Journal of dermatological science最新文献

{"title":"Visualization of intradermal blood vessel structures by dual-wavelength photoacoustic microscopy and characterization of three-dimensional construction of livedo-racemosa in cutaneous polyarteritis nodosa","authors":"Kazuyo Sujino ,&nbsp;Keiji Tanese ,&nbsp;Yasuko Saito ,&nbsp;Junko Kuramoto ,&nbsp;Hideaki Iwazaki ,&nbsp;Taiichiro Ida ,&nbsp;Sadakazu Aiso ,&nbsp;Nobuaki Imanishi ,&nbsp;Hiroki Kajita ,&nbsp;Keitaro Fukuda ,&nbsp;Masayuki Amagai ,&nbsp;Akiko Tanikawa","doi":"10.1016/j.jdermsci.2024.03.010","DOIUrl":"10.1016/j.jdermsci.2024.03.010","url":null,"abstract":"<div><h3>Background</h3><p>Photoacoustic microscopy is expected to have clinical applications as a noninvasive and three-dimensional (3D) method of observing intradermal structures.</p></div><div><h3>Objective</h3><p>Investigate the applicability of a photoacoustic microscope equipped with two types of pulsed lasers that can simultaneously recognize hemoglobin and melanin.</p></div><div><h3>Methods</h3><p>16 skin lesions including erythema, pigmented lesions, vitiligo and purpura, were analyzed to visualize 3D structure of melanin granule distribution and dermal blood vessels. 13 cases of livedo racemosa in cutaneous polyarteritis nodosa (cPN) were further analyzed to visualize the 3D structure of dermal blood vessels in detail. Vascular structure was also analyzed in the biopsy specimens obtained from tender indurated erythema of cPN by CD34 immunostaining.</p></div><div><h3>Results</h3><p>Hemoglobin-recognition signal clearly visualized the 3D structure of dermal blood vessels and melanin-recognition signal was consistently reduced in vitiligo. In livedo racemosa, the hemoglobin-recognition signal revealed a relatively thick and large reticular structure in the deeper layers that became denser and finer toward the upper layers. The numerical analysis revealed that the number of dermal blood vessels was 1.29-fold higher (p&lt;0.05) in the deeper region of the lesion than that of normal skin. The CD34 immunohistochemical analysis in tender indurated erythema revealed an increased number of dermal vessels compared with normal skin in 88.9% (8/9) of the cases, suggesting that vascular network remodeling had occurred in cPN.</p></div><div><h3>Conclusion</h3><p>The photoacoustic system has an advantage in noninvasively detecting dermal blood vessel structures that are difficult to recognize by two-dimensional histopathology specimen examination and is worth evaluating in various skin diseases.</p></div>","PeriodicalId":94076,"journal":{"name":"Journal of dermatological science","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0923181124000562/pdfft?md5=7d7bfd13601c7ef9c5cc256f9d4d7104&pid=1-s2.0-S0923181124000562-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140405902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lack of cutis verticis gyrata is associated with c.1279_1290del12 of SLCO2A1 in 43 Japanese patients with pachydermoperiostosis","authors":"H. Niizeki ,&nbsp;R. Tanaka ,&nbsp;T. Nomura ,&nbsp;A. Seki ,&nbsp;M. Miyasaka ,&nbsp;Y. Matsumoto ,&nbsp;M. Ishibashi ,&nbsp;S. Narumi ,&nbsp;K. Nakabayashi ,&nbsp;K. Yoshida","doi":"10.1016/j.jdermsci.2024.03.008","DOIUrl":"10.1016/j.jdermsci.2024.03.008","url":null,"abstract":"","PeriodicalId":94076,"journal":{"name":"Journal of dermatological science","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140399792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IL-4-induced decrease in both the number and CTLA-4 expression of Treg impairs suppression of Th2 type inflammation in severe atopic dermatitis","authors":"Bocheng Wang ,&nbsp;Zhiying Yu ,&nbsp;Jiao Liu ,&nbsp;Yuyang Tian ,&nbsp;Yijia Ruan ,&nbsp;Tinghui Kong ,&nbsp;Mingjun Hou ,&nbsp;Bihui Yu ,&nbsp;Shiqi Ling ,&nbsp;Di Wang ,&nbsp;Yishan Chen ,&nbsp;Yingping Xu ,&nbsp;Weiwei Deng ,&nbsp;Yunsheng Liang","doi":"10.1016/j.jdermsci.2024.03.007","DOIUrl":"10.1016/j.jdermsci.2024.03.007","url":null,"abstract":"<div><h3>Background</h3><p>T_reg plays a pivotal role in the suppression of Th2 cell and the maintenance of immune homeostasis. The precise molecular mechanism underlying the disruption of T_reg suppression of Th2 cell and the promotion of Th2 type inflammation in allergic diseases remains elusive.