JACS Au最新文献

{"title":"All-Hydrocarbon Macrocycle Enables Highly Potent Th1-Biased NKT Cell Agonists for Immunotherapy","authors":"Qian-Nan Sun,&nbsp;Yu Wen,&nbsp;Ye-Hui Wu,&nbsp;De-Xiang Mei,&nbsp;Zheng-Qin Liu,&nbsp;Xiao-Ya An,&nbsp;Jun Guo","doi":"10.1021/jacsau.6c01038","DOIUrl":"https://doi.org/10.1021/jacsau.6c01038","url":null,"abstract":"<p>Immunotherapy has markedly advanced cancer treatment,with Th1-biasednatural killer T (NKT) cell agonists emerging as promising candidatesowing to their ability to induce potent antitumor immunity. However,α-galactosylceramide (αGalCer), the prototypical NKT agonist,induces mixed Th1/Th2 responses with antagonistic cytokine effects,limiting therapeutic selectivity. The development of potent immunostimulatoryagents promote Th1 polarization remains a major challenge. Herein,we convert the linear aliphatic chain of αGalCer into a conformationallyconstrained all-hydrocarbon macrocyclic scaffold, establishing thefirst report of a purely hydrocarbon macrocycle pharmacophore. Guidedby the structural architecture of the CD1d antigen-binding groove,this design preorganizes the aliphatic chain to optimize A′pocket occupancy, reduce entropic penalties, and enhance binding stability.αGalCer macrocyclized (<strong>GCC</strong>) analogs <strong>GCC-1</strong> and <strong>GCC-2</strong> elicited potent Th1-biased responses, withan approximately 12-fold increase in <em>in vivo</em> IFN-γproduction relative to αGalCer, establishing them as highlypotent Th1-biased NKT cell agonists. They exhibited potent immunologicalactivity as effective antitumor immunotherapeutic agents and antiviralSARS-CoV-2 vaccine adjuvants, while retaining robust responsivenessin human NKT cells. Collectively, these findings establish the all-hydrocarbonmacrocycle as a rational conformational constraint strategy for selectivelybiasing NKT cell responses, with potential applications in cancerimmunotherapy and vaccine development.</p>","PeriodicalId":94060,"journal":{"name":"JACS Au","volume":"6 9","pages":"5379–5394"},"PeriodicalIF":8.5,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149067546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cascade MHAT Radical Cyclopentannulation of Skipped Enyne to Access Highly Functionalized Carbocycles","authors":"Santosh J. Gharpure,&nbsp;Simran R. Narang,&nbsp;Rupali S. Chavan","doi":"10.1021/jacsau.6c01108","DOIUrl":"https://doi.org/10.1021/jacsau.6c01108","url":null,"abstract":"<p>An iron-mediated metal-hydride hydrogen atom transfer(MHAT) radicalcyclization cascade has been developed for the efficient constructionof highly functionalized carbocyclic frameworks. This versatile [3+2]cyclopentannulation strategy starting from skipped enynes providesrapid access to a broad range of alkylidene cyclopentanes/cyclopentenes.Termination of this cascade with various radical trapping agents allowsefficient construction of annulated products via successive C–H/C–C/C–C/C–Xbond (X = C, H, S, Se, Te, I) formation. The method allows an expeditiousentry into diquinanes, angular triquinanes with 4 quaternary carbons(3 contiguous) and substituted cyclopentadienes, all amenable to complexcarbocycle synthesis.</p>","PeriodicalId":94060,"journal":{"name":"JACS Au","volume":"6 9","pages":"4903–4909"},"PeriodicalIF":8.5,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149067467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Descriptor-Guided Design of High-Efficiency Narrowband Phosphorescent Probes for Bioimaging","authors":"Meihui Liu,&nbsp;Xuedong Qi,&nbsp;Zhengyang Li,&nbsp;Kaikai Wen,&nbsp;Hao Chen,&nbsp;Hui Huang,&nbsp;Daniel Escudero,&nbsp;Qian Peng","doi":"10.1021/jacsau.6c01042","DOIUrl":"https://doi.org/10.1021/jacsau.6c01042","url":null,"abstract":"<p>Organic room-temperature phosphorescence (ORTP) withnarrow emissionbands is highly attractive for high-contrast biomedical imaging. However,most ORTP systems suffer from low efficiency due to weak spin–orbitcoupling, and their emission spectra are often broadened by strongelectron-vibration coupling. Herein, we propose a descriptor-guideddesign framework to achieve