Medicina intensivaPub Date : 2026-09-22DOI: 10.1016/j.medine.2026.502626
Blanca Lourdes More Sánchez, Manuel Valdivia Marchal, José Manuel Serrano Simón
{"title":"Combined phrenic and vagal nerve dysfunction after bilateral lung transplantation.","authors":"Blanca Lourdes More Sánchez, Manuel Valdivia Marchal, José Manuel Serrano Simón","doi":"10.1016/j.medine.2026.502626","DOIUrl":"https://doi.org/10.1016/j.medine.2026.502626","url":null,"abstract":"","PeriodicalId":94139,"journal":{"name":"Medicina intensiva","volume":" ","pages":"502626"},"PeriodicalIF":0.0,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149067078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medicina intensivaPub Date : 2026-09-19DOI: 10.1016/j.medine.2026.502543
María Slöcker Barrio, Cristina Schüffelmann, Ana Díaz Vico, Eider Oñate Vergara
{"title":"Narrative review of pediatric sepsis and septic shock: update on ultrasound-guided monitoring, diagnostic criteria and treatment.","authors":"María Slöcker Barrio, Cristina Schüffelmann, Ana Díaz Vico, Eider Oñate Vergara","doi":"10.1016/j.medine.2026.502543","DOIUrl":"https://doi.org/10.1016/j.medine.2026.502543","url":null,"abstract":"<p><p>Sepsis is a common cause of admission to pediatric intensive care and is associated with high morbidity and mortality. Since 2005, diagnostic criteria have evolved, culminating in the Phoenix Criteria (2023), which define sepsis as organ dysfunction secondary to a dysregulated immune response. Given its heterogeneity, monitoring and treatment should be tailored to the phase of shock. During resuscitation, the goal is to restore perfusion with fluids and vasopressors. In the optimization, stabilization, and de-escalation phases, the aim is to maintain perfusion and remove excess fluids without compromising tissue flow. Current strategies favor a more restrictive fluid approach and an early use of vasoactive drugs. Monitoring should be continuous and multimodal, integrating clinical signs, technology, and laboratory test parameters. In this context, ultrasound has become essential, allowing individualized assessment of volemia, cardiac function, fluid responsiveness, and fluid overload. Ultrasound plays a key role in decision-making throughout the management process.</p>","PeriodicalId":94139,"journal":{"name":"Medicina intensiva","volume":" ","pages":"502543"},"PeriodicalIF":0.0,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149009685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association between dysglycemia and mortality in patients with delirium: Based on the MIMIC-IV database.","authors":"Jingwen Zhu, Xinyu Zhao, Wei Pan, Yiyang Hu, Zixin Zhai","doi":"10.1016/j.medine.2026.502609","DOIUrl":"https://doi.org/10.1016/j.medine.2026.502609","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the influence of chronic hyperglycemia on the association between acute glycemic metrics and in-hospital mortality in patients with delirium.</p><p><strong>Design: </strong>Observational cohort study.</p><p><strong>Setting: </strong>Medical Information Mart for Intensive Care (MIMIC-IV) database.</p><p><strong>Patients or participants: </strong>3152 patients with delirium and available HbA1c measurements.</p><p><strong>Interventions: </strong>None.</p><p><strong>Main variables of interest: </strong>Chronic hyperglycemia (categories based on HbA1c: <6.5%, 6.5-7.9%, ≥8.0%); acute glycemic metrics (mean glucose, number of hyperglycemic events, glucose variability, cumulative hyperglycemic dose); in-hospital mortality.</p><p><strong>Results: </strong>Patients with HbA1c 6.5-7.9% showed higher mortality risk compared to the HbA1c <6.5% group (OR = 1.518; P = 0.040). The association between acute hyperglycemia and mortality was modified by chronic glycemic status: mean glucose was associated with mortality only in patients with HbA1c <6.5% (OR = 1.254; P < 0.001) and 6.5-7.9% (OR = 1.190; P = 0.009). The number of hyperglycemic events increased mortality risk only in non-diabetic patients (OR = 1.043; P = 0.005). Glycemic variability and cumulative hyperglycemic dose were associated with mortality exclusively in the HbA1c <6.5% group.</p><p><strong>Conclusions: </strong>The impact of acute glycemic dysregulation on mortality in delirious patients is moderated by underlying chronic hyperglycemia. Individualized glucose management based on chronic glycemic status may be preferable to uniform strict control.</p>","PeriodicalId":94139,"journal":{"name":"Medicina intensiva","volume":" ","pages":"502609"},"PeriodicalIF":0.0,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148984442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medicina intensivaPub Date : 2026-09-15DOI: 10.1016/j.medine.2026.502542