</p></div><div><h3>Objective</h3><p>This study aims to investigate the molecular mechanism underlying quantitative and functional changes of T_reg in AD.</p></div><div><h3>Methods</h3><p>The molecular mechanism was investigated using flow cytometry, mRNA sequencing, co-culture experiments, co-immunoprecipitation, chromatin immunoprecipitation, and bisulfite sequencing in vitro or in AD mice model and patients with AD.</p></div><div><h3>Results</h3><p>Increased proportion of T_reg was detected in mild and moderate AD. Conversely, characteristic decrease in both the number and CTLA-4 expression of T_reg was relevant to serum IL-4 level in severe AD patients, which was verified under a high concentration of IL-4 treatment in vitro. The underlying mechanism is that IL-4/pSTAT6 pathway recruits DNMT1 and HDAC2 to inhibit transcriptional regulation of Foxp3 and CTLA-4 loci. High level of IL-4 impaired the suppression of T_reg against Th2 cell differentiation mediated by CTLA-4, and blockade of IL-4Rα signaling in T_reg restored T_reg number and suppression of Th2 cell in AD model mice and patients with AD.</p></div><div><h3>Conclusion</h3><p>The number of T_reg is relevant to stratification of severity and serum IL-4 level in patients with AD. Abnormal high level of IL-4 epigenetically triggers a decrease in both the number and CTLA-4 expression of T_reg. The reduced expression of CTLA-4 on T_reg induced by IL-4 impairs suppression of Th2 cell differentiation.</p></div>","PeriodicalId":94076,"journal":{"name":"Journal of dermatological science","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140276538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"KTN1 mediated unfolded protein response protects keratinocytes from ionizing radiation-induced DNA damage","authors":"Xinli Niu ,&nbsp;Yi Shen ,&nbsp;Yunhan Wen,&nbsp;Xing Mi,&nbsp;Jing Xie,&nbsp;Ying Zhang,&nbsp;Zhenhua Ding","doi":"10.1016/j.jdermsci.2024.02.006","DOIUrl":"10.1016/j.jdermsci.2024.02.006","url":null,"abstract":"<div><h3>Background</h3><p>The unfolded protein response (UPR) is one of the cytoprotective mechanisms against various stresses and essential for the normal function of skin. Skin injury caused by ionizing radiation (IR) is a common side effect of radiotherapy and it is unclear how UPR affects IR-induced skin injury.</p></div><div><h3>Objectives</h3><p>To verify the effect of UPR on IR-induced DNA damage in keratinocytes and the relation between an endoplasmic reticulum (ER) protein KTN1 and UPR.</p></div><div><h3>Methods</h3><p>All experiments were performed on keratinocytes models: HaCaT and HEK-A. ER lumen and the expression levels of KTN1 and UPR pathway proteins (PERK, IRE1α and ATF6) were examined by transmission electron microscopy and immunoblotting, respectively. 4-PBA, an UPR inhibitor, was used to detected its effects on DNA damage and cell proliferation. Subsequently, the effects of KTN1 deletion on UPR, DNA damage and cell proliferation after IR were detected. Tunicamycin was used to reactivate UPR and then we examined its effects on DNA damage.</p></div><div><h3>Results</h3><p>UPR was activated by IR in keratinocytes. Inhibition of UPR aggravated DNA damage and suppressed cell proliferation after IR. KTN1 expression was upregulated by IR and KTN1 depletion reduced ER expansion and the expression of UPR-related proteins. Moreover, KTN1 depletion aggravated DNA damage and suppressed cell proliferation after IR could reversed by reactivation of UPR.