{"title":"Are we ready to integrate plaque radiomics into the prevention clinic? Not so fast!","authors":"Stephen J Nicholls, Andrew Lin","doi":"10.1016/j.jcct.2026.07.002","DOIUrl":"https://doi.org/10.1016/j.jcct.2026.07.002","url":null,"abstract":"","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148440447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Larissa Maria Isaac Maximo, William Border, Hunter C Wilson, Timothy Slesnick, Sanghee Ro
{"title":"Double outlet left ventricle: The importance of 3D imaging for diagnosis and management.","authors":"Larissa Maria Isaac Maximo, William Border, Hunter C Wilson, Timothy Slesnick, Sanghee Ro","doi":"10.1016/j.jcct.2026.06.016","DOIUrl":"https://doi.org/10.1016/j.jcct.2026.06.016","url":null,"abstract":"","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148427756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Karina Javalkar, Sunil J Ghelani, Stephen P Sanders, Nao Sasaki, Francesca Sperotto
{"title":"Not so right: An extremely rare case of anomalous origin of the right coronary artery from the left common carotid.","authors":"Karina Javalkar, Sunil J Ghelani, Stephen P Sanders, Nao Sasaki, Francesca Sperotto","doi":"10.1016/j.jcct.2026.06.018","DOIUrl":"https://doi.org/10.1016/j.jcct.2026.06.018","url":null,"abstract":"","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148427713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cardiac CT versus angiography for classifying single-versus dual-supply major aortopulmonary collateral arteries in infants: A paired non-inferiority study.","authors":"Khayri Shalhoub, Mohsin Ali, Sunil J Ghelani, Francesca Sperotto, Kimberlee Gauvreau, Ashwin Prakash, Nicola Maschietto","doi":"10.1016/j.jcct.2026.06.017","DOIUrl":"https://doi.org/10.1016/j.jcct.2026.06.017","url":null,"abstract":"<p><strong>Introduction: </strong>Accurate characterization of pulmonary blood flow is critical in patients with major aortopulmonary collaterals (MAPCAs). Although computed tomography (CT) has been shown to be accurate in delineating MAPCAs, its ability to differentiate between single- versus dual-supply MAPCAs is unclear. We investigated whether CT is non-inferior to angiography in discriminating single- versus dual-supply MAPCAs, while assessing procedural characteristics and outcomes.</p><p><strong>Methods: </strong>We retrospectively reviewed all patients with MAPCAs undergoing both CT and angiography (2016-2021). Images were independently reviewed by expert blinded readers. Diagnostic performance of CT in discriminating single- versus dual-supply MAPCAs was compared to angiography using non-inferiority paired testing.</p><p><strong>Results: </strong>Fifty-five MAPCAs in 17 patients were analyzed (median age at CT and angiography: 7 days [interquartile range, IQR, 1-745] and 74 days [IQR 49-751], respectively). Concordant classification (single/single and dual/dual) was observed in 53/55 vessels (96%); CT sensitivity and specificity was 97% (95% CI 84-100%) and 96% (95% CI 77-100%), respectively. CT versus angiography was non-inferior in discriminating single-versus dual-supply MAPCAs within 15%, 10%, and 5% margins (p < 0.001, p < 0.001, and p = 0.026). Inter-rater agreement between CT readers was excellent (91.3%, Kappa = 0.82). Compared to angiography, CT required less general anesthesia (p = 0.0001), lower radiation and contrast dose (p = 0.016; p < 0.001, respectively), and was associated with fewer complications (p = 0.008).</p><p><strong>Conclusions: </strong>CT is non-inferior to angiography in discriminating single- versus dual-supply MAPCAs. CT also requires less general anesthesia, lower radiation and contrast dose, and is associated with fewer complications. CT may potentially be used as initial diagnostic modality for MAPCAs delineation.</p>","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148427718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shihab Sarwar, Yoshito Kadoya, Valerie Shirobokov, Sayed Abdulmotaleb Almoosawy, Ghazal Razeghi, Gary R Small, Benjamin J W Chow, Kevin Emery Boczar
