JACS Au最新文献_第8页

Interface Feedback Effect in Molecular Tunnel Junctions.

IF 8.5

JACS Au Pub Date : 2025-02-14 eCollection Date: 2025-03-24 DOI: 10.1021/jacsau.4c01128

Yunxia Feng, Jinwei Chen, Ioan Bâldea, C Daniel Frisbie, Zuoti Xie

{"title":"Interface Feedback Effect in Molecular Tunnel Junctions.","authors":"Yunxia Feng, Jinwei Chen, Ioan Bâldea, C Daniel Frisbie, Zuoti Xie","doi":"10.1021/jacsau.4c01128","DOIUrl":"10.1021/jacsau.4c01128","url":null,"abstract":"Despite numerous prior studies on molecular tunnel junctions, many important questions remain about the nature of metal-molecule contacts. Using the conducting probe atomic force microscope (CP-AFM) platform, we report here an investigation of electrical contact effects in junctions based on oligophenylene and alkyl dithiols (OPDn, n = 1, 2, 3 and CnDT, n = 8, 9, 10) linked via thiol anchoring groups to dissimilar Ag, Au, and Pt metal electrodes. Our data reveal a peculiar effect: the two metal-molecule interfaces \"talk\" to each other, i.e., the choice of metal for the tip (t) electrode substantially changes the metal-HOMO electronic coupling Γ associated with the substrate (s) electrode, and vice versa. The metal-HOMO couplings Γt and Γs are not independent quantities. Their interdependence does not correlate with metal work function, chemisorption-driven work function change, or metal electronegativity, i.e., properties characterizing charge transfer at the molecule-metal interface. Overall, our results reveal an undiscovered complexity associated with electrical contacts in molecular tunnel junctions that must be considered in theoretical descriptions and ongoing efforts to design junctions with specific electronic functions.","PeriodicalId":94060,"journal":{"name":"JACS Au","volume":"5 3","pages":"1258-1267"},"PeriodicalIF":8.5,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthetic Cation Transporters Eradicate Drug-Resistant Staphylococcus aureus, Persisters, and Biofilms

IF 8.5

JACS Au Pub Date : 2025-02-13 DOI: 10.1021/jacsau.4c0119810.1021/jacsau.4c01198

Pak-Ming Fong, Victor Yat-Man Tang, Lu Xu, Bill Hin-Cheung Yam, Halebeedu Prakash Pradeep, Yuhui Feng, Liang Tao, Richard Yi-Tsun Kao* and Dan Yang*,

{"title":"Synthetic Cation Transporters Eradicate Drug-Resistant Staphylococcus aureus, Persisters, and Biofilms","authors":"Pak-Ming Fong, Victor Yat-Man Tang, Lu Xu, Bill Hin-Cheung Yam, Halebeedu Prakash Pradeep, Yuhui Feng, Liang Tao, Richard Yi-Tsun Kao* and Dan Yang*, ","doi":"10.1021/jacsau.4c0119810.1021/jacsau.4c01198","DOIUrl":"https://doi.org/10.1021/jacsau.4c01198https://doi.org/10.1021/jacsau.4c01198","url":null,"abstract":"New drugs are urgently required to address the ongoing health crisis caused by methicillin-resistant Staphylococcus aureus (MRSA) infections. Added to the challenge is the difficult-to-treat persister cells and biofilm which are tolerant to the antibiotics. Here we report a new approach to these problems, describing the design and synthesis of aminoxy-acid–based dipeptides that facilitate cation transport across cell membranes to disrupt bacterial ion homeostasis. Remarkably, these synthetic cation transporters display significant antibacterial activity against MRSA, while maintaining high selectivity over mammalian cells. They also effectively eliminate bacterial persisters and reduce established biofilms. Additionally, they inhibit biofilm formation and suppress bacterial virulent protein secretion, even at subinhibitory concentrations. Their associated antibiotic effects support their in vivo efficacy in murine skin and bloodstream MRSA infection models with no observable toxicity to the host. Mode-of-action analysis indicates that these cation transporters induce cytoplasmic acidification, hyperpolarization, and calcium influx, accelerating autolysis. Given their potent activity against bacterial persisters and biofilms, synthetic cation transporters are an emergent and promising class of compounds in the fight against MRSA infections.","PeriodicalId":94060,"journal":{"name":"JACS Au","volume":"5 3","pages":"1328–1339 1328–1339"},"PeriodicalIF":8.5,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/jacsau.4c01198","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143675733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering Dehalogenase Enzymes Using Variational Autoencoder-Generated Latent Spaces and Microfluidics.