</p></div><div><h3>Conclusion</h3><p>KTN1 deletion aggravates IR-induced keratinocyte DNA damage via inhibiting UPR. Our findings provide new insights into the mechanisms of keratinocytes in response to IR-induced damage.</p></div>","PeriodicalId":94076,"journal":{"name":"Journal of dermatological science","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S092318112400029X/pdfft?md5=739856660a84c089c0e3b2d867ba71a2&pid=1-s2.0-S092318112400029X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140011371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"JSID’s Fellowship Shiseido Research Grant","authors":"Manabu Ohyama (Secretary-General of JSID)","doi":"10.1016/j.jdermsci.2024.03.005","DOIUrl":"10.1016/j.jdermsci.2024.03.005","url":null,"abstract":"","PeriodicalId":94076,"journal":{"name":"Journal of dermatological science","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0923181124000513/pdfft?md5=f8c7392085493305488051f6e1f0026f&pid=1-s2.0-S0923181124000513-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140156442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rh family C glycoprotein contributes to psoriatic inflammation through regulating the dysdifferentiation and cytokine secretion of keratinocytes","authors":"Wei Liu,&nbsp;Yaqi Wang,&nbsp;Yitian Zhang,&nbsp;Mingzhu Zhou,&nbsp;Hanjiang Gu,&nbsp;Mei Lu,&nbsp;Yumin Xia","doi":"10.1016/j.jdermsci.2024.02.007","DOIUrl":"10.1016/j.jdermsci.2024.02.007","url":null,"abstract":"<div><h3>Background</h3><p>Keratinocyte dysdifferentiation and proinflammatory cytokine production play a central role in psoriatic inflammation. According to recent studies, the Rh family C glycoprotein (RHCG) enhances cell proliferation and disrupts cell differentiation. However, the specific role of RHCG psoriasis development remains unclear.</p></div><div><h3>Objective</h3><p>We here explored the effect of RHCG on keratinocytes under psoriatic inflammation.</p></div><div><h3>Methods</h3><p>The cell counting kit‑8 assay was conducted to assess proliferation. RHCG protein expression was assessed through western blotting and enzyme-linked immunosorbent assays. The expression of proinflammatory cytokines and differentiation markers was analyzed through a quantitative reverse-transcription polymerase chain reaction.</p></div><div><h3>Results</h3><p>Both RHCG mRNA and protein levels increased in psoriatic skin. Notably, cultured keratinocytes treated with an M5 cocktail, which mimics psoriatic inflammation, exhibited higher RHCG expression. Furthermore, RHCG overexpression promoted keratinocyte proliferation, accompanied by an increase in the production of interleukin (IL)-1β, IL-6, and IL-8, and tumor necrosis factor-α. RHCG overexpression also resulted in higher expression of keratin 17, a differentiation marker. Conversely, <em>RHCG</em> gene knockdown reduced keratinocyte proliferation and cytokine secretion. RHCG inhibition in cells recovered both keratin 1 and loricrin expression. Additionally, RHCG overexpression facilitated the phosphorylation of nuclear factor-kappa B and extracellular signal-regulated protein kinase signaling pathways. Importantly, when these signaling pathways were inhibited, the effect of RHCG on keratinocytes was attenuated.</p></div><div><h3>Conclusion</h3><p>These findings support the substantial role of RHCG in psoriatic inflammation development and suggest that RHCG serves as a potential target for psoriasis treatment.