Jordi A Matias-Guiu, Rosie E Curiel-Cid, Bruce P Hermann, David A Loewenstein
{"title":"A Call for Improving Clinical and Cognitive Assessments to Reduce the Gap Between Amyloid/Tau Pathology Onset and Detection of Cognitive Dysfunction.","authors":"Jordi A Matias-Guiu, Rosie E Curiel-Cid, Bruce P Hermann, David A Loewenstein","doi":"10.1111/jgs.19455","DOIUrl":"https://doi.org/10.1111/jgs.19455","url":null,"abstract":"<p><p>In this commentary, we discuss the new perspectives on the definition and criteria for Alzheimer's disease, particularly in relation to the biological and clinical-biological approaches. We argue that research must continue to focus on improving clinical and cognitive tools to contextualize biomarker findings and understand the clinical implications of different pathophysiological processes at the individual level. We propose several solutions, including the development of \"cognitive stress tests,\" digital clinical biomarkers, innovative analytical procedures, more refined studies for collecting rigorous and longitudinal normative data, and, ultimately, enhanced clinical skills. Overall, these strategies could help \"shorten\" the preclinical period and bridge the gap between the biological and clinical-biological approaches by aligning biomarker abnormalities with the onset of cognitive dysfunction more effectively.</p>","PeriodicalId":94112,"journal":{"name":"Journal of the American Geriatrics Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143757066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Short Story Changed How I Care for Persons Living With Dementia.","authors":"Jason Karlawish","doi":"10.1111/jgs.19454","DOIUrl":"https://doi.org/10.1111/jgs.19454","url":null,"abstract":"","PeriodicalId":94112,"journal":{"name":"Journal of the American Geriatrics Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143757067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David M Levine, Linda V DeCherrie, Albert Siu, Gabrielle Schiller, Chrisanne Timpe, Stephanie Murphy, Margaret Paulson, Christine Lum Lung, Michael Nottidge, Karen Titchener, Bruce Leff
{"title":"Practice Standards for Acute Hospital Care at Home.","authors":"David M Levine, Linda V DeCherrie, Albert Siu, Gabrielle Schiller, Chrisanne Timpe, Stephanie Murphy, Margaret Paulson, Christine Lum Lung, Michael Nottidge, Karen Titchener, Bruce Leff","doi":"10.1111/jgs.19427","DOIUrl":"https://doi.org/10.1111/jgs.19427","url":null,"abstract":"<p><strong>Background: </strong>Hospital at home (HaH) provides hospital-level care at home as a substitute for brick-and-mortar hospital care. Multiple HaH studies demonstrate HaH provides safe, high-quality, cost-effective care. However, practices have varied approaches to delivering care and no HaH-specific national standards exist. We aimed to develop national practice standards for HaH and assess practice performance against the standards.</p><p><strong>Methods: </strong>The HaH Users Group (HaHUG), the national convener of HaH practices, assembled the Practice Standards Council in 2019 to develop evidence-based standards for HaH. We reviewed existing international standards and the requirements of the Centers for Medicare and Medicaid Services Acute Hospital Care at Home Waiver. We engaged in multiple iterative rounds to develop domains and standards within each domain and then held an open comment period. We distributed an online survey for all HaHUG practices to self-assess whether they did not meet (score, -1), met (score, 0), or exceeded (score, +1) each standard. The American Hospital Association's Annual Survey was used to describe practices that did and did not complete the practice standards survey.</p><p><strong>Results: </strong>Final practice standards included 31 standards in 7 domains: leadership; education and training; human resources management; quality and quality improvement; safe practice and environment; and clinical standards and protocols. The majority of HaH practices self-rated that they met or exceeded standards: scores ranged from -5 to 31; mean score of 9.75 (SD, 12.60). Forty-nine of 213 eligible HaH practices completed the survey (response rate, 23.0%). Most hospitals were large (65% > 299 beds), nonprofit (85%), teaching (90%) centers that cared for a large proportion of patients with Medicaid.</p><p><strong>Conclusion: </strong>We present the first national practice standards for HaH. The vast majority of HaH practices met or exceeded these standards by their own assessment. There was a range of performance across standards, demonstrating strengths and opportunities for ongoing development and quality improvement.</p>","PeriodicalId":94112,"journal":{"name":"Journal of the American Geriatrics Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jimin J Lee, Émilie Bortolussi-Courval, Eva Filosa, Soham Rej, Claire Godard-Sebillote, Robyn Tamblyn, Todd C Lee, Emily G McDonald