IF 8.5

JACS Au Pub Date : 2025-02-13 eCollection Date: 2025-02-24 DOI: 10.1021/jacsau.4c01101

Pavel Kohout, Michal Vasina, Marika Majerova, Veronika Novakova, Jiri Damborsky, David Bednar, Martin Marek, Zbynek Prokop, Stanislav Mazurenko

{"title":"Engineering Dehalogenase Enzymes Using Variational Autoencoder-Generated Latent Spaces and Microfluidics.","authors":"Pavel Kohout, Michal Vasina, Marika Majerova, Veronika Novakova, Jiri Damborsky, David Bednar, Martin Marek, Zbynek Prokop, Stanislav Mazurenko","doi":"10.1021/jacsau.4c01101","DOIUrl":"10.1021/jacsau.4c01101","url":null,"abstract":"Enzymes play a crucial role in sustainable industrial applications, with their optimization posing a formidable challenge due to the intricate interplay among residues. Computational methodologies predominantly rely on evolutionary insights of homologous sequences. However, deciphering the evolutionary variability and complex dependencies among residues presents substantial hurdles. Here, we present a new machine-learning method based on variational autoencoders and evolutionary sampling strategy to address those limitations. We customized our method to generate novel sequences of model enzymes, haloalkane dehalogenases. Three design-build-test cycles improved the solubility of variants from 11% to 75%. Thorough experimental validation including the microfluidic device MicroPEX resulted in 20 multiple-point variants. Nine of them, sharing as little as 67% sequence similarity with the template, showed a melting temperature increase of up to 9 °C and an average improvement of 3 °C. The most stable variant demonstrated a 3.5-fold increase in activity compared to the template. High-quality experimental data collected with 20 variants represent a valuable data set for the critical validation of novel protein design approaches. Python scripts, jupyter notebooks, and data sets are available on GitHub (https://github.com/loschmidt/vae-dehalogenases), and interactive calculations will be possible via https://loschmidt.chemi.muni.cz/fireprotasr/.","PeriodicalId":94060,"journal":{"name":"JACS Au","volume":"5 2","pages":"838-850"},"PeriodicalIF":8.5,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11862945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering Dehalogenase Enzymes Using Variational Autoencoder-Generated Latent Spaces and Microfluidics

IF 8.5

JACS Au Pub Date : 2025-02-13 DOI: 10.1021/jacsau.4c0110110.1021/jacsau.4c01101

Pavel Kohout, Michal Vasina, Marika Majerova, Veronika Novakova, Jiri Damborsky, David Bednar, Martin Marek, Zbynek Prokop* and Stanislav Mazurenko*,

{"title":"Engineering Dehalogenase Enzymes Using Variational Autoencoder-Generated Latent Spaces and Microfluidics","authors":"Pavel Kohout, Michal Vasina, Marika Majerova, Veronika Novakova, Jiri Damborsky, David Bednar, Martin Marek, Zbynek Prokop* and Stanislav Mazurenko*, ","doi":"10.1021/jacsau.4c0110110.1021/jacsau.4c01101","DOIUrl":"https://doi.org/10.1021/jacsau.4c01101https://doi.org/10.1021/jacsau.4c01101","url":null,"abstract":"Enzymes play a crucial role in sustainable industrial applications, with their optimization posing a formidable challenge due to the intricate interplay among residues. Computational methodologies predominantly rely on evolutionary insights of homologous sequences. However, deciphering the evolutionary variability and complex dependencies among residues presents substantial hurdles. Here, we present a new machine-learning method based on variational autoencoders and evolutionary sampling strategy to address those limitations. We customized our method to generate novel sequences of model enzymes, haloalkane dehalogenases. Three design–build–test cycles improved the solubility of variants from 11% to 75%. Thorough experimental validation including the microfluidic device MicroPEX resulted in 20 multiple-point variants. Nine of them, sharing as little as 67% sequence similarity with the template, showed a melting temperature increase of up to 9 °C and an average improvement of 3 °C. The most stable variant demonstrated a 3.5-fold increase in activity compared to the template. High-quality experimental data collected with 20 variants represent a valuable data set for the critical validation of novel protein design approaches. Python scripts, jupyter notebooks, and data sets are available on GitHub (https://github.com/loschmidt/vae-dehalogenases), and interactive calculations will be possible via https://loschmidt.chemi.muni.cz/fireprotasr/.","PeriodicalId":94060,"journal":{"name":"JACS Au","volume":"5 2","pages":"838–850 838–850"},"PeriodicalIF":8.5,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/jacsau.4c01101","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetic Modifier Drug Valproic Acid Enhances Cancer Metaphase Chromosome Elasticity and Electron Transport: An Atomic Force Microscopy Approach