efficient and narrowband ORTP throughintramolecular noncovalent conformational locks (NoCLs). Two fundamentaldescriptors are established to link structure to photophysical properties:the NoCL strength <em>S</em>, a rigidity metric that governselectron-vibration coupling and dictates spectral bandwidth, and theorbital character <em>γ</em>, which controls intersystemcrossing and determines triplet-state abundance. Using these descriptors,we design a series of benzophenone derivatives bearing NoCL and identifythe 2SOBr system, which exhibits the highest phosphorescence efficiencyof 58.22% among the explored narrowband ORTP emitters, with a fullwidth at half maximum 36 nm under ambient conditions. As a biologicalprobe, 2SOBr enables lysosome-specific cellular imaging with highsignal-to-noise ratios of 15.93, outperforming commercial green fluorescentprobes (&lt;10). This work establishes a quantitative structure-descriptor-propertyrelationship that provides a strategy for the design of efficientnarrowband organic phosphorescent materials and expands their potentialfor high-contrast optical imaging.</p>","PeriodicalId":94060,"journal":{"name":"JACS Au","volume":"6 9","pages":"5370–5378"},"PeriodicalIF":8.5,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149067468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Axial Ligand Effects on Electronic Structures and H-Atom Abstraction by Oxidoiron(IV) Complexes Featuring Triplet-Only Reactivity","authors":"Isabelle Becker,&nbsp;Massimiliano Morganti,&nbsp;Haowei Chen,&nbsp;Akhil Bhardwaj,&nbsp;Pilar Bologna,&nbsp;Guilherme Tripodi,&nbsp;Serhiy Demeshko,&nbsp;Sebastian Dechert,&nbsp;Jana Roithová,&nbsp;Frank Neese,&nbsp;Bhaskar Mondal,&nbsp;Shengfa Ye,&nbsp;Franc Meyer","doi":"10.1021/jacsau.6c00781","DOIUrl":"https://doi.org/10.1021/jacsau.6c00781","url":null,"abstract":"<p>Oxidoiron(IV) speciesare crucial intermediates for the functionalizationof C–H bonds by biological oxidases and oxygenases, and understandingthe relations between ligation, electronic structure, and reactivityof the Fe^IV═O unit is key to the rational designof bioinspired catalysts. Here, a series of Fe^IV═Ocomplexes based on a macrocyclic tetracarbene ligand and with differentanionic <em>trans</em>-axial ligands (L^ax = CF₃COO^–, ^<em>t</em>BuS^–, AdaS^–) has been comprehensivelycharacterized, including X-ray crystallography in two cases, as wellas zero-field and applied-field ⁵⁷Fe Mössbauer spectroscopy,magnetic susceptibility measurements, magnetic circular dichroism(MCD), and helium-tagging infrared photodissociation (IRPD). Thisestablishes a detailed picture of the electronic structures of theseferryl complexes, featuring a well-separated <em>S</em> =1 ground state, and the influence of the <em>trans</em>-ligand.The confinement to triplet-only pathways in C–H bond activationsand comparison with the parent Fe^IV═O complex (L^ax = MeCN) allow uncovering trends in hydrogen atom abstraction(HAA) ability without perturbations from different extents of two-statereactivity (TSR). Kinetic studies on HAA for C–H substrateswith BDEs up to 78 kcal mol^–1 show relatively minoreffects of the axial ligands, with rates following an electrophilictrend in the order L^ax = MeCN &gt; CF₃COO^– ≈ RS^–. This contrasts theantielectrophilictrend found for a related series of tetramethylcyclam (TMC)-basedFe^IV═O complexes for which TSR is dominant. Forthe present systems, temperature-dependent KIEs, in combination withcomputations at the DFT and ab initio levels of theory, suggest asemiclassical model with modest tunneling contributions that are mostpronounced in the case of a strongly donating <em>trans</em>-thiolate. This study thus provides a combined experimental and computationalbasis for understanding intrinsic axial ligand effects and the effectof a <em>trans</em>-axial thiolate in <em>S</em> =1 ferryl intermediates.