{"title":"Criteria to Report Adverse Drug Withdrawal Events in Clinical Trials: A Systematic Review.","authors":"Jimin J Lee, Émilie Bortolussi-Courval, Eva Filosa, Soham Rej, Claire Godard-Sebillote, Robyn Tamblyn, Todd C Lee, Emily G McDonald","doi":"10.1111/jgs.19457","DOIUrl":"https://doi.org/10.1111/jgs.19457","url":null,"abstract":"<p><strong>Background: </strong>Polypharmacy is a major risk factor for adverse drug events (ADEs), which are a common cause of hospitalization, especially among older adults. Deprescribing is a promising strategy to prevent ADEs; however, clinicians may hesitate to deprescribe for fear of causing adverse drug withdrawal events (ADWEs). Collectively, ADWEs are the re-emergence of symptoms or a disease state due to the discontinuation of a medication. Although capturing ADWEs is critical to understanding the complications that might arise from deprescribing, these events may not be routinely or systematically captured in clinical trials.</p><p><strong>Objectives: </strong>We aimed to determine the frequency of ADWE reporting, compare the strengths and limitations of different approaches, and compare the rates of the number of ADWEs detected across trials.</p><p><strong>Methods: </strong>A systematic review was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist. The search strategy was developed with a research librarian, and studies were identified using Ovid Medline, Embase, and the Cochrane Central Register of Controlled Trials from inception to July 2, 2024. We included all randomized controlled trials testing a deprescribing intervention in older adults (mean or median age ≥ 65 years) and analyzed a subsample of the studies reporting ADWEs as an outcome.</p><p><strong>Results: </strong>Among the 139 eligible studies that were identified, only 12 reported an ADWE. These studies utilized 6 approaches to capture ADWEs: Naranjo ADWE Probability Scale; clinical monitoring for specific withdrawal symptoms; identification through ICD-10 codes; identification of ADWEs as a subset of confirmed ADEs; patient/caregiver self-report; and clinical judgment.</p><p><strong>Conclusion: </strong>Results confirmed that few deprescribing studies capture ADWEs and there is a lack of standardized reporting. A harmonized approach to capturing ADWEs with specific criteria could ensure more consistent results in deprescribing trials, improve our understanding of this important outcome, and facilitate future meta-analyses.</p>","PeriodicalId":94112,"journal":{"name":"Journal of the American Geriatrics Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anthony P Nunes, Heeyoon Jung, Yiyang Yuan, Jonggyu Baek, Jayne Pawasauskas, Anne L Hume, Shao-Hsien Liu, Kate L Lapane
{"title":"Comparative Safety of Short-Acting Opioid Dose Escalation and Long-Acting Opioid Initiation in Nursing Home Residents.","authors":"Anthony P Nunes, Heeyoon Jung, Yiyang Yuan, Jonggyu Baek, Jayne Pawasauskas, Anne L Hume, Shao-Hsien Liu, Kate L Lapane","doi":"10.1111/jgs.19417","DOIUrl":"https://doi.org/10.1111/jgs.19417","url":null,"abstract":"<p><strong>Background: </strong>For patients with continued pain while receiving an initial course of a short-acting opioid (SAO), clinicians may intensify the opioid regimen by escalating the SAO dose or initiating a long-acting opioid (LAO). The objective of this study was to assess the comparative safety of opioid intensification regimens in nursing home residents with nonmalignant pain.</p><p><strong>Methods: </strong>We conducted a retrospective cohort analysis of US long-stay nursing home residents identified from the national Minimum Data Set (MDS) 3.0 and linked Medicare data, 2011-2016. Opioid regimen changes were assessed using Part D claims to identify dose escalation of SAO, adding LAO to SAO, or a switch from SAO to LAO. The outcomes of interest were hospitalized falls/fractures and delirium identified in the MDS or hospitalization. Resident attributes were described by opioid regimen. Hazard ratios of study outcomes were quantified using as-treated (primary analysis) and intent-to-treat (secondary analysis) doubly robust inverse probability of treatment (IPT) weighted Fine & Gray regression models with a competing risk of death.