IF 8.5

JACS Au Pub Date : 2025-02-12 DOI: 10.1021/jacsau.4c0099110.1021/jacsau.4c00991

Tanya Agrawal, Debashish Paul, Amita Mishra, Ganesan Arunkumar and Tatini Rakshit*,

{"title":"Epigenetic Modifier Drug Valproic Acid Enhances Cancer Metaphase Chromosome Elasticity and Electron Transport: An Atomic Force Microscopy Approach","authors":"Tanya Agrawal, Debashish Paul, Amita Mishra, Ganesan Arunkumar and Tatini Rakshit*, ","doi":"10.1021/jacsau.4c0099110.1021/jacsau.4c00991","DOIUrl":"https://doi.org/10.1021/jacsau.4c00991https://doi.org/10.1021/jacsau.4c00991","url":null,"abstract":"The structural integrity of the chromosomes is essential to every functional process within eukaryotic nuclei. Chromosomes are DNA-histone complexes that are essential for the inheritance of genetic information to the offspring, and any defect in them is linked to mitotic errors, cancer growth, and cellular aging. Changes in the mechanical properties of a chromosome could lead to its compromised function and stability, leading to chromosome breaks. Here, we studied the changes in chromosome physical properties using metaphase chromosomes isolated from moderately malignant (MCF7) and highly malignant (MDA-MB-231) human breast cancer cells exposed to valproic acid (VPA), a known epigenetic modifier drug involved in histone hyperacetylation and DNA demethylation. Due to chromosomal structural intricacy and preparative and technical limitations of analytical tools, we employed a label-free atomic force microscopy approach for simultaneously visualizing and mapping single chromosome elasticity and stretching modulus. Additionally, we performed electron transport characteristics through metaphase chromosomes to elucidate the effect of VPA. The chromosomal elasticity and electron transport alterations are manifestations of VPA-mediated chromatin’s epigenetic changes. Our multiparametric strategy, as shown by receiver operating characteristics analyses with the physical properties of chromosomes, offers a new scope in terms of analytical tools for studying chromosomal structural changes/aberrations linked to cancer.","PeriodicalId":94060,"journal":{"name":"JACS Au","volume":"5 2","pages":"766–778 766–778"},"PeriodicalIF":8.5,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/jacsau.4c00991","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetic Modifier Drug Valproic Acid Enhances Cancer Metaphase Chromosome Elasticity and Electron Transport: An Atomic Force Microscopy Approach.

IF 8.5

JACS Au Pub Date : 2025-02-12 eCollection Date: 2025-02-24 DOI: 10.1021/jacsau.4c00991

