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Theranostic RGD@Fe3O4-Au/Gd NPs for the targeted radiotherapy and MR imaging of breast cancer TheranoticRGD@Fe3O4-Au/Gd NPs在癌症靶向放疗和MR成像中的应用
IF 5.7 2区 工程技术
Cancer Nanotechnology Pub Date : 2023-06-14 DOI: 10.1186/s12645-023-00214-6
A. Amraee, Z. Alamzadeh, Rasoul Irajirad, Abolfazl Sarikhani, H. Ghaznavi, Hossein Ghadiri Harvani, S. R. Mahdavi, Sakine Shirvalilou, S. Khoei
{"title":"Theranostic RGD@Fe3O4-Au/Gd NPs for the targeted radiotherapy and MR imaging of breast cancer","authors":"A. Amraee, Z. Alamzadeh, Rasoul Irajirad, Abolfazl Sarikhani, H. Ghaznavi, Hossein Ghadiri Harvani, S. R. Mahdavi, Sakine Shirvalilou, S. Khoei","doi":"10.1186/s12645-023-00214-6","DOIUrl":"https://doi.org/10.1186/s12645-023-00214-6","url":null,"abstract":"","PeriodicalId":9408,"journal":{"name":"Cancer Nanotechnology","volume":null,"pages":null},"PeriodicalIF":5.7,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47511169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An electrostatically conjugated-functional MNK1 aptamer reverts the intrinsic antitumor effect of polyethyleneimine-coated iron oxide nanoparticles in vivo in a human triple-negative cancer xenograft 一个静电偶联功能的MNK1适体在人三阴性肿瘤异种移植物体内恢复了聚乙烯亚胺包被氧化铁纳米颗粒固有的抗肿瘤作用
IF 5.7 2区 工程技术
Cancer Nanotechnology Pub Date : 2023-06-14 DOI: 10.1186/s12645-023-00204-8
Vladimir Mulens-Arias, Yadileiny Portilla, S. Pérez-Yagüe, R. Ferreras-Martín, M. E. Martín, V. Gonzalez, D. F. Barber
{"title":"An electrostatically conjugated-functional MNK1 aptamer reverts the intrinsic antitumor effect of polyethyleneimine-coated iron oxide nanoparticles in vivo in a human triple-negative cancer xenograft","authors":"Vladimir Mulens-Arias, Yadileiny Portilla, S. Pérez-Yagüe, R. Ferreras-Martín, M. E. Martín, V. Gonzalez, D. F. Barber","doi":"10.1186/s12645-023-00204-8","DOIUrl":"https://doi.org/10.1186/s12645-023-00204-8","url":null,"abstract":"","PeriodicalId":9408,"journal":{"name":"Cancer Nanotechnology","volume":null,"pages":null},"PeriodicalIF":5.7,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41734579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nickel-gallate metal–organic framework as an efficient antimicrobial and anticancer agent: in vitro study 没食子酸镍金属有机骨架作为高效抗菌抗癌剂的体外研究
IF 5.7 2区 工程技术
Cancer Nanotechnology Pub Date : 2023-06-09 DOI: 10.1186/s12645-023-00207-5
A. El-Shahawy, Esam M. Dief, S. El-Dek, A. Farghali, F. I. Abo El-Ela
{"title":"Nickel-gallate metal–organic framework as an efficient antimicrobial and anticancer agent: in vitro study","authors":"A. El-Shahawy, Esam M. Dief, S. El-Dek, A. Farghali, F. I. Abo El-Ela","doi":"10.1186/s12645-023-00207-5","DOIUrl":"https://doi.org/10.1186/s12645-023-00207-5","url":null,"abstract":"","PeriodicalId":9408,"journal":{"name":"Cancer Nanotechnology","volume":null,"pages":null},"PeriodicalIF":5.7,"publicationDate":"2023-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46504875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HB5 aptamer-tagged graphene oxide for co-delivery of doxorubicin and silibinin, and highly effective combination therapy in breast cancer HB5适配体标记的氧化石墨烯用于联合递送阿霉素和水飞蓟宾，以及乳腺癌的高效联合治疗
IF 5.7 2区 工程技术
Cancer Nanotechnology Pub Date : 2023-06-03 DOI: 10.1186/s12645-023-00212-8
M. Shahidi, B. Haghiralsadat, Omid Abazari, Mahdie Hemati, Parisa Dayati, H. Z. Jaliani, N. S. H. Motlagh, S. M. Naghib, A. Moradi
{"title":"HB5 aptamer-tagged graphene oxide for co-delivery of doxorubicin and silibinin, and highly effective combination therapy in breast cancer","authors":"M. Shahidi, B. Haghiralsadat, Omid Abazari, Mahdie Hemati, Parisa Dayati, H. Z. Jaliani, N. S. H. Motlagh, S. M. Naghib, A. Moradi","doi":"10.1186/s12645-023-00212-8","DOIUrl":"https://doi.org/10.1186/s12645-023-00212-8","url":null,"abstract":"","PeriodicalId":9408,"journal":{"name":"Cancer Nanotechnology","volume":null,"pages":null},"PeriodicalIF":5.7,"publicationDate":"2023-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42323665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in blood–brain barrier-crossing nanomedicine for anti-glioma 抗胶质瘤血脑屏障纳米药物研究进展