</p></div>","PeriodicalId":94076,"journal":{"name":"Journal of dermatological science","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140186668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editor's Choice","authors":"","doi":"10.1016/S0923-1811(24)00064-1","DOIUrl":"https://doi.org/10.1016/S0923-1811(24)00064-1","url":null,"abstract":"","PeriodicalId":94076,"journal":{"name":"Journal of dermatological science","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0923181124000641/pdfft?md5=ce9afcccb3e98cac39366ef4dc6c42cc&pid=1-s2.0-S0923181124000641-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140818357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High α-diversity of skin microbiome and mycobiome in Japanese patients with vitiligo","authors":"Yasutaka Kuroda ,&nbsp;Lingli Yang ,&nbsp;Takakazu Shibata ,&nbsp;Masahiro Hayashi ,&nbsp;Yuta Araki ,&nbsp;Makiko Nishida ,&nbsp;Takeshi Namiki ,&nbsp;Teruhiko Makino ,&nbsp;Tadamichi Shimizu ,&nbsp;Tamio Suzuki ,&nbsp;Tetsuya Sayo ,&nbsp;Yoshito Takahashi ,&nbsp;Daisuke Tsuruta ,&nbsp;Ichiro Katayama","doi":"10.1016/j.jdermsci.2024.02.008","DOIUrl":"10.1016/j.jdermsci.2024.02.008","url":null,"abstract":"<div><h3>Background</h3><p>Vitiligo is an acquired pigmentary disorder characterized by depigmented patches on the skin that majorly impact patients' quality of life. Although its etiology involves genetic and environmental factors, the role of microorganisms as environmental factors in vitiligo pathology remains under-researched.</p></div><div><h3>Objectives</h3><p>Our study explored the presence of characteristic bacterial and fungal flora in vitiligo-affected skin and investigated their potential roles in vitiligo pathogenesis.</p></div><div><h3>Methods</h3><p>We sequenced bacterial 16S rRNA and the fungal ITS1 region from skin swabs collected at frequently affected sites, namely the forehead and back, of patients with vitiligo. We analyzed bacterial and fungal flora in lesional and non-lesional areas of patients with vitiligo compared with corresponding sites in age- and sex-matched healthy subjects.</p></div><div><h3>Results</h3><p>Our findings revealed elevated α-diversity in both bacterial and fungal flora within vitiligo lesions compared with healthy controls. Notably, bacterial flora exhibited a distinctive composition in patients with vitiligo, and the proportional representation of <em>Enterococcus</em> was inversely correlated with the degree of vitiligo progression. <em>Gammaproteobacteria</em>, <em>Staphylococcus</em> spp., and <em>Corynebacterium</em> spp. were more abundant in vitiligo patients, with notable <em>Staphylococcus</em> spp. prevalence during the stable phase on the forehead. Conversely, the proportion of <em>Malassezia sympodialis</em> was lower and that of <em>Malassezia globosa</em> was higher in the progressive phase on the back of vitiligo patients.</p></div><div><h3>Conclusion</h3><p>Our study identified some characteristic bacterial and fungal groups associated with vitiligo activity and prognosis, highlighting the potential roles of microorganisms in pathogenesis and offering insights into personalized disease-management approaches.</p></div>","PeriodicalId":94076,"journal":{"name":"Journal of dermatological science","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0923181124000318/pdfft?md5=796a10391639e1c6cd440f6510cbb5c4&pid=1-s2.0-S0923181124000318-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140178327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcitriol modulates epidermal tight junction barrier function in human keratinocytes","authors":"Juan Valentin Trujillo-Paez ,&nbsp;Ge Peng ,&nbsp;Hai Le Thanh Nguyen ,&nbsp;Masahiro Nakamura ,&nbsp;Yoshie Umehara ,&nbsp;Hainan Yue ,&nbsp;Risa Ikutama ,&nbsp;Miho Takahashi ,&nbsp;Shigaku Ikeda ,&nbsp;Hideoki Ogawa ,&nbsp;Ko Okumura ,&nbsp;François Niyonsaba","doi":"10.1016/j.jdermsci.2024.02.001","DOIUrl":"10.1016/j.jdermsci.2024.02.001","url":null,"abstract":"<div><h3>Background</h3><p>The aberrant expression of tight junction (TJ) proteins play an important role in several diseases with impaired skin barriers, including atopic dermatitis, psoriasis, and chronic wounds. The evidence provided thus far suggests an important role of calcitriol in skin homeostasis. However, it is not known whether calcitriol improves the impaired skin barrier.</p></div><div><h3>Objective</h3><p>To investigate the effect of calcitriol on TJ barrier function in human primary keratinocytes.