International journal of hematology-oncology and stem cell research最新文献

{"title":"Human Wharton's Jelly Mesenchymal Stem Cells Improve Insulin Levels and Reduce Weight Gain in Aging Female Rats.","authors":"Wining Astini, Alif Iman Fitrianto, Adkhilni Utami, Adisti Dwijayanti, Frans Dyanagiri Suyatna, Adi Winarto, Arief Boediono","doi":"10.18502/ijhoscr.v20i2.21777","DOIUrl":"10.18502/ijhoscr.v20i2.21777","url":null,"abstract":"<p><p><b>Background:</b> This study aimed to analyze the effect of repeated intravenous injections of human Wharton's jelly mesenchymal stem cells (hWJ-MSCs), administered at a dose of 1 × 10⁶ cells/kg four times at 3-month intervals, on insulin levels and weight gain in aging female rats. <b>Materials and Methods:</b> Twelve female rats were divided into three groups: Group A (3-month-old young females, untreated control), Group B (24-month-old aged females injected with 0.4 mL of 0.9% NaCl as vehicle control), and Group C (24-month-old aged females injected with 1 × 10⁶ cells/kg of hWJ-MSCs suspended in 0.4 mL of 0.9% NaCl). Injections were administered at baseline and then every 3 months for a total of four doses. Twelve months after the first injection, the rats were anesthetized and sacrificed. Serum insulin levels were measured using ELISA, and immunohistochemical staining was performed to detect hWJ-MSCs homing to pancreatic tissue. <b>Results:</b> Rats treated with hWJ-MSCs showed a trend toward lower body weight compared to the aged vehicle-control group. Insulin levels in treated aged rats were significantly higher than those in the aged control group (p < 0.05). Immunohistochemical analysis revealed that hWJ-MSCs were extensively distributed within the islets of Langerhans of treated aged rats. <b>Conclusion:</b> Repeated intravenous administration of hWJ-MSCs (1 × 10⁶ cells/kg, four doses over 12 months) led to successful migration and homing to the islets of Langerhans in aging female rats. Treated animals exhibited significantly increased insulin levels and a trend toward reduced weight gain, suggesting a potential metabolic benefit of hWJ-MSC therapy in physiological aging.</p>","PeriodicalId":94048,"journal":{"name":"International journal of hematology-oncology and stem cell research","volume":"20 2","pages":"152-158"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13583152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148993169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review of Stem Cells in Iraqi Studies.","authors":"Maeda H Mohammad, Zaynab S Abdulganii, Aous Kahtan Almzaien, Ahmed Majeed Al-Shammari, Ayser A Ahmed, Hiba K Shaker, Aseel K Abedalsattar, Ahlam D Armash","doi":"10.18502/ijhoscr.v20i1.21014","DOIUrl":"10.18502/ijhoscr.v20i1.21014","url":null,"abstract":"<p><p>Over the past three decades, stem cell therapy has undergone rapid development and has emerged as a novel treatment for many major disorders. This systematic review aims to analyze the current landscape of stem cell research publications in Iraq comprehensively. By identifying and critically evaluating existing progress, this review provides a robust overview of the field, informing the development of a well-designed national roadmap for future advancements. This analysis serves as a valuable scientific reference both within Iraq and internationally, fostering further progress in Iraqi stem cell research. Data on Iraqi stem cell publications were collected from scientific databases such as the Iraqi Academic Scientific Journals Database, Google Scholar, Scopus, PubMed, Science Direct and other search engines. These publications were classified and analyzed to evaluate their status in the field. In our systematic review, we analyzed 132 articles on Iraqi stem cell research, including 21 review articles, 9 cancer stem cell studies, and 102 methodological studies, spanning from 1977-2024. Our findings highlight a rapid increase in publications, particularly in recent years, demonstrating significant progress in stem cell research within Iraq. Key areas of focus include the therapeutic applications of stem cells, cancer stem cells, and methodological advancements, with the majority of studies utilizing human, mouse, and rat samples. This comprehensive analysis underscores the evolving landscape and the need for continued collaboration and strategic planning in Iraqi stem cell research. Our systematic review revealed a significant increase in Iraqi stem cell research publications over recent years. This growth reflects substantial progress and the critical need for continued collaboration and strategic planning to further advance the field.