</p><p><strong>Results: </strong>In the as-treated analysis, relative to residents in the SAO escalation cohort, the hazard of delirium was elevated in the LAO cohorts (aHR [LAO switch]: 2.05, 95% CI: 1.57-2.67; aHR [LAO add-on]: 1.55, 95% CI: 1.23-1.96). Results for falls and fractures were inconclusive. We did not observe evidence of an association with falls and fractures in the primary as-treated analysis; however, the intent-to-treat analysis observed increased hazards in the LAO switch cohort relative to the SAO escalation cohort (aHR 2.86, 95% CI:1.64-4.99).</p><p><strong>Conclusions: </strong>There is limited evidence to inform the clinical judgment between escalating the SAO dose or incorporating a LAO. Our study suggests increased risks of delirium in nursing home residents with nonmalignant pain when switching or adding an LAO to the opioid regimen relative to increasing the dose of SAOs.</p>","PeriodicalId":94112,"journal":{"name":"Journal of the American Geriatrics Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eric Kai-Chung Wong, Wanrudee Isaranuwatchai, Joanna E M Sale, Andrea C Tricco, Sharon E Straus, David M J Naimark
{"title":"Cost-Effectiveness of the Geriatrician-Led Comprehensive Geriatric Assessment in Different Healthcare Settings: An Economic Evaluation.","authors":"Eric Kai-Chung Wong, Wanrudee Isaranuwatchai, Joanna E M Sale, Andrea C Tricco, Sharon E Straus, David M J Naimark","doi":"10.1111/jgs.19448","DOIUrl":"https://doi.org/10.1111/jgs.19448","url":null,"abstract":"<p><strong>Background: </strong>With a shortage of geriatricians, the appropriate distribution of geriatricians across healthcare settings (e.g., acute care, rehabilitation, or community clinics) is unknown. Our objective was to determine which setting(s) geriatricians should preferentially staff to be most economically attractive for the Canadian healthcare system.</p><p><strong>Methods: </strong>We conducted a cost-effectiveness analysis using a two-dimensional microsimulation model. The model simulated a population of frail adults aged ≥ 65 years. The simulation was done over a lifetime horizon from the Ontario public payer perspective. Strategies included (1) usual care (baseline proportions of geriatrician CGAs in each setting), (2) acute care only (100% receive CGA in acute care), (3) community care only, (4) rehabilitation only, (5) acute care and community combined, (6) acute care and rehabilitation combined, (7) community and rehabilitation combined, and (8) acute care, community, and rehabilitation combined. Primary model outputs included quality-adjusted life months (QALMs), lifetime costs, and incremental cost-effectiveness ratios (ICERs).</p><p><strong>Results: </strong>The acute care and rehabilitation combined strategy was undominated at a lifetime cost of C$139,987 and with an effectiveness of 42.09 QALM. At an ICER of C$1203 per QALM, the combination strategy of acute care, rehabilitation, and community clinics was cost-effective relative to acute care and rehabilitation, assuming a cost-effectiveness threshold of C$4167 per QALM (equivalent to C$50,000 per quality-adjusted life year). The other six strategies were dominated. When individually compared to usual care, all of the strategies were dominant or cost-effective.</p><p><strong>Conclusions: </strong>An undominated strategy of staffing geriatricians was in the acute care and rehabilitation settings, with the option of adding community clinics if cost and resources permit.</p>","PeriodicalId":94112,"journal":{"name":"Journal of the American Geriatrics Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mushood Ahmed, Areeba Ahsan, Aimen Shafiq, Tallal Mushtaq Hashmi, Raheel Ahmed, Mahboob Alam, Farhan Shahid, Jamal S Rana, Mamas A Mamas, Gregg C Fonarow
{"title":"Invasive Versus Conservative Treatment Strategy in Older Patients With Non-ST Segment Elevation Acute Coronary Syndromes: A Meta-Analysis of Randomized Controlled Trials.","authors":"Mushood Ahmed, Areeba Ahsan, Aimen Shafiq, Tallal Mushtaq Hashmi, Raheel Ahmed, Mahboob Alam, Farhan Shahid, Jamal S Rana, Mamas A Mamas, Gregg C Fonarow","doi":"10.1111/jgs.19447","DOIUrl":"https://doi.org/10.1111/jgs.19447","url":null,"abstract":"<p><strong>Background: </strong>Non-ST segment elevation acute coronary syndromes (NSTE-ACS) are a common cause of hospital admission in older patients. Our study aims to synthesize the available evidence from randomized controlled trials (RCTs) to compare clinical outcomes with invasive versus conservative medical management in this population.