</p>","PeriodicalId":94060,"journal":{"name":"JACS Au","volume":"6 9","pages":"5130–5144"},"PeriodicalIF":8.5,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149067488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whole-Cell Glycerol-free Fluorescence Cryo-Spectroscopy Reveals Electronic Excitation Dynamics in the Diatom Cyclotella meneghiniana","authors":"Lena Golubewa,&nbsp;Yaraslau Padrez,&nbsp;Patricija Zemaityte,&nbsp;Danielis Rutkauskas,&nbsp;Claudia Büchel,&nbsp;Andrius Gelzinis","doi":"10.1021/jacsau.6c00630","DOIUrl":"https://doi.org/10.1021/jacsau.6c00630","url":null,"abstract":"<p>Diatomspossess a unique photosynthetic apparatus that adapts toconstant, extreme changes in light intensity, enabling efficient lightharvesting and photoprotection. Fluorescence spectroscopy studiesat cryogenic temperatures can reveal details of the electronic excitationdynamics in these evolutionarily successful organisms. Whole-cellstudies are highly valuable since they allow investigation of thephotosynthetic machinery rather than separate complexes affected byisolation. In this study, we propose an approach that enables cryogenicfluorescence analysis of photosynthetic processes in the diatom <em>Cyclotella meneghiniana</em>, frozen in an intact stateat 16–130 K. We show the drastic effects on cell viabilitycaused by traditionally used glycerol-containing cryo-media, includingrapid cellular damage (with about 36% of cells losing membrane integrityimmediately upon medium exchange, reaching &gt;99% within 3.5 h),thylakoidmembrane disruption, likely detachment of fucoxanthin chlorophyllproteins (FCPs) from photosystem II (PSII) cores, and possible FCPaggregation. By omitting glycerol, we provide whole-cell cryo-measurementsof the photosynthetic apparatus in cells frozen in an intact stateand demonstrate the retention of some function (e.g., activation ofalternative electron transfer) of the photosynthetic complexes indamaged cells, which, however, differ from those in intact cells.We identified specific features of intact whole-cell temperature-dependentexcitation dynamics, including a gradual change in the relative contributionsof CP47 (690 nm) and CP43 (685 nm) emissions, slowed charge separationand energy transfer within PSII cores at low temperatures, and a monotonicincrease in PSI-FCP emission at 700 nm with decreasing temperature.Our results indicate that cryo-spectroscopy data obtained in glycerol-containingmedia should be interpreted with caution: cell viability must be ensuredbefore measurements, and pseudofunctioning of the photosynthetic machineryin damaged cells should be considered. This approach provides a reliableframework for investigating intact photosynthetic cells and offersnew insights into the complexity of excitation dynamics.</p>","PeriodicalId":94060,"journal":{"name":"JACS Au","volume":"6 9","pages":"5037–5054"},"PeriodicalIF":8.5,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149067604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conformational Preference Classification of Integrin-Binding Ligands Using Free Energy Perturbation","authors":"Martin Vögele,&nbsp;Rezvan Shahoei,&nbsp;Loukas Petridis,&nbsp;Jing Li,&nbsp;Fu-Yang Lin,&nbsp;Lingle Wang,&nbsp;Timothy A. Springer,&nbsp;Jeremie Vendome","doi":"10.1021/jacsau.6c00653","DOIUrl":"https://doi.org/10.1021/jacsau.6c00653","url":null,"abstract":"<p>Integrins are crucialcell adhesion receptors and attractive therapeutictargets, but developing safe small-molecule inhibitors has been challenging,at least in part due to inadvertent partial agonism caused by stabilizationof the integrin’s open, high-affinity state. To address thischallenge, we present a computational approach using Absolute BindingFree Energy Perturbation (AB-FEP) calculations to predict whethera ligand will stabilize the open or closed integrin states, leveragingthe difference between the ligand’s binding free energy tothe respective end states. Despite challenges posed by Ca and Mg ions,metal-coordinating residues in the binding pocket, and the subtletyof structural differences between states, AB-FEP achieved excellentclassification performance on a set of known opening and closing ligands,significantly outperforming docking scores and MM-GBSA results. Wealso showed a good correlation between AB-FEP binding free energydifferences and experimental values. Furthermore, AB-FEP providedinsights into intermediate integrin states and analysis of simulationtrajectories confirmed the formation of a water-mediated hydrogenbond network with an ion in the binding pocket to be characteristicfor closing ligands. This work demonstrates AB-FEP as a robust methodfor classifying integrin ligands by the conformation they stabilizeand for understanding their functional mechanisms, offering valuableguidance for designing safe and conformationally selective integrintherapeutics.