Medicina intensivaPub Date : 2025-07-01DOI: 10.1016/j.medine.2025.502135
Viktor Yordanov Zlatkov Aleksandrov, Fernando Martínez Sagasti, Juncal Pérez-Somarriba Moreno, Helena Huertas Mondéjar
{"title":"What should intensivists know about immune checkpoint inhibitors and their side effects?","authors":"Viktor Yordanov Zlatkov Aleksandrov, Fernando Martínez Sagasti, Juncal Pérez-Somarriba Moreno, Helena Huertas Mondéjar","doi":"10.1016/j.medine.2025.502135","DOIUrl":"10.1016/j.medine.2025.502135","url":null,"abstract":"<div><div>The pharmacological group of immune checkpoint-inhibitors (ICI) has revolutionized the field of oncology in the last ten years. The improvements in the survival of certain cancers thanks to these treatments comes at the cost of an increased morbidity and mortality due to certain immune related adverse events (irAE). This review will concentrate on the irAE that more frequently require intensive care unit (ICU) admission. The infectious burden of patients treated with ICI is also explored, shining light not only on the infections caused by the immunosuppression needed to manage the different irAE, but also on the specific infections arising from a unique immune dysregulation only seen in ICI treated patients.</div></div>","PeriodicalId":94139,"journal":{"name":"Medicina intensiva","volume":"49 7","pages":"Article 502135"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medicina intensivaPub Date : 2025-07-01DOI: 10.1016/j.medine.2025.502152
Antonio Padilla-Serrano , Carmen de la Cueva Coca , Antonio Cárdenas Cruz
{"title":"Congenital absence of the circumflex coronary artery","authors":"Antonio Padilla-Serrano , Carmen de la Cueva Coca , Antonio Cárdenas Cruz","doi":"10.1016/j.medine.2025.502152","DOIUrl":"10.1016/j.medine.2025.502152","url":null,"abstract":"","PeriodicalId":94139,"journal":{"name":"Medicina intensiva","volume":"49 7","pages":"Article 502152"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medicina intensivaPub Date : 2025-07-01DOI: 10.1016/j.medine.2025.502220
Juan Carlos Ruíz-Rodríguez , Ana Ochagavia , Lluís Zapata , Ricard Ferrer
{"title":"Reply to: “Vasopressin: Why not in severe traumatic disease?”","authors":"Juan Carlos Ruíz-Rodríguez , Ana Ochagavia , Lluís Zapata , Ricard Ferrer","doi":"10.1016/j.medine.2025.502220","DOIUrl":"10.1016/j.medine.2025.502220","url":null,"abstract":"","PeriodicalId":94139,"journal":{"name":"Medicina intensiva","volume":"49 7","pages":"Article 502220"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Predictive performance of ROX index and its variations for NIV failure","authors":"Lada Lijović , Tomislav Radočaj , Nataša Kovač , Marinko Vučić , Paul Elbers","doi":"10.1016/j.medine.2025.502136","DOIUrl":"10.1016/j.medine.2025.502136","url":null,"abstract":"<div><h3>Objective</h3><div>To determine whether the ROX index and its variations can predict the risk of intubation in ICU patients receiving NIV ventilation using large public ICU databases.</div></div><div><h3>Design</h3><div>Retrospective observational cohort study.</div></div><div><h3>Setting</h3><div>Patient data was extracted from both the AmsterdamUMCdb and the MIMIC-IV ICU databases, which contained data related to 20,109 and 50,920 unique patients.</div></div><div><h3>Patients</h3><div>Non-invasively mechanically ventilated.</div></div><div><h3>Interventions</h3><div>Retrospective review of variables.</div></div><div><h3>Main variables of interest</h3><div>To assess the predictive values of models for each index, the ROX and its variations mROX, ROX-HR and mROX-HR were calculated based on mean values of SpO<sub>2</sub>, respiratory rate, FiO<sub>2</sub> and PaO<sub>2</sub> from 2-h windows within the first 12 h of NIV.</div></div><div><h3>Results</h3><div>3344 patients were eligible for analysis of which 1344 were intubated, died or returned to NIV within 24 h of ending NIV. NIV failure group had higher SOFA scores and higher CRP levels at admission. There was no difference in duration of NIV therapy or 28-day mortality, but patients who failed NIV had longer length of stay. The best performing index was ROX with an AUROC of 0.626 at 10−12 h. All other indices for all other time windows were less discriminating.</div></div><div><h3>Conclusions</h3><div>The performance of ROX index and its variations to predict NIV failure in ICU patients across large public ICU databases was moderate at best and cannot currently be recommended for clinical decision support.</div></div>","PeriodicalId":94139,"journal":{"name":"Medicina intensiva","volume":"49 7","pages":"Article 502136"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medicina intensivaPub Date : 2025-07-01DOI: 10.1016/j.medine.2024.502115
C.M. Marín Marín , P. García Moreno , R. Vicho Pereira
{"title":"Diagnosis of colitis by ultrasound in an Intensive Care Unit","authors":"C.M. Marín Marín , P. García Moreno , R. Vicho Pereira","doi":"10.1016/j.medine.2024.502115","DOIUrl":"10.1016/j.medine.2024.502115","url":null,"abstract":"","PeriodicalId":94139,"journal":{"name":"Medicina intensiva","volume":"49 7","pages":"Article 502115"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medicina intensivaPub Date : 2025-07-01DOI: 10.1016/j.medine.2025.502173
Jesús Abelardo Barea-Mendoza , Juan Antonio Llompart-Pou , Adrian Marcos-Morales , Mario Chico-Fernández
{"title":"Vasopressin: Why not in severe traumatic disease?","authors":"Jesús Abelardo Barea-Mendoza , Juan Antonio Llompart-Pou , Adrian Marcos-Morales , Mario Chico-Fernández","doi":"10.1016/j.medine.2025.502173","DOIUrl":"10.1016/j.medine.2025.502173","url":null,"abstract":"","PeriodicalId":94139,"journal":{"name":"Medicina intensiva","volume":"49 7","pages":"Article 502173"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medicina intensivaPub Date : 2025-07-01DOI: 10.1016/j.medine.2025.502159
Alfonso Canabal Berlanga
{"title":"Safety and efficacy of beta-blockers and amiodarone in the management of new-onset atrial fibrillation in critically ill patients with sepsis","authors":"Alfonso Canabal Berlanga","doi":"10.1016/j.medine.2025.502159","DOIUrl":"10.1016/j.medine.2025.502159","url":null,"abstract":"","PeriodicalId":94139,"journal":{"name":"Medicina intensiva","volume":"49 7","pages":"Article 502159"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medicina intensivaPub Date : 2025-07-01DOI: 10.1016/j.medine.2025.502162
Manuel Quintana-Diaz , Daniel Agustin Godoy
{"title":"Optimal hemoglobin levels in the neurocritical patient: Are we there yet?","authors":"Manuel Quintana-Diaz , Daniel Agustin Godoy","doi":"10.1016/j.medine.2025.502162","DOIUrl":"10.1016/j.medine.2025.502162","url":null,"abstract":"","PeriodicalId":94139,"journal":{"name":"Medicina intensiva","volume":"49 7","pages":"Article 502162"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}