Tanya Agrawal, Debashish Paul, Amita Mishra, Ganesan Arunkumar, Tatini Rakshit

{"title":"Epigenetic Modifier Drug Valproic Acid Enhances Cancer Metaphase Chromosome Elasticity and Electron Transport: An Atomic Force Microscopy Approach.","authors":"Tanya Agrawal, Debashish Paul, Amita Mishra, Ganesan Arunkumar, Tatini Rakshit","doi":"10.1021/jacsau.4c00991","DOIUrl":"10.1021/jacsau.4c00991","url":null,"abstract":"The structural integrity of the chromosomes is essential to every functional process within eukaryotic nuclei. Chromosomes are DNA-histone complexes that are essential for the inheritance of genetic information to the offspring, and any defect in them is linked to mitotic errors, cancer growth, and cellular aging. Changes in the mechanical properties of a chromosome could lead to its compromised function and stability, leading to chromosome breaks. Here, we studied the changes in chromosome physical properties using metaphase chromosomes isolated from moderately malignant (MCF7) and highly malignant (MDA-MB-231) human breast cancer cells exposed to valproic acid (VPA), a known epigenetic modifier drug involved in histone hyperacetylation and DNA demethylation. Due to chromosomal structural intricacy and preparative and technical limitations of analytical tools, we employed a label-free atomic force microscopy approach for simultaneously visualizing and mapping single chromosome elasticity and stretching modulus. Additionally, we performed electron transport characteristics through metaphase chromosomes to elucidate the effect of VPA. The chromosomal elasticity and electron transport alterations are manifestations of VPA-mediated chromatin's epigenetic changes. Our multiparametric strategy, as shown by receiver operating characteristics analyses with the physical properties of chromosomes, offers a new scope in terms of analytical tools for studying chromosomal structural changes/aberrations linked to cancer.","PeriodicalId":94060,"journal":{"name":"JACS Au","volume":"5 2","pages":"766-778"},"PeriodicalIF":8.5,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11862959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanobiosensors Enable High-Efficiency Detection of Tuberculosis Nucleic Acid.

IF 8.5

JACS Au Pub Date : 2025-02-12 eCollection Date: 2025-02-24 DOI: 10.1021/jacsau.4c01206

Mei Li, Chen Shen, Min Lv, Yao Luo

{"title":"Nanobiosensors Enable High-Efficiency Detection of Tuberculosis Nucleic Acid.","authors":"Mei Li, Chen Shen, Min Lv, Yao Luo","doi":"10.1021/jacsau.4c01206","DOIUrl":"10.1021/jacsau.4c01206","url":null,"abstract":"Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb), with a complex pathogenesis that poses a long-term threat to human health globally. Early and accurate diagnosis of TB provides a critical window for timely and effective treatment. The development of nucleic acid testing (NAT) based on polymerase chain reaction (PCR) has greatly improved the diagnostic efficiency of TB. However, balancing detection accuracy, efficiency, and cost in TB NAT remains challenging. Functionalized nanomaterials-based nanobiosensors have demonstrated exceptional performance in detecting TB nucleic acid by integrating their unique physicochemical properties with diverse biological probes that exploit Mtb characteristics to effectively amplify biological signals. Compared to traditional NAT, nanobiosensors simplify nucleic acid detection, improve accuracy, and reduce reliance on external conditions, thereby contributing to more immediate and accurate TB diagnosis. In this perspective, we provide a comprehensive summary and discussion on current strategies for detecting Mtb biomarkers using nucleic acid along with novel solutions for TB diagnosis. Additionally, we explore the advantages and challenges associated with applying nanotechnology to the clinical management of TB, particularly point-of-care testing (POCT).","PeriodicalId":94060,"journal":{"name":"JACS Au","volume":"5 2","pages":"536-549"},"PeriodicalIF":8.5,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11862950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enantioselective Total Synthesis of Taiwaniadducts I, J, and L 台湾加合物 I、J 和 L 的对映选择性全合成

IF 8.5

JACS Au Pub Date : 2025-02-12 DOI: 10.1021/jacsau.4c0127610.1021/jacsau.4c01276

Debgopal Jana, Arindam Khatua, Sourav Kundu, Suman Noskar, Monosij Nandy and Alakesh Bisai*,