IF 5.7 2区 工程技术
Cancer Nanotechnology Pub Date : 2023-05-29 DOI: 10.1186/s12645-023-00211-9
Dongdong Liu, X. Dai, Zhen-chao Tao, Hu Zhou, Wenqing Hong, Haisheng Qian, Hongwei Cheng, Xianwen Wang
{"title":"Advances in blood–brain barrier-crossing nanomedicine for anti-glioma","authors":"Dongdong Liu, X. Dai, Zhen-chao Tao, Hu Zhou, Wenqing Hong, Haisheng Qian, Hongwei Cheng, Xianwen Wang","doi":"10.1186/s12645-023-00211-9","DOIUrl":"https://doi.org/10.1186/s12645-023-00211-9","url":null,"abstract":"","PeriodicalId":9408,"journal":{"name":"Cancer Nanotechnology","volume":null,"pages":null},"PeriodicalIF":5.7,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48225172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
ADAMTS9-AS1 inhibits tumor growth and drug resistance in clear cell renal cell carcinoma via recruiting HuR to enhance ADAMTS9 mRNA stability ADAMTS9-AS1通过募集HuR增强ADAMTS9 mRNA稳定性抑制透明细胞肾癌的肿瘤生长和耐药性
IF 5.7 2区 工程技术
Cancer Nanotechnology Pub Date : 2023-05-20 DOI: 10.1186/s12645-023-00210-w
Enyang Zhao, B. Geng, Ran Tao, Bosen You, Yunli Liu, Wen-Na Hou, Wanhui Wang, Changlin Wang, Xuedong Li
{"title":"ADAMTS9-AS1 inhibits tumor growth and drug resistance in clear cell renal cell carcinoma via recruiting HuR to enhance ADAMTS9 mRNA stability","authors":"Enyang Zhao, B. Geng, Ran Tao, Bosen You, Yunli Liu, Wen-Na Hou, Wanhui Wang, Changlin Wang, Xuedong Li","doi":"10.1186/s12645-023-00210-w","DOIUrl":"https://doi.org/10.1186/s12645-023-00210-w","url":null,"abstract":"","PeriodicalId":9408,"journal":{"name":"Cancer Nanotechnology","volume":null,"pages":null},"PeriodicalIF":5.7,"publicationDate":"2023-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46800598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early stage evaluation of cancer stem cells using platinum nanoparticles/CD133+ enhanced nanobiocomposite 铂纳米粒子/CD133+增强纳米生物复合材料对癌症干细胞的早期评价
IF 5.7 2区 工程技术
Cancer Nanotechnology Pub Date : 2023-05-20 DOI: 10.1186/s12645-023-00208-4
Solmaz Sadi, Balal Khalilzadeh, M. Mahdipour, Fatemeh Sokouti Nasimi, I. Isildak, S. Davaran, Mohammad Mehdi Rashidi, F. Bani
{"title":"Early stage evaluation of cancer stem cells using platinum nanoparticles/CD133+ enhanced nanobiocomposite","authors":"Solmaz Sadi, Balal Khalilzadeh, M. Mahdipour, Fatemeh Sokouti Nasimi, I. Isildak, S. Davaran, Mohammad Mehdi Rashidi, F. Bani","doi":"10.1186/s12645-023-00208-4","DOIUrl":"https://doi.org/10.1186/s12645-023-00208-4","url":null,"abstract":"","PeriodicalId":9408,"journal":{"name":"Cancer Nanotechnology","volume":null,"pages":null},"PeriodicalIF":5.7,"publicationDate":"2023-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48671748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting and sensitizing MDR cancer by an MMP2 and pH dual-responsive ZnO-based nanomedicine 基于MMP2和pH双重响应的ZnO纳米药物靶向和致敏MDR癌症
IF 5.7 2区 工程技术
Cancer Nanotechnology Pub Date : 2023-05-20 DOI: 10.1186/s12645-023-00205-7
Qing Zhou, Li Zhang, Yujiao Li, Jiao Wang, Xiaolu He, J. Zhang, Youbei Qiao, Hong Wu, Lin Zhu
{"title":"Targeting and sensitizing MDR cancer by an MMP2 and pH dual-responsive ZnO-based nanomedicine","authors":"Qing Zhou, Li Zhang, Yujiao Li, Jiao Wang, Xiaolu He, J. Zhang, Youbei Qiao, Hong Wu, Lin Zhu","doi":"10.1186/s12645-023-00205-7","DOIUrl":"https://doi.org/10.1186/s12645-023-00205-7","url":null,"abstract":"","PeriodicalId":9408,"journal":{"name":"Cancer Nanotechnology","volume":null,"pages":null},"PeriodicalIF":5.7,"publicationDate":"2023-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41699667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Generation of magnetic biohybrid microrobots based on MSC.sTRAIL for targeted stem cell delivery and treatment of cancer. 基于MSC的磁性生物混合微型机器人的研制。sTRAIL用于靶向干细胞输送和癌症治疗