</p>","PeriodicalId":94060,"journal":{"name":"JACS Au","volume":"6 9","pages":"5055–5067"},"PeriodicalIF":8.5,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149067574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging Visual Intuition and Chemical Expertise: A Virtual Collaborative Framework for Autonomous Nonadiabatic Dynamics Analysis","authors":"Yifei Zhu,&nbsp;Jiahui Zhang,&nbsp;Chuqiao Feng,&nbsp;Binni Huang,&nbsp;Wenyi Yang,&nbsp;Zhenggang Lan","doi":"10.1021/jacsau.6c01054","DOIUrl":"https://doi.org/10.1021/jacsau.6c01054","url":null,"abstract":"<p>Analyzing nonadiabaticmolecular dynamics trajectories traditionallyheavily relies on expert intuition and visual pattern recognition,a process that is difficult to formalize. We present VisU, a vision-drivenframework that leverages the complementary strengths of two state-of-the-artlarge language models (Doubao-Seed-1.6-Vision and DeepSeek-V3.2) toestablish a “virtual research cooperation”. This operatesthrough a “<em>Mentor–Engineer–Student</em>” paradigm that mimics the collaborative intelligence of aprofessional chemistry laboratory. Within this ecosystem, the <em>Mentor</em> provides physical intuition through visual reasoning,while the <em>Engineer</em> adaptively constructs analysisscripts, and the <em>Student</em> executes the pipeline andmanages the data and results. VisU autonomously orchestrates a four-stageworkflow comprising <em>Preprocessing</em>, <em>Recursive Channel Discovery</em>, <em>Important-Motion Identification</em>, and <em>Validation/Summary</em>. This systematic approachidentifies reaction channels and key nuclear motions while generatinga professional academic report at the end. By bridging visual insightwith chemical expertise, VisU establishes a new framework for human–AIcollaboration in the analysis of excited-state dynamics simulationresults, significantly reducing dependence on manual interpretationand enabling more intuitive, scalable mechanistic discovery in nonadiabaticdynamics simulations.</p>","PeriodicalId":94060,"journal":{"name":"JACS Au","volume":"6 9","pages":"5494–5509"},"PeriodicalIF":8.5,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149071170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Following Transient Conformational Adaptations during Peptide-Guided Calcium Phosphate Biomineralization with Hyperpolarized NMR","authors":"Fanny Kormout,&nbsp;Ertan Turhan,&nbsp;Mehdi Soussi-Therond,&nbsp;Milan Zachrdla,&nbsp;Dennis Kurzbach","doi":"10.1021/jacsau.6c01076","DOIUrl":"https://doi.org/10.1021/jacsau.6c01076","url":null,"abstract":"<p>Peptide-guided biomineralizationis a key process involvedin theformation of calcium phosphate (CaP) in bone, yet the peptide–ionencounter complexes at the onset of this process have remained structurallyinvisible: methods with sufficient resolution to decipher these intermediateswould already have lost them to precipitation. Here, we resolve howa mineralization peptide adapts its conformation to recruit inorganicions during the earliest stages of CaP formation. Using a peptidederived from the calcium-binding domain of secreted phosphoprotein1 (SPP1), a key regulator of bone formation, we find that Ca²⁺ association reorganizes the conformational ensemble toward stateswith increased solvent exposure of Ca²⁺-coated Asp-richstretches. These polyionic microenvironments subsequently exhibitspectral perturbations upon phosphate recruitment, consistent withthe formation of encounter complexes during the onset of CaP nucleationat the peptide–solvent interface. Access to these transientstates is enabled by NMR sensitized with hyperpolarized water (HyperW),which provides a two-order-of-magnitude sensitivity gain and reducesmultidimensional acquisition times from hours to seconds─fastenough to capture peptide–ion assemblies immediately afterencounter and before precipitation. Together, these results reveala stepwise mechanism by which an intrinsically disordered mineralizationpeptide senses and organizes calcium and phosphate ions at the onsetof biomineralization.