</p>","PeriodicalId":94048,"journal":{"name":"International journal of hematology-oncology and stem cell research","volume":"20 1","pages":"59-77"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13249103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148221360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When the Skin Speaks for the Bone Marrow: Sweet Syndrome and Pancytopenia as the Initial Manifestation of Occult AML.","authors":"Sohrab Aghabeigi, Nooshin Ahmadvand, Seyedeh Mohadese Mosavi Mirkalaie, Azadeh Sedighi Moghadam, Arefeh Aref-Eshghi","doi":"10.18502/ijhoscr.v20i1.21017","DOIUrl":"10.18502/ijhoscr.v20i1.21017","url":null,"abstract":"<p><p>This case report describes the presentation for a 65-year-old patient with Sweet's syndrome (SS) presenting with systemic symptoms of general weakness, fever, and painful skin lesions on the right arm. He reported a history of weight loss with night sweats, while skin lesions manifested as erythematous plaques and painful papules. The diagnosis was confirmed by skin biopsy, which showed features of significant neutrophilic infiltration on histopathology. Further investigations led to the diagnosis of AML associated with Sweet's syndrome. The study highlights the importance of prompt diagnosis of Sweet's syndrome as a paraneoplastic sign and of using multidisciplinary approach for diagnosis and management of patients with skin lesions and cytopenias.</p>","PeriodicalId":94048,"journal":{"name":"International journal of hematology-oncology and stem cell research","volume":"20 1","pages":"110-116"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13249097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148220698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allogenic Umbilical Cord Mesenchymal Secretome for Knee Osteoarthritis: A Clinical Efficacy, Imaging and Safety Study.","authors":"Bintang Soetjahjo, Udi Herunefi, Rieva Ermawan, Rhyan Dharma Saputra, Denny Adriansyah","doi":"10.18502/ijhoscr.v20i1.21012","DOIUrl":"10.18502/ijhoscr.v20i1.21012","url":null,"abstract":"<p><p><b>Background:</b> Osteoarthritis (OA) is a disease that causes disability, limited joint movement, and limitations in daily activities. No agreed-upon therapy or procedure has been proven to prevent the damage caused by osteoarthritis. However, research on the use of conditioned media in experimental animals demonstrated healing of cartilage defects, as proven by macroscopic, microscopic, and immunohistochemical analysis. <b>Materials and Methods:</b> The research was conducted at Dr. Moewardi General Hospital, Surakarta, Central Java, Indonesia. This was a translational clinical trial that included patients with Kellgren-Lawrence grade 2-3 knee joint OA (n=10) treated with intra-articular injections of umbilical cord mesenchymal stem cell-conditioned media. Injections were administered five times at one-week intervals. Patients were evaluated at 2, 4, and 6 months. The data collected included KOOS, KSS, and WOMAC scores, as well as MRI T2 mapping sequence (CartiGram) examination. <b>Results:</b> Functional score assessment using KOOS, KSS, and WOMAC showed significant differences between pre-treatment scores and those at the 2nd, 4th, and 6th months post-treatment. However, there were no significant differences between the scores at the 2nd and 4th months, or between the 4th and 6th months. MRI T2 mapping sequence (CartiGram) showed improvement in cartilage signal in all samples. <b>Conclusion:</b> Allogenic umbilical cord mesenchymal stem cell-conditioned media therapy led to improvement in cartilage quality on MRI T2 mapping sequence (CartiGram) and in knee functional scores. No patients experienced direct side effects from the therapy.