{"title":"Cardiac computed tomography imaging findings and perivascular adipose tissue fat attenuation index in patients with systemic vasculitis.","authors":"Shihab Sarwar, Yoshito Kadoya, Valerie Shirobokov, Sayed Abdulmotaleb Almoosawy, Ghazal Razeghi, Gary R Small, Benjamin J W Chow, Kevin Emery Boczar","doi":"10.1016/j.jcct.2026.06.015","DOIUrl":"https://doi.org/10.1016/j.jcct.2026.06.015","url":null,"abstract":"","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148407672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minju Han, Jaewook Chung, Seokhun Yang, Sang-Hyeon Park, Jinlong Zhang, Keehwan Lee, Doyeon Hwang, Kyu-Sun Lee, Sang-Hoon Na, Joon-Hyung Doh, Chang-Wook Nam, Tae Hyun Kim, Eun-Seok Shin, Eun Ju Chun, Su-Yeon Choi, Hyun Kuk Kim, Young Joon Hong, Hun-Jun Park, Song-Yi Kim, Mirza Husic, Jess Lambrechtsen, Jesper M Jensen, Bjarne L Nørgaard, Daniele Andreini, Pal Maurovich-Horvat, Bela Merkely, Martin Penicka, Bernard de Bruyne, Abdul Ihdayhid, Brian Ko, Georgios Tzimas, Jonathon Leipsic, Javier Sanz, Mark G Rabbat, Farhan Katchi, Moneal Shah, Nobuhiro Tanaka, Ryo Nakazato, Taku Asano, Mitsuyasu Terashima, Hiroaki Takashima, Tetsuya Amano, Yoshihiro Sobue, Hitoshi Matsuo, Hiromasa Otake, Takashi Kubo, Masahiro Takahata, Takashi Akasaka, Teruhito Kido, Teruhito Mochizuki, Hiroyoshi Yokoi, Taichi Okonogi, Tomohiro Kawasaki, Koichi Nakao, Tomohiro Sakamoto, Taishi Yonetsu, Tsunekazu Kakuta, Yohei Yamauchi, Jeroen J Bax, Leslee J Shaw, Peter H Stone, Jagat Narula, Bon-Kwon Koo
{"title":"Acute coronary syndrome risk in coronary side branch versus main vessel lesions: Lumen, plaque, and hemodynamic insights from coronary CT angiography.","authors":"Minju Han, Jaewook Chung, Seokhun Yang, Sang-Hyeon Park, Jinlong Zhang, Keehwan Lee, Doyeon Hwang, Kyu-Sun Lee, Sang-Hoon Na, Joon-Hyung Doh, Chang-Wook Nam, Tae Hyun Kim, Eun-Seok Shin, Eun Ju Chun, Su-Yeon Choi, Hyun Kuk Kim, Young Joon Hong, Hun-Jun Park, Song-Yi Kim, Mirza Husic, Jess Lambrechtsen, Jesper M Jensen, Bjarne L Nørgaard, Daniele Andreini, Pal Maurovich-Horvat, Bela Merkely, Martin Penicka, Bernard de Bruyne, Abdul Ihdayhid, Brian Ko, Georgios Tzimas, Jonathon Leipsic, Javier Sanz, Mark G Rabbat, Farhan Katchi, Moneal Shah, Nobuhiro Tanaka, Ryo Nakazato, Taku Asano, Mitsuyasu Terashima, Hiroaki Takashima, Tetsuya Amano, Yoshihiro Sobue, Hitoshi Matsuo, Hiromasa Otake, Takashi Kubo, Masahiro Takahata, Takashi Akasaka, Teruhito Kido, Teruhito Mochizuki, Hiroyoshi Yokoi, Taichi Okonogi, Tomohiro Kawasaki, Koichi Nakao, Tomohiro Sakamoto, Taishi Yonetsu, Tsunekazu Kakuta, Yohei Yamauchi, Jeroen J Bax, Leslee J Shaw, Peter H Stone, Jagat Narula, Bon-Kwon Koo","doi":"10.1016/j.jcct.2026.06.012","DOIUrl":"https://doi.org/10.1016/j.jcct.2026.06.012","url":null,"abstract":"<p><strong>Background: </strong>Risk assessment of coronary side branch (SB) lesions remains challenging because stenosis-based assessment alone often fails to identify clinically relevant lesions.</p><p><strong>Objectives: </strong>To characterize SB lesions associated with acute coronary syndrome (ACS), evaluate the performance of conventional main vessel (MV)-derived high-risk plaque criteria in SB lesions, and identify independent SB predictors of ACS.</p><p><strong>Methods: </strong>We analyzed 2451 coronary lesions (2011 MV, 440 SB) from the EMERALD-II study, in which coronary CT angiography was performed 1-36 months before ACS using an AI-assisted quantitative analysis platform. Lesion characteristics included stenosis severity, plaque burden, adverse plaque characteristics (APCs), and the change in CT-derived fractional flow reserve across the lesion (ΔFFR<sub>CT</sub>). Diagnostic performance of conventional high-risk plaque criteria was compared between MV and SB lesions.</p><p><strong>Results: </strong>Culprit lesions showed greater stenosis severity, plaque burden, APC count, and ΔFFR<sub>CT</sub> than non-culprit lesions in both vessels. However, these interrelationships were weaker in SB lesions. Among lesions meeting high-risk criteria, SB lesions were less often ACS culprits than MV lesions: ≥50% stenosis, 11.1% vs. 38.5%; plaque burden ≥70%, 8.6% vs. 23.8%; ≥2 APCs, 18.2% vs. 34.4%; and ΔFFR<sub>CT</sub> ≥0.10, 19.4% vs. 49.4%. Positive predictive values and F1-scores were consistently lower for SB lesions. APC count and ΔFFR<sub>CT</sub> were independent predictors of ACS in SB lesions.</p><p><strong>Conclusions: </strong>SB lesions had a substantially lower likelihood of subsequent ACS culprit status than equivalent MV lesions. These findings from AI-assisted CCTA analysis highlight the limitations of applying MV-derived thresholds to SB lesions and support the need for SB-specific risk assessment.</p>","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148400208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rakila Kurugalage, Arian Bhatia, Noreen Khan, Aditya Mukherjee, Jessica A Marathe, Peter J Psaltis