Alba López-Fdez, Rocío Ruiz-Cacho, Sonia Mas-Font, Pedro Castro
{"title":"Emergencies in the critically ill cancer patient.","authors":"Alba López-Fdez, Rocío Ruiz-Cacho, Sonia Mas-Font, Pedro Castro","doi":"10.1016/j.medine.2026.502542","DOIUrl":"https://doi.org/10.1016/j.medine.2026.502542","url":null,"abstract":"<p><p>Patients with cancer are an increasingly frequent population in Intensive Care Units (ICUs) worldwide. Although the main reasons for ICU admission are similar to those of other critically ill patients, cancer patients may experience severe complications that are specific to their underlying oncological condition. Such complications are known as oncological emergencies. These conditions differ from other critical illnesses in their pathophysiology and management, and prompt recognition is essential to improving patient outcomes. This article describes key features of selected oncological emergencies, outlines general management principles, and highlights the diagnostic and therapeutic particularities of the most relevant conditions.</p>","PeriodicalId":94139,"journal":{"name":"Medicina intensiva","volume":" ","pages":"502542"},"PeriodicalIF":0.0,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148979033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medicina intensivaPub Date : 2026-09-11DOI: 10.1016/j.medine.2026.502430
Eduard Argudo, Fernando Suárez Sipmann
{"title":"Introduction to the «Update series»: «ECMO. Current uses and challenges of extracorporeal membrane oxygenation in adults».","authors":"Eduard Argudo, Fernando Suárez Sipmann","doi":"10.1016/j.medine.2026.502430","DOIUrl":"https://doi.org/10.1016/j.medine.2026.502430","url":null,"abstract":"","PeriodicalId":94139,"journal":{"name":"Medicina intensiva","volume":" ","pages":"502430"},"PeriodicalIF":0.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148946482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medicina intensivaPub Date : 2026-09-11DOI: 10.1016/j.medine.2026.502552
Mario Royo-Villanova, María Luisa Rodríguez, Eva Oliver-Juan, Marina Pérez-Redondo
{"title":"Use of extracorporeal membrane oxygenation (ECMO) in Spain as a method of organ preservation for transplantation.","authors":"Mario Royo-Villanova, María Luisa Rodríguez, Eva Oliver-Juan, Marina Pérez-Redondo","doi":"10.1016/j.medine.2026.502552","DOIUrl":"https://doi.org/10.1016/j.medine.2026.502552","url":null,"abstract":"<p><p>Donation following the confirmation of death based on circulatory criteria has proven to be a valuable strategy for increasing the availability of organs for transplantation. However, the standard super-rapid extraction technique with ex situ static cold storage yields poor outcomes, particularly for livers. Normothermic regional perfusion, based on in situ perfusion with extracorporeal membrane oxygenation (ECMO), has emerged as a promising alternative to improve donor performance. Pioneered in Spain, this practice has become commonplace in many countries, improving effectiveness and post-transplant outcomes. Spain has established mobile units with highly qualified teams to support centers lacking ECMO technology or experience. In this article, we detail the normothermic regional perfusion technique, both abdominal and thoracoabdominal, the benefits in post-transplant outcomes, as well as the logistical requirements and ethical considerations that support its use.</p>","PeriodicalId":94139,"journal":{"name":"Medicina intensiva","volume":" ","pages":"502552"},"PeriodicalIF":0.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148946484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medicina intensivaPub Date : 2026-09-09DOI: 10.1016/j.medine.2026.502555
Fernando Alfonso, Jorge Salamanca, Sofía Sánchez-Fernández, Náyade Del Prado, Diego Alvaredo, José Luis Bernal, Cristina Fernández-Pérez, Álvaro Gamarra, Lidia Vilches, Iván Núñez-Gil, Javier Elola