</p>","PeriodicalId":94048,"journal":{"name":"International journal of hematology-oncology and stem cell research","volume":"20 1","pages":"38-45"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13249131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148221344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paraneoplastic Pemphigus Mimicking Stevens-Johnson Syndrome in a Patient with Multiple Myeloma: A Rare and Clinically Challenging Presentation.","authors":"Zahra Keshavarz, Alireza Zangooie, Elias Sadooghi Rad, Roya Bojaran, Zahra Salehi","doi":"10.18502/ijhoscr.v20i1.21016","DOIUrl":"10.18502/ijhoscr.v20i1.21016","url":null,"abstract":"<p><p>Paraneoplastic pemphigus (PNP) is a rare, severe autoimmune mucocutaneous disorder most commonly associated with lymphoproliferative malignancies. Here, we report the first documented case of PNP as a paraneoplastic manifestation of multiple myeloma (MM). A 61-year-old male with MM developed widespread mucocutaneous ulcerations shortly after his eleventh chemotherapy cycle, initially suspected to represent Stevens-Johnson syndrome. Clinical examination revealed diffuse skin peeling, mucosal involvement of the eyes, oral cavity, and genital region, and a positive Nikolsky sign. Laboratory evaluation demonstrated acute kidney injury requiring hemodialysis. Despite initial treatment with high-dose intravenous immunoglobulin, lesions persisted. Skin biopsy revealed lichenoid lymphocytic infiltration, basal vacuolar changes, subcorneal and suprabasal acantholysis, and keratinocyte dyskeratosis, confirming PNP. Viral serologies were negative, supporting the autoimmune etiology. The patient was subsequently treated with rituximab, resulting in significant improvement of cutaneous lesions over three months, with residual post-inflammatory hyperpigmentation. This case emphasizes the importance of early recognition and accurate differentiation of PNP from other blistering disorders in patients with underlying hematologic malignancies. Importantly, this represents the first reported instance of PNP presenting as a paraneoplastic manifestation of MM, highlighting the need for awareness of atypical autoimmune syndromes in this population.</p>","PeriodicalId":94048,"journal":{"name":"International journal of hematology-oncology and stem cell research","volume":"20 1","pages":"103-109"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13255714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148255004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesenchymal Stem Cell Therapy for Oral Lichen Planus: A Paradigm Shift from Palliation to Regeneration.","authors":"Shahabodin Babaeifard, Mohaddese Marzban, Ghazaleh Kheiri, Leyla Sharifi Aliabadi, Ghazal Razani, Maryam Barkhordar","doi":"10.18502/ijhoscr.v20i1.21020","DOIUrl":"10.18502/ijhoscr.v20i1.21020","url":null,"abstract":"<p><p>Oral lichen planus (OLP) is a chronic, T-cell-mediated inflammatory disease of the oral mucosa, notable for its symptomatic burden and potential for malignant transformation. While corticosteroids and immunosuppressants remain the standard of care, their transient efficacy and adverse effect profile underscore a significant unmet clinical need. Mesenchymal stem cells (MSCs), with their multifaceted immunomodulatory and regenerative capabilities, are emerging as a compelling therapeutic alternative. This editorial synthesizes current evidence, positing that MSCs can fundamentally disrupt the immunopathogenic cycle of OLP. We explore the mechanisms by which MSCs re-establish immune tolerance and promote tissue repair, and we critically assess the translational pathway from preclinical models to clinical application. Despite promising results, the journey to clinical adoption necessitates overcoming hurdles in standardization, delivery, and safety profiling. We argue that MSC-based therapy represents not merely an incremental improvement, but a potential paradigm shift towards a curative strategy for this recalcitrant disease.