndt.2024.77

Noémie Baroux, Élodie Magnat, Marina Cauchy, Jean-François Cantin, Raphael Cohen, Pascale Domingue-Mena

引用次数: 0

Nurse-assisted arterio-venous fistula cannulation during home hemodialysis: first results of the DIADIDEAL study 家庭血液透析期间护士协助动静脉瘘插管：DIADIDEAL 研究的初步结果

Nephrologie & therapeutique Pub Date : 2024-06-19 DOI: 10.1684/ndt.2024.82

Laurence Pautret, Anne-Céline Galle, Anne Radiguet, Catherine Thibault, Ludivine Videloup, Sonia Guillouët, Thierry Lobbedez, Patrick Henri, Maxence Ficheux, Clémence Béchade

{"title":"Nurse-assisted arterio-venous fistula cannulation during home hemodialysis: first results of the DIADIDEAL study","authors":"Laurence Pautret, Anne-Céline Galle, Anne Radiguet, Catherine Thibault, Ludivine Videloup, Sonia Guillouët, Thierry Lobbedez, Patrick Henri, Maxence Ficheux, Clémence Béchade","doi":"10.1684/ndt.2024.82","DOIUrl":"10.1684/ndt.2024.82","url":null,"abstract":"Introduction: We have launched a pilot study, called DIADIDEAL, to propose nurse-assistance at home for arterio-venous fistula (AVF) cannulation in home hemodialysis (HHD) patients. The aim of the present study was to describe enrollment of the patients and their nurses.Materials: All prevalent HD patients on 30th November 2018 with no medical contraindication to HDD treatment and all incident patients on dialysis from the 30th November 2018 to the 21st April 2023 were eligible.Results: Among 155 prevalent HD patients, 4 patients were included. Among the 276 incident patients on dialysis during the study period, 6 were included. We have phoned 23 nurse centers during the recruitment period. Eight of them agreed to learn in our unit how to cannulate AVF; 27 private nurses were enrolled.Discussion: The results of the DIADIDEAL study will be available in 2024; we hope it will lead to a reimbursement of nurse-AVF cannulation at home in HDD.","PeriodicalId":94153,"journal":{"name":"Nephrologie & therapeutique","volume":"20 3","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141422359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Withholding or withdrawing life support in nephrology: a perspective in the French-speaking background 肾脏病学中暂停或撤消生命支持：法语背景下的视角

Nephrologie & therapeutique Pub Date : 2024-06-19 DOI: 10.1684/ndt.2024.81

L Frimat

引用次数: 0