</p></div><div><h3>Methods</h3><p>Normal human primary keratinocytes were stimulated with calcitriol, and the expression of TJ-related proteins was measured by real-time PCR and Western blotting. Immunofluorescence was used to examine the intercellular distribution of TJ-related proteins. TJ barrier function was assessed by the transepithelial electrical resistance (TER) assay.</p></div><div><h3>Results</h3><p>We demonstrated that calcitriol increased the expression levels of TJ-related proteins, including claudin-4, claudin-7, occludin, and <em>zonula occludens</em> (ZO)− 1. Calcitriol enhanced the distribution of TJ-related proteins at cell<img>cell borders and induced the phosphorylation of pathways involved in the regulation of TJ barrier function, such as atypical protein kinase C (aPKC), Ras-related C3 botulinum toxin substrate 1 (Rac1), phosphoinositide 3-kinase (PI3K), and protein kinase B (Akt), as evidenced by the effects of specific inhibitors on the above pathways. Indeed, we confirmed that calcitriol enhanced TER in keratinocyte monolayers.</p></div><div><h3>Conclusion</h3><p>These findings showed that calcitriol could modify the expression of keratinocyte TJ proteins, contributing to the maintenance of homeostatic barrier function.</p></div>","PeriodicalId":94076,"journal":{"name":"Journal of dermatological science","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139830104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting antibody-mediated complement-independent mechanism in bullous pemphigoid with diacerein","authors":"Yung-Tsu Cho ,&nbsp;Chih-Hung Lee ,&nbsp;Jing-Yi Lee ,&nbsp;Chia-Yu Chu","doi":"10.1016/j.jdermsci.2024.03.001","DOIUrl":"10.1016/j.jdermsci.2024.03.001","url":null,"abstract":"<div><h3>Background</h3><p>Bullous pemphigoid (BP) is an antibody-mediated blistering disease predominantly affecting the elderly. The pathogenesis involves both complement-dependent and complement-independent mechanisms. The therapeutic potential of targeting complement-independent mechanism has not yet been determined. The mainstay of treatment, corticosteroid, has many side effects, indicating the needs of better treatments.</p></div><div><h3>Objective</h3><p>We tempted to establish an in vitro model of BP which resembles complement-independent mechanism and to examine the therapeutic potential of a novel anti-inflammatory agent, diacerein.</p></div><div><h3>Methods</h3><p>Cultured HaCaT cells were treated with purified antibodies from BP patients, with or without diacerein to measure the cell interface presence of BP180, protein kinase C, and the production of proinflammatory cytokines. An open-label, randomized, phase 2 trial was conducted to compare topical diacerein and clobetasol ointments in patients with mild-to-moderate BP (NCT03286582).</p></div><div><h3>Results</h3><p>The reduced presentation of BP180 at cell interface after treating with BP autoantibodies was noticed in immunofluorescence and western blotting studies. The phenomenon was restored by diacerein. Diacerein also reduced the autoantibody-induced increase of pro-inflammatory cytokines. Reciprocal changes of BP180 and protein kinase C at the cell interface were found after treating with BP autoantibodies. This phenomenon was also reversed by diacerein in a dose-dependent manner. The phase 2 trial showed that topical diacerein reduced the clinical symptoms which were comparable to those of topical clobetasol.</p></div><div><h3>Conclusion</h3><p>Diacerein inhibited BP autoantibody-induced reduction of BP180 and production of proinflammatory cytokines in vitro and showed therapeutic potential in patients with BP. It is a novel drug worthy of further investigations.</p></div>","PeriodicalId":94076,"journal":{"name":"Journal of dermatological science","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140074574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}