</p>","PeriodicalId":94048,"journal":{"name":"International journal of hematology-oncology and stem cell research","volume":"20 1","pages":"97-102"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13255707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148254967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Burden Metastatic Prostate Cancer Mimicking Lymphoma: A Case of Extensive Lymphadenopathy.","authors":"Rahmat Cahyanur, Dimas Priantono, Andree Kurniawan, Fakhri Rahman, Lam Sihardo, Monik Ediana Miranda, Nur Rahadiani, Endang Farihatul Izza","doi":"10.18502/ijhoscr.v20i1.21019","DOIUrl":"10.18502/ijhoscr.v20i1.21019","url":null,"abstract":"<p><p>Supradiaphragmatic lymphadenopathy is a rare finding in prostate cancer. The occurrence of multiple lymphadenopathies forming a conglomerate that resembles lymphoma is also rarely encountered in prostate cancer diagnosis. We present the case of a 71-year-old man who has experienced bilateral leg swelling in the last four months. Multiple lymphadenopathies were detected in the intra-abdominal and supradiaphragmatic regions, along with several metastatic bone lesions. Histopathological and immunohistochemical evaluations confirmed a diagnosis of prostate adenocarcinoma, not otherwise specified (NOS), with a Gleason score of 4+3=7, classified as grade group III, indicating high-volume metastatic prostate cancer. The patient was treated with docetaxel and anti-androgen therapy. His condition improved after eight cycles of chemotherapy, and his prostate-specific antigen (PSA) levels returned to normal.</p>","PeriodicalId":94048,"journal":{"name":"International journal of hematology-oncology and stem cell research","volume":"20 1","pages":"122-126"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13249202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148221395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WT1 as a Biomarker in Myelodysplastic Neoplasms: Clinical Correlations and Preliminary Data from an Iranian Cohort.","authors":"Forouzan Bahmani, Farhad Zaker, Bahram Chahardouli, Majid Safa, Nasrin Alizadehghandforoush, Saeed Mohammadi, Mohsen Nikbakht, Shahrbano Rostami, Davood Babakhani, Ghasem Janbabaei","doi":"10.18502/ijhoscr.v20i1.21009","DOIUrl":"10.18502/ijhoscr.v20i1.21009","url":null,"abstract":"<p><p><b>Background:</b> Although Wilms' tumor 1 (WT1) mRNA overexpression is frequently observed in myelodysplastic neoplasms (MDS), its clinical and molecular significance remains incompletely defined across diverse populations; this study is the first to evaluate WT1 expression in Iranian patients with MDS. <b>Materials and Methods:</b> WT1 expression was assessed in 58 MDS patients using an ELN-certified quantitative RT-PCR assay. Associations with clinical subtype, hematologic features, cytogenetic profiles, and molecular mutations were analyzed. Survival outcomes were evaluated using Kaplan-Meier and Cox regression analyses. <b>Results:</b> WT1 overexpression was detected in 79.3% of patients and was significantly associated with advanced subtypes (MDS-EB1/EB2) and higher IPSS-R risk groups. Elevated WT1 levels correlated with an increased bone marrow (BM) blast percentage (P < 0.01). Although cytogenetic abnormalities were more frequent in patients with WT1 overexpression, the association did not reach statistical significance. No significant correlations were observed with peripheral blood (PB) cytopenias or mutations in RNA splicing genes. Importantly, WT1 overexpression was associated with shorter overall survival (OS) and progression-free survival (PFS). However, in multivariate analysis, ≥10% BM blasts and an abnormal karyotype remained independent predictors of poor outcome, whereas WT1 overexpression itself was not independently prognostic. <b>Conclusion:</b> WT1 overexpression in MDS is associated with advanced disease features and poorer survival, though it is not an independent prognostic value. Its measurement may complement existing risk stratification, particularly in resource-limited settings.</p>","PeriodicalId":94048,"journal":{"name":"International journal of hematology-oncology and stem cell research","volume":"20 1","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13249214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148220853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics and Outcomes of Pediatric Hemophagocytic Lymphohistocytosis: A Retrospective Study from a Tertiary Center in Jordan.","authors":"Rahaf Jadee' Bakheet Alhasan, Hebah Yousef Alraiqib, Basheer Alghizzawi, Abdelrahman Al-Sweedan, Suleimman Al-Sweedan","doi":"10.18502/ijhoscr.v20i1.21011","DOIUrl":"10.18502/ijhoscr.v20i1.21011","url":null,"abstract":"<p><p><b>Background:</b> Hemophagocytic lymphohistiocytosis (HLH) is a rare but severe