{"title":"Diagnostic accuracy of photon-counting CT for in-stent restenosis: A preliminary meta-analysis.","authors":"Rakila Kurugalage, Arian Bhatia, Noreen Khan, Aditya Mukherjee, Jessica A Marathe, Peter J Psaltis","doi":"10.1016/j.jcct.2026.06.014","DOIUrl":"https://doi.org/10.1016/j.jcct.2026.06.014","url":null,"abstract":"","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148400253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christoph Ryffel, Elena A Igual, Raffael Ghenzi, Magdalena Stuetz, Konstantinos Bitos, Julia Duelli, Andreas A Giannopoulos, Dominik C Benz, Aju P Pazhenkottil, Christoph Gräni, Philipp A Kaufmann, Ronny R Buechel
{"title":"Coronary calcium to rule out obstructive coronary artery disease in patients with non-anginal chest pain.","authors":"Christoph Ryffel, Elena A Igual, Raffael Ghenzi, Magdalena Stuetz, Konstantinos Bitos, Julia Duelli, Andreas A Giannopoulos, Dominik C Benz, Aju P Pazhenkottil, Christoph Gräni, Philipp A Kaufmann, Ronny R Buechel","doi":"10.1016/j.jcct.2026.06.011","DOIUrl":"https://doi.org/10.1016/j.jcct.2026.06.011","url":null,"abstract":"<p><strong>Background: </strong>The use of coronary artery calcium score (CACS) to rule out obstructive coronary artery disease (CAD) remains debated, with performance differing across symptomatic patient subgroups. However, in patients with non-anginal chest pain, CACS may be particularly effective in identifying those who can be deferred from further testing.</p><p><strong>Objectives: </strong>To investigate the ability of zero CACS to rule out obstructive CAD in a large cohort of patients presenting with non-anginal chest pain.</p><p><strong>Methods: </strong>Consecutive patients with non-anginal chest pain who were referred for coronary computed tomography angiography (CCTA) were retrospectively included. Obstructive CAD was defined as ≥1 vessel with ≥50% stenosis on CCTA. Hemodynamically significant CAD was defined as CT-FFR ≤0.80.</p><p><strong>Results: </strong>The study included 3212 patients (age 57 ± 10 years; 59% male). Among the 1404 patients (43.7%) with zero CACS, only 7 (0.5%) had obstructive CAD, resulting in a NPV of zero CACS to rule out obstructive CAD of 99.5%. Two patients (0.1%) exhibited hemodynamically significant CAD, resulting in an NPV of zero CACS of 99.9%. Finally, only one patient (0.7‰) was revascularized. Consequently, among patients with zero CACS, the number needed to test with CCTA was 201 to detect one with obstructive CAD, 702 to detect one with hemodynamically significant CAD, and 1404 to identify one requiring revascularization.</p><p><strong>Conclusions: </strong>In a large cohort of patients with non-anginal chest pain who were referred for CCTA, zero CACS offers excellent rule-out capabilities for obstructive CAD and may be used to defer patients from further testing with CCTA.</p>","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148383394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammed Khayyal, Abdulrahman Dajam, Mohamed Emad El Deen Negm, Mubarak Ali Al Shaia, Waleed I Alqahtani, Mohammed Attia
{"title":"Pseudoxanthoma elasticum with cardiovascular involvement: A case report highlighting extensive myocardial calcification.","authors":"Mohammed Khayyal, Abdulrahman Dajam, Mohamed Emad El Deen Negm, Mubarak Ali Al Shaia, Waleed I Alqahtani, Mohammed Attia","doi":"10.1016/j.jcct.2026.06.009","DOIUrl":"https://doi.org/10.1016/j.jcct.2026.06.009","url":null,"abstract":"","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148321116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}