</p><p><strong>Methods: </strong>A literature search of online databases including PubMed/MEDLINE, Embase, and the Cochrane Library was conducted from inception to September 1, 2024. The search aimed to identify RCTs that reported clinical outcomes with invasive versus conservative strategies in older patients (≥ 70 years) with NSTE-ACS. The risk ratios (RRs) were used as summary estimates.</p><p><strong>Results: </strong>Seven RCTs with 2998 patients were included; 1490 patients in the invasive group and 1508 patients in the conservatively managed group. The pooled analysis demonstrated no statistically significant difference between the two strategies for the risk of all-cause death (RR: 1.03, 95% CI: 0.92-1.15), cardiovascular death (RR: 1.04, 95% CI: 0.82-1.33), stroke (RR: 0.78, 95% CI: 0.53-1.15), and major bleeding (RR: 1.23, 95% CI: 0.90-1.69). However, the invasive strategy was associated with a significantly reduced risk of myocardial infarction (RR: 0.74, 95% CI: 0.57-0.96) and unplanned revascularization (RR: 0.29, 95% CI: 0.21-0.40) compared to the conservative strategy.</p><p><strong>Conclusion: </strong>In older patients with NSTE-ACS, an invasive strategy reduces the risk of repeat myocardial infarction and unplanned revascularization without a significant increase in stroke or major bleeding. There was no associated reduction in all-cause or cardiovascular mortality with the invasive strategy compared to conservative management.</p>","PeriodicalId":94112,"journal":{"name":"Journal of the American Geriatrics Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Change in Fall Status of Older People With Dementia and Caregiving Difficulties: Moderation Effects of Living Arrangements.","authors":"Yuanjin Zhou, Kylie Meyer, Ellliane Irani, Xiao Liu, Namkee Choi","doi":"10.1111/jgs.19442","DOIUrl":"https://doi.org/10.1111/jgs.19442","url":null,"abstract":"<p><strong>Objectives: </strong>We aim to investigate the associations between 2-year fall status among community-dwelling older people with dementia and care partners' emotional, physical, and financial difficulties, with living arrangements (co-residence vs. separate residence) as a moderator.</p><p><strong>Method: </strong>We used the 2015-2017 National Health and Aging Trends Study and the linked survey 2017 National Study of Caregiving (935 care partners for 567 community-dwelling older people with dementia). We employed multilevel generalized linear regression models to examine the associations of fall status between 2015 and 2017 with caregiving difficulties in 2017 for co-residing and non-co-residing care partners. We then evaluated the moderation effect of care partners' living arrangements.</p><p><strong>Results: </strong>For co-residing care partners, high (p = 0.001), increased (p = 0.001), and decreased (p = 0.001) fall frequency over 2 years was significantly associated with emotional difficulties. For non-co-residing care partners, high (p < 0.001), increased (p = 0.001), and decreased (p = 0.002) fall frequency was significantly associated with their physical difficulties. Compared to co-residing care partners, those who lived apart experienced greater physical difficulties when the fall frequency increased over 2 years (p < 0.05), but this effect became non-significant after the Bonferroni correction. High fall frequency was significantly associated with financial difficulties for co-residing (p = 0.009) and non-co-residing (p = 0.003) care partners, and decreased fall frequency was only significantly associated with financial difficulties for non-co-residing care partners (p = 0.018). All findings for financial difficulties became non-significant after the Bonferroni correction.</p><p><strong>Discussion: </strong>This study found differential associations between fall status over 2 years and care-related difficulties by care partners' living arrangements. Preventing falls for this population can potentially reduce the informal caregiving burden, especially the emotional difficulties for co-residing care partners and the physical difficulties of non-co-residing caregivers. Tailored interventions to manage fall risk among older people with dementia and support care partners with different living arrangements are crucial to improving their well-being.</p>","PeriodicalId":94112,"journal":{"name":"Journal of the American Geriatrics Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jennifer A Schrack, Amal A Wanigatunga, Nancy W Glynn, Michelle L Arnold, Sheila Burgard, Theresa H Chisolm, David Couper, Jennifer A Deal, Theresa Gmelin, Adele M Goman, Alison R Huang, Lisa Gravens-Mueller, Kathleen M Hayden, Pablo Martinez-Amezcua, Christine M Mitchell, James S Pankow, James R Pike, Nicholas S Reed, Victoria A Sanchez, Kevin J Sullivan, Josef Coresh, Frank R Lin