hyperinflammatory syndrome caused by uncontrolled activation of macrophages and cytotoxic T cells. It is frequently underdiagnosed, leading to significant morbidity and mortality in pediatric populations. Early identification and treatment are critical to improving prognosis. <b>Materials and Methods:</b> This retrospective study analyzed demographic, clinical, and laboratory data of pediatric patients aged 0 to 18 years diagnosed with HLH according to the HLH-2004 criteria. Patients admitted to our center between February 2021 and February 2023 were included. We aimed to describe common presenting symptoms, laboratory abnormalities, treatment modalities, and patient outcomes. <b>Results:</b> A total of 35 children diagnosed with HLH were included; 51% were female. The mean age was 6.1 years, with an age range from birth to 18 years. Fever was the most frequent presenting symptom, reported in 85% of cases. Hemophagocytosis in bone marrow aspirates was detected in 41% of patients. The overall mortality rate was 11%. Notably, 20% of patients tested positive for anti-COVID-19 IgG antibodies, suggesting a possible temporal association with the development of HLH. Comparative analysis indicated that deceased patients had significantly lower fibrinogen levels (p = 0.04) and higher triglyceride levels (p = 0.03). Treatment regimens varied according to clinical presentation and severity. <b>Conclusion:</b> HLH remains a challenging diagnosis due to its variable presentation and potential to rapidly progress to life-threatening immune activation. Prompt recognition and timely initiation of appropriate therapy are vital for improving outcomes in affected children. Increased awareness among clinicians and early intervention can reduce morbidity and mortality associated with this condition.</p>","PeriodicalId":94048,"journal":{"name":"International journal of hematology-oncology and stem cell research","volume":"20 1","pages":"30-37"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13249100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148221380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone Marrow Metastasis of Embryonal Rhabdomyosarcoma in an Adult, Confounding as Acute Leukemia: A Diagnostic Challenge.","authors":"Shalini Singh, Jasmine Porwal, Karthik Kumar, Neha Singh, Uttam Kumar Nath","doi":"10.18502/ijhoscr.v20i1.21018","DOIUrl":"10.18502/ijhoscr.v20i1.21018","url":null,"abstract":"<p><p>Rhabdomyosarcoma (RMS) is a primitive mesenchymal malignancy of childhood and is very rare in adults. In the presence of a soft tissue mass, bone marrow metastasis of RMS is easy to diagnose. However, RMS can rarely present with extensive marrow replacement, without an obvious primary-a situation that is very challenging for the pathologist as well as the clinician. Owing to the classical round cell morphology, metastatic RMS is morphologically indistinguishable from acute leukemia, especially when the cells are singly scattered, rather than in clusters. We report a rare presentation of bone marrow metastasis of embryonal RMS in an adult, who presented only with pancytopenia and leucoerythroblastic blood picture. Bone marrow aspiration revealed near-total replacement of the hematopoietic elements by atypical blast-like cells, which were singly scattered as well as arranged in loose clusters focally. The case was worked up as acute leukemia. Flow cytometric immunophenotyping ruled out acute leukemia. The trephine biopsy was more in favor of a metastatic tumor; hence, a PET-CT was performed. The scan revealed diffuse uptake in the axial and appendicular skeleton, along with enlarged supraclavicular lymph nodes. An excision biopsy of the lymph node clinched the diagnosis of metastatic RMS, which was confirmed by immunohistochemistry for desmin and Myo-D1. This report highlights a rare case of adult embryonal RMS and emphasizes the importance of a multidisciplinary diagnostic approach for metastatic disease in this population.</p>","PeriodicalId":94048,"journal":{"name":"International journal of hematology-oncology and stem cell research","volume":"20 1","pages":"117-121"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13249204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148221352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}