{"title":"Enantioselective Total Synthesis of Taiwaniadducts I, J, and L","authors":"Debgopal Jana, Arindam Khatua, Sourav Kundu, Suman Noskar, Monosij Nandy and Alakesh Bisai*, ","doi":"10.1021/jacsau.4c0127610.1021/jacsau.4c01276","DOIUrl":"https://doi.org/10.1021/jacsau.4c01276https://doi.org/10.1021/jacsau.4c01276","url":null,"abstract":"The first enantioselective total synthesis of the structurally unique tetraterpenoid, (+)-taiwaniadduct J (1), has been accomplished via late-stage pericyclic reactions involving an intermolecular Diels–Alder reaction followed by an intramolecular [2 + 2]-cycloaddition reaction. In this reaction, trans-ozic acid methyl ester (20) serves as the diene (HOMO counterpart) and a p-benzoquinone of abeo-abietane 5 serves as the corresponding LUMO counterpart to affect the [4 + 2]-cycloaddition to set vicinal all-carbon quaternary stereogenic centers. In the process, the first total syntheses of (−)-taiwaniadducts I (2) and L (3) were also accomplished. The absolute configuration of (+)-taiwaniadduct J (1) was confirmed through an enantioselective total synthesis and X-ray analysis. This synthesis demonstrates the elegant application of pericyclic reactions, such as the Diels–Alder cycloaddition and [2 + 2] cycloaddition, to construct multiple quaternary centers in the synthesis of taiwaniadduct J (1).","PeriodicalId":94060,"journal":{"name":"JACS Au","volume":"5 3","pages":"1376–1381 1376–1381"},"PeriodicalIF":8.5,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/jacsau.4c01276","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143675731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipid-Directed Covalent Labeling of Plasma Membranes for Long-Term Imaging, Barcoding and Manipulation of Cells

IF 8.5

JACS Au Pub Date : 2025-02-12 DOI: 10.1021/jacsau.4c0113410.1021/jacsau.4c01134

Nathan Aknine, Remi Pelletier and Andrey S. Klymchenko*,

{"title":"Lipid-Directed Covalent Labeling of Plasma Membranes for Long-Term Imaging, Barcoding and Manipulation of Cells","authors":"Nathan Aknine, Remi Pelletier and Andrey S. Klymchenko*, ","doi":"10.1021/jacsau.4c0113410.1021/jacsau.4c01134","DOIUrl":"https://doi.org/10.1021/jacsau.4c01134https://doi.org/10.1021/jacsau.4c01134","url":null,"abstract":"Fluorescent probes for cell plasma membranes (PM) generally exploit a noncovalent labeling mechanism, which constitutes a fundamental limitation in multiple bioimaging applications. Here, we report a concept of lipid-directed covalent labeling of PM, which exploits transient binding to the lipid membrane surface generating a high local dye concentration, thus favoring covalent ligation to random proximal membrane proteins. This concept yielded fluorescent probes for PM called MemGraft, which are built of a dye (cyanine Cy3 or Cy5) bearing a low-affinity membrane anchor and a reactive group: an activated ester or a maleimide. In contrast to specially designed control dyes and commercial Cy3-based labels of amino or thiol groups, MemGraft probes stain efficiently PM, revealing the crucial role of the membrane anchor combined with optimal reactivity of the activated ester or the maleimide. MemGraft probes overcome existing limitations of noncovalent probes, which makes them compatible with cell fixation, permeabilization, trypsinization, and the presence of serum. The latter allows long-term cell tracking and video imaging of cell PM dynamics without the signs of phototoxicity. The covalent strategy also enables staining and long-term tracking of cocultured cells labeled in different colors without exchange of probes. Moreover, the combination of MemGraft-Cy3 and MemGraft-Cy5 probes at different ratios enabled long-term cell barcoding in at least 5 color codes, important for tracking and visualizing multiple populations of cells. Ultimately, we found that the MemGraft strategy enables efficient biotinylation of the cell surface, opening the path to cell surface engineering and cell manipulation.","PeriodicalId":94060,"journal":{"name":"JACS Au","volume":"5 2","pages":"922–936 922–936"},"PeriodicalIF":8.5,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/jacsau.4c01134","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enantioselective Total Synthesis of Taiwaniadducts I, J, and L. 台湾加合物 I、J 和 L 的对映选择性全合成。

IF 8.5

JACS Au Pub Date : 2025-02-12 eCollection Date: 2025-03-24 DOI: 10.1021/jacsau.4c01276

Debgopal Jana, Arindam Khatua, Sourav Kundu, Suman Noskar, Monosij Nandy, Alakesh Bisai

引用次数: 0