IF 5.7 2区 工程技术
Cancer Nanotechnology Pub Date : 2023-05-19 DOI: 10.1186/s12645-023-00203-9
Rebekah Anamarie Gundersen, Tianyuan Chu, Kiana Abolfathi, Serap Gokcen Dogan, Phoebe Elizabeth Blair, Nyasha Nago, Michael Hamblin, Greg Nicholas Brooke, Ralf Michael Zwacka, Ali Kafash Hoshiar, Andrea Mohr
{"title":"Generation of magnetic biohybrid microrobots based on MSC.sTRAIL for targeted stem cell delivery and treatment of cancer.","authors":"Rebekah Anamarie Gundersen,&nbsp;Tianyuan Chu,&nbsp;Kiana Abolfathi,&nbsp;Serap Gokcen Dogan,&nbsp;Phoebe Elizabeth Blair,&nbsp;Nyasha Nago,&nbsp;Michael Hamblin,&nbsp;Greg Nicholas Brooke,&nbsp;Ralf Michael Zwacka,&nbsp;Ali Kafash Hoshiar,&nbsp;Andrea Mohr","doi":"10.1186/s12645-023-00203-9","DOIUrl":"10.1186/s12645-023-00203-9","url":null,"abstract":"<p><strong>Background: </strong>Combining the power of magnetic guidance and the biological activities of stem cells transformed into biohybrid microrobots holds great promise for the treatment of several diseases including cancer.</p><p><strong>Results: </strong>We found that human MSCs can be readily loaded with magnetic particles and that the resulting biohybrid microrobots could be guided by a rotating magnetic field. Rotating magnetic fields have the potential to be applied in the human setting and steer therapeutic stem cells to the desired sites of action in the body. We could demonstrate that the required loading of magnetic particles into stem cells is compatible with their biological activities. We examined this issue with a particular focus on the expression and functionality of therapeutic genes inside of human MSC-based biohybrid microrobots. The loading with magnetic particles did not cause a loss of viability or apoptosis in the human MSCs nor did it impact on the therapeutic gene expression from the cells. Furthermore, the therapeutic effect of the gene products was not affected, and the cells also did not lose their migration potential.</p><p><strong>Conclusion: </strong>These results demonstrate that the fabrication of guidable MSC-based biohybrid microrobots is compatible with their biological and therapeutic functions. Thus, MSC-based biohybrid microrobots represent a novel way of delivering gene therapies to tumours as well as in the context of other diseases.</p>","PeriodicalId":9408,"journal":{"name":"Cancer Nanotechnology","volume":null,"pages":null},"PeriodicalIF":5.7,"publicationDate":"2023-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47149190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lipo-MGN nanoparticle hypoxia attenuation-mediated single-dose radiotherapy- and pH/ROS-responsive T1 contrast magnetic resonance imaging in hepatocellular carcinoma Lipo-MGN纳米粒子缺氧衰减介导的肝细胞癌单剂量放疗和pH/ROS响应性T1对比磁共振成像
IF 5.7 2区 工程技术
Cancer Nanotechnology Pub Date : 2023-05-16 DOI: 10.1186/s12645-023-00182-x
R. Thomas, Subin Kim, Raveena Nagareddy, Veena Vijayan, Ansuja Mathew Pullickal, M. Yoon, I. Park, Y. Jeong
{"title":"Lipo-MGN nanoparticle hypoxia attenuation-mediated single-dose radiotherapy- and pH/ROS-responsive T1 contrast magnetic resonance imaging in hepatocellular carcinoma","authors":"R. Thomas, Subin Kim, Raveena Nagareddy, Veena Vijayan, Ansuja Mathew Pullickal, M. Yoon, I. Park, Y. Jeong","doi":"10.1186/s12645-023-00182-x","DOIUrl":"https://doi.org/10.1186/s12645-023-00182-x","url":null,"abstract":"","PeriodicalId":9408,"journal":{"name":"Cancer Nanotechnology","volume":null,"pages":null},"PeriodicalIF":5.7,"publicationDate":"2023-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45752701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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