{"title":"Comparison of Takotsubo syndrome with acute myocardial infarction in Spain using hospital discharge data (MBDS).","authors":"Fernando Alfonso, Jorge Salamanca, Sofía Sánchez-Fernández, Náyade Del Prado, Diego Alvaredo, José Luis Bernal, Cristina Fernández-Pérez, Álvaro Gamarra, Lidia Vilches, Iván Núñez-Gil, Javier Elola","doi":"10.1016/j.medine.2026.502555","DOIUrl":"https://doi.org/10.1016/j.medine.2026.502555","url":null,"abstract":"<p><strong>Objective: </strong>To compare the profiles and outcomes of patients with Takotsubo syndrome (TTS) and acute myocardial infarction (AMI).</p><p><strong>Design: </strong>A retrospective observational study (2016-2022). Multilevel risk adjustments.</p><p><strong>Setting: </strong>Acute hospitals of the Spanish National Health System (SNS).</p><p><strong>Patients: </strong>Hospitalization episodes using the SNS Minimum Basic Data Set (MBDS).</p><p><strong>Interventions: </strong>TTS episodes without a recorded imaging procedure were excluded.</p><p><strong>Variables of interest: </strong>Crude and risk-adjusted hospital mortality and readmissions at 30 days due to circulatory causes.</p><p><strong>Results: </strong>4,112 TTS episodes and 275,835 AMI episodes were identified. Significant differences were observed in terms of age, gender, and associated comorbidities. The crude hospital mortality rate was 2.9% for TTS episodes compared to 7.2% for AMI episodes (p < 0.001). After adjusting for confounders, the risks of mortality (OR: 0.34; CI: 0.28-0.41; p < 0.01) and readmission in the first month due to circulatory system diseases (OR: 0.48; CI: 0.39-0.6; p < 0.01) were significantly lower in patients with TTS. The predictors of mortality and hospital readmission differed between the two disorders.</p><p><strong>Conclusions: </strong>TTS differs from AMI in its clinical characteristics. Risk-adjusted hospital mortality and 30-day readmissions due to circulatory causes were lower in patients with TTS than in those with AMI.</p>","PeriodicalId":94139,"journal":{"name":"Medicina intensiva","volume":" ","pages":"502555"},"PeriodicalIF":0.0,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148922318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medicina intensivaPub Date : 2026-09-08DOI: 10.1016/j.medine.2026.502554
José Higinio de Gea García, Diego Lorenzo Adánez, Antonia Del Amor Cantero Sandoval, Roxana Soledad Rojas Luán, M Gracia Adánez Martínez
{"title":"Gender perspective in cardiopulmonary resuscitation training: Evaluation of an educational intervention using a simulator with female anatomy.","authors":"José Higinio de Gea García, Diego Lorenzo Adánez, Antonia Del Amor Cantero Sandoval, Roxana Soledad Rojas Luán, M Gracia Adánez Martínez","doi":"10.1016/j.medine.2026.502554","DOIUrl":"https://doi.org/10.1016/j.medine.2026.502554","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate knowledge, skills and attitudes regarding cardiopulmonary resuscitation (CPR) according to patient sex, and to analyze whether a gender-perspective training intervention can influence these aspects.</p><p><strong>Design: </strong>Quasi-experimental study with random allocation and pre-post evaluation.</p><p><strong>Setting: </strong>Faculty of Medicine (University of Murcia).</p><p><strong>Participants: </strong>96 students; 42% men and 58% women.</p><p><strong>Interventions: </strong>Participants completed a baseline survey and performed a simulation using a mannequin with female anatomy. Subsequently, they were randomized to an experimental or control group. The experimental group received a CPR training workshop with a gender perspective and repeated both the survey and the simulation, while the control group completed both evaluations without training.</p><p><strong>Main variables of interest: </strong>Theoretical knowledge, perception of safety, performance of technical skills, and attitude toward CPR in women.</p><p><strong>Results: </strong>At baseline, no differences were observed between the two groups. After the intervention, the experimental group showed higher perception of safety, with significant improvements in chest exposure (5 [1-8] vs 2 [1-4], P < .001), reduction of fear of misinterpretations (7 [3-8] vs 3 [1-6], P < .001), and perception that breasts may affect CPR (6 [5-8] vs 3 [1-5], P < .001). In addition, better CPR performance and appropriate placement of defibrillator pads (31.6% vs 84.2%, P < .001) in relation to breast anatomy.</p><p><strong>Conclusions: </strong>Training with a gender perspective is associated with improved knowledge, skills, and attitudes toward the resuscitation of women and may contribute to reducing training barriers and increasing confidence of future professionals.</p>","PeriodicalId":94139,"journal":{"name":"Medicina intensiva","volume":" ","pages":"502554"},"PeriodicalIF":0.0,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148914720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}