{"title":"Effects of Hearing Intervention on Physical Activity Measured by Accelerometry: A Secondary Analysis of the ACHIEVE Study.","authors":"Jennifer A Schrack, Amal A Wanigatunga, Nancy W Glynn, Michelle L Arnold, Sheila Burgard, Theresa H Chisolm, David Couper, Jennifer A Deal, Theresa Gmelin, Adele M Goman, Alison R Huang, Lisa Gravens-Mueller, Kathleen M Hayden, Pablo Martinez-Amezcua, Christine M Mitchell, James S Pankow, James R Pike, Nicholas S Reed, Victoria A Sanchez, Kevin J Sullivan, Josef Coresh, Frank R Lin","doi":"10.1111/jgs.19435","DOIUrl":"10.1111/jgs.19435","url":null,"abstract":"<p><strong>Background: </strong>Hearing loss is prevalent in older adults and is associated with reduced daily physical activity, but whether hearing intervention attenuates declines in physical activity is unknown. We investigated the 3-year effect of a hearing intervention versus a health education control on accelerometer-measured physical activity in older adults with hearing loss.</p><p><strong>Methods: </strong>This secondary analysis of the ACHIEVE randomized controlled trial included 977 adults aged 70-84 years with hearing loss. Participants were randomized to either a hearing intervention group or a health education control group. Physical activity was measured using wrist-worn accelerometers at baseline, 1, 2, and 3 years. Linear mixed models assessed the impact of the intervention on changes in total activity counts, active minutes per day, and activity fragmentation.</p><p><strong>Results: </strong>Among 847 participants in the final analysis (mean age 76.2 years; 440 [52%] women; 87 [10%] Black; 5 [0.8%] Hispanic), total activity counts declined by 2.7% annually, and active minutes/day declined by 2.1% annually over 3 years in both intervention and control groups. Activity patterns also became more fragmented over time. No appreciable differences were observed between hearing intervention and health education control in the 3-year change in accelerometry-measured physical activity measures.</p><p><strong>Conclusions: </strong>Hearing intervention did not appreciably attenuate 3-year declines in physical activity compared to health education control in older adults with hearing loss. Alternative strategies beyond hearing treatment may be needed to enhance physical activity among older adults with hearing loss.</p>","PeriodicalId":94112,"journal":{"name":"Journal of the American Geriatrics Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andreas Moses Appel, Christina Jensen-Dahm, Thomas Munk Laursen, Gunhild Waldemar, Janet Janbek
{"title":"The Effect of Influenza Vaccination on Hospitalization and Mortality Among People With Dementia.","authors":"Andreas Moses Appel, Christina Jensen-Dahm, Thomas Munk Laursen, Gunhild Waldemar, Janet Janbek","doi":"10.1111/jgs.19392","DOIUrl":"https://doi.org/10.1111/jgs.19392","url":null,"abstract":"<p><strong>Introduction: </strong>People with dementia have an increased risk for infection-related complications, which may be mitigated by common vaccinations. The aim was to investigate the association between influenza vaccination and the rates of all-cause and influenza-related hospitalizations and deaths among older adults with dementia.</p><p><strong>Methods: </strong>We followed all Danish residents with dementia aged 65 and above from September 1, 2002, to August 31, 2018. Dementia was defined from records in the Danish national registries (positive predictive value 85.8%). People with dementia were identified on September 1 of each year. On this date, vaccination status was also reset, and the status of covariates was assessed. We used proportional hazard Cox regression to compare rates of all-cause hospitalization, hospitalization with a respiratory infection, hospitalization with influenza or pneumonia, and all-cause mortality for vaccinated and unvaccinated.</p><p><strong>Results: </strong>Across the entire study period, we included 134,002 people with dementia. Rates of hospitalization were 9%-10% lower, and the mortality rate 9% lower, for vaccinated compared to unvaccinated among people with dementia.</p><p><strong>Discussion: </strong>Influenza vaccination was associated with lower rates of hospitalization and mortality among people with dementia. Further exploration of the preventive potential of influenza vaccination among people with dementia is important for shaping interventions in this vulnerable group.</p>","PeriodicalId":94112,"journal":{"name":"Journal of the American Geriatrics Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}