</p>","PeriodicalId":94060,"journal":{"name":"JACS Au","volume":"6 9","pages":"5401–5409"},"PeriodicalIF":8.5,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149067581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Halogen-Guided Reconstructive Transformation of Hydroxycoumarin to Coumaranone","authors":"Yusuke Yoto,&nbsp;Yusei Matsumoto,&nbsp;Kotaro Kikushima,&nbsp;Mihoyo Fujitake,&nbsp;Hideyasu China,&nbsp;Toshifumi Dohi","doi":"10.1021/jacsau.6c00801","DOIUrl":"https://doi.org/10.1021/jacsau.6c00801","url":null,"abstract":"<p>Halogenation-drivenskeletal transformations play an importantrole in the biosynthesis of natural products, where halogenation canpromote C–C bond cleavage under mild conditions. Drawing inspirationfrom these biosynthetic processes, the halogenative skeletal reconstructionof hydroxycoumarins is reported, which unexpectedly facilitates carbonyldeletion to yield valuable heterocyclic scaffolds. Notably, cleavageof both the C–C and C–O bonds occurs under the mildestnonenzymatic conditions reported to date (low reaction temperatureand near-neutral reaction media), while also demonstrating broad substratescope. This transformation converts readily accessible hydroxycoumarinsinto biologically relevant coumaranone scaffolds via a halogen-identity-dependentdecarbonylative reconstruction. This work establishes halogenation-enabledcarbonyl deletion as a useful strategy for skeletal transformationand provides an efficient approach to molecular scaffold editing relevantto medicinal chemistry.</p>","PeriodicalId":94060,"journal":{"name":"JACS Au","volume":"6 9","pages":"5154–5162"},"PeriodicalIF":8.5,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149071075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Brittle to Ultraductile: Precise Ionic PEG with Dynamic Networks and Reconfigurable Crystallites","authors":"Jie Xu,&nbsp;Wenlin Zhang,&nbsp;Hung-Jue Sue,&nbsp;Shuyi Xie","doi":"10.1021/jacsau.6c00959","DOIUrl":"https://doi.org/10.1021/jacsau.6c00959","url":null,"abstract":"<p>Achieving high ductilityand toughness in semicrystalline polymerswithout sacrificing stiffness remains a longstanding challenge. Herewe show that sparse precise ionic functionalization can fundamentallyalter the mechanical behavior of a semicrystalline polymer. Ionicpoly(ethylene glycol) (iPEGs) containing precisely spaced imidazoliumgroups (∼1.5 mol %, every 62 repeat units) undergo a strikingtransition from brittle to ultraductile behavior, which exhibits stableneck propagation and apparent strain hardening at moderate molecularweight of 41 kDa. Tensile behavior, melt rheology, and X-ray scatteringspectra reveal that this highly ductile behavior arises from a coupledionic-semicrystalline architecture. Dynamic ionic associations introducelong-lived transient constraints that enhance the amorphous phaseresistance to deformation and sustain load-bearing connectivity betweencrystallites, while ionic incorporation suppresses lamellar thickeningand produces thin PEG crystallites capable of deformation-inducedreorganization. The resulting interplay between crystallite connectivity,tie-chain load transfer, and reconfigurable crystallites enable stableneck propagation rather than brittle fracture. These results establishsparse ionic “stickers” as a molecular design principlefor strengthening crystal-mobile semicrystalline polymers withoutintroducing additional phases or permanent covalent cross-links.</p>","PeriodicalId":94060,"journal":{"name":"JACS Au","volume":"6 9","pages":"5275–5286"},"PeriodicalIF":8.5,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149067520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}